GREMLIN Database
PURR - Pur operon repressor
UniProt: P37551 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (267)
Sequences: 436 (252)
Seq/√Len: 15.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
198_N225_N6.0631.00
195_T223_N5.4001.00
126_F230_G3.7781.00
135_M159_V3.2990.99
60_L70_K3.1530.99
122_F230_G2.9810.98
202_I230_G2.9310.98
83_F114_V2.9090.98
14_N18_T2.7820.97
23_L62_V2.6500.96
14_N56_I2.6120.95
135_M215_M2.6050.95
122_F126_F2.5930.95
19_H22_E2.4970.94
131_I154_V2.4660.94
11_D33_Y2.4050.93
84_V249_L2.2790.91
146_Y156_V2.2390.90
197_S224_A2.2210.90
241_R244_D2.1370.88
9_L30_S2.0980.87
138_A192_S2.0940.86
233_V252_L2.0790.86
200_L228_G2.0210.84
201_I215_M2.0100.84
165_V233_V1.9730.83
181_N208_A1.9110.81
5_R8_R1.8520.79
116_S150_S1.7630.75
115_L146_Y1.7170.73
164_K213_N1.7080.73
55_G196_G1.7000.72
173_I252_L1.6880.72
187_S217_N1.6700.71
66_A72_I1.6520.70
173_I184_Q1.6460.70
66_A157_V1.6410.70
181_N185_T1.6380.69
137_V161_K1.6320.69
148_A170_T1.6190.68
110_G158_I1.6050.68
39_S267_G1.5960.67
105_L161_K1.5710.66
158_I192_S1.5540.65
207_K229_I1.5360.64
132_D197_S1.5360.64
135_M219_L1.5270.64
90_S93_N1.5160.63
35_S40_I1.5100.63
134_V152_L1.5050.63
40_I44_L1.4990.62
164_K250_L1.4890.62
86_T130_E1.4860.62
106_T157_V1.4690.61
86_T134_V1.4590.60
105_L187_S1.4470.59
16_L19_H1.4450.59
5_R193_M1.4400.59
175_Y186_M1.4250.58
213_N217_N1.4160.58
105_L184_Q1.4110.57
206_M243_V1.4020.57
234_E238_V1.3770.56
219_L226_V1.3730.55
196_G224_A1.3710.55
115_L232_L1.3650.55
75_M197_S1.3590.55
166_T207_K1.3590.55
86_T117_K1.3550.54
130_E198_N1.3440.54
46_I192_S1.3360.53
142_I224_A1.3260.53
10_V13_T1.3210.52
126_F202_I1.3140.52
133_V193_M1.3130.52
24_I218_L1.3040.51
157_V164_K1.3040.51
44_L59_L1.2980.51
154_V207_K1.2800.50
174_N210_G1.2650.49
137_V162_D1.2620.49
235_A238_V1.2610.49
144_L184_Q1.2450.48
138_A217_N1.2380.48
149_A163_N1.2370.48
35_S264_I1.2260.47
7_G18_T1.2120.46
11_D63_P1.2110.46
52_E233_V1.2040.46
238_V241_R1.1990.45
179_S207_K1.1910.45
118_V231_V1.1880.45
56_I138_A1.1810.44
77_Q81_E1.1800.44
88_G264_I1.1740.44
159_V182_R1.1660.44
88_G250_L1.1620.43
86_T111_K1.1440.42
198_N227_A1.1420.42
139_T167_E1.1420.42
174_N188_L1.1380.42
91_L161_K1.1350.42
25_P110_G1.1340.42
94_P224_A1.1310.42
122_F202_I1.1250.41
9_L59_L1.1140.41
71_Y227_A1.1110.41
39_S110_G1.1050.40
98_L155_P1.0980.40
14_N138_A1.0960.40
173_I232_L1.0940.40
46_I152_L1.0890.39
86_T256_N1.0840.39
165_V226_V1.0840.39
137_V234_E1.0720.38
3_F106_T1.0700.38
123_A152_L1.0700.38
34_E76_K1.0680.38
16_L62_V1.0660.38
126_F137_V1.0620.38
35_S63_P1.0580.38
156_V185_T1.0550.37
199_V224_A1.0520.37
144_L213_N1.0480.37
49_Q53_Q1.0450.37
33_Y118_V1.0390.37
2_K106_T1.0270.36
137_V177_S1.0150.35
4_R34_E1.0150.35
21_H25_P1.0140.35
4_R183_I1.0110.35
46_I171_V1.0100.35
198_N245_E1.0040.35
71_Y95_E1.0010.35
