GREMLIN Database
YAAO - Uncharacterized protein YaaO
UniProt: P37536 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 480 (460)
Sequences: 2182 (1445)
Seq/√Len: 67.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
410_E420_R7.3031.00
178_I188_V4.2061.00
103_T156_D4.1141.00
79_S234_H4.0871.00
397_L441_R3.8401.00
230_G262_I3.8021.00
77_A236_N3.6491.00
3_T7_K3.6191.00
173_D176_E3.3471.00
66_A81_F3.3131.00
220_A232_Y3.2351.00
148_K183_H3.2101.00
395_T441_R3.0781.00
149_E153_A3.0591.00
64_K68_E3.0521.00
147_I177_I3.0501.00
70_A79_S3.0221.00
226_A230_G3.0081.00
415_E451_S3.0071.00
418_A447_V2.8581.00
144_L180_E2.8221.00
93_M189_L2.7891.00
82_L89_G2.7821.00
71_S76_S2.7141.00
418_A444_K2.6841.00
444_K448_Q2.6591.00
152_E184_Y2.5901.00
102_D158_K2.5861.00
19_S27_N2.3761.00
409_K423_A2.3271.00
296_F371_I2.2951.00
436_I442_I2.2831.00
175_T179_T2.2721.00
343_T353_L2.2661.00
95_L253_L2.2561.00
105_L157_A2.2421.00
106_V114_V2.2321.00
72_Q274_Q2.1671.00
86_T231_S2.1561.00
413_S416_E2.1341.00
80_F247_A2.1321.00
318_K352_L2.0881.00
168_Y347_D2.0791.00
8_A62_V2.0771.00
151_L186_I2.0581.00
160_L181_A2.0561.00
103_T154_Y2.0361.00
103_T124_E2.0231.00
192_E208_A2.0101.00
93_M215_I2.0071.00
189_L217_V2.0051.00
105_L128_L1.9741.00
9_L264_A1.9711.00
86_T217_V1.9691.00
339_A373_E1.9411.00
104_I159_G1.9401.00
292_L364_N1.9381.00
148_K152_E1.9201.00
412_V417_A1.9161.00
321_I371_I1.9131.00
332_L374_E1.9091.00
125_P400_P1.8781.00
66_A267_D1.8731.00
5_L263_M1.8601.00
272_Y281_K1.8591.00
196_A223_T1.8421.00
209_L216_V1.8251.00
343_T351_V1.8211.00
98_C123_A1.8181.00
82_L88_V1.8001.00
70_A74_Y1.7911.00
218_Q234_H1.7861.00
181_A188_V1.7831.00
359_G363_I1.7771.00
215_I246_V1.7691.00
78_E243_R1.7691.00
320_T352_L1.7601.00
20_F367_I1.7361.00
70_A232_Y1.7201.00
98_C102_D1.7191.00
65_E68_E1.7141.00
114_V161_V1.6960.99
77_A237_S1.6520.99
338_R377_K1.6410.99
78_E247_A1.6340.99
96_S246_V1.6250.99
295_T372_D1.6180.99
88_V253_L1.6180.99
291_T361_R1.6180.99
237_S240_R1.6120.99
292_L368_I1.6060.99
131_D146_T1.5990.99
69_L270_R1.5830.99
288_R361_R1.5830.99
227_M261_P1.5800.99
187_P240_R1.5730.99
267_D270_R1.5600.99
302_A371_I1.5580.99
271_A275_H1.5350.99
299_L375_I1.5260.99
92_A250_L1.5090.99
151_L184_Y1.5030.99
6_Y268_I1.4990.99
347_D350_Q1.4820.99
235_L243_R1.4740.99
361_R365_A1.4700.99
18_H341_I1.4530.98
100_P122_G1.4470.98
93_M217_V1.4440.98
164_N172_A1.4390.98
