GREMLIN Database
YABM - Uncharacterized membrane protein YabM
UniProt: P37555 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 532 (462)
Sequences: 15024 (12894)
Seq/√Len: 599.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
313_E316_I5.2631.00
458_M462_L3.6801.00
233_K237_L3.5411.00
108_G111_P3.3051.00
150_E153_P2.9801.00
50_Q281_D2.9401.00
385_Y388_F2.8921.00
357_T361_Q2.7781.00
351_F354_G2.7581.00
340_I361_Q2.6781.00
446_G449_I2.6491.00
149_H307_M2.5841.00
385_Y438_K2.5641.00
387_V391_I2.4691.00
256_D280_Y2.4631.00
343_L357_T2.4331.00
75_M147_G2.3681.00
106_Y126_Q2.3421.00
396_G427_V2.2301.00
362_V414_E2.1971.00
256_D404_N2.1891.00
352_Q355_E2.1711.00
403_L419_A2.1691.00
344_K348_I2.1371.00
338_G342_I2.1251.00
343_L361_Q2.1111.00
122_A126_Q2.0981.00
411_Y418_L2.0741.00
259_N408_V2.0731.00
369_F425_A2.0571.00
307_M311_N2.0421.00
308_A316_I2.0371.00
338_G489_V2.0311.00
244_V390_A2.0171.00
319_E323_S2.0091.00
74_L238_Y1.9991.00
359_A413_I1.9801.00
362_V421_A1.9401.00
392_A430_L1.9381.00
493_G497_I1.9361.00
18_V152_L1.9081.00
110_V122_A1.9061.00
256_D420_T1.9051.00
455_A458_M1.8961.00
229_K233_K1.8841.00
330_V500_M1.8601.00
408_V416_A1.8561.00
321_I379_V1.8471.00
314_L318_K1.8401.00
42_G45_G1.8391.00
85_T228_T1.8341.00
446_G450_P1.8221.00
259_N404_N1.8211.00
450_P453_G1.8121.00
453_G457_L1.7841.00
407_L411_Y1.7831.00
457_L461_V1.7641.00
228_T231_L1.7571.00
342_I345_P1.7461.00
109_A126_Q1.7381.00
316_I319_E1.7201.00
332_G371_S1.7191.00
399_V426_A1.7091.00
404_N408_V1.7021.00
105_L129_A1.6991.00
10_H14_Q1.6911.00
450_P454_S1.6841.00
461_V495_V1.6771.00
73_K77_D1.6751.00
415_G419_A1.6501.00
336_S368_L1.6371.00
309_V383_A1.6301.00
362_V417_S1.6181.00
342_I346_V1.6091.00
429_G433_Y1.5951.00
305_I317_M1.5931.00
165_R169_L1.5751.00
77_D384_G1.5701.00
454_S458_M1.5651.00
52_V128_A1.5631.00
84_H88_K1.5601.00
344_K361_Q1.5471.00
344_K357_T1.5341.00
351_F355_E1.5331.00
248_L394_G1.5221.00
39_N352_Q1.5171.00
347_N356_G1.5101.00
260_L277_K1.5081.00
38_Q282_R1.5001.00
189_A193_G1.4991.00
162_Q165_R1.4961.00
345_P348_I1.4831.00
447_V450_P1.4821.00
276_L413_I1.4791.00
447_V451_I1.4771.00
391_I395_A1.4701.00
315_K319_E1.4691.00
369_F428_A1.4681.00
87_L144_G1.4601.00
170_L174_F1.4551.00
463_L467_R1.4371.00
362_V418_L1.4371.00
366_S421_A1.4361.00
358_G414_E1.4351.00
149_H304_Y1.4311.00
358_G361_Q1.4231.00
419_A423_S1.4221.00
301_L324_S1.4101.00
318_K322_T1.4051.00
