DCK - BACSU - GREMLIN Contacts

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DCK - Deoxyadenosine/deoxycytidine kinase

UniProt:	P37529	Sequences: MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDHNPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHADKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTSRSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	217 (195)
Sequences:	1798 (1096)
Seq/√Len:	78.5

BACSU - DCK DGK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
140_D	189_E	4.263	1.00
196_D	199_S	3.850	1.00
26_T	37_T	3.345	1.00
192_D	195_N	3.141	1.00
138_E	172_E	3.121	1.00
137_L	188_I	2.912	1.00
109_K	113_K	2.875	1.00
143_N	146_N	2.856	1.00
32_R	208_A	2.718	1.00
28_T	200_I	2.674	1.00
165_E	169_T	2.641	1.00
138_E	185_K	2.607	1.00
103_D	170_R	2.450	1.00
24_T	194_L	2.419	1.00
138_E	187_R	2.408	1.00
143_N	147_R	2.259	1.00
49_E	53_H	2.253	1.00
102_A	109_K	2.203	1.00
173_N	177_G	2.180	1.00
187_R	190_D	2.142	1.00
20_V	139_G	2.141	1.00
15_A	92_E	2.086	1.00
159_T	164_W	2.052	1.00
47_Y	111_D	2.039	1.00
143_N	189_E	2.034	1.00
54_D	57_R	2.032	1.00
33_L	208_A	2.013	1.00
18_V	164_W	1.977	1.00
28_T	197_E	1.944	1.00
60_F	64_I	1.943	1.00
141_L	168_H	1.874	1.00
178_F	181_C	1.862	1.00
161_R	165_E	1.804	1.00
150_Q	195_N	1.738	1.00
139_G	144_I	1.731	1.00
146_N	150_Q	1.722	1.00
200_I	204_V	1.704	1.00
70_R	93_D	1.692	1.00
145_L	161_R	1.684	1.00
93_D	115_Y	1.644	1.00
151_R	156_E	1.624	1.00
112_Y	116_T	1.606	1.00
32_R	200_I	1.603	1.00
63_Q	93_D	1.568	0.99
145_L	164_W	1.557	0.99
50_K	110_V	1.533	0.99
153_R	156_E	1.527	0.99
25_L	193_L	1.409	0.99
205_D	209_S	1.395	0.99
98_A	107_M	1.393	0.99
172_E	176_S	1.383	0.99
139_G	188_I	1.367	0.99
202_N	206_Q	1.363	0.99
32_R	201_E	1.351	0.98
202_N	205_D	1.334	0.98
19_G	148_I	1.327	0.98
191_Y	202_N	1.284	0.98
13_T	89_S	1.276	0.98
197_E	201_E	1.265	0.98
111_D	114_T	1.259	0.98
204_V	208_A	1.253	0.97
51_F	163_Y	1.227	0.97
30_A	37_T	1.215	0.97
58_W	61_H	1.214	0.97
14_V	137_L	1.211	0.97
142_E	161_R	1.193	0.97
99_K	170_R	1.183	0.96
178_F	183_V	1.172	0.96
27_K	31_K	1.168	0.96
88_R	97_F	1.156	0.96
29_L	204_V	1.142	0.96
139_G	143_N	1.130	0.95
101_H	106_T	1.124	0.95
104_K	166_E	1.117	0.95
136_Y	172_E	1.117	0.95
17_T	144_I	1.097	0.95
48_L	52_Y	1.090	0.94
133_V	181_C	1.087	0.94
17_T	168_H	1.080	0.94
17_T	164_W	1.074	0.94
41_E	44_H	1.074	0.94
141_L	165_E	1.073	0.94
66_F	70_R	1.072	0.94
23_S	39_L	1.061	0.94
144_I	164_W	1.050	0.93
141_L	161_R	1.029	0.92
162_S	165_E	1.016	0.92
175_I	183_V	1.013	0.92
50_K	53_H	1.001	0.91
