GREMLIN Database
YABG - Sporulation-specific protease YabG
UniProt: P37548 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (280)
Sequences: 273 (209)
Seq/√Len: 12.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_F22_I7.3381.00
153_L195_A5.2331.00
10_A16_M4.6801.00
187_H190_E3.9950.99
146_S187_H3.8700.99
10_A56_V3.4470.98
35_A50_F3.3280.98
144_K148_S3.1580.97
161_L195_A2.8630.95
137_G236_H2.6640.93
111_V133_V2.6200.92
179_L246_K2.3810.87
154_D197_K2.3380.86
105_F284_G2.3140.86
200_P256_I2.1980.83
216_F238_L2.1540.81
135_V168_A2.1070.80
157_R190_E2.1030.80
14_Y171_K2.0930.79
237_A276_E2.0660.79
121_L137_G2.0020.76
3_F161_L2.0010.76
22_I243_I1.9900.76
45_I149_I1.9470.74
22_I71_R1.9440.74
79_L262_L1.9350.74
189_V218_S1.9130.73
194_T197_K1.8500.70
247_I261_V1.8440.70
178_D181_A1.8330.69
163_I191_T1.8180.69
44_L276_E1.7690.67
121_L236_H1.7620.66
241_V266_L1.6770.62
251_P261_V1.6560.61
108_P125_L1.6480.61
250_T260_E1.6440.61
146_S190_E1.6320.60
23_I124_C1.6100.59
16_M54_V1.5990.58
161_L244_V1.5900.58
21_R181_A1.5710.57
137_G267_T1.5670.57
42_V176_I1.5580.56
111_V134_P1.5570.56
96_S260_E1.5550.56
15_Q199_I1.5540.56
189_V201_H1.5410.55
148_S256_I1.5170.54
108_P249_F1.5130.54
150_E195_A1.5050.54
6_G10_A1.4960.53
61_Q248_S1.4910.53
123_K145_M1.4900.53
108_P203_D1.4680.52
133_V245_A1.4400.50
90_Q172_Q1.4380.50
83_Y220_I1.4270.50
153_L161_L1.4230.49
132_G197_K1.4230.49
195_A199_I1.4170.49
6_G278_R1.4050.49
140_C215_H1.3990.48
14_Y110_K1.3980.48
245_A287_Y1.3930.48
42_V110_K1.3870.48
37_L192_V1.3830.47
124_C137_G1.3720.47
200_P262_L1.3700.47
75_S163_I1.3540.46
41_E126_N1.3490.46
252_F287_Y1.3450.45
146_S149_I1.3390.45
76_L249_F1.3310.45
22_I34_I1.3260.45
185_S281_L1.3260.45
63_M110_K1.3150.44
21_R242_Y1.3110.44
109_G134_P1.2900.43
266_L272_L1.2880.43
71_R219_L1.2870.43
163_I238_L1.2830.42
252_F282_R1.2830.42
114_L226_F1.2800.42
228_S235_I1.2490.41
109_G133_V1.2450.40
130_K220_I1.2450.40
11_R20_F1.2410.40
191_T219_L1.2380.40
153_L256_I1.2340.40
168_A234_N1.2320.40
95_T257_N1.2320.40
40_D218_S1.2310.40
172_Q233_V1.2260.40
133_V248_S1.2230.39
27_Q33_S1.2200.39
114_L195_A1.2150.39
154_D195_A1.2040.38
122_K163_I1.1680.37
155_K275_I1.1640.37
237_A265_T1.1550.36
140_C278_R1.1310.35
22_I97_Q1.1260.35
178_D267_T1.1240.35
6_G180_N1.1200.34
282_R286_P1.1140.34
82_D174_G1.1000.34
104_Y114_L1.0930.33
40_D169_Y1.0900.33
10_A18_V1.0860.33
185_S218_S1.0860.33
11_R52_D1.0820.33
145_M242_Y1.0730.32
169_Y234_N1.0720.32
38_H287_Y1.0690.32
8_M16_M1.0680.32
168_A285_M1.0650.32
111_V219_L1.0510.31
41_E249_F1.0490.31
149_I272_L1.0490.31
122_K216_F1.0440.31
82_D262_L1.0420.31
92_Y98_Y1.0400.31
243_I262_L1.0280.30
149_I161_L1.0160.30
16_M56_V1.0130.30
175_G178_D1.0060.29
241_V282_R1.0050.29
220_I287_Y1.0040.29
155_K248_S1.0010.29
129_K153_L0.9970.29
25_I63_M0.9950.29
35_A44_L0.9900.29
204_Q287_Y0.9820.28
91_E94_A0.9780.28
162_V229_S0.9750.28
50_F272_L0.9730.28
119_A272_L0.9710.28
62_M179_L0.9710.28
27_Q51_S0.9650.28
