GREMLIN Database
DGK - Deoxyguanosine kinase
UniProt: P37530 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 207 (192)
Sequences: 1803 (1067)
Seq/√Len: 77.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_S184_D4.1881.00
191_N194_D3.8421.00
21_A32_M3.4491.00
187_D190_L3.3071.00
129_K163_E3.2471.00
128_I183_G3.0321.00
134_T137_H3.0071.00
156_E160_S2.7911.00
102_P106_E2.7581.00
129_K180_T2.6211.00
23_M195_F2.5451.00
19_T189_V2.4581.00
44_D48_D2.4371.00
129_K182_D2.3991.00
96_A161_D2.3681.00
134_T138_R2.3571.00
182_D185_S2.2421.00
13_I155_L2.2271.00
15_A130_A2.2171.00
150_I155_L2.2141.00
95_F102_P2.2101.00
49_N52_E2.1631.00
42_Y104_Q2.1411.00
164_V168_Q2.1261.00
10_E85_A2.1231.00
23_M192_K1.9761.00
141_K190_L1.9751.00
55_F59_M1.9461.00
134_T184_D1.9291.00
58_E86_D1.9251.00
132_L159_I1.9121.00
137_H141_K1.9091.00
130_A135_L1.7831.00
81_Q90_Y1.7811.00
169_L176_L1.7381.00
133_P152_T1.7341.00
65_R86_D1.7121.00
105_L109_K1.6711.00
86_D108_Y1.6581.00
163_E167_K1.6561.00
197_R201_H1.6481.00
152_T156_E1.6471.00
144_R147_E1.6411.00
91_K100_L1.6341.00
142_R147_E1.6171.00
136_L155_L1.5911.00
45_K103_H1.5800.99
136_L152_T1.5670.99
27_K195_F1.5390.99
20_L188_F1.5070.99
27_K196_E1.4820.99
195_F199_A1.4450.99
169_L178_V1.4150.99
130_A183_G1.4130.99
14_G139_I1.4050.99
192_K196_E1.3760.99
104_Q107_K1.3530.98
25_S32_M1.3290.98
196_E200_A1.2770.98
22_T26_Q1.2560.97
53_W56_Q1.2550.97
46_F154_Y1.2470.97
36_I39_D1.2340.97
92_N161_D1.2210.97
24_L199_A1.2120.97
67_K71_D1.2080.97
130_A134_T1.1730.96
94_I99_T1.1720.96
8_A82_P1.1520.96
92_N96_A1.1450.95
132_L152_T1.1440.95
45_K48_D1.1330.95
186_K197_R1.1320.95
9_I128_I1.1300.95
197_R200_A1.1240.95
127_Y163_E1.1180.95
12_P155_L1.1150.95
12_P159_I1.1010.94
58_E108_Y1.0820.94
97_E157_Q1.0610.93
12_P135_L1.0580.93
166_I178_V1.0440.93
194_D197_R1.0430.93
65_R108_Y1.0420.93
132_L156_E1.0290.92
153_S156_E1.0280.92
96_A100_L1.0160.92
182_D186_K0.9900.91
124_F176_L0.9900.91
179_L201_H0.9710.90
61_F65_R0.9660.89
132_L136_L0.9610.89
135_L155_L0.9600.89
193_S200_A0.9550.89
30_F76_F0.9540.89
42_Y107_K0.9500.89
19_T35_E0.9400.88
157_Q160_S0.9210.87
153_S157_Q0.9180.87
10_E127_Y0.9090.86
161_D164_V0.8930.85
18_T34_N0.8880.85
19_T190_L0.8800.85
63_C114_L0.8730.84
27_K199_A0.8720.84
133_P156_E0.8610.83
90_Y98_R0.8560.83
23_M188_F0.8550.83
46_F94_I0.8510.83
59_M111_I0.8490.82
93_V161_D0.8420.82
44_D146_F0.8380.82
58_E92_N0.8350.81
138_R183_G0.8310.81
71_D106_E0.8310.81
12_P93_V0.8300.81
135_L150_I0.8280.81
94_I100_L0.8250.81
43_L154_Y0.8220.80
28_F199_A0.8210.80
86_D122_P0.8200.80
53_W161_D0.8200.80
87_Y109_K0.8180.80
160_S164_V0.8130.80
12_P19_T0.8100.79
137_H140_E0.7950.78
91_K94_I0.7810.77
84_I91_K0.7780.76
54_S143_G0.7770.76
62_L108_Y0.7760.76
110_K113_H0.7750.76
13_I150_I0.7730.76
91_K105_L0.7580.75
58_E94_I0.7560.74
51_K126_I0.7530.74
12_P130_A0.7500.74
196_E201_H0.7490.74
51_K101_S0.7470.74
61_F86_D0.7450.73
83_V119_L0.7440.73
48_D149_K0.7440.73
12_P15_A0.7430.73
35_E47_Y0.7410.73
95_F105_L0.7380.73
46_F86_D0.7380.73
73_S192_K0.7360.72
11_G16_G0.7360.72
44_D145_P0.7350.72
11_G17_K0.7300.72
103_H107_K0.7210.71
52_E104_Q0.7180.71
