GREMLIN Database
YABE - Uncharacterized protein YabE
UniProt: P37546 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 437 (391)
Sequences: 260 (225)
Seq/√Len: 11.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
415_V426_W4.5191.00
356_C359_C4.2781.00
349_S417_F4.1470.99
349_S415_V3.9380.99
274_K303_E3.7700.99
419_E422_S3.6020.98
347_V433_I3.5050.98
367_V402_A3.4900.98
291_E294_R3.0890.96
349_S426_W2.7240.92
384_V411_N2.6770.91
346_T432_K2.5620.89
255_K307_D2.4900.87
401_A404_T2.4700.87
392_H434_K2.4550.87
273_G276_G2.3970.85
396_Y399_A2.3800.85
385_I401_A2.3760.85
356_C361_G2.3350.84
378_I391_V2.3110.83
380_V401_A2.2960.83
347_V378_I2.2930.82
347_V399_A2.2570.81
381_D413_I2.2440.81
347_V416_F2.2140.80
406_S428_N2.1980.80
382_P401_A2.1530.78
281_H298_K2.1220.77
380_V385_I2.1160.77
387_L408_I2.1040.76
347_V415_V2.0580.75
368_N418_P2.0430.74
367_V377_V2.0110.73
356_C360_S2.0030.73
385_I399_A1.9950.72
375_A416_F1.9710.71
349_S392_H1.9560.71
407_A412_K1.9180.69
385_I404_T1.8980.68
199_S204_D1.8950.68
199_S203_A1.8840.68
344_V347_V1.8750.67
199_S205_F1.8740.67
399_A404_T1.8420.66
267_E312_V1.8290.65
273_G313_G1.8240.65
271_Q309_V1.8160.65
396_Y401_A1.7930.64
355_S370_K1.7710.63
132_N309_V1.7620.62
380_V404_T1.7610.62
368_N376_K1.7460.62
382_P385_I1.7380.61
363_T386_P1.7330.61
213_I310_I1.7300.61
369_L377_V1.7240.61
347_V412_K1.7170.60
399_A415_V1.7070.60
397_G401_A1.7030.60
380_V399_A1.6970.59
387_L393_V1.6640.58
345_M389_S1.6560.57
273_G289_G1.6560.57
396_Y404_T1.6530.57
386_P405_G1.6300.56
390_K398_Y1.6290.56
382_P404_T1.6160.55
378_I426_W1.5960.55
58_T61_A1.5840.54
347_V394_E1.5830.54
219_I236_I1.5700.53
142_A151_E1.5670.53
69_S80_H1.5560.53
381_D408_I1.5540.52
276_G289_G1.5500.52
354_A416_F1.5500.52
188_D236_I1.5440.52
369_L416_F1.5420.52
347_V426_W1.5280.51
263_E266_K1.5280.51
265_G273_G1.5080.50
394_E399_A1.4970.50
389_S402_A1.4930.49
381_D384_V1.4840.49
380_V396_Y1.4820.49
138_L148_L1.4780.49
397_G404_T1.4670.48
384_V401_A1.4600.48
385_I396_Y1.4570.48
189_A288_N1.4560.48
432_K435_I1.4450.47
407_A428_N1.4220.46
285_V293_S1.4200.46
393_V413_I1.4170.46
358_G361_G1.4120.46
284_V294_R1.3930.45
50_C54_A1.3920.45
289_G313_G1.3860.44
353_T420_K1.3760.44
392_H398_Y1.3760.44
354_A389_S1.3750.44
393_V434_K1.3730.44
225_A261_S1.3480.42
53_L59_A1.3430.42
385_I408_I1.3400.42
348_S412_K1.3360.42
399_A431_V1.3190.41
217_D289_G1.3140.41
405_G414_D1.3120.41
217_D313_G1.3080.41
380_V408_I1.3080.41
380_V397_G1.3030.40