22_V48_T1.4330.98
182_H214_D1.4220.98
103_T126_V1.4140.98
355_L364_N1.4080.98
175_T206_V1.4040.98
10_I14_R1.4000.98
174_L188_V1.3960.98
47_V53_L1.3940.98
289_I355_L1.3890.98
89_G250_L1.3870.98
327_H332_L1.3680.98
290_E316_P1.3670.98
106_V118_V1.3670.98
131_D143_P1.3630.98
223_T354_V1.3620.98
42_L261_P1.3600.98
289_I293_K1.3550.97
81_F267_D1.3540.97
104_I161_V1.3410.97
319_L355_L1.3330.97
189_L215_I1.3300.97
206_V211_M1.3280.97
7_K11_Q1.3250.97
285_I355_L1.3230.97
292_L319_L1.3210.97
98_C159_G1.3120.97
227_M265_S1.3090.97
401_K405_H1.2980.97
162_L190_V1.2970.97
192_E218_Q1.2970.97
154_Y157_A1.2960.97
54_D59_P1.2940.97
15_R340_N1.2690.96
82_L250_L1.2620.96
128_L146_T1.2510.96
127_Y437_M1.2460.96
66_A270_R1.2450.96
185_G240_R1.2390.96
301_N375_I1.2390.96
283_S287_Q1.2350.96
79_S232_Y1.2330.96
159_G186_I1.2280.96
95_L121_S1.2270.95
115_F127_Y1.2230.95
176_E179_T1.2210.95
77_A243_R1.2140.95
90_N107_Q1.2130.95
335_I339_A1.1980.95
295_T298_S1.1950.95
148_K176_E1.1830.94
302_A321_I1.1820.94
118_V125_P1.1820.94
73_L270_R1.1760.94
333_Q346_A1.1750.94
22_V354_V1.1670.94
322_R350_Q1.1580.94
295_T368_I1.1560.94
122_G401_K1.1540.94
235_L246_V1.1530.94
5_L62_V1.1500.94
335_I338_R1.1470.94
133_D140_T1.1470.94
179_T183_H1.1450.93
180_E184_Y1.1440.93
178_I211_M1.1430.93
39_F42_L1.1430.93
136_M305_V1.1390.93
412_V420_R1.1390.93
26_H359_G1.1360.93
176_E180_E1.1340.93
147_I155_P1.1270.93
232_Y266_L1.1250.93
198_F205_P1.1230.93
335_I374_E1.1180.93
128_L147_I1.1060.92
425_D438_A1.1030.92
290_E294_Q1.1010.92
273_V282_L1.1010.92
84_N229_M1.0790.91
69_L274_Q1.0790.91
73_L274_Q1.0780.91
202_E279_E1.0770.91
178_I182_H1.0760.91
63_I67_Q1.0760.91
327_H378_T1.0750.91
49_E258_P1.0730.91
277_I280_Q1.0730.91
12_H342_F1.0730.91
148_K180_E1.0710.91
196_A224_L1.0700.91
104_I118_V1.0690.91
220_A266_L1.0670.91
345_L352_L1.0630.91
453_L458_T1.0620.91
397_L421_L1.0610.91
387_A392_Q1.0560.90
94_I161_V1.0490.90
109_N166_T1.0420.90
4_P270_R1.0410.90
443_T446_S1.0400.90
201_G286_L1.0390.90
54_D63_I1.0390.90
174_L178_I1.0390.90
99_E102_D1.0350.89
87_T91_L1.0270.89
11_Q14_R1.0180.89
284_D287_Q1.0060.88
32_F271_A1.0060.88
31_F43_L1.0040.88
83_V319_L0.9980.88
70_A81_F0.9960.88
83_V255_S0.9910.87
143_P146_T0.9890.87
204_F317_L0.9830.87
426_I436_I0.9810.87
366_E370_S0.9760.86
400_P403_V0.9740.86
215_I241_I0.9690.86
5_L63_I0.9680.86
57_H83_V0.9640.86
181_A186_I0.9640.86