24_V28_I1.3971.00
392_A434_Q1.3961.00
339_L364_S1.3941.00
317_M379_V1.3881.00
445_R449_I1.3861.00
412_G415_G1.3821.00
117_G120_H1.3751.00
402_V406_L1.3721.00
400_K404_N1.3711.00
406_L409_P1.3711.00
433_Y437_Q1.3601.00
264_L276_L1.3571.00
144_G148_R1.3521.00
259_N405_T1.3521.00
359_A417_S1.3511.00
283_G359_A1.3491.00
51_Q261_Y1.3381.00
451_I454_S1.3341.00
347_N360_L1.3281.00
49_Y53_Y1.3241.00
255_V401_W1.3211.00
168_V171_G1.3201.00
400_K420_T1.3201.00
260_L264_L1.3131.00
34_R285_P1.3071.00
496_F500_M1.2981.00
316_I320_K1.2971.00
458_M461_V1.2841.00
459_S463_L1.2831.00
124_L191_A1.2831.00
407_L419_A1.2761.00
50_Q278_G1.2701.00
152_L156_L1.2701.00
365_C421_A1.2681.00
407_L410_R1.2621.00
336_S340_I1.2571.00
109_A122_A1.2511.00
347_N357_T1.2511.00
309_V317_M1.2501.00
150_E212_T1.2491.00
264_L413_I1.2411.00
43_D279_I1.2391.00
406_L410_R1.2371.00
110_V126_Q1.2361.00
464_A467_R1.2341.00
314_L383_A1.2311.00
449_I453_G1.2281.00
404_N407_L1.2271.00
25_I159_M1.2271.00
497_I501_M1.2221.00
260_L416_A1.2171.00
90_S235_L1.2151.00
308_A320_K1.2121.00
499_C503_L1.2091.00
71_I90_S1.2061.00
31_A35_V1.2051.00
279_I356_G1.2021.00
93_F232_T1.2011.00
70_I238_Y1.2001.00
450_P458_M1.1961.00
80_E311_N1.1921.00
168_V172_L1.1891.00
338_G492_G1.1891.00
206_G210_F1.1851.00
399_V403_L1.1831.00
462_L466_T1.1831.00
322_T326_K1.1791.00
404_N420_T1.1791.00
392_A431_N1.1781.00
161_E165_R1.1771.00
278_G282_R1.1741.00
321_I376_A1.1721.00
241_T390_A1.1711.00
489_V493_G1.1691.00
339_L360_L1.1681.00
457_L465_Y1.1651.00
463_L466_T1.1631.00
165_R168_V1.1621.00
203_I207_F1.1551.00
77_D81_K1.1541.00
171_G175_W1.1481.00
43_D278_G1.1481.00
77_D234_K1.1481.00
414_E417_S1.1471.00
89_I232_T1.1421.00
433_Y436_R1.1361.00
486_L490_A1.1341.00
76_N147_G1.1341.00
102_F106_Y1.1301.00
133_L136_P1.1251.00
35_V39_N1.1211.00
113_A121_L1.1201.00
450_P457_L1.1181.00
457_L499_C1.1151.00
305_I382_G1.1151.00
107_L110_V1.1121.00
443_K446_G1.1091.00
240_V244_V1.1081.00
329_L333_T1.1081.00
172_L177_V1.1071.00
283_G356_G1.1021.00
376_A431_N1.1011.00
256_D400_K1.1011.00
411_Y415_G1.0991.00
394_G398_A1.0961.00
164_L168_V1.0901.00
287_L363_F1.0821.00
398_A402_V1.0791.00
78_Y83_H1.0781.00
70_I235_L1.0761.00
234_K384_G1.0751.00
134_L199_L1.0741.00
192_S196_A1.0741.00
22_A155_A1.0721.00
251_F397_V1.0651.00
302_V306_S1.0631.00
151_M300_S1.0621.00
265_S276_L1.0611.00
346_V350_L1.0601.00
308_A313_E1.0541.00
460_A464_A1.0471.00