139_W307_D1.2900.40
381_D387_L1.2850.39
262_L390_K1.2820.39
329_D333_V1.2800.39
384_V408_I1.2790.39
297_V305_S1.2710.39
351_A397_G1.2700.39
370_K416_F1.2620.38
375_A402_A1.2570.38
385_I397_G1.2550.38
352_Y366_G1.2530.38
379_A403_D1.2420.37
271_Q340_S1.2330.37
386_P414_D1.2300.37
218_K287_E1.2270.37
401_A408_I1.2220.37
53_L73_S1.1990.36
344_V390_K1.1910.35
274_K306_K1.1900.35
414_D427_G1.1850.35
386_P403_D1.1790.35
353_T401_A1.1760.35
219_I223_L1.1720.34
366_G403_D1.1700.34
382_P397_G1.1670.34
152_Q156_V1.1670.34
234_I343_K1.1460.33
399_A408_I1.1370.33
381_D401_A1.1320.33
275_E305_S1.1270.32
347_V411_N1.1210.32
382_P399_A1.1210.32
380_V406_S1.1180.32
66_T84_H1.1160.32
381_D391_V1.1140.32
150_D374_N1.1120.32
88_V133_G1.1100.32
59_A79_K1.1080.32
358_G367_V1.1020.31
349_S428_N1.1010.31
265_G289_G1.0980.31
381_D393_V1.0920.31
353_T356_C1.0920.31
199_S241_K1.0850.31
341_T406_S1.0840.31
103_D313_G1.0840.31
42_S180_P1.0800.30
255_K286_K1.0730.30
265_G276_G1.0690.30
360_S367_V1.0680.30
391_V408_I1.0670.30
384_V410_G1.0670.30
309_V435_I1.0650.30
368_N377_V1.0650.30
217_D276_G1.0610.30
217_D273_G1.0590.30
363_T405_G1.0590.30
396_Y431_V1.0570.29
49_A53_L1.0570.29
393_V408_I1.0560.29
376_K415_V1.0550.29
276_G285_V1.0510.29
202_V289_G1.0480.29
127_V297_V1.0470.29
401_A413_I1.0460.29
146_G304_Q1.0380.29
379_A405_G1.0380.29
49_A55_G1.0350.29
102_E183_Q1.0330.28
150_D153_D1.0310.28
268_K429_K1.0300.28
276_G313_G1.0300.28
244_D296_L1.0280.28
384_V399_A1.0270.28
45_I48_A1.0250.28
347_V381_D1.0240.28
344_V416_F1.0230.28
202_V217_D1.0200.28
379_A386_P1.0200.28
103_D217_D1.0190.28
392_H399_A1.0180.28
363_T416_F1.0170.28
49_A165_A1.0070.27
389_S400_I0.9970.27
48_A57_G0.9970.27
366_G405_G0.9950.27
348_S428_N0.9930.27
376_K396_Y0.9920.27
215_D389_S0.9910.27
317_S320_K0.9910.27
382_P396_Y0.9910.27
331_K335_S0.9900.27
42_S56_S0.9880.27
380_V384_V0.9870.27
391_V434_K0.9870.27
50_C53_L0.9860.27
105_I138_L0.9860.27
130_T184_V0.9800.26
349_S408_I0.9790.26
354_A358_G0.9770.26
378_I413_I0.9770.26
395_G405_G0.9740.26
403_D414_D0.9710.26
300_E389_S0.9710.26
148_L164_P0.9700.26
288_N313_G0.9700.26
381_D411_N0.9680.26
148_L170_I0.9640.26
400_I426_W0.9620.26
344_V434_K0.9620.26
98_K298_K0.9590.26
289_G294_R0.9560.26
352_Y403_D0.9500.25
396_Y429_K0.9480.25
366_G379_A0.9470.25
380_V431_V0.9440.25
425_R433_I0.9430.25
350_T407_A0.9400.25
401_A431_V0.9370.25
109_K422_S0.9340.25
191_K215_D0.9340.25
392_H402_A0.9330.25
42_S54_A0.9330.25
360_S416_F0.9320.25
