GREMLIN Database
SP5T - Stage V sporulation protein T
UniProt: P37554 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 178 (177)
Sequences: 526 (319)
Seq/√Len: 24.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_C147_A5.8091.00
77_C82_Y4.9021.00
59_A84_A3.7961.00
158_G161_E3.2741.00
70_L164_A3.2691.00
62_Y168_A3.2551.00
16_V25_T2.5660.99
98_I106_M2.5230.99
75_L82_Y2.4780.98
135_V147_A2.2820.97
106_M144_P2.2560.97
109_R143_D2.2500.97
105_T112_V2.2340.97
74_V150_I2.2330.97
136_G169_A2.2260.97
98_I102_L2.2170.97
38_V99_S2.0820.95
38_V102_L2.0510.95
111_S162_H1.8880.92
24_R29_R1.8580.92
31_G90_K1.8390.91
99_S102_L1.8380.91
72_H157_M1.7240.88
114_E133_Y1.7120.88
57_D69_S1.5800.83
116_D119_S1.5380.82
46_L68_D1.5030.80
102_L135_V1.4870.79
10_I16_V1.4470.77
96_K125_G1.4330.77
55_L176_M1.4280.76
160_V167_T1.3610.73
70_L150_I1.3290.71
145_I175_Q1.3280.71
60_K140_A1.3260.71
63_A168_A1.3210.71
163_K166_E1.3180.70
106_M147_A1.3050.70
70_L106_M1.3010.69
51_P54_E1.2950.69
46_L135_V1.2720.68
67_Y119_S1.2530.66
68_D173_A1.2350.65
100_E110_S1.2160.64
148_V165_V1.2090.64
26_L46_L1.2060.63
53_S95_N1.2030.63
34_L55_L1.1960.63
139_V173_A1.1830.62
170_G174_R1.1820.62
74_V149_V1.1810.62
62_Y66_L1.1790.62
44_V119_S1.1680.61
107_D127_D1.1630.60
1_M4_T1.1630.60
46_L60_K1.1450.59
123_V174_R1.1420.59
79_R107_D1.1330.58
82_Y149_V1.1320.58
45_I64_D1.1300.58
47_K80_D1.1130.57
85_V88_S1.1120.57
144_P173_A1.1090.57
57_D81_V1.0850.55
11_D17_V1.0760.54
8_R17_V1.0760.54
14_G17_V1.0760.54
11_D15_R1.0760.54
11_D14_G1.0760.54
8_R15_R1.0760.54
8_R14_G1.0760.54
8_R13_L1.0760.54
8_R11_D1.0760.54
13_L17_V1.0760.54
65_A130_M1.0760.54
3_A12_D1.0740.54
65_A136_G1.0730.54
27_R55_L1.0680.54
40_R65_A1.0660.54
10_I26_L1.0610.53
111_S136_G1.0480.52
2_K9_R1.0460.52
67_Y95_N1.0450.52
168_A175_Q1.0400.52
27_R32_D1.0380.52
145_I150_I1.0370.52
19_P23_R1.0360.52
104_R108_Q1.0200.50
120_V125_G0.9990.49
68_D174_R0.9960.49
95_N130_M0.9920.48
34_L39_D0.9680.47
50_S80_D0.9640.46
67_Y114_E0.9540.46
125_G128_E0.9380.45
93_Y130_M0.9380.45
27_R90_K0.9350.44
54_E63_A0.9340.44
52_I80_D0.9340.44
18_I137_P0.9320.44
38_V101_M0.9280.44
38_V68_D0.9240.44
61_E153_K0.9220.44
58_F62_Y0.9190.43
150_I165_V0.9110.43
113_L158_G0.9080.43
100_E122_L0.9050.42
20_K23_R0.9030.42
26_L133_Y0.9030.42
67_Y126_I0.9030.42
5_G11_D0.8970.42
5_G15_R0.8970.42
5_G14_G0.8970.42
5_G13_L0.8970.42
5_G8_R0.8970.42
5_G17_V0.8970.42
51_P62_Y0.8950.42
3_A7_V0.8890.41
89_S94_L0.8800.41
18_I45_I0.8790.41
13_L23_R0.8790.41
8_R19_P0.8790.41
15_R19_P0.8790.41
8_R23_R0.8790.41
13_L19_P0.8790.41
15_R23_R0.8790.41
14_G19_P0.8790.41
11_D23_R0.8790.41
17_V23_R0.8790.41
14_G23_R0.8790.41
11_D19_P0.8790.41
29_R32_D0.8770.40
113_L116_D0.8740.40
52_I90_K0.8690.40
99_S137_P0.8660.40
64_D84_A0.8650.40
70_L152_S0.8600.39
136_G150_I0.8510.39
140_A173_A0.8460.38
86_S117_A0.8370.38
134_T165_V0.8330.37
