GREMLIN Database
YAAR - Uncharacterized protein YaaR
UniProt: P37539 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 146 (144)
Sequences: 409 (331)
Seq/√Len: 27.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_K110_D4.0851.00
2_K5_K3.0501.00
114_I118_E2.9251.00
85_G114_I2.6050.99
89_E107_K2.5550.99
71_K117_T2.3740.99
131_L136_E2.3590.99
63_N66_D2.2910.98
52_E56_K2.2630.98
119_E122_D2.1560.98
135_G138_K2.1220.97
114_I143_N2.0630.97
110_D135_G2.0330.97
2_K7_I2.0230.96
85_G143_N1.8810.95
66_D101_R1.8450.94
16_I140_L1.7590.92
126_P129_D1.7410.92
54_F63_N1.7260.92
85_G145_Y1.6980.91
53_A56_K1.6930.91
87_S128_I1.6840.91
37_S50_D1.6820.91
105_L135_G1.5890.88
112_K136_E1.5650.87
32_M143_N1.5400.86
44_L77_F1.4950.84
79_K83_D1.4540.83
19_V23_E1.4390.82
111_D115_Q1.4300.82
109_I144_L1.4240.81
55_G134_I1.4240.81
93_S103_L1.4140.81
31_S135_G1.4100.81
124_E135_G1.3810.79
96_L99_N1.3780.79
131_L135_G1.3620.78
61_S66_D1.3500.78
59_T110_D1.3500.78
51_I103_L1.3450.77
55_G120_M1.3450.77
109_I141_L1.3440.77
91_S107_K1.3430.77
47_L73_L1.3250.76
44_L48_L1.3020.75
1_M141_L1.2980.75
69_R144_L1.2970.75
112_K115_Q1.2830.74
119_E133_R1.2700.73
26_A30_T1.2620.73
130_L142_I1.2600.73
49_S53_A1.2180.70
37_S125_K1.2080.69
135_G143_N1.2020.69
12_D78_V1.1710.67
115_Q128_I1.1620.66
74_V128_I1.1440.65
3_I84_S1.1410.65
41_L45_T1.1410.65
86_L114_I1.1220.63
20_K83_D1.1020.62
54_F64_F1.1000.62
73_L80_E1.0880.61
70_F81_A1.0820.61
105_L109_I1.0810.60
63_N134_I1.0800.60
4_N57_R1.0730.60
21_T134_I1.0670.59
27_S134_I1.0600.59
4_N8_R1.0570.59
6_D16_I1.0490.58
20_K53_A1.0290.57
112_K128_I1.0280.57
78_V102_T1.0220.56
138_K141_L1.0210.56
31_S106_V1.0200.56
21_T46_R1.0160.56
124_E127_A1.0150.56
118_E121_M1.0140.56
75_K120_M1.0100.55
6_D144_L1.0040.55
21_T24_I0.9970.54
44_L137_I0.9840.53
51_I73_L0.9830.53
2_K6_D0.9660.52
16_I59_T0.9620.52
4_N63_N0.9590.51
99_N103_L0.9550.51
105_L115_Q0.9550.51
28_F98_G0.9520.51
88_H104_G0.9510.51
108_E112_K0.9370.50
63_N101_R0.9280.49
16_I21_T0.9230.49
43_Q80_E0.9170.48
62_R136_E0.9030.47
122_D132_E0.9010.47
77_F109_I0.8980.47
64_F121_M0.8950.46
75_K134_I0.8920.46
31_S124_E0.8890.46
39_M47_L0.8840.46
106_V112_K0.8750.45
24_I128_I0.8570.44
67_L90_T0.8560.44
113_L136_E0.8500.43
32_M71_K0.8490.43
48_L87_S0.8410.42
71_K84_S0.8330.42
14_K43_Q0.8330.42
49_S144_L0.8320.42
59_T94_F0.8220.41
66_D120_M0.8160.41
54_F66_D0.8150.41
