GREMLIN Database
DCK - Deoxyadenosine/deoxycytidine kinase
UniProt: P37529 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (195)
Sequences: 1798 (1096)
Seq/√Len: 78.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_D189_E4.2631.00
196_D199_S3.8501.00
26_T37_T3.3451.00
192_D195_N3.1411.00
138_E172_E3.1211.00
137_L188_I2.9121.00
109_K113_K2.8751.00
143_N146_N2.8561.00
32_R208_A2.7181.00
28_T200_I2.6741.00
165_E169_T2.6411.00
138_E185_K2.6071.00
103_D170_R2.4501.00
24_T194_L2.4191.00
138_E187_R2.4081.00
143_N147_R2.2591.00
49_E53_H2.2531.00
102_A109_K2.2031.00
173_N177_G2.1801.00
187_R190_D2.1421.00
20_V139_G2.1411.00
15_A92_E2.0861.00
159_T164_W2.0521.00
47_Y111_D2.0391.00
143_N189_E2.0341.00
54_D57_R2.0321.00
33_L208_A2.0131.00
18_V164_W1.9771.00
28_T197_E1.9441.00
60_F64_I1.9431.00
141_L168_H1.8741.00
178_F181_C1.8621.00
161_R165_E1.8041.00
150_Q195_N1.7381.00
139_G144_I1.7311.00
146_N150_Q1.7221.00
200_I204_V1.7041.00
70_R93_D1.6921.00
145_L161_R1.6841.00
93_D115_Y1.6441.00
151_R156_E1.6241.00
112_Y116_T1.6061.00
32_R200_I1.6031.00
63_Q93_D1.5680.99
145_L164_W1.5570.99
50_K110_V1.5330.99
153_R156_E1.5270.99
25_L193_L1.4090.99
205_D209_S1.3950.99
98_A107_M1.3930.99
172_E176_S1.3830.99
139_G188_I1.3670.99
202_N206_Q1.3630.99
32_R201_E1.3510.98
202_N205_D1.3340.98
19_G148_I1.3270.98
191_Y202_N1.2840.98
13_T89_S1.2760.98
197_E201_E1.2650.98
111_D114_T1.2590.98
204_V208_A1.2530.97
51_F163_Y1.2270.97
30_A37_T1.2150.97
58_W61_H1.2140.97
14_V137_L1.2110.97
142_E161_R1.1930.97
99_K170_R1.1830.96
178_F183_V1.1720.96
27_K31_K1.1680.96
88_R97_F1.1560.96
29_L204_V1.1420.96
139_G143_N1.1300.95
101_H106_T1.1240.95
104_K166_E1.1170.95
136_Y172_E1.1170.95
17_T144_I1.0970.95
48_L52_Y1.0900.94
133_V181_C1.0870.94
17_T168_H1.0800.94
17_T164_W1.0740.94
41_E44_H1.0740.94
141_L165_E1.0730.94
66_F70_R1.0720.94
23_S39_L1.0610.94
144_I164_W1.0500.93
141_L161_R1.0290.92
162_S165_E1.0160.92
175_I183_V1.0130.92
50_K53_H1.0010.91
70_R115_Y0.9870.91
99_K103_D0.9870.91
72_K76_T0.9860.91
66_F93_D0.9750.90
17_T24_T0.9720.90
201_E205_D0.9690.90
35_F83_G0.9570.89
47_Y114_T0.9550.89
147_R188_I0.9470.89
24_T40_E0.9440.89
63_Q115_Y0.9320.88
199_S202_N0.9300.88
197_E200_I0.9250.88
15_A136_Y0.9100.87
77_I86_Q0.8970.86
40_E52_Y0.8950.86
198_N205_D0.8920.86
134_L181_C0.8910.86
141_L145_L0.8860.86
68_A121_A0.8800.85
102_A112_Y0.8700.84
133_V207_I0.8670.84
51_F101_H0.8660.84
49_E155_M0.8640.84
184_L206_Q0.8520.83
205_D208_A0.8490.83
51_F93_D0.8470.83
166_E169_T0.8430.83
201_E206_Q0.8390.82
76_T113_K0.8310.82
117_S120_E0.8300.82
169_T173_N0.8290.81
53_H158_Q0.8270.81
101_H107_M0.8210.81
28_T193_L0.8170.81
206_Q209_S0.8160.80
170_R173_N0.8110.80
31_K205_D0.8050.80
73_E82_G0.8040.79
198_N201_E0.8000.79
100_M170_R0.7970.79
162_S166_E0.7900.78
24_T195_N0.7870.78
186_L203_I0.7850.78
48_L163_Y0.7840.78
17_T20_V0.7840.78
96_I99_K0.7830.78
152_G157_L0.7810.77
175_I184_L0.7800.77
64_I118_L0.7800.77
133_V184_L0.7760.77
98_A112_Y0.7680.76
34_G162_S0.7670.76
52_Y163_Y0.7650.76
187_R191_Y0.7640.76
17_T100_M0.7580.75
88_R92_E0.7570.75
45_N66_F0.7560.75
17_T139_G0.7520.75
36_K84_F0.7500.75
18_V52_Y0.7480.74
94_T116_T0.7470.74
49_E154_E0.7430.74
141_L144_I0.7390.73
