GREMLIN Database
KTHY - Thymidylate kinase
UniProt: P37537 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (201)
Sequences: 4668 (3484)
Seq/√Len: 245.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
190_Q198_D3.7901.00
26_I200_L3.2391.00
33_Q90_F3.1661.00
135_F188_A3.0001.00
22_E196_V2.8581.00
107_Y171_G2.6981.00
136_S169_Q2.6141.00
24_K28_T2.4661.00
190_Q194_L2.3901.00
141_E144_K2.1741.00
191_S194_L2.1471.00
76_Q80_E2.1331.00
169_Q173_Q2.1191.00
186_V195_V2.0741.00
35_M90_F2.0581.00
37_T77_H2.0011.00
20_L36_A1.9751.00
20_L93_L1.9251.00
30_E204_D1.9221.00
19_V199_V1.8671.00
79_V83_K1.8621.00
136_S173_Q1.8471.00
32_L91_I1.8141.00
19_V196_V1.7951.00
4_L91_I1.7921.00
155_N158_D1.7871.00
24_K36_A1.7861.00
26_I30_E1.7291.00
83_K87_E1.7071.00
184_H202_V1.6841.00
196_V200_L1.6801.00
173_Q185_S1.6791.00
138_D189_G1.6671.00
14_A137_I1.6531.00
24_K93_L1.5781.00
133_V202_V1.5761.00
134_Y183_F1.5701.00
99_D182_R1.5281.00
19_V22_E1.5151.00
5_F94_C1.5051.00
137_I141_E1.4801.00
109_R160_E1.4561.00
184_H206_A1.4381.00
118_S121_E1.4341.00
170_E174_E1.3931.00
47_E73_A1.3661.00
83_K127_M1.3521.00
176_M185_S1.3511.00
48_Q51_E1.3491.00
134_Y185_S1.3481.00
166_T170_E1.3431.00
45_I61_M1.3391.00
26_I204_D1.3361.00
23_I203_I1.3321.00
25_N29_A1.3271.00
7_T94_C1.3181.00
12_E142_G1.3171.00
135_F199_V1.3121.00
133_V199_V1.2921.00
62_D79_V1.2881.00
26_I196_V1.2841.00
49_I69_L1.2711.00
174_E178_R1.2551.00
35_M85_A1.2461.00
162_L166_T1.2421.00
141_E189_G1.2371.00
99_D132_T1.2161.00
8_F23_I1.2151.00
11_P165_H1.2141.00
139_P162_L1.2081.00
22_E192_K1.2071.00
85_A90_F1.2051.00
22_E193_D1.2031.00
174_E177_K1.2031.00
200_L204_D1.1991.00
103_A107_Y1.1841.00
202_V206_A1.1741.00
142_G146_I1.1641.00
186_V202_V1.1591.00
43_I46_A1.1571.00
196_V199_V1.1541.00
30_E200_L1.1521.00
7_T99_D1.1471.00
71_A120_N1.1451.00
21_Q25_N1.1371.00
117_L178_R1.1371.00
140_E166_T1.1301.00
117_L121_E1.1161.00
175_L183_F1.1141.00
75_R79_V1.1121.00
51_E55_N1.1071.00
37_T94_C1.1031.00
78_L127_M1.0911.00
67_A71_A1.0891.00
163_D166_T1.0851.00
134_Y173_Q1.0851.00
163_D167_K1.0831.00
9_E100_S1.0771.00
18_T192_K1.0761.00
138_D141_E1.0751.00
24_K34_V1.0741.00
133_V184_H1.0731.00
134_Y176_M1.0701.00
124_I127_M1.0671.00
131_V184_H1.0611.00
36_A93_L1.0571.00
202_V205_E1.0491.00
137_I142_G1.0471.00
198_D201_K1.0461.00
192_K196_V1.0401.00
62_D75_R1.0371.00
197_Q201_K1.0281.00
35_M81_K1.0241.00
25_N28_T1.0241.00
71_A98_I1.0131.00
64_K115_E1.0101.00
198_D202_V1.0071.00
131_V206_A1.0071.00
56_E159_L0.9911.00
19_V192_K0.9841.00
128_M179_F0.9771.00
26_I197_Q0.9761.00
28_T34_V0.9751.00
194_L198_D0.9701.00
139_P169_Q0.9681.00
134_Y169_Q0.9641.00
71_A101_S0.9631.00
108_A167_K0.9611.00
114_D118_S0.9601.00
146_I149_N0.9551.00
187_D190_Q0.9401.00
143_L162_L0.9361.00
46_A73_A0.9331.00
143_L146_I0.9291.00
64_K79_V0.9241.00
73_A77_H0.9221.00
70_Y157_L0.9151.00
64_K122_F0.9111.00
33_Q88_Q0.9061.00
131_V202_V0.9051.00
98_I128_M0.9011.00
115_E122_F0.8901.00
99_D183_F0.8821.00
173_Q176_M0.8811.00
133_V186_V0.8770.99
82_V92_V0.8760.99
201_K204_D0.8760.99
26_I29_A0.8650.99
201_K205_E0.8600.99
17_T21_Q0.8590.99
11_P142_G0.8560.99
48_Q55_N0.8480.99
43_I81_K0.8420.99
136_S185_S0.8420.99
144_K148_A0.8380.99
102_L175_L0.8320.99
5_F97_F0.8310.99
22_E25_N0.8250.99
