GREMLIN Database
PDXT - Glutamine amidotransferase subunit PdxT
UniProt: P37528 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 196 (186)
Sequences: 1643 (1111)
Seq/√Len: 81.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_F73_K3.6631.00
160_K186_M3.3351.00
159_A166_G3.2341.00
3_T26_A2.8881.00
82_L166_G2.8121.00
139_I159_A2.7291.00
147_E160_K2.6861.00
69_A75_M2.6501.00
181_Q185_E2.3981.00
88_E103_V2.3461.00
20_I43_I2.3231.00
101_N161_Q2.2691.00
100_L159_A2.2541.00
158_A167_C2.2021.00
6_V17_I2.1861.00
88_E141_E2.0871.00
138_H155_R2.0771.00
119_D130_T2.0571.00
105_E140_L2.0481.00
67_E71_Q2.0461.00
76_F167_C2.0411.00
100_L164_F1.9611.00
17_I29_V1.9501.00
20_I25_A1.9371.00
8_G29_V1.9181.00
17_I27_G1.9031.00
165_L186_M1.8291.00
158_A179_V1.8221.00
132_V174_T1.8111.00
3_T28_L1.8041.00
82_L139_I1.7741.00
4_I41_G1.7671.00
87_K101_N1.7021.00
27_G43_I1.6971.00
102_V166_G1.6921.00
44_L84_I1.6691.00
62_M97_L1.6311.00
177_H181_Q1.6181.00
90_A140_L1.5921.00
53_R95_P1.5711.00
82_L168_S1.5631.00
123_K147_E1.5581.00
22_A177_H1.5421.00
119_D128_P1.5340.99
18_H21_E1.5250.99
103_V141_E1.5210.99
89_I96_H1.5150.99
5_G39_V1.5150.99
99_L164_F1.4920.99
151_E154_G1.4820.99
62_M66_R1.4610.99
108_S138_H1.4300.99
28_L38_E1.4250.99
109_F168_S1.4240.99
100_L166_G1.4190.99
138_H168_S1.3970.99
69_A99_L1.3860.99
53_R96_H1.3860.99
87_K99_L1.3820.99
120_L131_G1.3760.99
148_V156_I1.3440.99
82_L104_V1.3400.99
53_R57_D1.3120.98
129_F178_R1.2750.98
142_A156_I1.2370.98
101_N143_G1.2310.98
65_L68_F1.2220.97
90_A105_E1.2100.97
56_I84_I1.2000.97
17_I21_E1.1930.97
33_P60_Q1.1890.97
66_R70_A1.1860.97
122_I179_V1.1740.97
86_A104_V1.1650.97
117_E130_T1.1560.96
4_I184_V1.1520.96
142_A148_V1.1480.96
160_K182_L1.1410.96
19_A177_H1.1370.96
57_D62_M1.1290.96
13_V31_K1.1280.96
77_G167_C1.0850.95
76_F179_V1.0580.94
14_R18_H1.0400.94
39_V74_P1.0400.94
19_A23_C1.0350.93
149_L158_A1.0320.93
28_L39_V1.0300.93
39_V68_F1.0290.93
124_G147_E1.0160.93
52_M84_I1.0020.92
53_R94_N0.9960.92
51_T55_L0.9910.92
30_V39_V0.9890.92
32_R35_Q0.9880.92
128_P178_R0.9840.91
122_I129_F0.9730.91
165_L183_F0.9680.91
117_E132_V0.9590.90
61_F64_P0.9560.90
21_E27_G0.9540.90
151_E156_I0.9440.90
3_T38_E0.9430.90
56_I97_L0.9350.89
63_E67_E0.9330.89
69_A164_F0.9280.89
76_F165_L0.9260.89
23_C184_V0.9190.88
76_F183_F0.9180.88
25_A43_I0.9120.88
117_E174_T0.9080.88
143_G146_V0.9080.88
20_I180_T0.9070.88
30_V61_F0.9060.88
7_L42_L0.9050.88
33_P64_P0.8970.87
57_D95_P0.8940.87
109_F156_I0.8900.87
75_M99_L0.8900.87
36_L39_V0.8900.87
19_A180_T0.8670.85
122_I158_A0.8660.85
185_E188_E0.8620.85
21_E26_A0.8610.85
85_L164_F0.8470.84
8_G13_V0.8450.84
36_L65_L0.8350.83
122_I150_S0.8340.83
120_L150_S0.8250.82
36_L68_F0.8190.82
122_I125_L0.8190.82
4_I187_V0.8180.82
19_A22_A0.8130.81
54_R58_T0.8080.81
100_L161_Q0.8040.81
43_I77_G0.8020.81
129_F179_V0.7880.79
35_Q38_E0.7870.79
29_V35_Q0.7770.78
182_L186_M0.7770.78
111_R179_V0.7740.78
132_V173_L0.7700.78
148_V151_E0.7700.78
131_G150_S0.7650.77
165_L182_L0.7580.77
13_V29_V0.7580.77
65_L99_L0.7580.77
