GREMLIN Database
RIDA - 2-iminobutanoate/2-iminopropanoate deaminase
UniProt: P37552 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 125 (114)
Sequences: 6655 (4220)
Seq/√Len: 395.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_H93_Q3.3411.00
58_K68_F2.7911.00
66_A70_T2.7701.00
73_K119_E2.6111.00
45_D48_E2.6061.00
47_K86_E2.3191.00
51_H55_S2.1701.00
77_F105_V2.0661.00
76_V87_V2.0411.00
106_E109_R2.0401.00
47_K89_E2.0241.00
55_S94_Y1.9221.00
61_L122_A1.8351.00
33_I114_A1.8101.00
58_K62_E1.7761.00
57_L120_V1.7111.00
49_Q115_L1.7011.00
52_Q56_N1.6311.00
74_A120_V1.5651.00
51_H94_Y1.5621.00
109_R113_D1.5531.00
83_Q115_L1.5471.00
41_M114_A1.5471.00
23_V72_V1.5421.00
23_V123_L1.5301.00
55_S58_K1.5231.00
46_I50_T1.4791.00
27_F66_A1.4721.00
81_M106_E1.4631.00
78_I87_V1.4501.00
67_S70_T1.4391.00
34_P114_A1.4201.00
36_T42_V1.3531.00
88_N102_R1.3501.00
103_S119_E1.3211.00
78_I104_C1.3101.00
22_I25_N1.3031.00
52_Q55_S1.3021.00
40_E112_K1.2991.00
31_G117_E1.2761.00
28_Y121_I1.2521.00
91_Y102_R1.2431.00
61_L66_A1.2071.00
83_Q86_E1.1991.00
10_A19_Q1.1941.00
71_V120_V1.1841.00
79_A83_Q1.1531.00
86_E89_E1.1411.00
43_N48_E1.1321.00
22_I27_F1.1191.00
27_F64_A1.1171.00
29_S60_V1.1121.00
26_M123_L1.1041.00
90_V93_Q1.0711.00
34_P53_V1.0611.00
29_S120_V1.0561.00
62_E67_S1.0531.00
79_A109_R1.0531.00
89_E92_G1.0461.00
71_V95_F1.0391.00
77_F107_V1.0311.00
46_I87_V1.0191.00
26_M72_V1.0191.00
36_T40_E1.0151.00
96_D99_K1.0101.00
77_F103_S0.9981.00
51_H90_V0.9971.00
61_L71_V0.9901.00
50_T87_V0.9811.00
22_I66_A0.9791.00
75_T119_E0.9531.00
79_A113_D0.9451.00
47_K90_V0.9401.00
80_D83_Q0.9391.00
82_E109_R0.9361.00
20_G60_V0.8891.00
68_F71_V0.8851.00
89_E93_Q0.8681.00
40_E43_N0.8651.00
84_F104_C0.8531.00
79_A115_L0.8511.00
35_L39_G0.8501.00
32_Q60_V0.8491.00
34_P49_Q0.8381.00
74_A91_Y0.8271.00
59_A62_E0.8081.00
58_K94_Y0.8031.00
37_P52_Q0.7971.00
54_F94_Y0.7841.00
46_I83_Q0.7831.00
90_V94_Y0.7821.00
92_G99_K0.7771.00
47_K51_H0.7761.00
25_N123_L0.7731.00
16_P88_N0.7601.00
46_I90_V0.7521.00
54_F68_F0.7511.00
46_I116_V0.7451.00
79_A108_A0.7431.00
44_G48_E0.7411.00
74_A95_F0.7411.00
44_G49_Q0.7401.00
79_A107_V0.7361.00
54_F118_I0.7361.00
69_E96_D0.7301.00
45_D115_L0.7091.00
66_A122_A0.7051.00
29_S57_L0.7051.00
54_F91_Y0.6991.00
27_F122_A0.6971.00
71_V122_A0.6941.00
20_G64_A0.6860.99
20_G27_F0.6860.99
78_I81_M0.6740.99
88_N91_Y0.6720.99
76_V118_I0.6700.99
19_Q60_V0.6650.99
14_I112_K0.6640.99
23_V28_Y0.6630.99
45_D86_E0.6620.99
68_F94_Y0.6530.99
50_T116_V0.6490.99
47_K93_Q0.6450.99
75_T103_S0.6420.99
77_F119_E0.6360.99
73_K103_S0.6310.99
85_A89_E0.6300.99
53_V118_I0.6270.99
61_L68_F0.6260.99
48_E51_H0.6240.99
81_M109_R0.6220.99
80_D115_L0.6140.99
33_I112_K0.6100.99
37_P59_A0.5900.98
17_Y31_G0.5880.98
42_V52_Q0.5840.98
76_V102_R0.5830.98
33_I53_V0.5820.98
78_I83_Q0.5810.98
84_F111_P0.5800.98
21_I72_V0.5800.98
29_S103_S0.5740.98
88_N92_G0.5720.98
24_N123_L0.5690.98
55_S59_A0.5690.98
71_V74_A0.5680.98
66_A123_L0.5600.98
19_Q63_E0.5560.98
26_M121_I0.5460.97
30_S101_A0.5460.97
43_N49_Q0.5450.97
70_T123_L0.5440.97
52_Q59_A0.5360.97
32_Q57_L0.5360.97
32_Q56_N0.5330.97
60_V63_E0.5290.97
46_I86_E0.5270.97
84_F88_N0.5260.97
27_F60_V0.5230.97
45_D49_Q0.5220.97
43_N115_L0.5180.97
23_V26_M0.5150.96
34_P41_M0.5140.96
76_V116_V0.5140.96
75_T121_I0.5100.96
69_E97_T0.5100.96
61_L120_V0.5090.96
13_A18_S0.5080.96
50_T118_I0.5050.96
87_V104_C0.5010.96
79_A106_E0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b33A 3 0.992 100 0.119 Contact Map
2cvlA 3 0.992 100 0.132 Contact Map
1xrgA 3 0.992 100 0.132 Contact Map
1qd9A 3 0.992 100 0.134 Contact Map
3vczA 5 0.984 100 0.135 Contact Map
3m1xA 3 0.984 100 0.135 Contact Map
2dyyA 3 1 100 0.137 Contact Map
3r0pA 5 0.992 100 0.14 Contact Map
1qahA 3 1 100 0.143 Contact Map
1x25A 3 1 100 0.146 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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