134_P248_S0.9640.28
102_E285_M0.9640.28
145_M280_V0.9620.28
4_Q55_A0.9580.27
44_L193_Q0.9560.27
3_F10_A0.9560.27
114_L188_F0.9500.27
123_K242_Y0.9470.27
202_L258_V0.9470.27
6_G83_Y0.9450.27
61_Q256_I0.9430.27
138_I191_T0.9420.27
151_V267_T0.9400.27
125_L155_K0.9370.27
105_F282_R0.9340.26
55_A138_I0.9330.26
213_Q227_A0.9320.26
179_L192_V0.9260.26
8_M61_Q0.9250.26
87_R90_Q0.9240.26
110_K270_K0.9230.26
129_K256_I0.9210.26
64_R161_L0.9190.26
56_V61_Q0.9180.26
144_K147_A0.9170.26
24_G186_K0.9150.26
88_E93_Y0.9140.26
46_A52_D0.9100.26
13_S20_F0.9060.25
58_K76_L0.9030.25
45_I106_H0.9020.25
76_L79_L0.9010.25
183_R270_K0.9000.25
116_G236_H0.8930.25
114_L133_V0.8930.25
149_I191_T0.8910.25
13_S52_D0.8890.25
183_R192_V0.8870.25
117_D236_H0.8810.24
149_I194_T0.8810.24
236_H241_V0.8800.24
186_K278_R0.8780.24
245_A278_R0.8760.24
145_M245_A0.8740.24
95_T262_L0.8740.24
72_M157_R0.8680.24
201_H204_Q0.8630.24
262_L285_M0.8630.24
242_Y267_T0.8620.24
63_M144_K0.8590.24
63_M66_K0.8590.24
23_I247_I0.8580.24
13_S17_D0.8560.23
106_H255_R0.8550.23
21_R254_E0.8530.23
108_P268_R0.8460.23
20_F52_D0.8400.23
157_R249_F0.8320.23
58_K102_E0.8320.23
176_I234_N0.8310.23
15_Q198_K0.8310.23
195_A237_A0.8290.22
130_K259_W0.8280.22
11_R17_D0.8280.22
109_G248_S0.8280.22
203_D273_G0.8270.22
200_P260_E0.8230.22
241_V277_T0.8220.22
4_Q15_Q0.8210.22
51_S201_H0.8200.22
40_D263_R0.8190.22
236_H267_T0.8190.22
215_H285_M0.8190.22
18_V136_Y0.8180.22
110_K184_H0.8160.22
27_Q66_K0.8150.22
195_A276_E0.8140.22
108_P278_R0.8110.22
191_T251_P0.8110.22
123_K127_V0.8100.22
79_L245_A0.8000.21
19_L83_Y0.7940.21
203_D267_T0.7920.21
137_G276_E0.7910.21
5_I14_Y0.7910.21
8_M244_V0.7910.21
90_Q114_L0.7870.21
151_V155_K0.7860.21
245_A248_S0.7850.21
209_A227_A0.7810.21
209_A213_Q0.7810.21
203_D278_R0.7740.21
50_F174_G0.7730.21
105_F286_P0.7720.21
69_E72_M0.7680.20
135_V234_N0.7650.20
200_P254_E0.7630.20
4_Q152_L0.7580.20
50_F141_H0.7570.20
14_Y149_I0.7560.20
156_Y161_L0.7550.20
41_E134_P0.7520.20
105_F215_H0.7510.20
123_K250_T0.7460.20
206_V280_V0.7420.20
241_V264_N0.7380.19
77_E262_L0.7380.19
25_I70_S0.7350.19
12_K261_V0.7330.19
266_L277_T0.7270.19
200_P281_L0.7260.19
133_V243_I0.7260.19
216_F222_A0.7250.19
265_T271_G0.7250.19
157_R251_P0.7240.19
65_K275_I0.7230.19
163_I193_Q0.7220.19
105_F216_F0.7220.19
74_E175_G0.7200.19
171_K222_A0.7190.19
140_C148_S0.7190.19
153_L206_V0.7180.19
11_R46_A0.7170.19
207_I278_R0.7160.19
236_H265_T0.7140.19
89_K219_L0.7120.19
24_G51_S0.7100.19
84_K262_L0.7090.18
203_D282_R0.7090.18
170_S181_A0.7090.18
90_Q194_T0.7080.18
5_I141_H0.7060.18
137_G265_T0.7050.18
4_Q190_E0.7050.18
225_N277_T0.7040.18
126_N133_V0.7010.18
114_L149_I0.7000.18
121_L276_E0.6970.18
109_G120_Y0.6940.18
215_H276_E0.6920.18
242_Y280_V0.6910.18
3_F183_R0.6910.18
208_F241_V0.6900.18
54_V101_Q0.6890.18
47_D183_R0.6880.18
63_M76_L0.6860.18
8_M272_L0.6860.18
35_A244_V0.6830.18
137_G237_A0.6830.18
186_K190_E0.6790.18
124_C267_T0.6760.17
169_Y244_V0.6750.17
