GREMLIN Database
YAAN - Uncharacterized protein YaaN
UniProt: P37535 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 386 (347)
Sequences: 949 (593)
Seq/√Len: 31.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
314_E339_K5.8731.00
313_A343_S5.5271.00
317_K346_S5.1951.00
195_E199_T5.0291.00
338_K368_E4.8541.00
353_T357_E4.4721.00
322_E325_R4.3311.00
59_D62_N4.3041.00
208_Q218_A3.7571.00
360_I364_Q3.6761.00
292_R296_D3.6291.00
339_K343_S3.5901.00
310_L339_K3.3721.00
314_E343_S3.3181.00
191_E240_L3.0431.00
245_I332_V2.9681.00
342_E346_S2.9681.00
190_G236_V2.9321.00
200_K204_E2.8921.00
202_I229_A2.6151.00
49_E53_Q2.5401.00
197_L225_L2.5261.00
166_N260_N2.4740.99
196_E200_K2.4410.99
364_Q367_E2.3530.99
204_E208_Q2.3100.99
43_L51_A2.2790.99
75_S79_N2.2340.99
317_K343_S2.2270.99
329_R333_D2.2240.99
47_N50_K2.2200.99
53_Q57_Q2.1810.99
317_K321_I2.1210.98
53_Q56_G2.1010.98
103_L270_S2.0820.98
204_E207_Q1.9780.97
259_T274_A1.9300.97
32_A35_E1.8920.97
48_K52_I1.8770.96
307_E310_L1.8760.96
169_L253_I1.8690.96
38_R41_D1.8120.96
249_S319_N1.8100.96
235_R244_Q1.7670.95
222_V226_I1.7590.95
241_L330_G1.7320.94
299_Q303_D1.7220.94
237_H241_L1.7170.94
205_L225_L1.7120.94
335_D338_K1.6990.94
100_L263_L1.6820.93
190_G313_A1.6550.93
128_G131_S1.6420.93
304_T315_L1.6280.92
51_A55_A1.6060.92
143_K146_V1.5890.91
303_D307_E1.5820.91
357_E361_K1.5770.91
206_K226_I1.5710.91
306_N336_T1.5460.90
317_K350_E1.5390.90
43_L47_N1.5260.89
303_D329_R1.5250.89
321_I353_T1.5230.89
44_P47_N1.5120.89
371_M374_G1.4700.88
350_E353_T1.4430.87
231_R265_E1.4420.87
371_M375_D1.4220.86
200_K203_P1.4090.85
47_N54_L1.4000.85
288_L291_Q1.4000.85
213_D216_Q1.3990.85
103_L264_A1.3800.84
318_T322_E1.3800.84
234_K327_N1.3750.84
34_K45_E1.3740.84
299_Q326_A1.3730.84
310_L343_S1.3410.82
198_K229_A1.3400.82
218_A221_E1.3280.82
361_K364_Q1.3270.82
49_E52_I1.3230.81
314_E318_T1.3040.80
169_L260_N1.3010.80
252_Q275_I1.2940.80
149_D288_L1.2870.80
223_N249_S1.2830.79
175_K178_E1.2770.79
50_K53_Q1.2760.79
35_E38_R1.2730.79
194_L233_D1.2670.78
288_L304_T1.2650.78
192_L325_R1.2620.78
139_S142_Q1.2500.77
296_D300_K1.2450.77
291_Q304_T1.2450.77
320_T324_A1.2410.77
142_Q146_V1.2370.77
96_I267_I1.2350.77
135_Q139_S1.2300.76
46_E50_K1.2220.76
342_E375_D1.2210.76
321_I350_E1.2210.76
110_V272_V1.2070.75
267_I294_A1.2060.75
122_F126_M1.2010.75
215_N218_A1.1960.74
256_I300_K1.1810.73
288_L319_N1.1810.73
127_F130_V1.1720.73
176_N250_A1.1710.73
332_V335_D1.1700.73
295_V319_N1.1700.73
375_D378_Q1.1630.72
238_D354_I1.1590.72
310_L336_T1.1550.72
197_L363_R1.1520.71
224_D254_R1.1430.71
246_T249_S1.1380.70
311_K314_E1.1370.70
130_V148_I1.1350.70
356_E360_I1.1250.70
59_D64_Q1.1230.69
45_E48_K1.1220.69
49_E363_R1.1190.69
287_T341_Q1.1140.69