296_F302_A0.9620.86
200_L273_V0.9620.86
292_L296_F0.9590.86
17_S342_F0.9590.86
389_W392_Q0.9560.85
168_Y350_Q0.9530.85
201_G283_S0.9520.85
6_Y267_D0.9500.85
396_V399_Y0.9470.85
119_D400_P0.9460.85
286_L316_P0.9460.85
450_L460_V0.9450.85
224_L273_V0.9440.85
329_G351_V0.9440.85
199_I207_S0.9430.85
127_Y396_V0.9290.84
110_C127_Y0.9270.84
3_T271_A0.9270.84
89_G217_V0.9260.83
4_P69_L0.9200.83
228_T259_S0.9200.83
18_H366_E0.9200.83
12_H17_S0.9170.83
333_Q343_T0.9140.83
225_P272_Y0.9050.82
318_K354_V0.9040.82
12_H50_L0.9030.82
206_V210_K0.8990.82
332_L351_V0.8960.81
399_Y402_K0.8950.81
226_A269_A0.8950.81
110_C163_T0.8930.81
18_H363_I0.8890.81
398_P403_V0.8890.81
394_V400_P0.8870.81
281_K357_L0.8870.81
90_N113_S0.8860.81
160_L188_V0.8860.81
99_E245_R0.8820.80
108_R440_E0.8810.80
329_G346_A0.8810.80
279_E283_S0.8770.80
19_S26_H0.8720.80
180_E183_H0.8720.80
336_L371_I0.8690.79
77_A238_S0.8680.79
167_Y344_E0.8660.79
428_P453_L0.8660.79
201_G204_F0.8660.79
256_S278_E0.8570.78
91_L253_L0.8560.78
375_I378_T0.8550.78
226_A262_I0.8540.78
82_L233_L0.8530.78
21_H48_T0.8520.78
278_E281_K0.8510.78
11_Q15_R0.8510.78
6_Y38_I0.8500.78
165_P195_G0.8500.78
333_Q342_F0.8470.78
124_E399_Y0.8430.77
321_I353_L0.8430.77
51_A337_E0.8420.77
220_A234_H0.8370.77
237_S241_I0.8340.76
398_P402_K0.8270.76
89_G254_Q0.8250.76
80_F235_L0.8240.76
48_T346_A0.8200.75
54_D228_T0.8190.75
88_V254_Q0.8190.75
285_I289_I0.8180.75
142_V162_L0.8180.75
94_I117_A0.8170.75
94_I104_I0.8170.75
328_S331_T0.8120.75
416_E445_E0.8090.74
288_R364_N0.8090.74
118_V123_A0.8080.74
237_S243_R0.8000.73
330_Y458_T0.7990.73
7_K34_D0.7970.73
373_E376_E0.7950.73
372_D376_E0.7930.73
421_L441_R0.7930.73
61_G65_E0.7930.73
369_R373_E0.7920.73
76_S209_L0.7910.73
151_L180_E0.7910.73
83_V88_V0.7890.72
339_A374_E0.7870.72
166_T229_M0.7870.72
146_T149_E0.7860.72
112_K461_Q0.7850.72
291_T295_T0.7850.72
23_P46_D0.7830.72
220_A223_T0.7810.72
109_N130_P0.7780.71
81_F266_L0.7770.71
38_I41_P0.7710.71
67_Q71_S0.7700.71
360_K363_I0.7690.70
16_N340_N0.7690.70
303_E322_R0.7680.70
173_D310_P0.7640.70
271_A274_Q0.7640.70
424_E465_K0.7630.70
422_N463_N0.7600.70
26_H318_K0.7570.69
105_L146_T0.7570.69
8_A11_Q0.7560.69
323_S326_G0.7520.69
327_H374_E0.7510.69
264_A267_D0.7490.68
22_V228_T0.7480.68
8_A53_L0.7470.68
79_S218_Q0.7470.68
204_F256_S0.7470.68
247_A250_L0.7460.68
317_L354_V0.7440.68
295_T365_A0.7430.68