163_N187_S0.9980.34
94_P253_S0.9930.34
206_M242_L0.9830.34
91_L137_V0.9790.34
36_A61_T0.9790.34
51_F138_A0.9770.33
179_S242_L0.9750.33
159_V219_L0.9750.33
227_A258_K0.9710.33
164_K187_S0.9680.33
240_E243_V0.9680.33
121_L197_S0.9640.33
137_V219_L0.9600.33
91_L105_L0.9600.33
87_L191_R0.9560.32
109_L211_T0.9560.32
232_L250_L0.9550.32
55_G59_L0.9540.32
9_L193_M0.9510.32
73_P169_S0.9430.32
241_R268_N0.9350.31
219_L224_A0.9310.31
90_S264_I0.9280.31
183_I186_M0.9270.31
162_D190_K0.9250.31
183_I187_S0.9220.31
87_L118_V0.9190.31
152_L222_F0.9170.30
61_T228_G0.9140.30
129_R134_V0.9130.30
103_V122_F0.9130.30
105_L183_I0.9100.30
60_L133_V0.9070.30
109_L200_L0.9070.30
89_Q92_A0.9010.30
176_V255_I0.8990.30
108_I259_E0.8970.29
50_T249_L0.8940.29
76_K108_I0.8930.29
21_H169_S0.8890.29
148_A195_T0.8880.29
115_L156_V0.8870.29
33_Y120_K0.8820.29
51_F144_L0.8700.28
50_T54_Q0.8690.28
52_E116_S0.8680.28
111_K114_V0.8670.28
84_V144_L0.8650.28
72_I202_I0.8630.28
7_G146_Y0.8610.28
2_K163_N0.8580.28
111_K144_L0.8550.28
199_V215_M0.8500.27
7_G49_Q0.8460.27
170_T190_K0.8400.27
150_S241_R0.8390.27
138_A154_V0.8390.27
90_S111_K0.8360.27
103_V173_I0.8350.27
4_R80_A0.8320.26
4_R7_G0.8250.26
18_T95_E0.8180.26
49_Q52_E0.8160.26
122_F148_A0.8160.26
16_L36_A0.8150.26
13_T17_L0.8150.26
187_S230_G0.8130.26
82_E128_E0.8100.26
176_V188_L0.8080.25
110_G206_M0.8070.25
5_R10_V0.8060.25
3_F116_S0.8040.25
15_Y24_I0.7990.25
252_L255_I0.7960.25
253_S265_Q0.7920.25
23_L199_V0.7890.25
104_Y198_N0.7880.25
15_Y135_M0.7880.25
121_L259_E0.7860.25
165_V191_R0.7850.24
172_S179_S0.7850.24
38_S42_E0.7850.24
109_L161_K0.7840.24
137_V183_I0.7790.24
51_F102_Y0.7750.24
16_L28_F0.7730.24
39_S151_Y0.7720.24
244_D260_K0.7670.24
4_R71_Y0.7660.24
118_V153_N0.7660.24
229_I268_N0.7650.24
55_G76_K0.7590.23
264_I268_N0.7590.23
138_A148_A0.7580.23
206_M235_A0.7540.23
21_H135_M0.7510.23
105_L181_N0.7490.23
71_Y239_D0.7430.23
91_L227_A0.7430.23
69_V164_K0.7420.23
74_K127_A0.7410.23
206_M244_D0.7410.23
3_F52_E0.7380.23
112_P123_A0.7350.22
253_S266_N0.7350.22
5_R41_S0.7330.22
19_H266_N0.7320.22
12_L40_I0.7300.22
199_V219_L0.7270.22
131_I151_Y0.7260.22
116_S233_V0.7240.22
135_M228_G0.7240.22
172_S208_A0.7150.22
52_E252_L0.7070.21
18_T83_F0.7030.21
60_L202_I0.6980.21
213_N241_R0.6970.21
28_F108_I0.6920.21
71_Y165_V0.6920.21
156_V187_S0.6880.21
49_Q184_Q0.6870.21
146_Y185_T0.6820.20
66_A87_L0.6800.20
75_M121_L0.6760.20
2_K8_R0.6750.20
32_R44_L0.6750.20
47_I54_Q0.6750.20
38_S61_T0.6730.20
102_Y233_V0.6700.20
2_K44_L0.6700.20
91_L128_E0.6690.20
110_G267_G0.6680.20
19_H97_I0.6680.20
156_V184_Q0.6650.20
218_L232_L0.6640.20
123_A222_F0.6630.20
39_S46_I0.6630.20
18_T149_A0.6610.20
208_A230_G0.6590.20
208_A226_V0.6580.20
134_V216_I0.6580.20
15_Y202_I0.6550.19
33_Y151_Y0.6550.19
161_K184_Q0.6540.19
91_L212_I0.6540.19
131_I161_K0.6520.19