96_L99_I1.0441.00
106_Y110_V1.0421.00
391_I394_G1.0411.00
188_A191_A1.0401.00
19_L300_S1.0391.00
238_Y386_T1.0341.00
334_G496_F1.0331.00
34_R351_F1.0311.00
173_S176_L1.0301.00
168_V193_G1.0291.00
403_L407_L1.0261.00
167_A171_G1.0231.00
74_L77_D1.0221.00
11_W14_Q1.0211.00
70_I239_S1.0181.00
85_T89_I1.0161.00
164_L200_V1.0141.00
254_L257_A1.0141.00
193_G197_G1.0121.00
430_L434_Q1.0091.00
109_A113_A1.0061.00
28_I32_V1.0021.00
430_L433_Y1.0001.00
126_Q130_Y1.0001.00
283_G363_F0.9991.00
96_L100_L0.9941.00
379_V435_L0.9881.00
192_S195_L0.9861.00
64_T68_P0.9861.00
400_K423_S0.9851.00
342_I488_A0.9831.00
359_A414_E0.9821.00
436_R439_E0.9821.00
381_Q389_P0.9811.00
444_L447_V0.9811.00
263_L266_G0.9801.00
248_L390_A0.9791.00
337_A341_C0.9741.00
260_L280_Y0.9721.00
57_G61_M0.9701.00
376_A432_L0.9681.00
315_K318_K0.9671.00
123_V188_A0.9661.00
340_I343_L0.9651.00
372_L428_A0.9641.00
102_F105_L0.9621.00
462_L465_Y0.9591.00
86_I90_S0.9571.00
395_A430_L0.9551.00
349_M485_S0.9541.00
47_Y278_G0.9511.00
451_I455_A0.9501.00
130_Y195_L0.9471.00
92_L96_L0.9471.00
264_L275_C0.9461.00
455_A459_S0.9461.00
462_L492_G0.9441.00
33_Y166_V0.9441.00
104_C108_G0.9431.00
129_A133_L0.9411.00
130_Y133_L0.9391.00
35_V351_F0.9371.00
453_G458_M0.9341.00
47_Y266_G0.9341.00
241_T387_V0.9331.00
165_R197_G0.9331.00
280_Y363_F0.9321.00
260_L413_I0.9321.00
75_M148_R0.9321.00
109_A129_A0.9321.00
266_G275_C0.9301.00
366_S417_S0.9281.00
16_A300_S0.9261.00
157_S204_I0.9231.00
26_T162_Q0.9231.00
451_I458_M0.9221.00
16_A297_I0.9221.00
261_Y277_K0.9211.00
380_L434_Q0.9171.00
241_T386_T0.9171.00
52_V124_L0.9161.00
338_G493_G0.9151.00
36_P40_I0.9131.00
448_L452_I0.9121.00
95_S99_I0.9111.00
489_V492_G0.9061.00
275_C279_I0.9031.00
458_M492_G0.9031.00
337_A459_S0.9031.00
102_F133_L0.8991.00
252_I400_K0.8951.00
300_S303_P0.8931.00
356_G359_A0.8931.00
421_A424_F0.8921.00
426_A430_L0.8921.00
227_T232_T0.8911.00
418_L422_A0.8901.00
481_A484_E0.8891.00
484_E488_A0.8881.00
242_I386_T0.8861.00
488_A492_G0.8831.00
464_A468_L0.8821.00
409_P416_A0.8801.00
245_S389_P0.8791.00
278_G281_D0.8781.00
343_L360_L0.8771.00
35_V38_Q0.8731.00
78_Y81_K0.8731.00
259_N263_L0.8731.00
111_P115_F0.8721.00
454_S499_C0.8711.00
88_K92_L0.8701.00
13_W17_F0.8681.00
340_I365_C0.8651.00
466_T470_T0.8631.00
111_P114_L0.8601.00
51_Q277_K0.8601.00
434_Q437_Q0.8601.00
334_G337_A0.8591.00
403_L422_A0.8521.00
107_L111_P0.8521.00
37_F190_A0.8511.00
