GREMLIN Database
YAAI - Uncharacterized isochorismatase family protein YaaI
UniProt: P37532 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (165)
Sequences: 10366 (7342)
Seq/√Len: 571.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_H110_T3.3821.00
54_N93_I2.8201.00
116_H141_S2.7901.00
106_H140_Y2.7711.00
43_A48_W2.6901.00
98_S134_D2.6471.00
6_K116_H2.4701.00
36_I120_T2.4491.00
106_H138_R2.3351.00
13_M36_I2.2811.00
116_H143_T2.2791.00
39_L145_P2.2461.00
119_I132_A2.1641.00
154_D158_E2.1011.00
5_D115_R2.0791.00
16_N76_S2.0331.00
129_L133_N1.9741.00
104_A108_L1.9511.00
15_N75_R1.9451.00
164_M170_A1.9301.00
35_H148_C1.8851.00
7_A114_V1.8661.00
42_H46_N1.8391.00
92_L108_L1.7921.00
135_A142_I1.7901.00
99_A131_T1.7521.00
146_K172_I1.7471.00
35_H38_S1.7401.00
15_N81_T1.7041.00
51_I108_L1.6781.00
146_K174_T1.6731.00
6_K118_I1.6071.00
44_R89_D1.5921.00
18_E80_I1.5831.00
124_G157_N1.5751.00
10_I40_K1.5371.00
28_K31_K1.5291.00
53_I99_A1.5251.00
75_R78_D1.5121.00
43_A118_I1.4861.00
90_Y108_L1.4731.00
118_I145_P1.4631.00
37_L41_E1.4471.00
49_P112_L1.4121.00
117_I135_A1.3961.00
10_I120_T1.3681.00
66_N69_Q1.3521.00
129_L163_M1.3441.00
128_V144_I1.3431.00
124_G149_I1.3351.00
151_S157_N1.3331.00
119_I131_T1.3281.00
108_L112_L1.3181.00
56_H77_K1.3081.00
124_G161_L1.2991.00
41_E45_Q1.2981.00
125_N151_S1.2941.00
134_D138_R1.2931.00
37_L82_K1.2901.00
155_E158_E1.2791.00
9_L119_I1.2671.00
144_I149_I1.2211.00
158_E162_T1.2151.00
54_N79_I1.2061.00
32_I36_I1.2041.00
56_H93_I1.1911.00
11_V127_C1.1881.00
107_T111_E1.1831.00
10_I13_M1.1811.00
34_P82_K1.1691.00
39_L148_C1.1631.00
110_T140_Y1.1621.00
10_I36_I1.1551.00
8_L43_A1.1481.00
146_K161_L1.1331.00
129_L160_A1.1121.00
35_H147_D1.0991.00
54_N91_F1.0861.00
15_N78_D1.0591.00
40_K44_R1.0491.00
118_I143_T1.0471.00
73_N93_I1.0381.00
130_F133_N1.0061.00
40_K52_Y1.0061.00
132_A144_I1.0021.00
6_K48_W0.9921.00
117_I142_I0.9831.00
155_E159_F0.9721.00
141_S171_E0.9631.00
143_T171_E0.9581.00
108_L111_E0.9551.00
124_G151_S0.9531.00
104_A107_T0.9531.00
38_S42_H0.9501.00
78_D84_A0.9501.00
86_V89_D0.9481.00
100_F135_A0.9471.00
32_I150_A0.9351.00
7_A51_I0.9341.00
60_W63_D0.9231.00
149_I157_N0.9211.00
12_D94_K0.9141.00
132_A164_M0.9041.00
109_L140_Y0.8871.00
157_N161_L0.8841.00
145_P148_C0.8831.00
79_I91_F0.8751.00
56_H73_N0.8701.00
9_L105_L0.8641.00
52_Y85_P0.8601.00
153_S156_D0.8591.00
143_T173_T0.8581.00
37_L85_P0.8481.00
155_E162_T0.8431.00
49_P114_V0.8331.00
42_H45_Q0.8321.00
33_V37_L0.8311.00
52_Y79_I0.8311.00
115_R141_S0.8271.00
96_K139_E0.8261.00
99_A105_L0.8121.00
13_M122_I0.8101.00
7_A109_L0.8101.00
120_T148_C0.8071.00
39_L120_T0.7991.00
75_R81_T0.7971.00
145_P173_T0.7961.00
74_E77_K0.7821.00
38_S41_E0.7811.00
101_Y138_R0.7741.00