81_Q219_L0.6660.17
71_R118_E0.6660.17
265_T273_G0.6650.17
72_M80_R0.6630.17
99_Q118_E0.6610.17
157_R255_R0.6600.17
248_S255_R0.6580.17
91_E95_T0.6560.17
14_Y158_P0.6550.17
244_V276_E0.6550.17
123_K139_H0.6520.17
16_M109_G0.6520.17
81_Q174_G0.6510.17
34_I63_M0.6490.17
99_Q173_K0.6460.17
88_E201_H0.6460.17
168_A262_L0.6420.17
38_H74_E0.6420.17
145_M216_F0.6390.16
99_Q119_A0.6380.16
113_H284_G0.6370.16
109_G125_L0.6350.16
35_A41_E0.6340.16
180_N233_V0.6320.16
129_K150_E0.6310.16
139_H215_H0.6290.16
51_S96_S0.6290.16
148_S186_K0.6260.16
143_K243_I0.6250.16
57_K104_Y0.6220.16
105_F242_Y0.6220.16
17_D52_D0.6210.16
84_K99_Q0.6190.16
37_L42_V0.6160.16
177_D220_I0.6150.16
6_G74_E0.6150.16
198_K281_L0.6150.16
17_D20_F0.6120.16
187_H258_V0.6120.16
61_Q88_E0.6120.16
39_G43_R0.6080.16
140_C254_E0.6080.16
249_F282_R0.6070.16
57_K190_E0.6040.15
36_I219_L0.6020.15
135_V269_E0.5990.15
16_M248_S0.5980.15
134_P187_H0.5980.15
96_S114_L0.5980.15
54_V68_D0.5970.15
236_H276_E0.5970.15
45_I114_L0.5960.15
8_M191_T0.5960.15
78_L145_M0.5960.15
19_L60_E0.5940.15
72_M79_L0.5900.15
55_A59_D0.5870.15
8_M50_F0.5860.15
270_K287_Y0.5850.15
63_M67_K0.5850.15
36_I61_Q0.5790.15
79_L263_R0.5780.15
44_L106_H0.5770.15
170_S173_K0.5760.15
4_Q102_E0.5750.15
140_C206_V0.5750.15
225_N250_T0.5750.15
33_S51_S0.5740.15
63_M141_H0.5740.15
232_R239_D0.5740.15
44_L251_P0.5730.15
257_N277_T0.5720.15
49_D118_E0.5690.15
119_A242_Y0.5690.15
34_I71_R0.5680.15
202_L246_K0.5680.15
22_I84_K0.5650.14
78_L264_N0.5650.14
132_G285_M0.5610.14
66_K71_R0.5600.14
90_Q94_A0.5590.14
44_L237_A0.5590.14
111_V195_A0.5580.14
61_Q261_V0.5560.14
236_H282_R0.5550.14
40_D70_S0.5520.14
44_L255_R0.5490.14
105_F220_I0.5490.14
96_S100_H0.5470.14
203_D265_T0.5470.14
82_D264_N0.5450.14
216_F247_I0.5430.14
108_P155_K0.5410.14
185_S189_V0.5390.14
62_M243_I0.5390.14
149_I243_I0.5390.14
4_Q93_Y0.5370.14
22_I143_K0.5300.14
34_I66_K0.5280.14
57_K87_R0.5270.14
54_V58_K0.5260.13
140_C178_D0.5250.13
33_S37_L0.5250.13
116_G120_Y0.5240.13
174_G219_L0.5240.13
108_P281_L0.5220.13
88_E99_Q0.5210.13
71_R188_F0.5180.13
216_F234_N0.5170.13
40_D157_R0.5160.13
189_V287_Y0.5160.13
117_D120_Y0.5140.13
34_I141_H0.5140.13
79_L193_Q0.5140.13
96_S148_S0.5130.13
135_V170_S0.5130.13
234_N264_N0.5130.13
19_L56_V0.5120.13
68_D243_I0.5120.13
64_R100_H0.5100.13
19_L195_A0.5080.13
249_F284_G0.5070.13
205_L267_T0.5050.13
48_S231_S0.5030.13
82_D143_K0.5030.13
93_Y118_E0.5020.13
38_H218_S0.5000.13
58_K219_L0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2plnA 2 0.3897 92.7 0.959 Contact Map
4r3uC 1 0.4276 87.7 0.963 Contact Map
3kyjB 1 0.4 86.9 0.964 Contact Map
4igaA 1 0.3931 84.6 0.965 Contact Map
3eulA 2 0.4207 84.3 0.965 Contact Map
4myrA 1 0.4207 79 0.967 Contact Map
2j48A 1 0.4034 78.9 0.967 Contact Map
4lzlA 1 0.4172 78.8 0.967 Contact Map
4jgiA 2 0.6276 78 0.967 Contact Map
1mvoA 2 0.3897 77.6 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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