YAAH - BACSU - GREMLIN Contacts

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YAAH - Spore germination protein YaaH

UniProt:	P37531	Sequences: MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPIAGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESNAYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNTTLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQDREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLMTYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPARAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIKELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	427 (361)
Sequences:	785 (629)
Seq/√Len:	33.1

BACSU - YAAH YDHD
HALSA - Q9HR84 Q9HR83

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
49_Y	55_D	4.991	1.00
231_R	241_I	4.789	1.00
49_Y	64_F	4.397	1.00
297_R	393_E	3.802	1.00
200_A	208_I	3.739	1.00
189_K	229_E	3.675	1.00
335_R	345_I	3.478	1.00
231_R	235_H	3.400	1.00
309_A	395_N	3.195	1.00
391_I	399_I	3.162	1.00
201_R	237_E	3.124	1.00
243_T	266_H	3.075	1.00
210_F	230_A	3.033	1.00
300_I	314_M	2.966	1.00
362_P	380_D	2.885	1.00
138_Q	142_T	2.611	1.00
297_R	301_E	2.591	1.00
193_L	230_A	2.548	1.00
300_I	304_L	2.545	1.00
345_I	364_F	2.541	1.00
198_E	202_R	2.443	1.00
342_A	346_A	2.416	0.99
216_R	219_D	2.330	0.99
354_Q	363_F	2.304	0.99
58_T	62_R	2.280	0.99
194_N	233_L	2.260	0.99
49_Y	52_K	2.227	0.99
274_V	400_S	2.197	0.99
251_A	306_E	2.190	0.99
190_R	229_E	2.187	0.99
180_R	184_N	2.181	0.99
291_S	296_V	2.165	0.99
291_S	317_N	2.164	0.99
275_L	300_I	2.156	0.99
264_R	268_E	2.129	0.99
300_I	396_L	2.110	0.99
224_N	266_H	2.105	0.98
365_R	375_E	2.103	0.98
241_I	270_V	2.076	0.98
180_R	219_D	2.073	0.98
362_P	383_S	2.073	0.98
324_T	374_H	2.051	0.98
243_T	270_V	2.006	0.98
304_L	309_A	2.001	0.98
161_T	206_R	1.961	0.98
190_R	233_L	1.950	0.97
328_T	331_G	1.945	0.97
329_A	344_V	1.872	0.97
266_H	270_V	1.866	0.97
356_D	359_A	1.853	0.97
379_E	387_K	1.838	0.96
340_Q	343_I	1.819	0.96
401_Y	411_N	1.792	0.96
67_T	70_E	1.776	0.96
228_R	268_E	1.776	0.96
100_E	397_R	1.761	0.95
193_L	233_L	1.756	0.95
345_I	349_N	1.734	0.95
70_E	73_R	1.709	0.95
225_Q	228_R	1.695	0.94
224_N	243_T	1.689	0.94
182_L	192_L	1.669	0.94
265_A	269_I	1.666	0.94
235_H	271_D	1.655	0.94
211_D	276_M	1.638	0.93
280_W	292_P	1.609	0.93
219_D	222_A	1.583	0.92
54_G	59_S	1.564	0.91
226_F	230_A	1.562	0.91
55_D	64_F	1.548	0.91
360_Q	386_A	1.525	0.90
342_A	345_I	1.523	0.90
384_I	401_Y	1.522	0.90
227_L	266_H	1.511	0.90
208_I	264_R	1.489	0.89
187_T	191_R	1.485	0.89
304_L	307_M	1.483	0.89
337_V	341_Q	1.458	0.88
227_L	270_V	1.454	0.88
64_F	91_I	1.448	0.88
163_M	207_D	1.445	0.88
66_T	74_V	1.430	0.87
221_E	224_N	1.427	0.87
196_I	208_I	1.426	0.87
327_Y	330_G	1.416	0.87
105_L	109_G	1.410	0.86