11_V119_I0.7691.00
85_P89_D0.7681.00
119_I128_V0.7581.00
161_L172_I0.7541.00
34_P38_S0.7501.00
51_I112_L0.7471.00
162_T165_E0.7371.00
40_K50_I0.7311.00
80_I83_I0.7301.00
5_D116_H0.7271.00
70_E73_N0.7261.00
36_I148_C0.7251.00
17_F127_C0.7241.00
136_Y170_A0.7161.00
134_D137_M0.7141.00
122_I150_A0.7131.00
125_N163_M0.7101.00
52_Y88_A0.7091.00
156_D159_F0.7061.00
90_Y112_L0.7031.00
15_N80_I0.7021.00
96_K102_E0.7011.00
37_L84_A0.7011.00
85_P91_F0.6971.00
34_P37_L0.6931.00
49_P108_L0.6931.00
32_I122_I0.6921.00
21_M25_L0.6901.00
160_A164_M0.6771.00
132_A142_I0.6761.00
13_M80_I0.6721.00
18_E33_V0.6711.00
31_K34_P0.6691.00
10_I52_Y0.6681.00
29_T122_I0.6641.00
119_I142_I0.6621.00
159_F163_M0.6611.00
107_T110_T0.6581.00
58_G73_N0.6571.00
40_K43_A0.6571.00
41_E84_A0.6521.00
33_V80_I0.6501.00
156_D162_T0.6501.00
63_D66_N0.6461.00
8_L120_T0.6461.00
22_G25_L0.6421.00
41_E86_V0.6421.00
125_N156_D0.6301.00
52_Y91_F0.6301.00
125_N152_N0.6291.00
159_F162_T0.6251.00
51_I90_Y0.6241.00
162_T166_N0.6231.00
81_T84_A0.6191.00
123_A126_I0.6191.00
101_Y137_M0.6181.00
123_A151_S0.6121.00
52_Y89_D0.6101.00
8_L39_L0.6091.00
39_L118_I0.6071.00
149_I161_L0.6071.00
98_S137_M0.6061.00
58_G61_Q0.6031.00
44_R88_A0.6021.00
27_K31_K0.6001.00
40_K89_D0.5981.00
102_E107_T0.5971.00
5_D113_Q0.5951.00
33_V83_I0.5931.00
123_A152_N0.5921.00
51_I92_L0.5911.00
44_R50_I0.5881.00
13_M32_I0.5811.00
52_Y83_I0.5751.00
18_E29_T0.5660.99
54_N77_K0.5660.99
146_K165_E0.5650.99
27_K150_A0.5620.99
146_K157_N0.5610.99
132_A170_A0.5560.99
161_L165_E0.5510.99
8_L50_I0.5510.99
144_I161_L0.5500.99
128_V149_I0.5500.99
8_L40_K0.5480.99
44_R86_V0.5480.99
97_H137_M0.5420.99
61_Q65_K0.5420.99
54_N78_D0.5360.99
58_G63_D0.5360.99
97_H131_T0.5350.99
26_A123_A0.5340.99
43_A49_P0.5340.99
97_H136_Y0.5330.99
126_I152_N0.5320.99
120_T145_P0.5320.99
97_H126_I0.5310.99
61_Q64_I0.5310.99
13_M83_I0.5280.99
144_I164_M0.5280.99
39_L43_A0.5260.99
16_N22_G0.5240.99
49_P90_Y0.5230.99
101_Y134_D0.5210.99
31_K35_H0.5210.99
28_K150_A0.5180.99
142_I145_P0.5180.99
11_V128_V0.5170.99
156_D160_A0.5120.99
92_L104_A0.5100.99
33_V82_K0.5070.99
26_A29_T0.5070.99
30_E82_K0.5060.99
17_F123_A0.5050.99
85_P88_A0.5030.99
44_R52_Y0.5030.99
58_G95_P0.5010.99
118_I147_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hb7A 3 0.989 100 0.128 Contact Map
3hu5A 3 0.9834 100 0.146 Contact Map
3irvA 2 0.9945 100 0.146 Contact Map
3kl2A 4 0.9945 100 0.154 Contact Map
1nbaA 4 0.9945 100 0.161 Contact Map
4l07A 4 0.989 100 0.164 Contact Map
2fq1A 2 0.989 100 0.165 Contact Map
3ot4A 4 0.989 100 0.167 Contact Map
3o94A 4 0.9724 100 0.171 Contact Map
3txyA 2 0.9779 100 0.172 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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