DGK - BACSU - GREMLIN Contacts

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DGK - Deoxyguanosine kinase

UniProt:	P37530	Sequences: MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLDKFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSPHQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLISDYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	207 (192)
Sequences:	1803 (1067)
Seq/√Len:	77.0

BACSU - DGK DCK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
131_S	184_D	4.188	1.00
191_N	194_D	3.842	1.00
21_A	32_M	3.449	1.00
187_D	190_L	3.307	1.00
129_K	163_E	3.247	1.00
128_I	183_G	3.032	1.00
134_T	137_H	3.007	1.00
156_E	160_S	2.791	1.00
102_P	106_E	2.758	1.00
129_K	180_T	2.621	1.00
23_M	195_F	2.545	1.00
19_T	189_V	2.458	1.00
44_D	48_D	2.437	1.00
129_K	182_D	2.399	1.00
96_A	161_D	2.368	1.00
134_T	138_R	2.357	1.00
182_D	185_S	2.242	1.00
13_I	155_L	2.227	1.00
15_A	130_A	2.217	1.00
150_I	155_L	2.214	1.00
95_F	102_P	2.210	1.00
49_N	52_E	2.163	1.00
42_Y	104_Q	2.141	1.00
164_V	168_Q	2.126	1.00
10_E	85_A	2.123	1.00
23_M	192_K	1.976	1.00
141_K	190_L	1.975	1.00
55_F	59_M	1.946	1.00
134_T	184_D	1.929	1.00
58_E	86_D	1.925	1.00
132_L	159_I	1.912	1.00
137_H	141_K	1.909	1.00
130_A	135_L	1.783	1.00
81_Q	90_Y	1.781	1.00
169_L	176_L	1.738	1.00
133_P	152_T	1.734	1.00
65_R	86_D	1.712	1.00
105_L	109_K	1.671	1.00
86_D	108_Y	1.658	1.00
163_E	167_K	1.656	1.00
197_R	201_H	1.648	1.00
152_T	156_E	1.647	1.00
144_R	147_E	1.641	1.00
91_K	100_L	1.634	1.00
142_R	147_E	1.617	1.00
136_L	155_L	1.591	1.00
45_K	103_H	1.580	0.99
136_L	152_T	1.567	0.99
27_K	195_F	1.539	0.99
20_L	188_F	1.507	0.99
27_K	196_E	1.482	0.99
195_F	199_A	1.445	0.99
169_L	178_V	1.415	0.99
130_A	183_G	1.413	0.99
14_G	139_I	1.405	0.99
192_K	196_E	1.376	0.99
104_Q	107_K	1.353	0.98
25_S	32_M	1.329	0.98
196_E	200_A	1.277	0.98
22_T	26_Q	1.256	0.97
53_W	56_Q	1.255	0.97
46_F	154_Y	1.247	0.97
36_I	39_D	1.234	0.97
92_N	161_D	1.221	0.97
24_L	199_A	1.212	0.97
67_K	71_D	1.208	0.97
130_A	134_T	1.173	0.96
94_I	99_T	1.172	0.96
8_A	82_P	1.152	0.96
92_N	96_A	1.145	0.95
132_L	152_T	1.144	0.95
45_K	48_D	1.133	0.95
186_K	197_R	1.132	0.95
9_I	128_I	1.130	0.95
197_R	200_A	1.124	0.95
127_Y	163_E	1.118	0.95
12_P	155_L	1.115	0.95
12_P	159_I	1.101	0.94
58_E	108_Y	1.082	0.94
97_E	157_Q	1.061	0.93
12_P	135_L	1.058	0.93
166_I	178_V	1.044	0.93
194_D	197_R	1.043	0.93
65_R	108_Y	1.042	0.93
132_L	156_E	1.029	0.92
153_S	156_E	1.028	0.92
96_A	100_L	1.016	0.92
182_D	186_K	0.990	0.91