410_R414_E0.8501.00
98_G136_P0.8491.00
366_S369_F0.8481.00
445_R450_P0.8451.00
248_L397_V0.8441.00
166_V170_L0.8421.00
123_V126_Q0.8401.00
14_Q152_L0.8391.00
443_K450_P0.8351.00
388_F434_Q0.8351.00
404_N416_A0.8341.00
72_S143_G0.8341.00
392_A396_G0.8311.00
38_Q351_F0.8311.00
12_I16_A0.8311.00
457_L462_L0.8301.00
54_P257_A0.8281.00
349_M482_V0.8251.00
204_I208_F0.8241.00
449_I455_A0.8221.00
282_R285_P0.8221.00
42_G354_G0.8211.00
100_L104_C0.8211.00
134_L202_L0.8201.00
103_L107_L0.8171.00
449_I457_L0.8151.00
342_I492_G0.8151.00
443_K447_V0.8131.00
347_N351_F0.8131.00
361_Q365_C0.8131.00
345_P488_A0.8121.00
280_Y284_Q0.8101.00
35_V350_L0.8091.00
231_L234_K0.8061.00
43_D354_G0.8061.00
248_L393_V0.8051.00
79_S82_N0.8051.00
237_L387_V0.8051.00
99_I103_L0.8001.00
40_I174_F0.7991.00
172_L175_W0.7981.00
188_A192_S0.7981.00
71_I75_M0.7971.00
380_L389_P0.7931.00
236_L239_S0.7901.00
405_T409_P0.7891.00
265_S277_K0.7861.00
134_L195_L0.7851.00
283_G360_L0.7851.00
40_I173_S0.7841.00
376_A428_A0.7831.00
236_L240_V0.7821.00
282_R351_F0.7821.00
113_A122_A0.7801.00
46_F50_Q0.7801.00
157_S205_L0.7791.00
17_F21_L0.7771.00
171_G174_F0.7741.00
73_K384_G0.7731.00
19_L155_A0.7721.00
60_V64_T0.7711.00
447_V458_M0.7711.00
447_V455_A0.7701.00
23_G27_K0.7691.00
168_V196_A0.7681.00
15_G149_H0.7671.00
91_A141_L0.7661.00
207_F211_K0.7651.00
418_L421_A0.7641.00
340_I364_S0.7641.00
142_R146_Q0.7641.00
304_Y307_M0.7641.00
190_A193_G0.7611.00
454_S457_L0.7611.00
389_P393_V0.7581.00
49_Y190_A0.7571.00
498_Y502_R0.7521.00
73_K382_G0.7471.00
317_M383_A0.7451.00
257_A277_K0.7391.00
320_K324_S0.7371.00
306_S310_K0.7371.00
67_F90_S0.7361.00
153_P208_F0.7351.00
365_C368_L0.7341.00
388_F391_I0.7321.00
452_I455_A0.7261.00
467_R470_T0.7261.00
265_S275_C0.7231.00
323_S326_K0.7221.00
302_V382_G0.7211.00
308_A311_N0.7211.00
74_L78_Y0.7191.00
340_I344_K0.7191.00
256_D284_Q0.7171.00
45_G48_I0.7161.00
328_C371_S0.7131.00
294_A298_A0.7121.00
141_L206_G0.7101.00
18_V22_A0.7101.00
485_S489_V0.7091.00
326_K330_V0.7081.00
238_Y242_I0.7081.00
403_L406_L0.7071.00
169_L193_G0.7051.00
125_I129_A0.7041.00
106_Y109_A0.7031.00
287_L367_I0.7021.00
102_F129_A0.7021.00
297_I301_L0.6991.00
66_G239_S0.6991.00
21_L25_I0.6981.00
254_L258_L0.6981.00
145_F209_W0.6961.00
131_A198_S0.6941.00
230_E233_K0.6931.00
194_S198_S0.6921.00
328_C375_T0.6911.00
78_Y231_L0.6911.00
237_L240_V0.6891.00
48_I266_G0.6881.00
335_A338_G0.6881.00
