GREMLIN Database
YAAH - Spore germination protein YaaH
UniProt: P37531 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 427 (361)
Sequences: 785 (629)
Seq/√Len: 33.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_Y55_D4.9911.00
231_R241_I4.7891.00
49_Y64_F4.3971.00
297_R393_E3.8021.00
200_A208_I3.7391.00
189_K229_E3.6751.00
335_R345_I3.4781.00
231_R235_H3.4001.00
309_A395_N3.1951.00
391_I399_I3.1621.00
201_R237_E3.1241.00
243_T266_H3.0751.00
210_F230_A3.0331.00
300_I314_M2.9661.00
362_P380_D2.8851.00
138_Q142_T2.6111.00
297_R301_E2.5911.00
193_L230_A2.5481.00
300_I304_L2.5451.00
345_I364_F2.5411.00
198_E202_R2.4431.00
342_A346_A2.4160.99
216_R219_D2.3300.99
354_Q363_F2.3040.99
58_T62_R2.2800.99
194_N233_L2.2600.99
49_Y52_K2.2270.99
274_V400_S2.1970.99
251_A306_E2.1900.99
190_R229_E2.1870.99
180_R184_N2.1810.99
291_S296_V2.1650.99
291_S317_N2.1640.99
275_L300_I2.1560.99
264_R268_E2.1290.99
300_I396_L2.1100.99
224_N266_H2.1050.98
365_R375_E2.1030.98
241_I270_V2.0760.98
180_R219_D2.0730.98
362_P383_S2.0730.98
324_T374_H2.0510.98
243_T270_V2.0060.98
304_L309_A2.0010.98
161_T206_R1.9610.98
190_R233_L1.9500.97
328_T331_G1.9450.97
329_A344_V1.8720.97
266_H270_V1.8660.97
356_D359_A1.8530.97
379_E387_K1.8380.96
340_Q343_I1.8190.96
401_Y411_N1.7920.96
67_T70_E1.7760.96
228_R268_E1.7760.96
100_E397_R1.7610.95
193_L233_L1.7560.95
345_I349_N1.7340.95
70_E73_R1.7090.95
225_Q228_R1.6950.94
224_N243_T1.6890.94
182_L192_L1.6690.94
265_A269_I1.6660.94
235_H271_D1.6550.94
211_D276_M1.6380.93
280_W292_P1.6090.93
219_D222_A1.5830.92
54_G59_S1.5640.91
226_F230_A1.5620.91
55_D64_F1.5480.91
360_Q386_A1.5250.90
342_A345_I1.5230.90
384_I401_Y1.5220.90
227_L266_H1.5110.90
208_I264_R1.4890.89
187_T191_R1.4850.89
304_L307_M1.4830.89
337_V341_Q1.4580.88
227_L270_V1.4540.88
64_F91_I1.4480.88
163_M207_D1.4450.88
66_T74_V1.4300.87
221_E224_N1.4270.87
196_I208_I1.4260.87
327_Y330_G1.4160.87
105_L109_G1.4100.86
208_I234_F1.4090.86
303_A312_I1.4060.86
295_P298_D1.3840.85
245_L273_V1.3810.85
304_L314_M1.3800.85
104_Y244_A1.3640.85
246_A258_Y1.3630.85
181_I188_V1.3490.84
334_A338_S1.3470.84
192_L196_I1.3410.84
104_Y108_R1.3380.83
224_N265_A1.3370.83
346_A364_F1.3250.83
163_M240_E1.2980.81
354_Q364_F1.2950.81
403_K406_L1.2930.81
170_E174_F1.2710.80
176_D180_R1.2640.80
246_A261_H1.2630.80
220_R262_D1.2600.79
200_A239_L1.2560.79
61_A66_T1.2510.79
137_A182_L1.2500.79
273_V307_M1.2500.79
56_T59_S1.2490.79
109_G112_V1.2480.79
209_H215_L1.2450.79
322_D374_H1.2290.78
272_F397_R1.2260.78
103_A109_G1.2220.77
385_Q389_N1.2160.77
47_Q64_F1.2110.77
389_N392_K1.2080.76
134_S167_T1.2070.76
304_L396_L1.2040.76
228_R269_I1.1940.76
211_D319_Y1.1850.75
137_A212_F1.1840.75
70_E74_V1.1810.75
102_N105_L1.1800.75
49_Y91_I1.1750.74
113_S332_T1.1720.74
49_Y61_A1.1670.74
101_S399_I1.1640.74
135_F164_M1.1630.74
213_E276_M1.1600.73
196_I230_A1.1540.73
