GREMLIN Database
ISPE - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
UniProt: P37550 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 289 (261)
Sequences: 6016 (4378)
Seq/√Len: 271.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_T86_S3.4511.00
122_S125_T3.1871.00
40_R90_T3.0931.00
135_S151_R3.0711.00
52_R86_S2.9881.00
256_V265_I2.8261.00
110_L126_L2.7911.00
43_L112_G2.5921.00
54_S88_M2.5751.00
64_Q73_K2.4891.00
74_L132_E2.4451.00
29_E147_L2.3741.00
168_L251_T2.3201.00
180_V217_L2.2531.00
127_A142_Y2.2261.00
178_A182_R2.1521.00
46_L86_S2.1191.00
74_L129_L2.0551.00
42_E88_M2.0441.00
228_V252_V2.0331.00
75_I119_L2.0231.00
29_E149_T2.0141.00
259_E263_Q2.0051.00
166_V255_L2.0041.00
258_Y261_K1.9981.00
78_R132_E1.9281.00
114_N121_L1.8691.00
42_E90_T1.8311.00
114_N120_N1.8251.00
167_I256_V1.8231.00
229_A233_N1.8171.00
73_K77_D1.8151.00
30_M148_A1.7981.00
218_E222_L1.7801.00
19_R27_E1.7801.00
183_A224_M1.7701.00
69_Y73_K1.7661.00
78_R125_T1.7551.00
28_V181_Y1.7271.00
51_V69_Y1.6971.00
46_L49_D1.6971.00
213_L242_A1.6761.00
33_T145_T1.6711.00
68_A109_T1.6471.00
125_T128_E1.6431.00
165_W259_E1.6201.00
179_E182_R1.5871.00
73_K76_K1.5831.00
74_L78_R1.5631.00
44_T88_M1.5571.00
75_I110_L1.5571.00
40_R92_V1.5521.00
149_T156_K1.5431.00
78_R129_L1.5331.00
68_A89_I1.5301.00
75_I117_W1.5091.00
175_V180_V1.5091.00
41_I109_T1.5041.00
205_S208_K1.5031.00
218_E232_K1.4981.00
233_N237_R1.4961.00
232_K252_V1.4951.00
227_E230_M1.4901.00
79_Y119_L1.4771.00
222_L229_A1.4481.00
43_L87_I1.4361.00
176_S179_E1.4131.00
234_Q238_F1.4081.00
18_T27_E1.3941.00
240_A254_G1.3841.00
170_K251_T1.3811.00
52_R88_M1.3761.00
32_M148_A1.3671.00
72_A87_I1.3611.00
96_A174_G1.3591.00
244_L253_F1.3541.00
72_A76_K1.3511.00
175_V221_T1.3471.00
167_I262_V1.3441.00
183_A186_L1.3411.00
45_E83_K1.3221.00
113_L117_W1.3211.00
50_E86_S1.3121.00
54_S86_S1.3011.00
257_Q261_K1.2991.00
17_V184_L1.2981.00
168_L253_F1.2721.00
228_V245_M1.2641.00
79_Y121_L1.2441.00
114_N119_L1.2381.00
64_Q69_Y1.2381.00
131_A151_R1.2301.00
25_Y135_S1.2231.00
41_I68_A1.2211.00
148_A155_I1.2141.00
243_V254_G1.2131.00
235_M254_G1.2121.00
34_T145_T1.2101.00
21_R27_E1.1971.00
123_A142_Y1.1801.00
61_P65_R1.1631.00
41_I108_A1.1611.00
14_S194_V1.1521.00
46_L84_G1.1361.00
39_D93_I1.1291.00
71_A133_I1.1291.00
35_I38_A1.1281.00
246_S251_T1.1261.00
74_L77_D1.1221.00
87_I109_T1.1171.00
67_L133_I1.1121.00
109_T113_L1.1121.00
146_A155_I1.1071.00
179_E183_A1.1051.00
114_N122_S1.1041.00
217_L221_T1.0971.00
179_E224_M1.0921.00
173_I227_E1.0921.00
200_A209_M1.0901.00
76_K117_W1.0891.00
223_D229_A1.0891.00
67_L106_A1.0861.00
263_Q266_Y1.0811.00
114_N126_L1.0781.00
167_I266_Y1.0731.00
97_A170_K1.0711.00
230_M233_N1.0691.00
169_A231_I1.0481.00
104_S140_C1.0461.00
222_L228_V1.0451.00
184_L188_G1.0431.00
38_A93_I1.0411.00