237_T287_E0.9310.25
247_E296_L0.9310.25
103_D206_L0.9280.24
93_E272_K0.9250.24
53_L101_D0.9230.24
399_A411_N0.9210.24
408_I428_N0.9200.24
286_K291_E0.9160.24
376_K402_A0.9140.24
181_A198_T0.9120.24
387_L404_T0.9110.24
112_K400_I0.9100.24
136_K268_K0.9070.24
367_V400_I0.9060.24
212_N303_E0.9030.24
257_Q268_K0.9020.24
347_V376_K0.9010.24
171_S266_K0.9010.24
348_S355_S0.9000.23
369_L372_N0.9000.23
399_A429_K0.8970.23
366_G386_P0.8930.23
71_S78_K0.8920.23
401_A406_S0.8860.23
288_N398_Y0.8850.23
291_E436_L0.8830.23
277_K303_E0.8770.23
376_K434_K0.8760.23
205_F245_V0.8750.23
393_V426_W0.8750.23
381_D385_I0.8750.23
385_I428_N0.8690.22
394_E397_G0.8690.22
347_V396_Y0.8670.22
425_R432_K0.8650.22
119_V260_A0.8640.22
217_D265_G0.8630.22
351_A396_Y0.8620.22
202_V313_G0.8600.22
384_V407_A0.8560.22
265_G269_V0.8540.22
408_I411_N0.8510.22
290_K295_E0.8490.22
397_G408_I0.8490.22
202_V206_L0.8450.22
353_T380_V0.8450.22
339_E429_K0.8440.22
53_L114_T0.8430.22
54_A86_N0.8430.22
305_S309_V0.8420.22
62_A68_Q0.8400.21
386_P395_G0.8390.21
396_Y415_V0.8380.21
369_L434_K0.8380.21
53_L407_A0.8370.21
172_K426_W0.8360.21
53_L80_H0.8360.21
260_A422_S0.8360.21
72_V80_H0.8360.21
350_T378_I0.8360.21
52_L55_G0.8350.21
384_V431_V0.8300.21
341_T374_N0.8290.21
391_V410_G0.8280.21
366_G388_G0.8270.21
351_A401_A0.8270.21
285_V289_G0.8260.21
349_S404_T0.8240.21
344_V432_K0.8220.21
370_K377_V0.8210.21
392_H401_A0.8210.21
248_E304_Q0.8170.21
353_T358_G0.8170.21
51_L57_G0.8120.21
68_Q207_K0.8100.20
353_T399_A0.8060.20
75_N123_A0.8050.20
163_D227_L0.8040.20
378_I433_I0.8030.20
270_V294_R0.8020.20
394_E404_T0.8020.20
394_E432_K0.8000.20
225_A316_Q0.7940.20
406_S411_N0.7920.20
378_I432_K0.7890.20
248_E280_K0.7890.20
85_A90_D0.7880.20
381_D404_T0.7860.20
235_T389_S0.7820.20
347_V387_L0.7790.19
356_C416_F0.7780.19
353_T392_H0.7780.19
103_D202_V0.7780.19
99_T419_E0.7770.19
409_K413_I0.7760.19
259_D265_G0.7750.19
252_F289_G0.7750.19
384_V404_T0.7720.19
405_G427_G0.7700.19
379_A414_D0.7640.19
266_K425_R0.7620.19
271_Q308_K0.7600.19
363_T423_A0.7600.19
401_A407_A0.7590.19
131_I207_K0.7580.19
89_G93_E0.7580.19
352_Y405_G0.7570.19
356_C423_A0.7530.19
186_V201_T0.7530.19
195_I329_D0.7520.19
366_G414_D0.7520.19
333_V337_S0.7510.19
189_A213_I0.7480.19
418_P422_S0.7470.19
354_A369_L0.7440.18
341_T393_V0.7430.18
262_L266_K0.7420.18
353_T402_A0.7350.18
53_L389_S0.7330.18
301_T406_S0.7320.18
347_V408_I0.7320.18
276_G288_N0.7320.18
394_E411_N0.7320.18
404_T431_V0.7300.18