50_K54_L1.1020.68
48_K196_E1.0950.67
121_G124_A1.0910.67
353_T356_E1.0890.67
144_T242_S1.0880.67
188_A192_L1.0850.67
374_G378_Q1.0820.67
270_S294_A1.0760.66
245_I274_A1.0720.66
50_K58_I1.0710.66
33_E38_R1.0690.66
292_R295_V1.0690.66
56_G307_E1.0660.65
71_S75_S1.0660.65
174_E178_E1.0630.65
35_E39_L1.0570.65
165_D290_R1.0500.64
126_M130_V1.0370.63
171_Q174_E1.0340.63
48_K51_A1.0270.62
360_I363_R1.0270.62
118_K307_E1.0250.62
52_I192_L1.0250.62
194_L229_A1.0240.62
192_L196_E1.0230.62
284_I315_L1.0200.62
337_L347_T1.0170.62
171_Q190_G1.0070.61
69_Y306_N1.0060.61
100_L274_A1.0060.61
121_G127_F1.0040.61
248_Q305_T1.0020.60
349_E379_K0.9880.59
212_S221_E0.9870.59
76_K95_E0.9870.59
39_L45_E0.9730.58
203_P206_K0.9720.58
295_V313_A0.9660.58
270_S319_N0.9600.57
192_L235_R0.9560.57
100_L348_L0.9540.57
66_I150_R0.9540.57
37_V40_V0.9480.56
31_K36_Q0.9450.56
379_K382_T0.9450.56
306_N333_D0.9440.56
325_R357_E0.9410.56
63_M170_E0.9380.55
54_L57_Q0.9340.55
291_Q319_N0.9310.55
103_L295_V0.9290.55
107_L263_L0.9290.55
255_L320_T0.9270.54
45_E208_Q0.9270.54
33_E36_Q0.9260.54
259_T323_T0.9240.54
186_Y239_L0.9200.54
159_K162_L0.9170.54
212_S236_V0.9160.54
103_L263_L0.9160.54
41_D44_P0.9090.53
357_E360_I0.9060.53
344_L372_M0.9040.53
375_D379_K0.9030.53
173_Y254_R0.9000.52
254_R257_Q0.9000.52
78_L86_N0.8950.52
238_D266_K0.8930.52
358_G365_A0.8920.52
202_I222_V0.8880.51
374_G377_K0.8820.51
316_L347_T0.8800.51
41_D45_E0.8770.50
107_L270_S0.8730.50
58_I189_A0.8690.50
220_Q224_D0.8680.50
148_I338_K0.8680.50
260_N288_L0.8650.49
81_S186_Y0.8570.49
212_S218_A0.8560.49
31_K34_K0.8550.49
215_N263_L0.8530.48
184_N243_R0.8530.48
233_D363_R0.8490.48
40_V48_K0.8480.48
251_P276_P0.8420.48
321_I370_M0.8410.47
33_E42_V0.8410.47
353_T371_M0.8410.47
100_L104_M0.8390.47
367_E371_M0.8330.47
77_L176_N0.8320.47
235_R248_Q0.8320.47
242_S291_Q0.8270.46
102_E199_T0.8210.46
273_T291_Q0.8200.46
120_K370_M0.8200.46
68_L72_Q0.8190.46
177_K247_I0.8150.45
126_M380_L0.8140.45
278_W362_R0.8130.45
272_V379_K0.8110.45
141_Y151_I0.8010.44
76_K221_E0.8000.44
59_D206_K0.8000.44
114_D140_K0.7990.44
49_E374_G0.7970.44
330_G335_D0.7950.44
242_S319_N0.7900.43
265_E301_V0.7900.43
267_I270_S0.7890.43
87_H226_I0.7870.43
58_I174_E0.7850.43
199_T204_E0.7850.43
346_S350_E0.7840.43
51_A320_T0.7840.43
266_K354_I0.7830.43
251_P266_K0.7830.43
292_R322_E0.7820.43
328_E358_G0.7780.42
245_I309_L0.7760.42
41_D51_A0.7750.42
224_D281_Q0.7730.42
321_I325_R0.7720.42
259_T262_A0.7720.42
270_S301_V0.7700.42
241_L308_L0.7690.42
49_E123_L0.7690.42
259_T316_L0.7620.41
42_V56_G0.7600.41
209_A222_V0.7560.41
327_N358_G0.7560.41
113_D205_L0.7520.40
296_D346_S0.7510.40
119_K125_R0.7510.40
31_K48_K0.7490.40
49_E56_G0.7450.40
207_Q371_M0.7450.40
77_L250_A0.7440.40