124_F	176_L	0.990	0.91
179_L	201_H	0.971	0.90
61_F	65_R	0.966	0.89
132_L	136_L	0.961	0.89
135_L	155_L	0.960	0.89
193_S	200_A	0.955	0.89
30_F	76_F	0.954	0.89
42_Y	107_K	0.950	0.89
19_T	35_E	0.940	0.88
157_Q	160_S	0.921	0.87
153_S	157_Q	0.918	0.87
10_E	127_Y	0.909	0.86
161_D	164_V	0.893	0.85
18_T	34_N	0.888	0.85
19_T	190_L	0.880	0.85
63_C	114_L	0.873	0.84
27_K	199_A	0.872	0.84
133_P	156_E	0.861	0.83
90_Y	98_R	0.856	0.83
23_M	188_F	0.855	0.83
46_F	94_I	0.851	0.83
59_M	111_I	0.849	0.82
93_V	161_D	0.842	0.82
44_D	146_F	0.838	0.82
58_E	92_N	0.835	0.81
138_R	183_G	0.831	0.81
71_D	106_E	0.831	0.81
12_P	93_V	0.830	0.81
135_L	150_I	0.828	0.81
94_I	100_L	0.825	0.81
43_L	154_Y	0.822	0.80
28_F	199_A	0.821	0.80
86_D	122_P	0.820	0.80
53_W	161_D	0.820	0.80
87_Y	109_K	0.818	0.80
160_S	164_V	0.813	0.80
12_P	19_T	0.810	0.79
137_H	140_E	0.795	0.78
91_K	94_I	0.781	0.77
84_I	91_K	0.778	0.76
54_S	143_G	0.777	0.76
62_L	108_Y	0.776	0.76
110_K	113_H	0.775	0.76
13_I	150_I	0.773	0.76
91_K	105_L	0.758	0.75
58_E	94_I	0.756	0.74
51_K	126_I	0.753	0.74
12_P	130_A	0.750	0.74
196_E	201_H	0.749	0.74
51_K	101_S	0.747	0.74
61_F	86_D	0.745	0.73
83_V	119_L	0.744	0.73
48_D	149_K	0.744	0.73
12_P	15_A	0.743	0.73
35_E	47_Y	0.741	0.73
95_F	105_L	0.738	0.73
46_F	86_D	0.738	0.73
73_S	192_K	0.736	0.72
11_G	16_G	0.736	0.72
44_D	145_P	0.735	0.72
11_G	17_K	0.730	0.72
103_H	107_K	0.721	0.71
52_E	104_Q	0.718	0.71
45_K	53_W	0.713	0.70
143_G	148_K	0.713	0.70
91_K	99_T	0.709	0.70
187_D	191_N	0.708	0.70
6_F	122_P	0.697	0.68
95_F	100_L	0.695	0.68
9_I	20_L	0.693	0.68
140_E	150_I	0.693	0.68
125_I	178_V	0.690	0.68
181_V	198_I	0.688	0.67
192_K	195_F	0.688	0.67
138_R	142_R	0.687	0.67
86_D	154_Y	0.685	0.67
18_T	139_I	0.685	0.67
114_L	117_D	0.680	0.66
57_L	61_F	0.677	0.66
131_S	134_T	0.676	0.66
132_L	135_L	0.670	0.65
124_F	179_L	0.668	0.65
124_F	162_Y	0.666	0.65
20_L	202_V	0.663	0.64
62_L	162_Y	0.662	0.64
124_F	202_V	0.660	0.64
92_N	105_L	0.648	0.63
58_E	69_L	0.645	0.62
145_P	149_K	0.644	0.62
127_Y	180_T	0.642	0.62
84_I	128_I	0.640	0.62
91_K	96_A	0.640	0.62
81_Q	85_A	0.640	0.62
144_R	154_Y	0.638	0.61
160_S	171_E	0.636	0.61
75_H	79_K	0.635	0.61
14_G	47_Y	0.634	0.61
96_A	99_T	0.632	0.61
75_H	191_N	0.625	0.60
10_E	87_Y	0.625	0.60
72_T	79_K	0.623	0.60
18_T	22_T	0.620	0.59
18_T	31_P	0.620	0.59
148_K	152_T	0.620	0.59
156_E	159_I	0.618	0.59
141_K	189_V	0.617	0.59
139_I	147_E	0.617	0.59
13_I	154_Y	0.611	0.58
130_A	195_F	0.610	0.58
27_K	51_K	0.610	0.58
44_D	56_Q	0.609	0.58
131_S	137_H	0.609	0.58