184_N222_A1.1460.73
313_V397_R1.1460.73
50_D88_R1.1460.73
96_K99_I1.1430.72
104_Y112_V1.1330.72
300_I307_M1.1300.72
179_G215_L1.1230.71
51_V89_L1.1190.71
135_F203_Y1.1140.70
341_Q407_S1.1020.70
221_E265_A1.1010.69
324_T372_R1.0970.69
291_S316_Q1.0970.69
177_E216_R1.0950.69
213_E278_Y1.0890.69
104_Y109_G1.0850.68
179_G260_A1.0830.68
71_L149_T1.0820.68
192_L210_F1.0720.67
66_T70_E1.0700.67
52_K63_Q1.0690.67
71_L91_I1.0660.67
229_E233_L1.0630.67
325_L372_R1.0560.66
316_Q384_I1.0480.66
124_S160_T1.0400.65
51_V60_I1.0380.65
335_R341_Q1.0340.65
162_L204_G1.0340.65
341_Q345_I1.0270.64
177_E241_I1.0180.63
223_Y261_H1.0130.63
77_I80_N1.0050.62
290_V377_W1.0010.62
331_G335_R0.9980.62
213_E244_A0.9980.62
186_E229_E0.9900.61
197_V241_I0.9870.61
181_I185_D0.9850.61
197_V233_L0.9840.61
104_Y107_P0.9810.60
190_R194_N0.9780.60
379_E384_I0.9720.60
221_E225_Q0.9720.60
128_T397_R0.9660.59
176_D216_R0.9620.59
308_P311_K0.9610.59
353_I380_D0.9590.59
337_V342_A0.9590.59
281_G288_Q0.9540.58
289_A375_E0.9500.58
109_G113_S0.9500.58
246_A279_E0.9490.58
333_P337_V0.9350.57
209_H214_Y0.9350.57
276_M319_Y0.9330.57
98_D395_N0.9320.56
294_G361_A0.9290.56
297_R390_L0.9280.56
266_H269_I0.9270.56
258_Y279_E0.9270.56
103_A106_E0.9250.56
99_I105_L0.9180.55
176_D214_Y0.9170.55
144_V147_P0.9140.55
326_P374_H0.9130.55
297_R394_L0.9110.55
68_A72_A0.9110.55
134_S165_I0.9070.54
300_I309_A0.9060.54
289_A387_K0.9060.54
244_A278_Y0.9050.54
71_L388_F0.9040.54
51_V238_G0.9030.54
344_V347_D0.9030.54
214_Y257_W0.9020.54
163_M320_G0.9020.54
337_V376_V0.9020.54
227_L295_P0.8990.54
234_F239_L0.8870.53
289_A361_A0.8860.53
79_L84_Q0.8830.52
134_S282_Y0.8810.52
149_T153_S0.8810.52
217_P260_A0.8790.52
383_S387_K0.8780.52
320_G376_V0.8780.52
119_A337_V0.8750.52
337_V345_I0.8750.52
102_N274_V0.8750.52
108_R112_V0.8730.52
244_A276_M0.8730.52
343_I346_A0.8700.51
380_D383_S0.8680.51
275_L314_M0.8670.51
56_T68_A0.8660.51
61_A64_F0.8650.51
196_I226_F0.8610.51
213_E247_P0.8570.50
267_G308_P0.8570.50
251_A259_E0.8560.50
134_S169_L0.8560.50
312_I381_A0.8540.50
60_I89_L0.8530.50
59_S65_N0.8500.50
355_Y360_Q0.8490.50
68_A71_L0.8480.49
277_T314_M0.8470.49
58_T61_A0.8450.49
301_E304_L0.8450.49
99_I104_Y0.8440.49
103_A404_L0.8410.49
277_T285_G0.8400.49
53_R68_A0.8380.49
194_N198_E0.8350.48
77_I89_L0.8350.48
196_I241_I0.8330.48
224_N269_I0.8300.48
207_D316_Q0.8290.48
209_H274_V0.8270.48
276_M402_W0.8230.47
302_Y305_T0.8200.47
213_E319_Y0.8140.47
99_I108_R0.8120.46
244_A258_Y0.8110.46
73_R93_P0.8070.46
328_T335_R0.8030.46
166_I208_I0.8010.46
55_D91_I0.8010.46
70_E76_R0.8000.45
192_L234_F0.7980.45
296_V301_E0.7970.45
334_A337_V0.7960.45
224_N262_D0.7950.45
336_A343_I0.7940.45
290_V317_N0.7930.45
148_L152_R0.7920.45
142_T195_E0.7900.45
265_A268_E0.7850.44
82_V87_F0.7850.44
257_W283_S0.7840.44
273_V312_I0.7840.44
398_G402_W0.7840.44
122_E185_D0.7820.44
48_F60_I0.7820.44