73_L200_L0.7420.68
87_T256_S0.7420.68
92_A254_Q0.7410.68
19_S22_V0.7410.68
164_N198_F0.7370.67
91_L116_H0.7360.67
17_S340_N0.7320.67
203_P283_S0.7300.66
199_I210_K0.7290.66
49_E194_H0.7250.66
106_V161_V0.7220.66
281_K358_G0.7220.66
128_L142_V0.7220.66
22_V49_E0.7220.66
90_N114_V0.7220.66
69_L73_L0.7210.66
216_V234_H0.7210.66
147_I160_L0.7200.65
280_Q284_D0.7180.65
43_L227_M0.7180.65
84_N88_V0.7180.65
117_A121_S0.7180.65
35_A268_I0.7180.65
45_I261_P0.7170.65
145_G148_K0.7160.65
81_F270_R0.7150.65
178_I181_A0.7120.65
21_H50_L0.7120.65
266_L270_R0.7110.64
48_T345_L0.7110.64
105_L150_A0.7110.64
105_L160_L0.7090.64
209_L236_N0.7080.64
463_N466_I0.7080.64
398_P406_S0.7060.64
224_L258_P0.7030.64
356_P359_G0.7030.64
6_Y45_I0.7030.64
162_L174_L0.7030.64
401_K404_L0.7020.63
207_S210_K0.7010.63
408_K420_R0.7010.63
413_S444_K0.7000.63
112_K116_H0.7000.63
204_F286_L0.6990.63
151_L160_L0.6970.63
107_Q163_T0.6970.63
48_T57_H0.6970.63
49_E260_Y0.6940.63
429_Y432_G0.6880.62
22_V50_L0.6880.62
194_H228_T0.6880.62
102_D124_E0.6880.62
107_Q110_C0.6860.62
359_G364_N0.6830.61
159_G189_L0.6800.61
250_L256_S0.6790.61
220_A224_L0.6780.61
50_L53_L0.6780.61
291_T365_A0.6770.61
388_E391_V0.6770.61
100_P405_H0.6770.61
195_G259_S0.6760.61
435_M450_L0.6760.61
68_E280_Q0.6760.61
21_H260_Y0.6730.60
172_A177_I0.6710.60
168_Y352_L0.6710.60
330_Y346_A0.6700.60
442_I446_S0.6690.60
25_H46_D0.6690.60
144_L418_A0.6690.60
157_A186_I0.6680.60
362_R370_S0.6660.59
171_S205_P0.6660.59
117_A293_K0.6640.59
82_L217_V0.6630.59
60_S319_L0.6610.59
228_T260_Y0.6600.59
168_Y345_L0.6600.59
36_K40_D0.6600.59
119_D403_V0.6590.59
76_S236_N0.6580.58
119_D256_S0.6580.58
136_M350_Q0.6570.58
80_F96_S0.6560.58
119_D438_A0.6550.58
56_L260_Y0.6550.58
22_V259_S0.6540.58
204_F223_T0.6530.58
90_N194_H0.6530.58
201_G205_P0.6520.58
3_T6_Y0.6520.58
162_L321_I0.6500.58
250_L254_Q0.6490.57
190_V208_A0.6460.57
228_T344_E0.6450.57
233_L246_V0.6450.57
140_T168_Y0.6430.57
97_V187_P0.6420.57
110_C161_V0.6410.56
69_L72_Q0.6380.56
48_T260_Y0.6380.56
138_V166_T0.6370.56
113_S429_Y0.6370.56
133_D136_M0.6370.56
6_Y10_I0.6360.56
67_Q250_L0.6360.56
144_L148_K0.6350.56
49_E89_G0.6340.56
448_Q451_S0.6320.55
16_N338_R0.6310.55
365_A369_R0.6310.55
422_N436_I0.6310.55
87_T235_L0.6300.55
164_N178_I0.6300.55
144_L160_L0.6290.55
284_D288_R0.6280.55
91_L112_K0.6260.55
449_K453_L0.6260.55
285_I317_L0.6250.55
