GREMLIN Database
YABA - Initiation-control protein YabA
UniProt: P37542 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 119 (109)
Sequences: 324 (229)
Seq/√Len: 22.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_Y104_V4.6091.00
100_H110_L3.4311.00
83_Y88_R2.5830.98
18_G25_G2.4610.98
14_E28_K2.2990.97
108_D116_L2.2710.96
110_L116_L2.2520.96
61_K72_Q2.1940.96
82_G115_F1.8680.90
73_K76_Q1.7690.87
62_F76_Q1.7570.87
20_L91_Q1.7070.85
81_E84_D1.6730.84
99_V118_K1.6560.83
80_G88_R1.6320.82
16_Q23_Q1.6120.82
72_Q75_E1.5510.79
18_G21_Y1.5390.79
6_L11_I1.5360.78
51_R103_S1.5170.78
82_G88_R1.5010.77
79_I117_N1.4730.75
59_I62_F1.4720.75
9_T23_Q1.4390.74
39_H104_V1.4250.73
57_Q72_Q1.4120.72
100_H103_S1.3900.71
31_I34_M1.3870.71
4_K8_D1.3850.71
79_I116_L1.3550.69
96_I116_L1.3320.68
14_E92_E1.3180.67
81_E88_R1.2890.65
30_H33_E1.2780.64
3_K38_N1.2710.64
35_I43_L1.2510.63
88_R115_F1.2270.61
16_Q34_M1.1980.59
40_H107_E1.1970.59
9_T13_L1.1820.58
10_V30_H1.1750.58
109_C112_C1.1750.58
82_G116_L1.1640.57
10_V17_I1.1420.55
62_F73_K1.1420.55
110_L117_N1.1410.55
56_T61_K1.1210.54
19_S72_Q1.1160.54
13_L20_L1.1080.53
9_T78_D1.1070.53
91_Q104_V1.1040.53
47_H51_R1.0960.52
2_D56_T1.0700.51
81_E115_F1.0670.50
89_L92_E1.0220.47
17_I24_L1.0160.47
80_G84_D1.0140.47
79_I88_R1.0110.47
43_L56_T0.9940.45
62_F75_E0.9910.45
18_G35_I0.9860.45
5_E12_N0.9830.45
81_E87_A0.9730.44
5_E19_S0.9590.43
84_D115_F0.9550.43
8_D101_Y0.9540.43
114_S118_K0.9530.43
29_Q33_E0.9490.42
39_H43_L0.9450.42
87_A108_D0.9310.41
58_Q62_F0.9290.41
25_G35_I0.9270.41
43_L72_Q0.9230.41
16_Q118_K0.9080.40
27_L35_I0.9030.39
79_I87_A0.9020.39
55_T60_E0.8980.39
27_L89_L0.8970.39
87_A115_F0.8900.39
58_Q74_T0.8890.38
17_I25_G0.8880.38
50_K101_Y0.8770.38
15_E22_R0.8720.37
22_R29_Q0.8710.37
74_T77_T0.8700.37
84_D113_L0.8510.36
17_I23_Q0.8510.36
79_I96_I0.8500.36
60_E76_Q0.8490.36
61_K74_T0.8430.36
72_Q76_Q0.8280.35
83_Y96_I0.8180.34
96_I117_N0.8070.33
91_Q106_K0.7950.33
84_D116_L0.7950.33
40_H51_R0.7890.32
10_V118_K0.7840.32
8_D75_E0.7620.31
1_M43_L0.7560.30
47_H99_V0.7560.30
56_T107_E0.7530.30
99_V103_S0.7440.30
21_Y101_Y0.7390.29
47_H103_S0.7320.29
40_H101_Y0.7140.28
46_K50_K0.7070.28
3_K101_Y0.6980.27
85_N113_L0.6970.27
11_I31_I0.6910.27
46_K98_N0.6870.27
8_D47_H0.6860.26
8_D72_Q0.6860.26
28_K99_V0.6740.26
57_Q62_F0.6620.25
12_N26_D0.6500.25
110_L113_L0.6490.25
62_F72_Q0.6480.25
82_G108_D0.6410.24
32_G47_H0.6400.24
22_R26_D0.6300.24
88_R96_I0.6230.23
28_K108_D0.6200.23
31_I99_V0.6090.23
21_Y25_G0.6070.23
40_H89_L0.6060.22
110_L114_S0.6060.22
17_I47_H0.6050.22
19_S61_K0.6040.22
49_R52_L0.6000.22
8_D54_D0.6000.22
22_R59_I0.5960.22
84_D88_R0.5890.22
22_R101_Y0.5860.22
12_N23_Q0.5850.21
103_S114_S0.5840.21
44_E48_L0.5790.21
32_G89_L0.5760.21
1_M7_F0.5750.21
7_F16_Q0.5740.21
73_K77_T0.5700.21
19_S50_K0.5690.21
8_D15_E0.5650.21
106_K118_K0.5600.20
33_E57_Q0.5590.20
54_D73_K0.5590.20
36_E92_E0.5460.20
26_D30_H0.5430.20
57_Q76_Q0.5420.20
13_L31_I0.5370.19
48_L86_L0.5360.19
6_L55_T0.5350.19
91_Q114_S0.5330.19
40_H106_K0.5310.19
22_R25_G0.5260.19
80_G110_L0.5190.19
3_K7_F0.5180.19
59_I73_K0.5130.18
29_Q50_K0.5100.18
62_F74_T0.5100.18
29_Q39_H0.5090.18
32_G53_D0.5080.18
99_V110_L0.5040.18
8_D104_V0.5000.18
5_E96_I0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s9gA 2 0.437 86.1 0.895 Contact Map
1dipA 2 0.5966 81.7 0.9 Contact Map
3i00A 2 0.4538 71.3 0.909 Contact Map
1kd8A 1 0.2941 70.3 0.909 Contact Map
3w92A 3 0.2605 67.7 0.911 Contact Map
3c3gA 2 0.1681 63.1 0.914 Contact Map
4tl1A 2 0.2689 62.2 0.914 Contact Map
1kd8B 1 0.2941 61 0.915 Contact Map
3c3fA 3 0.1933 59.5 0.915 Contact Map
2jeeA 2 0.6555 57.7 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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