45_K53_W0.7130.70
143_G148_K0.7130.70
91_K99_T0.7090.70
187_D191_N0.7080.70
6_F122_P0.6970.68
95_F100_L0.6950.68
9_I20_L0.6930.68
140_E150_I0.6930.68
125_I178_V0.6900.68
181_V198_I0.6880.67
192_K195_F0.6880.67
138_R142_R0.6870.67
86_D154_Y0.6850.67
18_T139_I0.6850.67
114_L117_D0.6800.66
57_L61_F0.6770.66
131_S134_T0.6760.66
132_L135_L0.6700.65
124_F179_L0.6680.65
124_F162_Y0.6660.65
20_L202_V0.6630.64
62_L162_Y0.6620.64
124_F202_V0.6600.64
92_N105_L0.6480.63
58_E69_L0.6450.62
145_P149_K0.6440.62
127_Y180_T0.6420.62
84_I128_I0.6400.62
91_K96_A0.6400.62
81_Q85_A0.6400.62
144_R154_Y0.6380.61
160_S171_E0.6360.61
75_H79_K0.6350.61
14_G47_Y0.6340.61
96_A99_T0.6320.61
75_H191_N0.6250.60
10_E87_Y0.6250.60
72_T79_K0.6230.60
18_T22_T0.6200.59
18_T31_P0.6200.59
148_K152_T0.6200.59
156_E159_I0.6180.59
141_K189_V0.6170.59
139_I147_E0.6170.59
13_I154_Y0.6110.58
130_A195_F0.6100.58
27_K51_K0.6100.58
44_D56_Q0.6090.58
131_S137_H0.6090.58
193_S196_E0.6080.58
43_L47_Y0.6050.57
167_K180_T0.6040.57
44_D53_W0.6040.57
37_V146_F0.6030.57
90_Y165_A0.6030.57
7_I148_K0.6010.57
70_E115_L0.6010.57
15_A183_G0.6010.57
7_I24_L0.6000.57
80_G85_A0.5970.56
30_F196_E0.5970.56
53_W125_I0.5950.56
111_I115_L0.5950.56
113_H145_P0.5940.56
78_K98_R0.5930.56
125_I176_L0.5930.56
21_A40_N0.5910.56
7_I143_G0.5900.56
26_Q200_A0.5880.55
70_E118_D0.5880.55
20_L169_L0.5880.55
138_R147_E0.5870.55
74_D156_E0.5860.55
159_I163_E0.5860.55
23_M148_K0.5840.55
47_Y154_Y0.5830.55
6_F79_K0.5820.55
37_V43_L0.5810.54
140_E152_T0.5800.54
22_T34_N0.5800.54
13_I47_Y0.5750.54
71_D190_L0.5740.54
82_P90_Y0.5730.53
24_L108_Y0.5720.53
101_S104_Q0.5710.53
153_S197_R0.5710.53
10_E13_I0.5690.53
51_K106_E0.5690.53
85_A93_V0.5670.53
186_K194_D0.5650.52
102_P171_E0.5620.52
26_Q75_H0.5600.52
40_N162_Y0.5600.52
54_S98_R0.5600.52
78_K82_P0.5560.51
191_N200_A0.5540.51
80_G90_Y0.5530.51
29_G153_S0.5480.50
97_E164_V0.5480.50
111_I159_I0.5470.50
74_D190_L0.5450.50
137_H196_E0.5430.50
61_F162_Y0.5430.50
38_E110_K0.5430.50
46_F108_Y0.5380.49
113_H200_A0.5370.49
102_P113_H0.5370.49
171_E177_T0.5370.49
85_A90_Y0.5360.49
33_I68_Q0.5360.49
137_H190_L0.5330.48
117_D126_I0.5330.48
145_P148_K0.5310.48
42_Y79_K0.5300.48
66_Y105_L0.5260.47
40_N47_Y0.5250.47
46_F65_R0.5240.47
60_F110_K0.5230.47
63_C115_L0.5230.47
14_G61_F0.5230.47
69_L77_L0.5220.47
188_F195_F0.5220.47
31_P77_L0.5210.47
108_Y154_Y0.5200.47
168_Q182_D0.5170.46
87_Y92_N0.5160.46
136_L140_E0.5160.46
45_K57_L0.5150.46
37_V66_Y0.5140.46
60_F64_H0.5120.46
146_F188_F0.5110.46
22_T193_S0.5110.46
45_K101_S0.5090.45
66_Y119_L0.5060.45
11_G14_G0.5040.45
57_L63_C0.5020.44
7_I124_F0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vp4A 3 0.8889 100 0.484 Contact Map
2ocpA 2 0.9855 100 0.484 Contact Map
1p5zB 2 0.9807 100 0.505 Contact Map
1osnA 4 0.9372 100 0.508 Contact Map
2jaqA 2 0.9034 100 0.523 Contact Map
1p6xA 3 0.971 100 0.536 Contact Map
3czpA 2 0.8261 99.9 0.62 Contact Map
4eaqA 2 0.8986 99.9 0.64 Contact Map
2plrA 2 0.8841 99.9 0.648 Contact Map
3rhfA 3 0.8841 99.9 0.65 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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