242_S272_F0.7770.44
228_R265_A0.7690.43
379_E383_S0.7690.43
353_I382_R0.7670.43
197_V200_A0.7590.42
128_T272_F0.7580.42
257_W261_H0.7580.42
304_L394_L0.7550.42
59_S78_Q0.7540.42
338_S346_A0.7530.42
178_L214_Y0.7460.41
247_P299_V0.7450.41
362_P387_K0.7450.41
315_G319_Y0.7440.41
74_V92_P0.7440.41
246_A257_W0.7420.41
137_A166_I0.7410.41
318_L384_I0.7410.41
152_R156_E0.7410.41
288_Q295_P0.7410.41
227_L338_S0.7380.40
208_I230_A0.7380.40
214_Y258_Y0.7370.40
243_T269_I0.7350.40
290_V321_Y0.7330.40
191_R295_P0.7320.40
139_R170_E0.7320.40
227_L269_I0.7300.40
58_T79_L0.7290.40
193_L229_E0.7280.40
316_Q401_Y0.7270.40
128_T147_P0.7230.39
209_H244_A0.7220.39
105_L108_R0.7210.39
70_E181_I0.7210.39
69_A73_R0.7200.39
155_T160_T0.7190.39
317_N400_S0.7170.39
51_V87_F0.7160.39
49_Y58_T0.7150.39
177_E260_A0.7130.38
170_E173_A0.7100.38
231_R269_I0.7100.38
262_D265_A0.7090.38
166_I184_N0.7080.38
143_L166_I0.7080.38
138_Q144_V0.7050.38
131_G134_S0.7050.38
109_G116_L0.7040.38
174_F177_E0.7030.38
309_A396_L0.7030.38
164_M378_F0.7020.38
101_S104_Y0.7010.37
232_D236_R0.7010.37
55_D85_I0.6990.37
293_I390_L0.6950.37
100_E104_Y0.6930.37
48_F90_Y0.6930.37
71_L74_V0.6840.36
364_F376_V0.6820.36
55_D59_S0.6810.36
245_L303_A0.6810.36
355_Y383_S0.6760.36
71_L344_V0.6730.35
147_P150_N0.6730.35
284_G296_V0.6730.35
194_N229_E0.6700.35
385_Q392_K0.6690.35
131_G165_I0.6690.35
320_G378_F0.6680.35
207_D317_N0.6660.35
84_Q144_V0.6640.35
196_I210_F0.6640.35
238_G381_A0.6630.35
338_S341_Q0.6610.34
191_R195_E0.6600.34
354_Q365_R0.6580.34
116_L119_A0.6580.34
197_V239_L0.6560.34
157_S160_T0.6540.34
182_L193_L0.6510.34
136_Q144_V0.6510.34
359_A363_F0.6500.34
351_A363_F0.6500.34
261_H266_H0.6490.34
301_E394_L0.6460.33
366_Y376_V0.6450.33
135_F143_L0.6430.33
213_E248_K0.6420.33
210_F312_I0.6420.33
195_E198_E0.6400.33
267_G273_V0.6400.33
79_L82_V0.6390.33
271_D398_G0.6380.33
374_H378_F0.6380.33
52_K55_D0.6370.33
62_R70_E0.6350.32
79_L90_Y0.6330.32
228_R232_D0.6330.32
316_Q388_F0.6320.32
224_N264_R0.6310.32
159_N201_R0.6300.32
165_I172_Q0.6270.32
184_N219_D0.6270.32
187_T190_R0.6260.32
138_Q309_A0.6240.32
227_L243_T0.6240.32
49_Y149_T0.6240.32
56_T383_S0.6220.32
137_A243_T0.6200.31
244_A315_G0.6200.31
99_I395_N0.6190.31
179_G183_L0.6180.31
137_A208_I0.6170.31
320_G342_A0.6170.31
357_Q393_E0.6150.31
183_L230_A0.6120.31
301_E357_Q0.6120.31
331_G370_E0.6090.31
318_L361_A0.6090.31
336_A342_A0.6080.31
209_H406_L0.6080.31
210_F406_L0.6060.30
101_S391_I0.6060.30
99_I102_N0.6060.30
337_V396_L0.6040.30
83_L138_Q0.6040.30
207_D361_A0.6030.30
273_V308_P0.6010.30
229_E293_I0.5980.30
326_P393_E0.5970.30
211_D278_Y0.5960.30
119_A196_I0.5930.29
348_Q395_N0.5920.29
135_F275_L0.5910.29
248_K258_Y0.5910.29
198_E310_N0.5910.29
105_L112_V0.5900.29
191_R264_R0.5900.29
178_L181_I0.5900.29
62_R84_Q0.5890.29
77_I83_L0.5870.29
142_T191_R0.5860.29
107_P112_V0.5860.29
134_S284_G0.5850.29