70_R	115_Y	0.987	0.91
99_K	103_D	0.987	0.91
72_K	76_T	0.986	0.91
66_F	93_D	0.975	0.90
17_T	24_T	0.972	0.90
201_E	205_D	0.969	0.90
35_F	83_G	0.957	0.89
47_Y	114_T	0.955	0.89
147_R	188_I	0.947	0.89
24_T	40_E	0.944	0.89
63_Q	115_Y	0.932	0.88
199_S	202_N	0.930	0.88
197_E	200_I	0.925	0.88
15_A	136_Y	0.910	0.87
77_I	86_Q	0.897	0.86
40_E	52_Y	0.895	0.86
198_N	205_D	0.892	0.86
134_L	181_C	0.891	0.86
141_L	145_L	0.886	0.86
68_A	121_A	0.880	0.85
102_A	112_Y	0.870	0.84
133_V	207_I	0.867	0.84
51_F	101_H	0.866	0.84
49_E	155_M	0.864	0.84
184_L	206_Q	0.852	0.83
205_D	208_A	0.849	0.83
51_F	93_D	0.847	0.83
166_E	169_T	0.843	0.83
201_E	206_Q	0.839	0.82
76_T	113_K	0.831	0.82
117_S	120_E	0.830	0.82
169_T	173_N	0.829	0.81
53_H	158_Q	0.827	0.81
101_H	107_M	0.821	0.81
28_T	193_L	0.817	0.81
206_Q	209_S	0.816	0.80
170_R	173_N	0.811	0.80
31_K	205_D	0.805	0.80
73_E	82_G	0.804	0.79
198_N	201_E	0.800	0.79
100_M	170_R	0.797	0.79
162_S	166_E	0.790	0.78
24_T	195_N	0.787	0.78
186_L	203_I	0.785	0.78
48_L	163_Y	0.784	0.78
17_T	20_V	0.784	0.78
96_I	99_K	0.783	0.78
152_G	157_L	0.781	0.77
175_I	184_L	0.780	0.77
64_I	118_L	0.780	0.77
133_V	184_L	0.776	0.77
98_A	112_Y	0.768	0.76
34_G	162_S	0.767	0.76
52_Y	163_Y	0.765	0.76
187_R	191_Y	0.764	0.76
17_T	100_M	0.758	0.75
88_R	92_E	0.757	0.75
45_N	66_F	0.756	0.75
17_T	139_G	0.752	0.75
36_K	84_F	0.750	0.75
18_V	52_Y	0.748	0.74
94_T	116_T	0.747	0.74
49_E	154_E	0.743	0.74
141_L	144_I	0.739	0.73
126_P	129_P	0.737	0.73
78_F	108_S	0.737	0.73
16_G	22_K	0.736	0.73
56_E	108_S	0.733	0.73
57_R	111_D	0.733	0.73
144_I	159_T	0.726	0.72
58_W	170_R	0.724	0.72
203_I	206_Q	0.722	0.72
49_E	58_W	0.720	0.72
16_G	21_G	0.718	0.71
165_E	168_H	0.715	0.71
87_D	92_E	0.708	0.70
136_Y	185_K	0.705	0.70
93_D	163_Y	0.705	0.70
68_A	96_I	0.704	0.70
19_G	52_Y	0.703	0.70
91_Y	98_A	0.703	0.70
97_F	174_W	0.701	0.70
38_S	73_E	0.698	0.69
63_Q	74_Q	0.695	0.69
35_F	96_I	0.691	0.68
133_V	171_Y	0.690	0.68
156_E	163_Y	0.690	0.68
11_I	131_P	0.687	0.68
56_E	135_I	0.686	0.68
140_D	143_N	0.683	0.68
136_Y	175_I	0.681	0.67
25_L	207_I	0.679	0.67
63_Q	99_K	0.678	0.67
50_K	58_W	0.677	0.67
110_V	114_T	0.675	0.67
85_V	190_D	0.670	0.66
33_L	204_V	0.663	0.65
12_I	157_L	0.658	0.65
147_R	151_R	0.648	0.63
103_D	107_M	0.643	0.63
118_L	168_H	0.641	0.63
104_K	173_N	0.641	0.63
24_T	193_L	0.640	0.62
15_A	18_V	0.639	0.62
14_V	25_L	0.638	0.62
91_Y	137_L	0.637	0.62
146_N	149_E	0.637	0.62
193_L	200_I	0.634	0.62
35_F	201_E	0.634	0.62
142_E	165_E	0.634	0.62
80_A	142_E	0.632	0.62
197_E	205_D	0.632	0.62
18_V	159_T	0.631	0.61