32_D122_L0.8300.37
26_L44_V0.8280.37
18_I44_V0.8280.37
31_G44_V0.8250.37
111_S129_D0.8160.36
82_Y127_D0.8120.36
62_Y175_Q0.8090.36
24_R142_G0.8040.36
73_S88_S0.7990.35
53_S141_N0.7920.35
37_F54_E0.7870.34
46_L157_M0.7680.33
83_I152_S0.7620.33
117_A121_Q0.7620.33
65_A69_S0.7560.32
33_P42_G0.7510.32
8_R20_K0.7500.32
11_D20_K0.7500.32
13_L20_K0.7500.32
17_V20_K0.7500.32
14_G20_K0.7500.32
15_R20_K0.7500.32
62_Y139_V0.7490.32
56_G83_I0.7440.32
12_D30_E0.7420.32
82_Y129_D0.7400.31
67_Y73_S0.7390.31
80_D103_E0.7330.31
122_L156_T0.7320.31
89_S93_Y0.7300.31
126_I133_Y0.7280.31
43_E84_A0.7260.31
24_R49_Y0.7230.30
22_I37_F0.7220.30
67_Y121_Q0.7180.30
3_A42_G0.7150.30
121_Q124_N0.7140.30
118_K155_Q0.7000.29
95_N160_V0.6990.29
5_G19_P0.6990.29
5_G23_R0.6990.29
54_E175_Q0.6870.28
38_V120_V0.6770.28
110_S131_N0.6760.28
64_D69_S0.6730.28
76_I148_V0.6720.27
113_L120_V0.6680.27
17_V21_E0.6650.27
11_D21_E0.6650.27
13_L21_E0.6650.27
8_R21_E0.6650.27
15_R21_E0.6650.27
14_G21_E0.6650.27
69_S77_C0.6630.27
93_Y121_Q0.6560.27
124_N156_T0.6500.26
130_M152_S0.6480.26
76_I120_V0.6470.26
68_D144_P0.6420.26
28_I36_I0.6330.25
51_P176_M0.6290.25
160_V166_E0.6280.25
10_I76_I0.6280.25
124_N127_D0.6270.25
7_V24_R0.6210.25
7_V10_I0.6200.25
149_V152_S0.6180.25
139_V144_P0.6150.24
112_V135_V0.6150.24
87_G176_M0.6130.24
121_Q133_Y0.6120.24
147_A165_V0.6100.24
43_E59_A0.6070.24
65_A111_S0.6050.24
46_L145_I0.6020.24
82_Y174_R0.5970.23
73_S125_G0.5960.23
51_P168_A0.5890.23
133_Y141_N0.5840.23
57_D85_V0.5810.23
32_D154_D0.5790.23
94_L174_R0.5760.22
67_Y170_G0.5740.22
3_A6_I0.5740.22
73_S85_V0.5720.22
5_G20_K0.5700.22
95_N173_A0.5680.22
100_E108_Q0.5610.22
97_S156_T0.5580.22
116_D159_E0.5540.21
89_S112_V0.5530.21
87_G148_V0.5520.21
105_T114_E0.5510.21
3_A16_V0.5470.21
26_L32_D0.5470.21
134_T161_E0.5450.21
56_G127_D0.5440.21
51_P87_G0.5430.21
81_V140_A0.5410.21
120_V124_N0.5360.20
74_V129_D0.5350.20
115_S132_S0.5280.20
59_A172_L0.5270.20
104_R149_V0.5260.20
55_L165_V0.5260.20
45_I175_Q0.5230.20
116_D126_I0.5210.20
55_L167_T0.5210.20
114_E119_S0.5170.20
100_E104_R0.5170.20
9_R24_R0.5160.20
12_D172_L0.5130.19
123_V141_N0.5120.19
106_M132_S0.5110.19
62_Y145_I0.5110.19
101_M121_Q0.5080.19
67_Y166_E0.5080.19
18_I73_S0.5070.19
70_L140_A0.5060.19
40_R145_I0.5050.19
97_S123_V0.5040.19
101_M126_I0.5040.19
63_A91_K0.5020.19
40_R130_M0.5010.19
51_P55_L0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w1tA 2 0.9831 100 0.43 Contact Map
2w1rA 2 0.6573 99.8 0.7 Contact Map
1yfbA 2 0.2865 99.2 0.807 Contact Map
2mrnA 2 0.2865 98.6 0.849 Contact Map
2l66A 2 0.2921 98.6 0.849 Contact Map
3o27A 2 0.2921 98.2 0.864 Contact Map
1mvfD 1 0.2472 97.8 0.88 Contact Map
2glwA 1 0.2584 97.4 0.887 Contact Map
2gx5A 2 0.7697 96.8 0.898 Contact Map
4mn7A 2 0.7303 95.9 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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