93_I99_L1.0371.00
112_G116_L1.0361.00
96_A250_P1.0281.00
75_I79_Y1.0241.00
266_Y270_R1.0211.00
210_C242_A1.0081.00
196_G212_R1.0051.00
114_N123_A1.0001.00
43_L109_T0.9991.00
213_L244_L0.9831.00
34_T144_G0.9811.00
110_L130_G0.9771.00
234_Q272_F0.9761.00
121_L129_L0.9701.00
72_A113_L0.9621.00
180_V221_T0.9581.00
235_M240_A0.9491.00
21_R33_T0.9441.00
85_V117_W0.9431.00
37_L99_L0.9431.00
115_R119_L0.9411.00
39_D91_K0.9391.00
96_A251_T0.9371.00
53_V66_N0.9291.00
236_K243_V0.9261.00
130_G137_V0.9251.00
54_S90_T0.9231.00
107_A141_V0.9221.00
49_D84_G0.9221.00
123_A127_A0.9201.00
222_L232_K0.9171.00
104_S143_G0.9131.00
127_A141_V0.9111.00
74_L133_I0.9081.00
183_A223_D0.9071.00
130_G141_V0.9061.00
165_W262_V0.9011.00
173_I225_H0.8981.00
53_V56_H0.8981.00
23_D27_E0.8981.00
46_L50_E0.8951.00
154_K157_H0.8941.00
207_Q257_Q0.8941.00
35_I168_L0.8881.00
240_A256_V0.8831.00
32_M139_F0.8811.00
60_V95_V0.8801.00
72_A85_V0.8751.00
207_Q211_S0.8731.00
62_D65_R0.8721.00
150_G153_E0.8721.00
20_K140_C0.8681.00
227_E231_I0.8641.00
199_E202_E0.8621.00
28_V32_M0.8581.00
16_D214_G0.8581.00
71_A110_L0.8551.00
232_K236_K0.8551.00
254_G265_I0.8521.00
48_E84_G0.8481.00
238_F256_V0.8461.00
100_A140_C0.8451.00
238_F265_I0.8451.00
71_A74_L0.8431.00
124_E142_Y0.8421.00
217_L248_S0.8340.99
93_I104_S0.8340.99
149_T154_K0.8340.99
127_A130_G0.8280.99
236_K240_A0.8280.99
142_Y155_I0.8260.99
34_T139_F0.8220.99
200_A208_K0.8190.99
124_E128_E0.8180.99
109_T112_G0.8170.99
167_I265_I0.8160.99
170_K174_G0.8130.99
232_K243_V0.8130.99
34_T143_G0.8110.99
267_N271_G0.8100.99
49_D76_K0.8090.99
175_V248_S0.8030.99
241_D257_Q0.8020.99
121_L125_T0.8020.99
175_V225_H0.7990.99
111_R141_V0.7950.99
63_D66_N0.7910.99
235_M243_V0.7910.99
234_Q237_R0.7900.99
75_I113_L0.7880.99
238_F268_G0.7860.99
66_N89_I0.7840.99
175_V250_P0.7810.99
85_V113_L0.7790.99
58_R62_D0.7780.99
99_L246_S0.7680.99
51_V55_S0.7650.99
25_Y151_R0.7600.99
243_V252_V0.7570.99
263_Q267_N0.7550.99
97_A251_T0.7420.99
256_V262_V0.7390.99
35_I166_V0.7390.99
121_L126_L0.7340.99
270_R273_C0.7320.99
72_A109_T0.7320.99
129_L132_E0.7290.99
131_A153_E0.7280.99
193_D196_G0.7270.99
16_D216_V0.7220.99
76_K84_G0.7180.98
53_V60_V0.7150.98
234_Q269_L0.7080.98
124_E127_A0.7070.98
264_R268_G0.7070.98
230_M234_Q0.7050.98
72_A84_G0.7050.98
43_L85_V0.7030.98
236_K242_A0.6980.98
16_D38_A0.6940.98
99_L168_L0.6940.98
139_F148_A0.6930.98
28_V184_L0.6900.98
254_G269_L0.6840.98
35_I253_F0.6830.98
34_T140_C0.6810.98
75_I120_N0.6800.98
210_C241_D0.6780.98
46_L52_R0.6770.98
221_T228_V0.6750.98
165_W258_Y0.6740.98
53_V89_I0.6730.98
199_E203_E0.6730.98
27_E184_L0.6730.98
225_H245_M0.6710.98
78_R128_E0.6710.98
267_N270_R0.6690.98
268_G272_F0.6680.98
20_K139_F0.6670.98
189_I216_V0.6580.97
69_Y87_I0.6570.97
110_L129_L0.6560.97
139_F181_Y0.6560.97