95_P98_G0.7520.76
9_L55_L0.7480.76
3_T188_E0.7430.75
41_G73_K0.7360.75
125_L128_P0.7290.74
89_I92_S0.7290.74
74_P163_Q0.7280.74
13_V23_C0.7180.73
123_K151_E0.7180.73
129_F176_D0.7170.73
14_R17_I0.7140.72
39_V73_K0.7100.72
102_V139_I0.7090.72
89_I93_D0.7070.72
152_H167_C0.6980.71
25_A184_V0.6940.70
103_V140_L0.6900.70
125_L129_F0.6890.70
30_V42_L0.6820.69
139_I168_S0.6790.69
121_T128_P0.6790.69
94_N98_G0.6770.68
105_E138_H0.6730.68
156_I159_A0.6720.68
117_E120_L0.6710.68
156_I168_S0.6700.68
35_Q61_F0.6700.68
155_R168_S0.6690.67
125_L179_V0.6680.67
109_F131_G0.6680.67
5_G36_L0.6620.67
147_E186_M0.6620.67
42_L75_M0.6520.65
23_C177_H0.6470.65
50_T116_F0.6460.65
53_R62_M0.6460.65
87_K164_F0.6440.64
13_V17_I0.6430.64
183_F187_V0.6430.64
53_R93_D0.6410.64
118_A131_G0.6390.64
109_F113_V0.6350.63
86_A102_V0.6350.63
109_F158_A0.6340.63
108_S166_G0.6330.63
146_V149_L0.6330.63
158_A165_L0.6320.63
69_A97_L0.6280.63
12_A51_T0.6280.63
36_L61_F0.6190.61
108_S155_R0.6140.61
83_I139_I0.6140.61
18_H22_A0.6120.61
105_E108_S0.6110.60
12_A173_L0.6090.60
55_L58_T0.6080.60
13_V54_R0.6060.60
9_L36_L0.6040.60
62_M95_P0.6020.59
85_L99_L0.6000.59
124_G182_L0.5940.58
87_K102_V0.5930.58
55_L59_Y0.5930.58
88_E144_E0.5920.58
109_F117_E0.5920.58
20_I27_G0.5920.58
33_P61_F0.5910.58
145_N161_Q0.5880.57
152_H158_A0.5880.57
23_C111_R0.5870.57
65_L73_K0.5870.57
12_A138_H0.5840.57
174_T182_L0.5830.57
8_G98_G0.5780.56
109_F120_L0.5750.56
65_L97_L0.5730.56
82_L138_H0.5720.55
163_Q186_M0.5720.55
42_L65_L0.5710.55
127_E178_R0.5710.55
6_V27_G0.5690.55
82_L146_V0.5680.55
66_R99_L0.5640.54
117_E131_G0.5630.54
55_L108_S0.5590.54
92_S96_H0.5590.54
52_M65_L0.5560.53
70_A99_L0.5540.53
53_R92_S0.5540.53
69_A74_P0.5520.53
90_A103_V0.5490.52
87_K161_Q0.5420.52
125_L130_T0.5410.51
9_L56_I0.5400.51
120_L157_V0.5390.51
86_A89_I0.5360.51
114_D152_H0.5350.51
77_G100_L0.5340.50
31_K108_S0.5340.50
119_D129_F0.5340.50
37_N64_P0.5330.50
41_G184_V0.5320.50
129_F174_T0.5310.50
71_Q144_E0.5300.50
101_N145_N0.5280.50
28_L35_Q0.5270.50
55_L86_A0.5270.50
56_I69_A0.5260.49
35_Q59_Y0.5250.49
56_I62_M0.5250.49
69_A85_L0.5250.49
34_E37_N0.5250.49
121_T127_E0.5230.49
66_R184_V0.5230.49
57_D96_H0.5230.49
162_G185_E0.5210.49
6_V20_I0.5200.49
32_R113_V0.5180.48
5_G117_E0.5170.48
41_G183_F0.5160.48
54_R57_D0.5150.48
44_L52_M0.5140.48
31_K59_Y0.5140.48
161_Q179_V0.5130.48
140_L155_R0.5090.47
119_D125_L0.5090.47
92_S95_P0.5080.47
65_L69_A0.5050.47
69_A163_Q0.5020.46
91_G94_N0.5020.46
56_I68_F0.5010.46
12_A130_T0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nv0A 1 0.9796 100 0.599 Contact Map
2issD 1 0.9388 100 0.62 Contact Map
1q7rA 1 1 100 0.625 Contact Map
2abwA 1 0.9949 100 0.628 Contact Map
2ywdA 1 0.9541 100 0.646 Contact Map
2ywjA 1 0.9337 100 0.648 Contact Map
3en0A 2 0.9643 100 0.661 Contact Map
1jvnA 1 0.9847 100 0.684 Contact Map
1ka9H 1 0.9337 99.9 0.699 Contact Map
1gpwB 1 0.9184 99.9 0.717 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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