208_I	234_F	1.409	0.86
303_A	312_I	1.406	0.86
295_P	298_D	1.384	0.85
245_L	273_V	1.381	0.85
304_L	314_M	1.380	0.85
104_Y	244_A	1.364	0.85
246_A	258_Y	1.363	0.85
181_I	188_V	1.349	0.84
334_A	338_S	1.347	0.84
192_L	196_I	1.341	0.84
104_Y	108_R	1.338	0.83
224_N	265_A	1.337	0.83
346_A	364_F	1.325	0.83
163_M	240_E	1.298	0.81
354_Q	364_F	1.295	0.81
403_K	406_L	1.293	0.81
170_E	174_F	1.271	0.80
176_D	180_R	1.264	0.80
246_A	261_H	1.263	0.80
220_R	262_D	1.260	0.79
200_A	239_L	1.256	0.79
61_A	66_T	1.251	0.79
137_A	182_L	1.250	0.79
273_V	307_M	1.250	0.79
56_T	59_S	1.249	0.79
109_G	112_V	1.248	0.79
209_H	215_L	1.245	0.79
322_D	374_H	1.229	0.78
272_F	397_R	1.226	0.78
103_A	109_G	1.222	0.77
385_Q	389_N	1.216	0.77
47_Q	64_F	1.211	0.77
389_N	392_K	1.208	0.76
134_S	167_T	1.207	0.76
304_L	396_L	1.204	0.76
228_R	269_I	1.194	0.76
211_D	319_Y	1.185	0.75
137_A	212_F	1.184	0.75
70_E	74_V	1.181	0.75
102_N	105_L	1.180	0.75
49_Y	91_I	1.175	0.74
113_S	332_T	1.172	0.74
49_Y	61_A	1.167	0.74
101_S	399_I	1.164	0.74
135_F	164_M	1.163	0.74
213_E	276_M	1.160	0.73
196_I	230_A	1.154	0.73
184_N	222_A	1.146	0.73
313_V	397_R	1.146	0.73
50_D	88_R	1.146	0.73
96_K	99_I	1.143	0.72
104_Y	112_V	1.133	0.72
300_I	307_M	1.130	0.72
179_G	215_L	1.123	0.71
51_V	89_L	1.119	0.71
135_F	203_Y	1.114	0.70
341_Q	407_S	1.102	0.70
221_E	265_A	1.101	0.69
324_T	372_R	1.097	0.69
291_S	316_Q	1.097	0.69
177_E	216_R	1.095	0.69
213_E	278_Y	1.089	0.69
104_Y	109_G	1.085	0.68
179_G	260_A	1.083	0.68
71_L	149_T	1.082	0.68
192_L	210_F	1.072	0.67
66_T	70_E	1.070	0.67
52_K	63_Q	1.069	0.67
71_L	91_I	1.066	0.67
229_E	233_L	1.063	0.67
325_L	372_R	1.056	0.66
316_Q	384_I	1.048	0.66
124_S	160_T	1.040	0.65
51_V	60_I	1.038	0.65
335_R	341_Q	1.034	0.65
162_L	204_G	1.034	0.65
341_Q	345_I	1.027	0.64
177_E	241_I	1.018	0.63
223_Y	261_H	1.013	0.63
77_I	80_N	1.005	0.62
290_V	377_W	1.001	0.62
331_G	335_R	0.998	0.62
213_E	244_A	0.998	0.62
186_E	229_E	0.990	0.61
197_V	241_I	0.987	0.61
181_I	185_D	0.985	0.61
197_V	233_L	0.984	0.61
104_Y	107_P	0.981	0.60
190_R	194_N	0.978	0.60
379_E	384_I	0.972	0.60
221_E	225_Q	0.972	0.60
128_T	397_R	0.966	0.59
176_D	216_R	0.962	0.59
308_P	311_K	0.961	0.59
353_I	380_D	0.959	0.59
337_V	342_A	0.959	0.59
281_G	288_Q	0.954	0.58
289_A	375_E	0.950	0.58
109_G	113_S	0.950	0.58
246_A	279_E	0.949	0.58
333_P	337_V	0.935	0.57
209_H	214_Y	0.935	0.57
276_M	319_Y	0.933	0.57
98_D	395_N	0.932	0.56
294_G	361_A	0.929	0.56
297_R	390_L	0.928	0.56
266_H	269_I	0.927	0.56
258_Y	279_E	0.927	0.56
103_A	106_E	0.925	0.56
99_I	105_L	0.918	0.55
176_D	214_Y	0.917	0.55
144_V	147_P	0.914	0.55
326_P	374_H	0.913	0.55
297_R	394_L	0.911	0.55
68_A	72_A	0.911	0.55
134_S	165_I	0.907	0.54
300_I	309_A	0.906	0.54
289_A	387_K	0.906	0.54
244_A	278_Y	0.905	0.54