125_V133_V0.6520.19
178_G208_A0.6500.19
254_T261_S0.6480.19
138_A162_D0.6470.19
9_L133_V0.6460.19
146_Y219_L0.6460.19
255_I260_K0.6440.19
184_Q187_S0.6420.19
220_D255_I0.6410.19
78_A121_L0.6410.19
31_E82_E0.6400.19
108_I185_T0.6370.19
13_T47_I0.6360.19
12_L234_E0.6350.19
134_V202_I0.6350.19
21_H260_K0.6350.19
14_N241_R0.6340.19
52_E265_Q0.6310.19
76_K79_E0.6300.19
114_V232_L0.6260.18
33_Y219_L0.6250.18
7_G153_N0.6250.18
35_S102_Y0.6240.18
69_V161_K0.6230.18
71_Y247_M0.6230.18
69_V169_S0.6200.18
39_S201_I0.6200.18
33_Y40_I0.6160.18
86_T227_A0.6140.18
62_V131_I0.6130.18
72_I78_A0.6130.18
126_F247_M0.6110.18
174_N189_A0.6100.18
7_G189_A0.6100.18
50_T238_V0.6090.18
103_V177_S0.6090.18
30_S123_A0.6060.18
7_G30_S0.6060.18
59_L207_K0.6040.18
237_G244_D0.6030.18
144_L232_L0.6020.18
44_L127_A0.5970.17
155_P199_V0.5930.17
195_T202_I0.5920.17
82_E86_T0.5920.17
39_S106_T0.5920.17
208_A237_G0.5910.17
148_A262_I0.5900.17
36_A42_E0.5890.17
153_N185_T0.5890.17
130_E245_E0.5880.17
87_L211_T0.5870.17
81_E197_S0.5870.17
3_F266_N0.5850.17
111_K238_V0.5840.17
78_A82_E0.5820.17
41_S222_F0.5800.17
10_V73_P0.5770.17
140_K160_R0.5730.17
50_T250_L0.5730.17
164_K190_K0.5720.17
4_R118_V0.5720.17
29_F214_G0.5700.17
14_N108_I0.5700.17
195_T224_A0.5680.16
33_Y201_I0.5670.16
3_F181_N0.5650.16
97_I121_L0.5630.16
29_F210_G0.5600.16
7_G33_Y0.5570.16
88_G225_N0.5560.16
121_L172_S0.5520.16
48_K61_T0.5520.16
82_E191_R0.5510.16
118_V248_S0.5510.16
4_R49_Q0.5510.16
128_E158_I0.5510.16
190_K256_N0.5500.16
108_I239_D0.5470.16
118_V195_T0.5470.16
6_S110_G0.5450.16
109_L119_G0.5450.16
211_T215_M0.5430.16
118_V147_A0.5410.16
4_R199_V0.5410.16
40_I207_K0.5400.16
144_L148_A0.5380.16
118_V144_L0.5370.16
49_Q198_N0.5370.16
224_A251_T0.5350.15
4_R169_S0.5350.15
106_T173_I0.5340.15
190_K213_N0.5340.15
184_Q252_L0.5320.15
239_D255_I0.5310.15
23_L66_A0.5310.15
9_L32_R0.5300.15
40_I99_P0.5280.15
98_L222_F0.5270.15
94_P254_T0.5250.15
197_S225_N0.5250.15
103_V184_Q0.5240.15
30_S135_M0.5240.15
101_G119_G0.5230.15
106_T201_I0.5220.15
48_K69_V0.5220.15
10_V212_I0.5180.15
75_M249_L0.5170.15
74_K85_Q0.5150.15
47_I117_K0.5130.15
118_V199_V0.5120.15
72_I200_L0.5110.15
102_Y138_A0.5100.15
234_E248_S0.5070.15
207_K211_T0.5060.15
70_K247_M0.5060.15
134_V154_V0.5050.15
3_F24_I0.5050.15
48_K199_V0.5020.15
31_E129_R0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o57A 2 0.9509 100 0.484 Contact Map
4lzaA 2 0.586 99.9 0.808 Contact Map
1y0bA 2 0.6526 99.9 0.809 Contact Map
4pawA 2 0.5684 99.9 0.814 Contact Map
1qb7A 2 0.7579 99.9 0.814 Contact Map
4m0kA 2 0.5965 99.9 0.815 Contact Map
3qw4B 4 0.8316 99.9 0.825 Contact Map
2wnsA 2 0.6421 99.9 0.827 Contact Map
2dy0A 2 0.614 99.8 0.831 Contact Map
3mjdA 2 0.6351 99.8 0.832 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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