361_G377_V0.7300.18
53_L58_T0.7220.18
389_S398_Y0.7200.18
57_G61_A0.7180.18
56_S224_D0.7170.18
202_V265_G0.7160.18
377_V416_F0.7120.18
344_V399_A0.7100.17
103_D276_G0.7100.17
60_Y64_E0.7100.17
400_I432_K0.7090.17
241_K244_D0.7070.17
174_M192_Q0.7040.17
380_V407_A0.7040.17
216_E256_K0.7040.17
80_H150_D0.7030.17
364_A387_L0.7030.17
113_I277_K0.7010.17
339_E419_E0.7000.17
408_I431_V0.6960.17
48_A389_S0.6960.17
48_A55_G0.6960.17
242_V245_V0.6930.17
351_A380_V0.6900.17
408_I413_I0.6900.17
88_V140_S0.6890.17
107_P111_T0.6870.17
411_N416_F0.6860.17
77_K81_I0.6850.17
359_C423_A0.6840.17
229_K412_K0.6840.17
135_E298_K0.6840.17
309_V317_S0.6830.17
74_I95_L0.6810.17
134_E341_T0.6790.17
376_K394_E0.6770.17
70_V349_S0.6760.17
351_A427_G0.6670.16
103_D289_G0.6660.16
353_T365_T0.6660.16
202_V273_G0.6640.16
48_A71_S0.6640.16
347_V432_K0.6630.16
354_A367_V0.6620.16
310_I313_G0.6620.16
401_A411_N0.6620.16
386_P427_G0.6620.16
161_Q429_K0.6610.16
378_I415_V0.6610.16
369_L408_I0.6560.16
239_I242_V0.6550.16
351_A394_E0.6550.16
101_D277_K0.6550.16
202_V269_V0.6540.16
382_P392_H0.6530.16
268_K274_K0.6520.16
210_K227_L0.6510.16
244_D336_R0.6500.16
243_T247_E0.6500.16
385_I413_I0.6490.16
202_V252_F0.6490.16
83_T238_R0.6480.16
230_G295_E0.6460.16
99_T136_K0.6450.16
421_S436_L0.6450.16
352_Y379_A0.6450.16
402_A436_L0.6440.16
53_L57_G0.6440.16
298_K301_T0.6440.16
237_T311_A0.6440.16
392_H396_Y0.6410.16
385_I406_S0.6410.16
185_T348_S0.6390.16
132_N158_E0.6370.15
140_S170_I0.6370.15
394_E412_K0.6350.15
346_T394_E0.6330.15
62_A213_I0.6320.15
403_D427_G0.6320.15
349_S401_A0.6300.15
167_D421_S0.6260.15
248_E425_R0.6240.15
395_G403_D0.6230.15
352_Y386_P0.6210.15
58_T62_A0.6200.15
349_S381_D0.6160.15
182_F200_T0.6160.15
152_Q166_I0.6140.15
126_P300_E0.6130.15
176_I217_D0.6130.15
392_H404_T0.6110.15
363_T414_D0.6100.15
195_I309_V0.6080.15
330_S335_S0.6080.15
399_A413_I0.6070.15
381_D409_K0.6050.15
265_G313_G0.6040.15
375_A418_P0.6040.15
64_E67_K0.6030.15
77_K421_S0.6030.15
388_G403_D0.6010.15
376_K418_P0.6000.15
397_G427_G0.5980.15
226_K270_V0.5950.14
54_A75_N0.5950.14
129_L171_S0.5950.14
86_N93_E0.5940.14
91_L119_V0.5920.14
268_K290_K0.5910.14
293_S297_V0.5910.14
60_Y86_N0.5910.14
138_L164_P0.5900.14
67_K84_H0.5900.14
401_A412_K0.5890.14
67_K369_L0.5880.14
245_V369_L0.5880.14
206_L273_G0.5870.14
384_V406_S0.5870.14
347_V393_V0.5860.14
227_L232_A0.5860.14
351_A385_I0.5860.14
394_E401_A0.5840.14
252_F265_G0.5840.14
222_A250_I0.5840.14
401_A410_G0.5830.14