72_G76_R0.8070.40
35_Q43_Q0.8060.40
86_L145_Y0.8060.40
104_G135_G0.8000.39
11_I27_S0.8000.39
9_T14_K0.7990.39
45_T70_F0.7950.39
58_L126_P0.7810.38
38_K45_T0.7780.38
67_L123_Q0.7740.38
35_Q57_R0.7740.38
37_S49_S0.7710.37
70_F78_V0.7510.36
55_G74_V0.7480.36
77_F138_K0.7460.36
20_K32_M0.7450.35
54_F73_L0.7440.35
93_S102_T0.7370.35
108_E143_N0.7360.35
48_L74_V0.7300.34
78_V145_Y0.7230.34
3_I22_S0.7100.33
43_Q109_I0.7100.33
56_K60_K0.7060.33
93_S99_N0.7030.33
47_L80_E0.7020.33
40_K86_L0.7000.32
97_Y103_L0.6990.32
60_K65_K0.6960.32
64_F103_L0.6930.32
94_F100_S0.6890.32
74_V109_I0.6860.31
32_M80_E0.6850.31
62_R127_A0.6810.31
93_S101_R0.6800.31
60_K144_L0.6770.31
58_L90_T0.6770.31
33_E37_S0.6760.31
117_T120_M0.6730.31
63_N88_H0.6690.30
33_E38_K0.6650.30
34_N41_L0.6640.30
64_F131_L0.6630.30
54_F67_L0.6520.29
70_F103_L0.6500.29
100_S133_R0.6400.29
93_S96_L0.6400.29
3_I20_K0.6360.28
50_D69_R0.6300.28
58_L101_R0.6260.28
70_F128_I0.6240.28
45_T49_S0.6230.28
57_R66_D0.6160.27
133_R142_I0.6150.27
19_V33_E0.6140.27
77_F98_G0.6110.27
36_S128_I0.6080.27
53_A72_G0.6070.27
88_H94_F0.5950.26
59_T80_E0.5940.26
112_K117_T0.5940.26
118_E143_N0.5860.25
48_L63_N0.5830.25
90_T94_F0.5810.25
118_E125_K0.5760.25
67_L120_M0.5600.24
34_N121_M0.5570.24
37_S84_S0.5570.24
94_F112_K0.5570.24
13_N23_E0.5560.24
11_I14_K0.5550.24
122_D128_I0.5550.24
105_L130_L0.5540.24
82_V106_V0.5530.23
82_V141_L0.5510.23
17_P109_I0.5480.23
50_D73_L0.5460.23
122_D125_K0.5460.23
7_I19_V0.5450.23
112_K140_L0.5450.23
50_D76_R0.5390.23
11_I128_I0.5360.23
86_L94_F0.5350.22
68_A111_D0.5350.22
62_R82_V0.5330.22
95_D99_N0.5310.22
92_K95_D0.5290.22
29_K34_N0.5260.22
13_N115_Q0.5260.22
77_F101_R0.5240.22
10_F45_T0.5240.22
67_L101_R0.5210.22
18_S122_D0.5200.22
6_D9_T0.5190.22
3_I69_R0.5180.22
21_T48_L0.5050.21
23_E26_A0.5030.21
14_K121_M0.5030.21
85_G135_G0.5020.21
62_R134_I0.5010.21
44_L74_V0.5010.21
101_R124_E0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qupA 1 0.8151 100 0.113 Contact Map
2p61A 1 0.774 100 0.156 Contact Map
2hc5A 1 0.7466 66.2 0.908 Contact Map
3d5aX 1 0.7329 14.4 0.937 Contact Map
3ns4A 2 0.2945 11.2 0.94 Contact Map
3wdgB 1 0.3767 9.4 0.942 Contact Map
2kw6A 2 0.3836 8.3 0.943 Contact Map
4e0gA 2 0.9315 7.7 0.944 Contact Map
3bghA 4 0.3836 6 0.947 Contact Map
4yubA 2 0.7055 5.3 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0063 seconds.