71_L	388_F	0.904	0.54
51_V	238_G	0.903	0.54
344_V	347_D	0.903	0.54
214_Y	257_W	0.902	0.54
163_M	320_G	0.902	0.54
337_V	376_V	0.902	0.54
227_L	295_P	0.899	0.54
234_F	239_L	0.887	0.53
289_A	361_A	0.886	0.53
79_L	84_Q	0.883	0.52
134_S	282_Y	0.881	0.52
149_T	153_S	0.881	0.52
217_P	260_A	0.879	0.52
383_S	387_K	0.878	0.52
320_G	376_V	0.878	0.52
119_A	337_V	0.875	0.52
337_V	345_I	0.875	0.52
102_N	274_V	0.875	0.52
108_R	112_V	0.873	0.52
244_A	276_M	0.873	0.52
343_I	346_A	0.870	0.51
380_D	383_S	0.868	0.51
275_L	314_M	0.867	0.51
56_T	68_A	0.866	0.51
61_A	64_F	0.865	0.51
196_I	226_F	0.861	0.51
213_E	247_P	0.857	0.50
267_G	308_P	0.857	0.50
251_A	259_E	0.856	0.50
134_S	169_L	0.856	0.50
312_I	381_A	0.854	0.50
60_I	89_L	0.853	0.50
59_S	65_N	0.850	0.50
355_Y	360_Q	0.849	0.50
68_A	71_L	0.848	0.49
277_T	314_M	0.847	0.49
58_T	61_A	0.845	0.49
301_E	304_L	0.845	0.49
99_I	104_Y	0.844	0.49
103_A	404_L	0.841	0.49
277_T	285_G	0.840	0.49
53_R	68_A	0.838	0.49
194_N	198_E	0.835	0.48
77_I	89_L	0.835	0.48
196_I	241_I	0.833	0.48
224_N	269_I	0.830	0.48
207_D	316_Q	0.829	0.48
209_H	274_V	0.827	0.48
276_M	402_W	0.823	0.47
302_Y	305_T	0.820	0.47
213_E	319_Y	0.814	0.47
99_I	108_R	0.812	0.46
244_A	258_Y	0.811	0.46
73_R	93_P	0.807	0.46
328_T	335_R	0.803	0.46
166_I	208_I	0.801	0.46
55_D	91_I	0.801	0.46
70_E	76_R	0.800	0.45
192_L	234_F	0.798	0.45
296_V	301_E	0.797	0.45
334_A	337_V	0.796	0.45
224_N	262_D	0.795	0.45
336_A	343_I	0.794	0.45
290_V	317_N	0.793	0.45
148_L	152_R	0.792	0.45
142_T	195_E	0.790	0.45
265_A	268_E	0.785	0.44
82_V	87_F	0.785	0.44
257_W	283_S	0.784	0.44
273_V	312_I	0.784	0.44
398_G	402_W	0.784	0.44
122_E	185_D	0.782	0.44
48_F	60_I	0.782	0.44
242_S	272_F	0.777	0.44
228_R	265_A	0.769	0.43
379_E	383_S	0.769	0.43
353_I	382_R	0.767	0.43
197_V	200_A	0.759	0.42
128_T	272_F	0.758	0.42
257_W	261_H	0.758	0.42
304_L	394_L	0.755	0.42
59_S	78_Q	0.754	0.42
338_S	346_A	0.753	0.42
178_L	214_Y	0.746	0.41
247_P	299_V	0.745	0.41
362_P	387_K	0.745	0.41
315_G	319_Y	0.744	0.41
74_V	92_P	0.744	0.41
246_A	257_W	0.742	0.41
137_A	166_I	0.741	0.41
318_L	384_I	0.741	0.41
152_R	156_E	0.741	0.41
288_Q	295_P	0.741	0.41
227_L	338_S	0.738	0.40
208_I	230_A	0.738	0.40
214_Y	258_Y	0.737	0.40
243_T	269_I	0.735	0.40
290_V	321_Y	0.733	0.40
191_R	295_P	0.732	0.40
139_R	170_E	0.732	0.40
227_L	269_I	0.730	0.40
58_T	79_L	0.729	0.40
193_L	229_E	0.728	0.40
316_Q	401_Y	0.727	0.40
128_T	147_P	0.723	0.39
209_H	244_A	0.722	0.39
105_L	108_R	0.721	0.39
70_E	181_I	0.721	0.39
69_A	73_R	0.720	0.39
155_T	160_T	0.719	0.39
317_N	400_S	0.717	0.39
51_V	87_F	0.716	0.39
49_Y	58_T	0.715	0.39
177_E	260_A	0.713	0.38
170_E	173_A	0.710	0.38
231_R	269_I	0.710	0.38
262_D	265_A	0.709	0.38
166_I	184_N	0.708	0.38
143_L	166_I	0.708	0.38
138_Q	144_V	0.705	0.38