256_I360_I0.7430.40
253_I256_I0.7430.40
255_L259_T0.7400.39
100_L323_T0.7400.39
36_Q39_L0.7380.39
55_A62_N0.7360.39
234_K365_A0.7330.39
113_D124_A0.7320.39
31_K38_R0.7320.39
108_E346_S0.7310.39
34_K378_Q0.7290.38
47_N58_I0.7280.38
83_D209_A0.7280.38
252_Q298_Q0.7270.38
45_E54_L0.7240.38
87_H259_T0.7230.38
236_V240_L0.7230.38
194_L269_S0.7210.38
150_R338_K0.7200.38
233_D362_R0.7190.38
278_W281_Q0.7180.38
142_Q182_A0.7180.38
110_V269_S0.7140.37
298_Q302_S0.7100.37
312_N316_L0.7100.37
192_L195_E0.7080.37
40_V54_L0.7050.37
76_K79_N0.7030.36
52_I55_A0.7030.36
54_L235_R0.7020.36
173_Y177_K0.7000.36
33_E37_V0.7000.36
263_L270_S0.7000.36
260_N319_N0.7000.36
239_L257_Q0.6980.36
335_D378_Q0.6970.36
135_Q369_L0.6950.36
180_F247_I0.6930.36
34_K367_E0.6910.36
77_L249_S0.6890.35
46_E54_L0.6880.35
34_K37_V0.6880.35
217_M379_K0.6840.35
81_S305_T0.6820.35
176_N246_T0.6810.35
88_V97_G0.6800.35
43_L46_E0.6790.35
97_G170_E0.6770.35
126_M134_L0.6750.34
113_D134_L0.6750.34
61_K221_E0.6750.34
110_V242_S0.6750.34
202_I318_T0.6740.34
99_I154_K0.6740.34
276_P362_R0.6720.34
58_I139_S0.6720.34
257_Q276_P0.6700.34
85_I186_Y0.6690.34
244_Q372_M0.6670.34
119_K353_T0.6670.34
49_E68_L0.6670.34
131_S135_Q0.6660.34
187_I285_A0.6660.34
281_Q312_N0.6660.34
74_Q271_I0.6660.34
182_A185_V0.6630.34
43_L50_K0.6620.33
84_M171_Q0.6620.33
149_D171_Q0.6610.33
51_A185_V0.6600.33
85_I239_L0.6590.33
233_D266_K0.6590.33
263_L291_Q0.6580.33
40_V52_I0.6570.33
351_T355_Q0.6570.33
154_K190_G0.6520.33
60_H66_I0.6520.33
239_L253_I0.6510.33
162_L267_I0.6500.33
286_L343_S0.6470.32
36_Q40_V0.6470.32
254_R358_G0.6440.32
124_A318_T0.6440.32
51_A58_I0.6440.32
160_N164_S0.6440.32
97_G257_Q0.6430.32
119_K123_L0.6420.32
147_Q349_E0.6380.32
193_K196_E0.6380.32
129_R307_E0.6360.32
71_S107_L0.6350.32
194_L236_V0.6310.31
37_V41_D0.6310.31
234_K355_Q0.6310.31
316_L328_E0.6300.31
74_Q165_D0.6290.31
52_I142_Q0.6270.31
165_D316_L0.6260.31
168_L235_R0.6260.31
373_E376_L0.6260.31
259_T320_T0.6260.31
307_E311_K0.6260.31
51_A166_N0.6240.31
368_E371_M0.6240.31
219_V376_L0.6230.31
103_L319_N0.6220.31
278_W341_Q0.6210.31
98_E105_K0.6200.30
78_L216_Q0.6190.30
361_K366_E0.6170.30
243_R257_Q0.6170.30
46_E61_K0.6140.30
80_F84_M0.6120.30
302_S326_A0.6110.30
146_V150_R0.6090.30
51_A92_D0.6080.30
142_Q150_R0.6050.29
279_K366_E0.6040.29
154_K348_L0.6030.29
46_E56_G0.6020.29
103_L304_T0.6020.29
89_Q315_L0.6010.29
98_E102_E0.6000.29
354_I362_R0.5990.29
32_A36_Q0.5980.29
295_V303_D0.5970.29
240_L252_Q0.5970.29
146_V153_L0.5950.29
270_S341_Q0.5940.29
217_M246_T0.5930.29
38_R126_M0.5930.29
133_S136_E0.5910.28
259_T291_Q0.5910.28
32_A66_I0.5910.28
169_L257_Q0.5900.28
205_L221_E0.5900.28
48_K318_T0.5890.28
355_Q358_G0.5890.28
46_E58_I0.5880.28