126_P129_P0.7370.73
78_F108_S0.7370.73
16_G22_K0.7360.73
56_E108_S0.7330.73
57_R111_D0.7330.73
144_I159_T0.7260.72
58_W170_R0.7240.72
203_I206_Q0.7220.72
49_E58_W0.7200.72
16_G21_G0.7180.71
165_E168_H0.7150.71
87_D92_E0.7080.70
136_Y185_K0.7050.70
93_D163_Y0.7050.70
68_A96_I0.7040.70
19_G52_Y0.7030.70
91_Y98_A0.7030.70
97_F174_W0.7010.70
38_S73_E0.6980.69
63_Q74_Q0.6950.69
35_F96_I0.6910.68
133_V171_Y0.6900.68
156_E163_Y0.6900.68
11_I131_P0.6870.68
56_E135_I0.6860.68
140_D143_N0.6830.68
136_Y175_I0.6810.67
25_L207_I0.6790.67
63_Q99_K0.6780.67
50_K58_W0.6770.67
110_V114_T0.6750.67
85_V190_D0.6700.66
33_L204_V0.6630.65
12_I157_L0.6580.65
147_R151_R0.6480.63
103_D107_M0.6430.63
118_L168_H0.6410.63
104_K173_N0.6410.63
24_T193_L0.6400.62
15_A18_V0.6390.62
14_V25_L0.6380.62
91_Y137_L0.6370.62
146_N149_E0.6370.62
193_L200_I0.6340.62
35_F201_E0.6340.62
142_E165_E0.6340.62
80_A142_E0.6320.62
197_E205_D0.6320.62
18_V159_T0.6310.61
58_W134_L0.6300.61
62_L66_F0.6290.61
67_L115_Y0.6250.61
66_F171_Y0.6240.61
201_E208_A0.6240.61
29_L115_Y0.6230.60
20_V188_I0.6190.60
120_E154_E0.6190.60
42_V155_M0.6190.60
28_T157_L0.6180.60
118_L122_M0.6160.60
42_V45_N0.6130.59
36_K80_A0.6120.59
59_S152_G0.6090.59
94_T99_K0.6070.58
194_L205_D0.6060.58
149_E159_T0.6040.58
109_K120_E0.6020.58
192_D196_D0.6010.58
201_E209_S0.6000.58
50_K89_S0.5980.57
176_S185_K0.5970.57
15_A94_T0.5970.57
69_E137_L0.5960.57
100_M103_D0.5960.57
98_A106_T0.5960.57
169_T209_S0.5960.57
148_I156_E0.5940.57
85_V89_S0.5940.57
27_K198_N0.5880.56
146_N189_E0.5870.56
168_H172_E0.5860.56
77_I119_F0.5860.56
11_I86_Q0.5850.56
71_F128_F0.5820.55
120_E205_D0.5820.55
104_K162_S0.5800.55
12_I133_V0.5790.55
191_Y199_S0.5780.55
99_K116_T0.5770.55
23_S148_I0.5760.55
18_V163_Y0.5750.54
20_V177_G0.5750.54
26_T171_Y0.5690.54
27_K39_L0.5690.54
67_L171_Y0.5680.54
140_D146_N0.5670.53
62_L68_A0.5670.53
146_N195_N0.5660.53
198_N206_Q0.5650.53
23_S27_K0.5640.53
134_L183_V0.5630.53
63_Q101_H0.5610.53
85_V88_R0.5570.52
114_T174_W0.5510.51
80_A189_E0.5510.51
92_E100_M0.5500.51
100_M116_T0.5490.51
61_H111_D0.5460.51
12_I152_G0.5460.51
65_Y117_S0.5400.50
91_Y101_H0.5380.50
85_V105_G0.5380.50
62_L187_R0.5360.49
87_D101_H0.5320.49
132_D182_P0.5320.49
145_L149_E0.5310.49
42_V48_L0.5310.49
56_E146_N0.5280.48
45_N65_Y0.5220.48
80_A205_D0.5200.47
19_G66_F0.5200.47
42_V153_R0.5200.47
193_L196_D0.5200.47
48_L167_M0.5170.47
173_N205_D0.5160.47
47_Y86_Q0.5140.47
92_E97_F0.5130.46
195_N205_D0.5130.46
141_L164_W0.5120.46
28_T204_V0.5110.46
12_I16_G0.5100.46
23_S36_K0.5100.46
199_S203_I0.5070.46
134_L174_W0.5070.46
120_E190_D0.5050.45
17_T92_E0.5050.45
68_A122_M0.5030.45
173_N176_S0.5010.45
75_K122_M0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ocpA 2 0.9401 100 0.499 Contact Map
2vp4A 3 0.8479 100 0.503 Contact Map
2jaqA 2 0.8618 100 0.527 Contact Map
1p5zB 2 0.9263 100 0.53 Contact Map
1osnA 4 0.9171 100 0.53 Contact Map
1p6xA 3 0.9539 100 0.562 Contact Map
3czpA 2 0.8065 99.9 0.621 Contact Map
4eaqA 2 0.8618 99.9 0.654 Contact Map
1gtvA 2 0.8433 99.9 0.656 Contact Map
3rhfA 3 0.871 99.9 0.657 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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