193_S	196_E	0.608	0.58
43_L	47_Y	0.605	0.57
167_K	180_T	0.604	0.57
44_D	53_W	0.604	0.57
37_V	146_F	0.603	0.57
90_Y	165_A	0.603	0.57
7_I	148_K	0.601	0.57
70_E	115_L	0.601	0.57
15_A	183_G	0.601	0.57
7_I	24_L	0.600	0.57
80_G	85_A	0.597	0.56
30_F	196_E	0.597	0.56
53_W	125_I	0.595	0.56
111_I	115_L	0.595	0.56
113_H	145_P	0.594	0.56
78_K	98_R	0.593	0.56
125_I	176_L	0.593	0.56
21_A	40_N	0.591	0.56
7_I	143_G	0.590	0.56
26_Q	200_A	0.588	0.55
70_E	118_D	0.588	0.55
20_L	169_L	0.588	0.55
138_R	147_E	0.587	0.55
74_D	156_E	0.586	0.55
159_I	163_E	0.586	0.55
23_M	148_K	0.584	0.55
47_Y	154_Y	0.583	0.55
6_F	79_K	0.582	0.55
37_V	43_L	0.581	0.54
140_E	152_T	0.580	0.54
22_T	34_N	0.580	0.54
13_I	47_Y	0.575	0.54
71_D	190_L	0.574	0.54
82_P	90_Y	0.573	0.53
24_L	108_Y	0.572	0.53
101_S	104_Q	0.571	0.53
153_S	197_R	0.571	0.53
10_E	13_I	0.569	0.53
51_K	106_E	0.569	0.53
85_A	93_V	0.567	0.53
186_K	194_D	0.565	0.52
102_P	171_E	0.562	0.52
26_Q	75_H	0.560	0.52
40_N	162_Y	0.560	0.52
54_S	98_R	0.560	0.52
78_K	82_P	0.556	0.51
191_N	200_A	0.554	0.51
80_G	90_Y	0.553	0.51
29_G	153_S	0.548	0.50
97_E	164_V	0.548	0.50
111_I	159_I	0.547	0.50
74_D	190_L	0.545	0.50
137_H	196_E	0.543	0.50
61_F	162_Y	0.543	0.50
38_E	110_K	0.543	0.50
46_F	108_Y	0.538	0.49
113_H	200_A	0.537	0.49
102_P	113_H	0.537	0.49
171_E	177_T	0.537	0.49
85_A	90_Y	0.536	0.49
33_I	68_Q	0.536	0.49
137_H	190_L	0.533	0.48
117_D	126_I	0.533	0.48
145_P	148_K	0.531	0.48
42_Y	79_K	0.530	0.48
66_Y	105_L	0.526	0.47
40_N	47_Y	0.525	0.47
46_F	65_R	0.524	0.47
60_F	110_K	0.523	0.47
63_C	115_L	0.523	0.47
14_G	61_F	0.523	0.47
69_L	77_L	0.522	0.47
188_F	195_F	0.522	0.47
31_P	77_L	0.521	0.47
108_Y	154_Y	0.520	0.47
168_Q	182_D	0.517	0.46
87_Y	92_N	0.516	0.46
136_L	140_E	0.516	0.46
45_K	57_L	0.515	0.46
37_V	66_Y	0.514	0.46
60_F	64_H	0.512	0.46
146_F	188_F	0.511	0.46
22_T	193_S	0.511	0.46
45_K	101_S	0.509	0.45
66_Y	119_L	0.506	0.45
11_G	14_G	0.504	0.45
57_L	63_C	0.502	0.44
7_I	124_F	0.500	0.44

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vp4A	3	0.8889	100	0.484	Contact Map
2ocpA	2	0.9855	100	0.484	Contact Map
1p5zB	2	0.9807	100	0.505	Contact Map
1osnA	4	0.9372	100	0.508	Contact Map
2jaqA	2	0.9034	100	0.523	Contact Map
1p6xA	3	0.971	100	0.536	Contact Map
3czpA	2	0.8261	99.9	0.62	Contact Map
4eaqA	2	0.8986	99.9	0.64	Contact Map
2plrA	2	0.8841	99.9	0.648	Contact Map
3rhfA	3	0.8841	99.9	0.65	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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