GREMLIN Database
SSPF - Protein SspF
UniProt: P37549 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 61 (57)
Sequences: 187 (78)
Seq/√Len: 10.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_I39_A2.7990.91
47_I51_E2.5950.87
45_R49_I2.5590.86
22_F39_A2.2380.77
16_L49_I2.0230.70
22_F34_I1.9650.67
29_G33_E1.8130.61
16_L42_M1.7200.56
10_D14_Y1.6790.55
8_M13_K1.5970.51
5_R25_T1.5670.49
8_M42_M1.5050.46
2_G55_A1.4570.44
42_M49_I1.4350.43
52_Q56_Q1.3520.39
16_L45_R1.3460.39
19_D56_Q1.3460.39
23_Y31_W1.2930.37
18_K31_W1.2790.36
48_E52_Q1.2490.35
4_R24_D1.2130.33
15_E26_V1.1960.33
36_A48_E1.1900.32
39_A45_R1.1340.30
4_R44_K1.1300.30
18_K23_Y1.1100.29
22_F42_M1.1070.29
15_E31_W1.1070.29
47_I53_Q1.0580.27
4_R29_G1.0060.25
14_Y53_Q1.0020.25
36_A39_A0.9840.25
15_E18_K0.9760.24
34_I45_R0.9700.24
32_G37_R0.9660.24
13_K32_G0.9340.23
4_R41_N0.9240.23
3_R6_G0.9230.23
10_D56_Q0.8990.22
10_D55_A0.8980.22
38_D42_M0.8960.22
2_G56_Q0.8960.22
22_F33_E0.8850.21
33_E38_D0.8780.21
35_R39_A0.8710.21
19_D54_M0.8550.20
26_V31_W0.8340.20
33_E37_R0.8180.19
11_E37_R0.8080.19
2_G37_R0.7890.19
5_R48_E0.7760.18
22_F45_R0.7690.18
1_M6_G0.7490.17
14_Y19_D0.7090.16
28_N41_N0.6990.16
12_F43_V0.6880.16
11_E14_Y0.6870.16
18_K50_A0.6770.16
37_R54_M0.6760.16
12_F16_L0.6710.15
38_D48_E0.6680.15
5_R51_E0.6470.15
18_K26_V0.6460.15
27_K39_A0.6380.15
23_Y27_K0.6270.14
27_K34_I0.6250.14
14_Y23_Y0.6190.14
16_L54_M0.6000.14
6_G27_K0.5870.14
34_I42_M0.5830.13
7_V11_E0.5810.13
12_F52_Q0.5720.13
42_M45_R0.5690.13
19_D45_R0.5600.13
31_W48_E0.5550.13
43_V47_I0.5540.13
22_F35_R0.5420.13
10_D31_W0.5390.12
22_F36_A0.5350.12
24_D54_M0.5270.12
29_G35_R0.5190.12
48_E56_Q0.5150.12
48_E54_M0.5080.12
13_K38_D0.5040.12
3_R15_E0.5030.12
4_R28_N0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z3xA 3 0.7869 99 0.623 Contact Map
3dnfA 2 0.5574 35.6 0.894 Contact Map
4h4dA 1 0.541 15.7 0.91 Contact Map
4n7bA 1 0.5738 13.1 0.913 Contact Map
4d10E 1 0.3607 7.5 0.922 Contact Map
4plpA 2 1 7.3 0.923 Contact Map
2fk5A 4 0.8197 7 0.924 Contact Map
2e1vA 1 0.3115 6.4 0.925 Contact Map
1k0wA 3 0.8361 6.3 0.925 Contact Map
3te6A 1 0.8525 6 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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