39_E77_H0.8120.99
137_I188_A0.8070.99
117_L179_F0.8070.99
120_N123_A0.7970.99
40_P74_R0.7940.99
7_T182_R0.7900.99
53_I70_Y0.7730.99
98_I120_N0.7700.99
167_K170_E0.7680.99
8_F199_V0.7630.99
194_L197_Q0.7610.99
28_T33_Q0.7590.99
186_V199_V0.7590.99
115_E118_S0.7580.99
34_V91_I0.7580.99
103_A108_A0.7550.98
12_E165_H0.7540.98
67_A119_I0.7530.98
81_K85_A0.7480.98
8_F20_L0.7470.98
71_A116_V0.7440.98
62_D65_T0.7440.98
143_L147_Y0.7400.98
102_L113_I0.7400.98
171_G174_E0.7370.98
21_Q36_A0.7340.98
140_E162_L0.7320.98
19_V23_I0.7320.98
133_V203_I0.7320.98
21_Q24_K0.7300.98
113_I174_E0.7290.98
77_H94_C0.7280.98
50_R54_L0.7280.98
150_G154_K0.7270.98
176_M183_F0.7270.98
104_Y164_F0.7230.98
84_P88_Q0.7140.98
103_A171_G0.7110.98
179_F182_R0.7090.98
132_T182_R0.7080.98
154_K159_L0.7010.98
74_R101_S0.7010.98
34_V90_F0.6990.98
112_G115_E0.6960.97
48_Q58_N0.6910.97
85_A88_Q0.6870.97
67_A116_V0.6850.97
117_L128_M0.6820.97
7_T183_F0.6740.97
46_A49_I0.6680.97
11_P134_Y0.6660.97
78_L82_V0.6640.97
55_N58_N0.6630.97
28_T36_A0.6600.96
195_V198_D0.6580.96
70_Y73_A0.6550.96
46_A76_Q0.6550.96
68_L119_I0.6500.96
19_V195_V0.6490.96
17_T38_R0.6480.96
121_E128_M0.6460.96
13_G146_I0.6450.96
19_V188_A0.6390.96
39_E74_R0.6350.96
58_N61_M0.6310.95
147_Y154_K0.6270.95
65_T75_R0.6270.95
179_F183_F0.6260.95
71_A123_A0.6250.95
101_S116_V0.6230.95
45_I58_N0.6220.95
64_K125_G0.6210.95
108_A112_G0.6200.95
8_F19_V0.6160.95
8_F135_F0.6150.95
139_P166_T0.6150.95
55_N59_I0.6150.95
109_R164_F0.6150.95
114_D117_L0.6130.95
98_I124_I0.6130.95
5_F86_L0.6100.95
4_L206_A0.6070.94
65_T72_A0.6060.94
85_A92_V0.6000.94
4_L130_H0.5960.94
31_G34_V0.5910.94
14_A142_G0.5890.94
108_A168_V0.5870.93
8_F133_V0.5840.93
112_G116_V0.5810.93
34_V93_L0.5800.93
38_R47_E0.5790.93
155_N159_L0.5770.93
101_S105_Q0.5750.93
103_A168_V0.5720.93
6_I130_H0.5650.92
102_L117_L0.5620.92
164_F168_V0.5620.92
97_F127_M0.5620.92
110_G167_K0.5610.92
139_P142_G0.5610.92
19_V135_F0.5600.92
132_T183_F0.5590.92
44_D60_L0.5590.92
192_K195_V0.5580.92
62_D76_Q0.5580.92
98_I123_A0.5580.92
140_E144_K0.5530.91
38_R42_G0.5530.91
67_A101_S0.5520.91
118_S122_F0.5490.91
41_G54_L0.5490.91
100_S172_Y0.5480.91
40_P70_Y0.5460.91
9_E104_Y0.5430.90
9_E134_Y0.5430.90
7_T132_T0.5420.90
78_L83_K0.5420.90
160_E164_F0.5410.90
123_A126_D0.5370.90
66_E157_L0.5340.90
37_T92_V0.5330.90
119_I122_F0.5330.90
99_D179_F0.5270.89
106_G112_G0.5260.89
23_I196_V0.5240.89
157_L160_E0.5180.88
70_Y102_L0.5170.88
41_G77_H0.5170.88
56_E70_Y0.5160.88
22_E199_V0.5140.88
41_G50_R0.5130.88
108_A164_F0.5130.88
68_L122_F0.5100.88
38_R95_D0.5070.87
48_Q56_E0.5050.87
5_F82_V0.5040.87
170_E173_Q0.5030.87
56_E59_I0.5020.87
98_I101_S0.5020.87
3_G89_G0.5010.87
45_I48_Q0.5010.87
19_V26_I0.5000.87
65_T76_Q0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3czpA 2 0.816 100 0.356 Contact Map
4edhA 2 0.9906 100 0.401 Contact Map
2plrA 2 0.9387 100 0.404 Contact Map
2yogA 1 0.8821 100 0.419 Contact Map
1p6xA 3 0.967 100 0.42 Contact Map
4eaqA 2 0.9434 100 0.423 Contact Map
1nn5A 2 0.9198 100 0.423 Contact Map
4tmkA 3 0.9717 100 0.425 Contact Map
1gtvA 2 0.9198 100 0.428 Contact Map
4hlcA 2 0.934 100 0.429 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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