313_I316_P0.6250.55
287_Q291_T0.6250.55
281_K285_I0.6240.54
402_K406_S0.6230.54
267_D273_V0.6230.54
180_E188_V0.6220.54
47_V50_L0.6210.54
151_L155_P0.6200.54
56_L255_S0.6200.54
92_A194_H0.6190.54
21_H57_H0.6190.54
60_S255_S0.6170.54
126_V154_Y0.6150.53
73_L267_D0.6140.53
297_D306_N0.6120.53
396_V400_P0.6120.53
220_A270_R0.6120.53
447_V451_S0.6090.53
413_S451_S0.6090.53
293_K304_A0.6090.53
148_K184_Y0.6090.53
74_Y232_Y0.6080.53
209_L218_Q0.6080.53
155_P158_K0.6060.52
300_T375_I0.6050.52
12_H27_N0.6030.52
250_L259_S0.6030.52
150_A155_P0.6030.52
112_K168_Y0.6020.52
89_G194_H0.6020.52
83_V254_Q0.5990.52
103_T157_A0.5990.52
195_G228_T0.5980.51
83_V194_H0.5980.51
194_H250_L0.5970.51
294_Q298_S0.5970.51
22_V47_V0.5970.51
286_L290_E0.5960.51
98_C105_L0.5960.51
288_R292_L0.5950.51
327_H331_T0.5940.51
142_V147_I0.5940.51
48_T258_P0.5930.51
80_F243_R0.5920.51
10_I45_I0.5920.51
230_G265_S0.5910.51
10_I37_S0.5900.50
195_G198_F0.5890.50
163_T427_I0.5890.50
75_G199_I0.5890.50
208_A213_A0.5880.50
107_Q172_A0.5880.50
384_F387_A0.5880.50
151_L181_A0.5860.50
181_A240_R0.5860.50
149_E448_Q0.5850.50
112_K427_I0.5850.50
427_I461_Q0.5840.50
48_T259_S0.5840.50
117_A161_V0.5840.50
144_L176_E0.5840.50
91_L256_S0.5840.50
50_L259_S0.5830.50
236_N240_R0.5820.49
48_T352_L0.5810.49
74_Y199_I0.5810.49
28_G53_L0.5810.49
116_H332_L0.5810.49
128_L150_A0.5790.49
151_L157_A0.5780.49
115_F437_M0.5780.49
12_H15_R0.5780.49
50_L318_K0.5770.49
426_I450_L0.5750.49
50_L353_L0.5740.49
453_L460_V0.5740.49
370_S373_E0.5730.48
165_P197_H0.5730.48
54_D62_V0.5690.48
66_A70_A0.5690.48
296_F303_E0.5680.48
436_I450_L0.5680.48
331_T334_S0.5670.48
171_S313_I0.5670.48
53_L266_L0.5660.48
96_S249_Y0.5660.48
420_R423_A0.5640.47
243_R246_V0.5630.47
227_M231_S0.5630.47
24_G228_T0.5630.47
451_S454_I0.5610.47
48_T52_G0.5600.47
12_H47_V0.5590.47
141_H189_L0.5590.47
22_V26_H0.5580.47
49_E344_E0.5580.47
144_L147_I0.5570.47
287_Q361_R0.5550.46
340_N426_I0.5550.46
21_H461_Q0.5550.46
152_E246_V0.5550.46
47_V62_V0.5550.46
67_Q247_A0.5540.46
237_S242_N0.5540.46
338_R373_E0.5520.46
108_R429_Y0.5510.46
166_T170_H0.5500.46
403_V438_A0.5500.46
200_L256_S0.5490.46
92_A118_V0.5490.46
426_I460_V0.5490.46
83_V91_L0.5490.46
161_V401_K0.5490.46
82_L254_Q0.5490.46
33_D37_S0.5490.46
415_E444_K0.5460.45
56_L344_E0.5420.45
228_T263_M0.5410.45
119_D248_E0.5410.45
49_E56_L0.5410.45
338_R448_Q0.5410.45
116_H252_R0.5360.44