211_D246_A0.5850.29
209_H213_E0.5850.29
207_D398_G0.5850.29
248_K257_W0.5830.29
296_V300_I0.5830.29
102_N400_S0.5820.29
59_S69_A0.5800.29
325_L375_E0.5800.29
55_D68_A0.5780.28
56_T62_R0.5770.28
245_L258_Y0.5770.28
162_L203_Y0.5760.28
279_E283_S0.5750.28
106_E114_E0.5730.28
52_K194_N0.5730.28
190_R382_R0.5720.28
165_I168_N0.5710.28
352_S357_Q0.5700.28
301_E393_E0.5680.28
214_Y244_A0.5680.28
56_T66_T0.5670.28
258_Y281_G0.5640.28
382_R386_A0.5640.28
286_P404_L0.5630.27
103_A108_R0.5620.27
101_S105_L0.5620.27
263_Y267_G0.5610.27
272_F318_L0.5600.27
99_I160_T0.5590.27
180_R222_A0.5590.27
230_A266_H0.5590.27
235_H241_I0.5560.27
317_N384_I0.5550.27
263_Y377_W0.5540.27
61_A68_A0.5540.27
74_V80_N0.5530.27
220_R224_N0.5520.27
334_A344_V0.5520.27
245_L311_K0.5510.27
212_F226_F0.5490.27
210_F397_R0.5490.27
152_R203_Y0.5490.27
119_A123_A0.5490.27
129_Y163_M0.5450.26
159_N373_R0.5450.26
227_L292_P0.5450.26
302_Y362_P0.5440.26
193_L197_V0.5430.26
269_I298_D0.5420.26
249_T257_W0.5420.26
61_A266_H0.5420.26
187_T389_N0.5410.26
245_L263_Y0.5400.26
126_Y363_F0.5400.26
49_Y89_L0.5400.26
128_T320_G0.5390.26
120_A130_L0.5380.26
167_T341_Q0.5380.26
78_Q187_T0.5370.26
371_N374_H0.5370.26
151_L239_L0.5370.26
102_N107_P0.5370.26
291_S377_W0.5360.26
102_N272_F0.5350.26
52_K69_A0.5350.26
281_G299_V0.5330.25
110_N147_P0.5310.25
215_L321_Y0.5310.25
50_D363_F0.5300.25
133_F140_N0.5300.25
151_L244_A0.5300.25
201_R300_I0.5290.25
169_L336_A0.5280.25
209_H316_Q0.5270.25
264_R335_R0.5260.25
355_Y382_R0.5260.25
277_T319_Y0.5260.25
53_R348_Q0.5260.25
278_Y315_G0.5250.25
142_T222_A0.5250.25
296_V316_Q0.5250.25
199_N241_I0.5230.25
290_V320_G0.5230.25
268_E308_P0.5230.25
171_N174_F0.5220.25
188_V222_A0.5220.25
85_I89_L0.5210.25
187_T198_E0.5210.25
193_L208_I0.5200.25
131_G251_A0.5200.25
405_G409_P0.5200.25
143_L146_P0.5200.25
175_S291_S0.5200.25
54_G334_A0.5200.25
64_F74_V0.5190.25
283_S321_Y0.5160.24
223_Y243_T0.5160.24
50_D84_Q0.5150.24
282_Y306_E0.5150.24
267_G270_V0.5130.24
221_E228_R0.5130.24
225_Q352_S0.5120.24
283_S318_L0.5100.24
51_V293_I0.5090.24
318_L406_L0.5070.24
339_P342_A0.5070.24
328_T332_T0.5070.24
50_D53_R0.5050.24
60_I111_Q0.5050.24
50_D68_A0.5050.24
59_S218_Q0.5050.24
381_A410_Q0.5040.24
104_Y406_L0.5040.24
326_P353_I0.5020.24
78_Q84_Q0.5020.24
100_E404_L0.5010.24
71_L93_P0.5010.24
76_R88_R0.5000.23
156_E204_G0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q6tA 1 0.7237 100 0.476 Contact Map
3cz8A 2 0.7049 100 0.476 Contact Map
3w4rA 1 0.7424 100 0.479 Contact Map
4wiwA 1 0.7494 100 0.48 Contact Map
1wb0A 2 0.7283 100 0.491 Contact Map
3fy1A 1 0.7354 100 0.492 Contact Map
1vf8A 1 0.7354 100 0.492 Contact Map
4wkaA 1 0.7307 100 0.494 Contact Map
1edqA 1 0.9391 100 0.496 Contact Map
1itxA 1 0.7447 100 0.496 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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