235_R274_A0.5880.28
152_S271_I0.5870.28
67_V151_I0.5860.28
270_S300_K0.5860.28
111_N256_I0.5850.28
99_I111_N0.5850.28
58_I69_Y0.5840.28
122_F125_R0.5820.28
113_D157_H0.5810.28
256_I288_L0.5800.28
260_N291_Q0.5800.28
362_R365_A0.5800.28
173_Y250_A0.5780.28
184_N188_A0.5780.28
82_H175_K0.5770.28
88_V253_I0.5770.28
35_E212_S0.5760.27
155_L248_Q0.5750.27
41_D46_E0.5740.27
276_P354_I0.5740.27
225_L259_T0.5720.27
94_G243_R0.5710.27
126_M177_K0.5700.27
288_L315_L0.5670.27
260_N304_T0.5670.27
113_D199_T0.5660.27
338_K342_E0.5650.27
119_K124_A0.5650.27
203_P207_Q0.5640.27
137_V282_V0.5630.27
172_L245_I0.5610.27
262_A295_V0.5590.26
298_Q301_V0.5570.26
281_Q316_L0.5570.26
87_H169_L0.5550.26
270_S315_L0.5540.26
84_M263_L0.5530.26
372_M375_D0.5520.26
48_K150_R0.5520.26
80_F250_A0.5500.26
280_N302_S0.5490.26
378_Q381_I0.5480.26
100_L244_Q0.5480.26
242_S249_S0.5480.26
113_D116_Q0.5470.26
99_I148_I0.5460.26
121_G264_A0.5450.26
321_I346_S0.5440.25
52_I61_K0.5440.25
295_V327_N0.5420.25
243_R247_I0.5420.25
38_R42_V0.5400.25
55_A188_A0.5390.25
162_L165_D0.5390.25
248_Q263_L0.5390.25
318_T325_R0.5380.25
45_E49_E0.5370.25
257_Q354_I0.5360.25
31_K35_E0.5360.25
173_Y380_L0.5350.25
78_L285_A0.5350.25
274_A282_V0.5350.25
369_L372_M0.5330.25
80_F252_Q0.5310.25
173_Y182_A0.5310.25
60_H363_R0.5300.25
89_Q171_Q0.5300.25
273_T341_Q0.5280.24
233_D278_W0.5270.24
127_F131_S0.5260.24
37_V42_V0.5250.24
314_E375_D0.5240.24
222_V359_R0.5230.24
48_K57_Q0.5230.24
36_Q371_M0.5230.24
162_L294_A0.5220.24
364_Q368_E0.5220.24
92_D185_V0.5220.24
191_E303_D0.5220.24
309_L312_N0.5210.24
46_E346_S0.5200.24
39_L50_K0.5200.24
34_K213_D0.5200.24
242_S267_I0.5190.24
54_L58_I0.5190.24
31_K52_I0.5190.24
122_F209_A0.5190.24
238_D248_Q0.5190.24
278_W358_G0.5180.24
61_K370_M0.5160.24
313_A318_T0.5160.24
132_S320_T0.5150.24
248_Q316_L0.5140.24
258_N262_A0.5140.24
197_L202_I0.5130.24
121_G129_R0.5130.24
101_G104_M0.5120.24
44_P237_H0.5120.24
199_T203_P0.5120.24
242_S288_L0.5100.23
45_E206_K0.5100.23
155_L298_Q0.5090.23
170_E257_Q0.5090.23
50_K185_V0.5080.23
242_S277_L0.5080.23
260_N287_T0.5080.23
288_L305_T0.5070.23
284_I288_L0.5060.23
165_D245_I0.5060.23
149_D363_R0.5060.23
237_H267_I0.5050.23
73_A191_E0.5040.23
244_Q247_I0.5040.23
37_V371_M0.5020.23
156_E159_K0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a01A 1 0.5751 32.4 0.964 Contact Map
1fxkA 2 0.272 31.8 0.964 Contact Map
2zqmA 5 0.2953 31.3 0.964 Contact Map
1c1gA 2 0.6788 29 0.965 Contact Map
3vkgA 2 0.8057 27.7 0.965 Contact Map
4uxvA 1 0.8549 27.4 0.965 Contact Map
2ic6A 1 0.1969 22.1 0.967 Contact Map
3wuqA 1 0.4767 19.1 0.968 Contact Map
4cgkA 3 0.4845 17.5 0.968 Contact Map
1ykhB 1 0.272 17 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0112 seconds.