190_V213_A0.5360.44
292_L355_L0.5360.44
157_A181_A0.5360.44
341_I363_I0.5360.44
40_D44_T0.5360.44
333_Q352_L0.5350.44
199_I273_V0.5340.44
70_A267_D0.5340.44
55_D256_S0.5340.44
314_T320_T0.5330.44
182_H188_V0.5330.44
22_V344_E0.5330.44
94_I97_V0.5330.44
105_L151_L0.5330.44
144_L173_D0.5320.44
218_Q232_Y0.5320.44
229_M262_I0.5320.44
228_T261_P0.5320.44
220_A225_P0.5320.44
39_F261_P0.5300.43
70_A266_L0.5300.43
49_E318_K0.5300.43
96_S189_L0.5300.43
19_S359_G0.5290.43
54_D342_F0.5290.43
90_N162_L0.5290.43
387_A390_G0.5280.43
68_E72_Q0.5280.43
292_L371_I0.5280.43
251_N255_S0.5270.43
97_V241_I0.5270.43
116_H427_I0.5270.43
13_A44_T0.5260.43
52_G84_N0.5260.43
148_K151_L0.5250.43
278_E317_L0.5240.43
218_Q258_P0.5240.43
167_Y260_Y0.5230.43
93_M159_G0.5230.43
337_E342_F0.5220.42
198_F207_S0.5220.42
331_T335_I0.5200.42
64_K361_R0.5200.42
4_P8_A0.5200.42
399_Y403_V0.5190.42
171_S198_F0.5190.42
125_P396_V0.5190.42
95_L120_L0.5180.42
230_G261_P0.5170.42
57_H194_H0.5170.42
84_N163_T0.5170.42
369_R376_E0.5160.42
381_D387_A0.5160.42
55_D112_K0.5140.41
83_V178_I0.5130.41
49_E57_H0.5130.41
185_G452_R0.5130.41
231_S352_L0.5130.41
152_E175_T0.5130.41
64_K371_I0.5130.41
162_L177_I0.5120.41
22_V345_L0.5120.41
410_E416_E0.5120.41
122_G125_P0.5120.41
159_G187_P0.5120.41
112_K347_D0.5120.41
101_G444_K0.5110.41
293_K314_T0.5110.41
69_L267_D0.5100.41
14_R148_K0.5100.41
86_T427_I0.5090.41
291_T368_I0.5090.41
395_T398_P0.5080.41
377_K382_Q0.5080.41
130_P147_I0.5080.41
151_L154_Y0.5070.41
23_P344_E0.5060.41
21_H258_P0.5060.41
112_K140_T0.5060.41
49_E167_Y0.5060.41
384_F388_E0.5060.41
380_P389_W0.5050.40
146_T150_A0.5050.40
147_I152_E0.5040.40
160_L180_E0.5040.40
50_L345_L0.5040.40
54_D58_H0.5030.40
80_F347_D0.5030.40
51_A346_A0.5020.40
208_A352_L0.5020.40
63_I263_M0.5010.40
203_P287_Q0.5010.40
30_V272_Y0.5010.40
297_D304_A0.5000.40
57_H254_Q0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vycA 5 0.9875 100 0.422 Contact Map
3n75A 4 0.9812 100 0.433 Contact Map
2x3lA 2 0.8729 100 0.436 Contact Map
1c4kA 2 0.9958 100 0.442 Contact Map
4q6rA 2 0.8354 100 0.738 Contact Map
3mc6A 2 0.7792 100 0.744 Contact Map
4w8iA 2 0.6979 100 0.765 Contact Map
3bc8A 3 0.7542 100 0.786 Contact Map
3hl2A 3 0.7542 100 0.789 Contact Map
3wkrA 2 0.7 100 0.801 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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