63_D69_Y0.6550.97
18_T185_K0.6510.97
175_V224_M0.6500.97
71_A109_T0.6490.97
197_M200_A0.6490.97
127_A138_S0.6490.97
31_I194_V0.6470.97
29_E195_Q0.6470.97
139_F146_A0.6460.97
197_M209_M0.6400.97
96_A170_K0.6400.97
208_K211_S0.6380.97
108_A140_C0.6380.97
189_I193_D0.6380.97
83_K117_W0.6340.97
70_Q133_I0.6320.97
41_I105_D0.6310.97
131_A138_S0.6300.97
142_Y146_A0.6290.97
75_I129_L0.6280.97
41_I104_S0.6280.97
77_D80_N0.6260.96
170_K250_P0.6240.96
188_G217_L0.6200.96
169_A273_C0.6170.96
127_A131_A0.6140.96
106_A133_I0.6130.96
268_G271_G0.6120.96
75_I109_T0.6100.96
129_L133_I0.6090.96
70_Q74_L0.6090.96
261_K264_R0.6090.96
128_E132_E0.6070.96
224_M227_E0.6060.96
79_Y114_N0.6050.96
15_L28_V0.6040.96
81_V117_W0.6040.96
71_A137_V0.6030.96
132_E135_S0.5970.95
264_R267_N0.5950.95
107_A130_G0.5930.95
169_A269_L0.5920.95
210_C236_K0.5880.95
239_G242_A0.5880.95
53_V68_A0.5870.95
43_L116_L0.5860.95
115_R118_N0.5850.95
23_D151_R0.5830.95
75_I114_N0.5820.95
51_V89_I0.5770.94
75_I121_L0.5770.94
164_C206_F0.5730.94
68_A87_I0.5720.94
95_V250_P0.5670.94
31_I158_I0.5670.94
29_E32_M0.5670.94
24_G33_T0.5660.94
133_I137_V0.5650.94
217_L245_M0.5610.94
51_V84_G0.5610.94
256_V261_K0.5580.93
197_M201_I0.5570.93
27_E131_A0.5570.93
111_R115_R0.5560.93
57_N60_V0.5560.93
208_K212_R0.5540.93
209_M242_A0.5540.93
109_T116_L0.5520.93
218_E245_M0.5520.93
236_K264_R0.5470.93
26_H197_M0.5470.93
20_K185_K0.5460.93
84_G116_L0.5440.93
260_S264_R0.5420.92
17_V140_C0.5410.92
103_S140_C0.5410.92
72_A117_W0.5400.92
31_I145_T0.5380.92
27_E154_K0.5350.92
131_A135_S0.5330.92
21_R153_E0.5330.92
32_M181_Y0.5330.92
220_V223_D0.5310.92
111_R143_G0.5290.91
54_S57_N0.5280.91
17_V217_L0.5260.91
106_A137_V0.5260.91
269_L273_C0.5240.91
180_V224_M0.5240.91
228_V232_K0.5230.91
93_I101_G0.5220.91
259_E262_V0.5220.91
191_H194_V0.5210.91
134_G181_Y0.5200.91
75_I126_L0.5190.91
18_T29_E0.5190.91
233_N236_K0.5180.91
210_C213_L0.5180.91
20_K186_L0.5180.91
145_T160_T0.5170.91
111_R123_A0.5170.91
41_I89_I0.5170.91
140_C146_A0.5130.90
194_V197_M0.5120.90
231_I252_V0.5100.90
219_S222_L0.5090.90
228_V231_I0.5090.90
18_T32_M0.5090.90
85_V116_L0.5090.90
19_R22_P0.5080.90
134_G137_V0.5040.89
219_S232_K0.5020.89
85_V112_G0.5020.89
219_S223_D0.5020.89
240_A243_V0.5020.89
108_A111_R0.5010.89
20_K27_E0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pyfA 1 0.9965 100 0.314 Contact Map
2v8pA 1 0.9239 100 0.317 Contact Map
1uekA 1 0.9239 100 0.328 Contact Map
2ww4A 2 0.9481 100 0.347 Contact Map
3ltoA 2 0.9516 100 0.404 Contact Map
3hulA 4 0.8927 100 0.407 Contact Map
4rpfA 2 0.9619 100 0.414 Contact Map
2gs8A 1 0.9723 100 0.417 Contact Map
1h72C 2 0.9446 100 0.418 Contact Map
4p52A 2 0.9619 100 0.424 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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