131_G	134_S	0.705	0.38
109_G	116_L	0.704	0.38
174_F	177_E	0.703	0.38
309_A	396_L	0.703	0.38
164_M	378_F	0.702	0.38
101_S	104_Y	0.701	0.37
232_D	236_R	0.701	0.37
55_D	85_I	0.699	0.37
293_I	390_L	0.695	0.37
100_E	104_Y	0.693	0.37
48_F	90_Y	0.693	0.37
71_L	74_V	0.684	0.36
364_F	376_V	0.682	0.36
55_D	59_S	0.681	0.36
245_L	303_A	0.681	0.36
355_Y	383_S	0.676	0.36
71_L	344_V	0.673	0.35
147_P	150_N	0.673	0.35
284_G	296_V	0.673	0.35
194_N	229_E	0.670	0.35
385_Q	392_K	0.669	0.35
131_G	165_I	0.669	0.35
320_G	378_F	0.668	0.35
207_D	317_N	0.666	0.35
84_Q	144_V	0.664	0.35
196_I	210_F	0.664	0.35
238_G	381_A	0.663	0.35
338_S	341_Q	0.661	0.34
191_R	195_E	0.660	0.34
354_Q	365_R	0.658	0.34
116_L	119_A	0.658	0.34
197_V	239_L	0.656	0.34
157_S	160_T	0.654	0.34
182_L	193_L	0.651	0.34
136_Q	144_V	0.651	0.34
359_A	363_F	0.650	0.34
351_A	363_F	0.650	0.34
261_H	266_H	0.649	0.34
301_E	394_L	0.646	0.33
366_Y	376_V	0.645	0.33
135_F	143_L	0.643	0.33
213_E	248_K	0.642	0.33
210_F	312_I	0.642	0.33
195_E	198_E	0.640	0.33
267_G	273_V	0.640	0.33
79_L	82_V	0.639	0.33
271_D	398_G	0.638	0.33
374_H	378_F	0.638	0.33
52_K	55_D	0.637	0.33
62_R	70_E	0.635	0.32
79_L	90_Y	0.633	0.32
228_R	232_D	0.633	0.32
316_Q	388_F	0.632	0.32
224_N	264_R	0.631	0.32
159_N	201_R	0.630	0.32
165_I	172_Q	0.627	0.32
184_N	219_D	0.627	0.32
187_T	190_R	0.626	0.32
138_Q	309_A	0.624	0.32
227_L	243_T	0.624	0.32
49_Y	149_T	0.624	0.32
56_T	383_S	0.622	0.32
137_A	243_T	0.620	0.31
244_A	315_G	0.620	0.31
99_I	395_N	0.619	0.31
179_G	183_L	0.618	0.31
137_A	208_I	0.617	0.31
320_G	342_A	0.617	0.31
357_Q	393_E	0.615	0.31
183_L	230_A	0.612	0.31
301_E	357_Q	0.612	0.31
331_G	370_E	0.609	0.31
318_L	361_A	0.609	0.31
336_A	342_A	0.608	0.31
209_H	406_L	0.608	0.31
210_F	406_L	0.606	0.30
101_S	391_I	0.606	0.30
99_I	102_N	0.606	0.30
337_V	396_L	0.604	0.30
83_L	138_Q	0.604	0.30
207_D	361_A	0.603	0.30
273_V	308_P	0.601	0.30
229_E	293_I	0.598	0.30
326_P	393_E	0.597	0.30
211_D	278_Y	0.596	0.30
119_A	196_I	0.593	0.29
348_Q	395_N	0.592	0.29
135_F	275_L	0.591	0.29
248_K	258_Y	0.591	0.29
198_E	310_N	0.591	0.29
105_L	112_V	0.590	0.29
191_R	264_R	0.590	0.29
178_L	181_I	0.590	0.29
62_R	84_Q	0.589	0.29
77_I	83_L	0.587	0.29
142_T	191_R	0.586	0.29
107_P	112_V	0.586	0.29
134_S	284_G	0.585	0.29
211_D	246_A	0.585	0.29
209_H	213_E	0.585	0.29
207_D	398_G	0.585	0.29
248_K	257_W	0.583	0.29
296_V	300_I	0.583	0.29
102_N	400_S	0.582	0.29
59_S	69_A	0.580	0.29
325_L	375_E	0.580	0.29
55_D	68_A	0.578	0.28
56_T	62_R	0.577	0.28
245_L	258_Y	0.577	0.28
162_L	203_Y	0.576	0.28
279_E	283_S	0.575	0.28
106_E	114_E	0.573	0.28
52_K	194_N	0.573	0.28
190_R	382_R	0.572	0.28
165_I	168_N	0.571	0.28
352_S	357_Q	0.570	0.28
301_E	393_E	0.568	0.28
214_Y	244_A	0.568	0.28
56_T	66_T	0.567	0.28
258_Y	281_G	0.564	0.28