365_T406_S0.5820.14
368_N391_V0.5820.14
46_L57_G0.5820.14
53_L60_Y0.5820.14
42_S58_T0.5810.14
215_D242_V0.5800.14
150_D271_Q0.5800.14
413_I432_K0.5800.14
394_E431_V0.5800.14
261_S267_E0.5800.14
272_K286_K0.5770.14
61_A65_L0.5760.14
163_D222_A0.5720.14
283_E339_E0.5700.14
122_E125_K0.5690.14
43_K60_Y0.5690.14
395_G414_D0.5670.14
203_A257_Q0.5670.14
54_A180_P0.5650.14
290_K348_S0.5640.14
416_F434_K0.5630.14
78_K116_D0.5630.14
115_A295_E0.5620.14
308_K348_S0.5620.14
176_I394_E0.5610.14
376_K391_V0.5600.14
202_V205_F0.5590.14
252_F273_G0.5590.14
115_A315_K0.5590.14
202_V276_G0.5580.14
426_W431_V0.5570.14
97_I103_D0.5570.14
272_K355_S0.5570.14
174_M389_S0.5570.14
293_S307_D0.5560.14
353_T413_I0.5560.14
244_D247_E0.5550.14
171_S426_W0.5540.13
151_E314_T0.5520.13
363_T403_D0.5520.13
380_V413_I0.5510.13
350_T413_I0.5490.13
397_G431_V0.5490.13
62_A126_P0.5490.13
381_D397_G0.5490.13
47_V51_L0.5480.13
393_V405_G0.5470.13
140_S387_L0.5470.13
51_L55_G0.5470.13
417_F426_W0.5460.13
251_A275_E0.5460.13
213_I217_D0.5440.13
384_V413_I0.5430.13
307_D313_G0.5430.13
351_A382_P0.5420.13
262_L289_G0.5400.13
54_A62_A0.5400.13
57_G167_D0.5400.13
171_S263_E0.5390.13
58_T81_I0.5390.13
127_V176_I0.5390.13
336_R389_S0.5380.13
352_Y388_G0.5360.13
110_Q137_T0.5340.13
345_M435_I0.5340.13
151_E234_I0.5340.13
230_G250_I0.5330.13
352_Y395_G0.5320.13
352_Y427_G0.5310.13
152_Q194_K0.5310.13
92_L176_I0.5310.13
368_N393_V0.5300.13
68_Q305_S0.5300.13
138_L389_S0.5300.13
387_L401_A0.5290.13
49_A82_R0.5270.13
86_N105_I0.5270.13
426_W429_K0.5240.13
391_V413_I0.5230.13
215_D355_S0.5210.13
385_I407_A0.5200.13
48_A167_D0.5200.13
282_F288_N0.5190.13
125_K393_V0.5190.13
135_E146_G0.5180.13
392_H416_F0.5180.13
353_T412_K0.5160.13
359_C416_F0.5120.13
49_A71_S0.5120.13
103_D145_V0.5110.13
65_L409_K0.5090.12
90_D94_T0.5080.12
322_E329_D0.5060.12
215_D321_F0.5060.12
352_Y414_D0.5060.12
290_K378_I0.5060.12
213_I236_I0.5050.12
304_Q428_N0.5030.12
54_A57_G0.5030.12
416_F419_E0.5020.12
127_V268_K0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wjtA 2 0.2426 100 0.723 Contact Map
2ae0X 1 0.6407 99.9 0.816 Contact Map
2pnwA 1 0.5789 99.8 0.846 Contact Map
2g5dA 1 0.5584 99.7 0.857 Contact Map
3czbA 2 0.6224 99.7 0.858 Contact Map
3eo5A 1 0.3684 99.5 0.883 Contact Map
4fuoA 2 0.4416 99.3 0.891 Contact Map
2ltjA 1 0.2471 99.1 0.902 Contact Map
4fzqA 4 0.1808 99.1 0.903 Contact Map
4wveA 1 0.4485 98.9 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0115 seconds.