195_L198_S0.6851.00
72_S76_N0.6851.00
43_D275_C0.6841.00
208_F212_T0.6811.00
395_A398_A0.6801.00
93_F97_I0.6801.00
304_Y308_A0.6781.00
255_V259_N0.6771.00
286_L351_F0.6761.00
394_G397_V0.6751.00
285_P288_Q0.6751.00
287_L290_G0.6731.00
414_E418_L0.6731.00
197_G201_A0.6711.00
160_T204_I0.6691.00
41_V187_G0.6691.00
64_T94_L0.6691.00
450_P465_Y0.6691.00
79_S148_R0.6691.00
164_L167_A0.6661.00
434_Q438_K0.6651.00
302_V378_A0.6651.00
34_R38_Q0.6651.00
461_V464_A0.6651.00
19_L151_M0.6641.00
365_C369_F0.6631.00
20_I296_S0.6631.00
16_A20_I0.6601.00
127_V191_A0.6571.00
482_V489_V0.6571.00
110_V114_L0.6541.00
56_L132_F0.6541.00
156_L160_T0.6541.00
195_L199_L0.6531.00
345_P484_E0.6531.00
74_L234_K0.6501.00
366_S420_T0.6501.00
164_L169_L0.6501.00
190_A194_S0.6491.00
51_Q54_P0.6491.00
390_A394_G0.6491.00
72_S147_G0.6471.00
363_F417_S0.6461.00
339_L346_V0.6421.00
285_P289_L0.6411.00
459_S462_L0.6401.00
99_I133_L0.6391.00
417_S421_A0.6381.00
435_L438_K0.6371.00
263_L408_V0.6371.00
10_H13_W0.6371.00
123_V127_V0.6351.00
336_S364_S0.6331.00
445_R448_L0.6321.00
404_N419_A0.6311.00
425_A429_G0.6291.00
70_I74_L0.6281.00
386_T389_P0.6271.00
135_F198_S0.6271.00
108_G112_I0.6241.00
98_G102_F0.6221.00
127_V192_S0.6221.00
235_L239_S0.6211.00
88_K216_N0.6211.00
91_A94_L0.6211.00
47_Y277_K0.6201.00
73_K386_T0.6191.00
495_V499_C0.6191.00
53_Y57_G0.6181.00
25_I29_L0.6181.00
401_W405_T0.6171.00
109_A112_I0.6171.00
41_V45_G0.6161.00
105_L125_I0.6151.00
126_Q129_A0.6151.00
252_I397_V0.6151.00
348_I357_T0.6141.00
461_V465_Y0.6121.00
250_L254_L0.6111.00
399_V402_V0.6111.00
447_V454_S0.6101.00
201_A205_L0.6101.00
85_T88_K0.6071.00
324_S375_T0.6041.00
480_A484_E0.6041.00
89_I93_F0.6031.00
277_K281_D0.6021.00
15_G300_S0.6011.00
329_L368_L0.6001.00
169_L173_S0.5991.00
432_L436_R0.5991.00
308_A317_M0.5991.00
172_L176_L0.5981.00
360_L364_S0.5971.00
230_E234_K0.5941.00
348_I352_Q0.5921.00
343_L364_S0.5911.00
314_L317_M0.5911.00
205_L208_F0.5881.00
234_K238_Y0.5881.00
22_A159_M0.5871.00
370_A374_V0.5861.00
101_L105_L0.5841.00
466_T469_W0.5841.00
453_G461_V0.5831.00
29_L33_Y0.5831.00
46_F282_R0.5811.00
242_I381_Q0.5811.00
77_D310_K0.5801.00
13_W16_A0.5801.00
51_Q257_A0.5771.00
170_L173_S0.5751.00
378_A381_Q0.5731.00
445_R455_A0.5731.00
11_W149_H0.5721.00
465_Y468_L0.5701.00
436_R440_W0.5681.00
75_M87_L0.5671.00
281_D285_P0.5651.00
106_Y129_A0.5631.00
56_L60_V0.5621.00
500_M503_L0.5611.00
68_P143_G0.5611.00