58_W	134_L	0.630	0.61
62_L	66_F	0.629	0.61
67_L	115_Y	0.625	0.61
66_F	171_Y	0.624	0.61
201_E	208_A	0.624	0.61
29_L	115_Y	0.623	0.60
20_V	188_I	0.619	0.60
120_E	154_E	0.619	0.60
42_V	155_M	0.619	0.60
28_T	157_L	0.618	0.60
118_L	122_M	0.616	0.60
42_V	45_N	0.613	0.59
36_K	80_A	0.612	0.59
59_S	152_G	0.609	0.59
94_T	99_K	0.607	0.58
194_L	205_D	0.606	0.58
149_E	159_T	0.604	0.58
109_K	120_E	0.602	0.58
192_D	196_D	0.601	0.58
201_E	209_S	0.600	0.58
50_K	89_S	0.598	0.57
176_S	185_K	0.597	0.57
15_A	94_T	0.597	0.57
69_E	137_L	0.596	0.57
100_M	103_D	0.596	0.57
98_A	106_T	0.596	0.57
169_T	209_S	0.596	0.57
148_I	156_E	0.594	0.57
85_V	89_S	0.594	0.57
27_K	198_N	0.588	0.56
146_N	189_E	0.587	0.56
168_H	172_E	0.586	0.56
77_I	119_F	0.586	0.56
11_I	86_Q	0.585	0.56
71_F	128_F	0.582	0.55
120_E	205_D	0.582	0.55
104_K	162_S	0.580	0.55
12_I	133_V	0.579	0.55
191_Y	199_S	0.578	0.55
99_K	116_T	0.577	0.55
23_S	148_I	0.576	0.55
18_V	163_Y	0.575	0.54
20_V	177_G	0.575	0.54
26_T	171_Y	0.569	0.54
27_K	39_L	0.569	0.54
67_L	171_Y	0.568	0.54
140_D	146_N	0.567	0.53
62_L	68_A	0.567	0.53
146_N	195_N	0.566	0.53
198_N	206_Q	0.565	0.53
23_S	27_K	0.564	0.53
134_L	183_V	0.563	0.53
63_Q	101_H	0.561	0.53
85_V	88_R	0.557	0.52
114_T	174_W	0.551	0.51
80_A	189_E	0.551	0.51
92_E	100_M	0.550	0.51
100_M	116_T	0.549	0.51
61_H	111_D	0.546	0.51
12_I	152_G	0.546	0.51
65_Y	117_S	0.540	0.50
91_Y	101_H	0.538	0.50
85_V	105_G	0.538	0.50
62_L	187_R	0.536	0.49
87_D	101_H	0.532	0.49
132_D	182_P	0.532	0.49
145_L	149_E	0.531	0.49
42_V	48_L	0.531	0.49
56_E	146_N	0.528	0.48
45_N	65_Y	0.522	0.48
80_A	205_D	0.520	0.47
19_G	66_F	0.520	0.47
42_V	153_R	0.520	0.47
193_L	196_D	0.520	0.47
48_L	167_M	0.517	0.47
173_N	205_D	0.516	0.47
47_Y	86_Q	0.514	0.47
92_E	97_F	0.513	0.46
195_N	205_D	0.513	0.46
141_L	164_W	0.512	0.46
28_T	204_V	0.511	0.46
12_I	16_G	0.510	0.46
23_S	36_K	0.510	0.46
199_S	203_I	0.507	0.46
134_L	174_W	0.507	0.46
120_E	190_D	0.505	0.45
17_T	92_E	0.505	0.45
68_A	122_M	0.503	0.45
173_N	176_S	0.501	0.45
75_K	122_M	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ocpA	2	0.9401	100	0.499	Contact Map
2vp4A	3	0.8479	100	0.503	Contact Map
2jaqA	2	0.8618	100	0.527	Contact Map
1p5zB	2	0.9263	100	0.53	Contact Map
1osnA	4	0.9171	100	0.53	Contact Map
1p6xA	3	0.9539	100	0.562	Contact Map
3czpA	2	0.8065	99.9	0.621	Contact Map
4eaqA	2	0.8618	99.9	0.654	Contact Map
1gtvA	2	0.8433	99.9	0.656	Contact Map
3rhfA	3	0.871	99.9	0.657	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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