382_R	386_A	0.564	0.28
286_P	404_L	0.563	0.27
103_A	108_R	0.562	0.27
101_S	105_L	0.562	0.27
263_Y	267_G	0.561	0.27
272_F	318_L	0.560	0.27
99_I	160_T	0.559	0.27
180_R	222_A	0.559	0.27
230_A	266_H	0.559	0.27
235_H	241_I	0.556	0.27
317_N	384_I	0.555	0.27
263_Y	377_W	0.554	0.27
61_A	68_A	0.554	0.27
74_V	80_N	0.553	0.27
220_R	224_N	0.552	0.27
334_A	344_V	0.552	0.27
245_L	311_K	0.551	0.27
212_F	226_F	0.549	0.27
210_F	397_R	0.549	0.27
152_R	203_Y	0.549	0.27
119_A	123_A	0.549	0.27
129_Y	163_M	0.545	0.26
159_N	373_R	0.545	0.26
227_L	292_P	0.545	0.26
302_Y	362_P	0.544	0.26
193_L	197_V	0.543	0.26
269_I	298_D	0.542	0.26
249_T	257_W	0.542	0.26
61_A	266_H	0.542	0.26
187_T	389_N	0.541	0.26
245_L	263_Y	0.540	0.26
126_Y	363_F	0.540	0.26
49_Y	89_L	0.540	0.26
128_T	320_G	0.539	0.26
120_A	130_L	0.538	0.26
167_T	341_Q	0.538	0.26
78_Q	187_T	0.537	0.26
371_N	374_H	0.537	0.26
151_L	239_L	0.537	0.26
102_N	107_P	0.537	0.26
291_S	377_W	0.536	0.26
102_N	272_F	0.535	0.26
52_K	69_A	0.535	0.26
281_G	299_V	0.533	0.25
110_N	147_P	0.531	0.25
215_L	321_Y	0.531	0.25
50_D	363_F	0.530	0.25
133_F	140_N	0.530	0.25
151_L	244_A	0.530	0.25
201_R	300_I	0.529	0.25
169_L	336_A	0.528	0.25
209_H	316_Q	0.527	0.25
264_R	335_R	0.526	0.25
355_Y	382_R	0.526	0.25
277_T	319_Y	0.526	0.25
53_R	348_Q	0.526	0.25
278_Y	315_G	0.525	0.25
142_T	222_A	0.525	0.25
296_V	316_Q	0.525	0.25
199_N	241_I	0.523	0.25
290_V	320_G	0.523	0.25
268_E	308_P	0.523	0.25
171_N	174_F	0.522	0.25
188_V	222_A	0.522	0.25
85_I	89_L	0.521	0.25
187_T	198_E	0.521	0.25
193_L	208_I	0.520	0.25
131_G	251_A	0.520	0.25
405_G	409_P	0.520	0.25
143_L	146_P	0.520	0.25
175_S	291_S	0.520	0.25
54_G	334_A	0.520	0.25
64_F	74_V	0.519	0.25
283_S	321_Y	0.516	0.24
223_Y	243_T	0.516	0.24
50_D	84_Q	0.515	0.24
282_Y	306_E	0.515	0.24
267_G	270_V	0.513	0.24
221_E	228_R	0.513	0.24
225_Q	352_S	0.512	0.24
283_S	318_L	0.510	0.24
51_V	293_I	0.509	0.24
318_L	406_L	0.507	0.24
339_P	342_A	0.507	0.24
328_T	332_T	0.507	0.24
50_D	53_R	0.505	0.24
60_I	111_Q	0.505	0.24
50_D	68_A	0.505	0.24
59_S	218_Q	0.505	0.24
381_A	410_Q	0.504	0.24
104_Y	406_L	0.504	0.24
326_P	353_I	0.502	0.24
78_Q	84_Q	0.502	0.24
100_E	404_L	0.501	0.24
71_L	93_P	0.501	0.24
76_R	88_R	0.500	0.23
156_E	204_G	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4q6tA	1	0.7237	100	0.476	Contact Map
3cz8A	2	0.7049	100	0.476	Contact Map
3w4rA	1	0.7424	100	0.479	Contact Map
4wiwA	1	0.7494	100	0.48	Contact Map
1wb0A	2	0.7283	100	0.491	Contact Map
3fy1A	1	0.7354	100	0.492	Contact Map
1vf8A	1	0.7354	100	0.492	Contact Map
4wkaA	1	0.7307	100	0.494	Contact Map
1edqA	1	0.9391	100	0.496	Contact Map
1itxA	1	0.7447	100	0.496	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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