320_K323_S0.5611.00
247_L251_F0.5601.00
366_S424_F0.5601.00
402_V405_T0.5601.00
29_L166_V0.5601.00
92_L218_T0.5581.00
487_S490_A0.5571.00
444_L448_L0.5571.00
284_Q288_Q0.5571.00
461_V491_I0.5571.00
86_I231_L0.5571.00
232_T236_L0.5540.99
421_A425_A0.5530.99
499_C502_R0.5530.99
89_I227_T0.5530.99
176_L189_A0.5520.99
424_F428_A0.5510.99
420_T423_S0.5500.99
380_L435_L0.5500.99
109_A125_I0.5500.99
383_A438_K0.5490.99
280_Y417_S0.5470.99
458_M466_T0.5460.99
207_F210_F0.5460.99
457_L460_A0.5450.99
455_A462_L0.5450.99
482_V486_L0.5410.99
385_Y389_P0.5410.99
92_L95_S0.5410.99
454_S462_L0.5410.99
210_F214_R0.5400.99
335_A339_L0.5400.99
110_V113_A0.5390.99
256_D259_N0.5390.99
347_N355_E0.5380.99
295_V299_T0.5370.99
89_I92_L0.5360.99
378_A382_G0.5360.99
48_I124_L0.5350.99
338_G458_M0.5340.99
454_S461_V0.5320.99
30_S34_R0.5320.99
348_I351_F0.5310.99
202_L206_G0.5310.99
210_F213_K0.5310.99
390_A393_V0.5310.99
491_I494_A0.5310.99
296_S299_T0.5310.99
396_G423_S0.5310.99
407_L415_G0.5300.99
146_Q154_S0.5300.99
376_A435_L0.5290.99
448_L451_I0.5290.99
450_P462_L0.5290.99
94_L98_G0.5290.99
461_V492_G0.5280.99
480_A483_I0.5280.99
348_I481_A0.5270.99
86_I235_L0.5260.99
153_P156_L0.5260.99
58_I250_L0.5250.99
449_I458_M0.5240.99
89_I229_K0.5240.99
43_D355_E0.5240.99
492_G496_F0.5210.99
37_F169_L0.5210.99
85_T226_I0.5210.99
337_A340_I0.5200.99
20_I24_V0.5200.99
490_A494_A0.5180.99
71_I86_I0.5160.99
333_T455_A0.5160.99
137_F202_L0.5160.99
145_F153_P0.5140.99
162_Q166_V0.5130.99
400_K403_L0.5130.99
88_K91_A0.5120.99
141_L209_W0.5120.99
132_F136_P0.5110.99
451_I457_L0.5100.99
63_S136_P0.5100.99
399_V423_S0.5090.99
450_P455_A0.5090.99
328_C332_G0.5080.99
127_V131_A0.5080.99
143_G147_G0.5080.99
306_S309_V0.5080.99
245_S393_V0.5070.99
245_S248_L0.5060.99
317_M320_K0.5060.99
187_G190_A0.5050.99
87_L141_L0.5050.99
317_M321_I0.5040.99
127_V188_A0.5020.99
37_F41_V0.5010.99
498_Y501_M0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.8026 100 0.429 Contact Map
3w4tA 1 0.7876 100 0.446 Contact Map
4humA 1 0.8252 100 0.448 Contact Map
3mktA 1 0.8195 100 0.462 Contact Map
3wdoA 1 0.7632 67.3 0.943 Contact Map
4pypA 1 0.7594 60.8 0.945 Contact Map
3o7qA 1 0.7143 56.4 0.947 Contact Map
1pw4A 1 0.7538 54.4 0.947 Contact Map
4xnjA 1 0.718 35.8 0.953 Contact Map
4tphA 2 0.7575 29.6 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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