GREMLIN Database
PDXS - Pyridoxal biosynthesis lyase PdxS
UniProt: P37527 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 294 (288)
Sequences: 868 (240)
Seq/√Len: 14.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_V264_I5.8911.00
129_C167_V4.7071.00
91_R226_Q4.1491.00
68_E269_K4.0141.00
140_A183_M3.9481.00
62_A66_I3.8531.00
152_P289_M3.5400.99
156_N280_I3.2610.99
117_N120_E3.2440.98
208_V231_G3.2010.98
164_M229_A3.1160.98
242_D276_K3.0120.97
288_R291_E2.9910.97
131_D170_Q2.9360.97
198_Q202_D2.8920.97
148_T209_N2.8490.96
28_A69_E2.8400.96
174_V196_L2.7960.96
6_T10_K2.6620.95
62_A290_Q2.5960.94
174_V200_K2.5060.93
65_T270_E2.4760.92
7_E11_R2.4740.92
36_E245_A2.4350.92
264_I267_L2.3430.90
156_N279_E2.3070.89
27_N69_E2.2310.87
185_E189_L2.2240.87
13_M17_Q2.1030.84
183_M193_Y2.1010.84
65_T269_K2.0770.83
112_E158_V2.0750.83
71_M97_G2.0110.81
94_E122_T1.9840.80
263_L267_L1.8930.77
88_V222_A1.8630.76
159_E162_R1.8580.76
177_M185_E1.8490.75
13_M100_Y1.8420.75
164_M224_M1.8390.75
156_N159_E1.8260.74
204_K230_D1.8200.74
157_I215_V1.7850.73
136_T195_L1.7530.71
262_K266_E1.7480.71
242_D273_T1.7330.70
253_E266_E1.7260.70
215_V255_T1.6820.68
156_N162_R1.6710.67
276_K279_E1.6480.66
140_A193_Y1.6350.66
232_V255_T1.5960.64
87_I226_Q1.5900.63
174_V185_E1.5720.62
71_M98_V1.5660.62
208_V229_A1.5650.62
131_D166_K1.5590.62
112_E156_N1.5420.61
51_D240_K1.5240.60
65_T69_E1.5220.60
253_E257_H1.4960.58
5_G9_V1.4950.58
17_Q100_Y1.4890.58
12_G16_M1.4800.58
52_I57_G1.4770.57
199_I202_D1.4730.57
63_D271_L1.4700.57
87_I91_R1.4420.56
208_V230_D1.4060.54
159_E280_I1.3790.52
140_A191_A1.3770.52
242_D279_E1.3650.51
148_T211_A1.3630.51
179_E197_L1.3490.51
139_I146_L1.3370.50
15_E231_G1.3330.50
6_T12_G1.3300.49
130_R209_N1.3140.49
112_E162_R1.3140.49
10_K144_S1.2970.48
7_E144_S1.2930.47
168_N172_R1.2840.47
198_Q201_K1.2810.47
15_E100_Y1.2790.47
113_E169_A1.2610.46
247_F273_T1.2540.45
88_V91_R1.2530.45
246_K270_E1.2520.45
136_T199_I1.2420.45
265_A269_K1.2410.45
131_D190_G1.2380.44
172_R181_E1.2310.44
140_A192_P1.2250.44
117_N129_C1.2200.44
92_V219_A1.2190.43
166_K290_Q1.2060.43
181_E191_A1.1980.42
208_V211_A1.1940.42
11_R144_S1.1940.42
183_M187_K1.1780.41
5_G10_K1.1780.41
16_M256_T1.1600.40
191_A196_L1.1590.40
50_A276_K1.1530.40
279_E282_N1.1480.40
166_K170_Q1.1430.39
130_R148_T1.1240.38
181_E187_K1.0800.36
9_V12_G1.0760.36
156_N278_I1.0730.36
193_Y197_L1.0710.36
32_K35_E1.0700.36
199_I204_K1.0690.36
211_A229_A1.0660.35
82_A116_L1.0510.35
26_I30_Q1.0510.35
175_V203_G1.0500.35
12_G98_V1.0270.34
146_L157_I1.0270.34
96_M265_A1.0170.33
202_D230_D1.0110.33
169_A177_M1.0110.33
50_A242_D1.0060.33
65_T68_E1.0050.33
287_Q291_E1.0040.32
198_Q204_K1.0030.32
10_K98_V1.0030.32
15_E208_V1.0010.32
66_I290_Q0.9980.32
87_I116_L0.9960.32
185_E200_K0.9950.32
52_I59_A0.9890.32
145_M208_V0.9860.32
47_R62_A0.9860.32
26_I130_R0.9850.32
32_K36_E0.9810.31
8_R11_R0.9800.31
255_T267_L0.9760.31
48_V52_I0.9710.31
130_R223_L0.9650.31
55_A62_A0.9640.31
177_M187_K0.9590.30
263_L266_E0.9580.30
120_E179_E0.9540.30
241_S244_P0.9500.30
88_V226_Q0.9500.30
129_C146_L0.9400.29
67_V152_P0.9380.29
50_A54_A0.9340.29
257_H260_D0.9310.29
242_D278_I0.9300.29
164_M168_N0.9300.29
12_G30_Q0.9250.29
87_I247_F0.9150.28
170_Q177_M0.9130.28
36_E75_S0.9130.28
179_E200_K0.9100.28
68_E72_N0.9070.28
88_V247_F0.9020.28
6_T9_V0.9000.28
145_M231_G0.8970.28
221_A251_I0.8940.27
282_N286_E0.8910.27
90_A116_L0.8850.27
168_N176_A0.8830.27
158_V165_R0.8750.27
66_I69_E0.8750.27
200_K204_K0.8710.26
169_A196_L0.8690.26
280_I283_L0.8670.26
175_V200_K0.8660.26
284_L287_Q0.8650.26
59_A159_E0.8640.26
5_G11_R0.8640.26
286_E291_E0.8630.26
273_T276_K0.8630.26
70_V144_S0.8620.26
224_M265_A0.8600.26
87_I121_Y0.8500.26
192_P195_L0.8440.25
7_E17_Q0.8430.25
167_V211_A0.8400.25
88_V264_I0.8350.25
48_V96_M0.8270.25
100_Y208_V0.8260.25
46_E52_I0.8220.24
92_V267_L0.8220.24
268_S271_L0.8220.24
174_V199_I0.8200.24
121_Y125_F0.8120.24
28_A66_I0.8070.24
159_E281_S0.8050.24
63_D267_L0.8010.24
136_T196_L0.8010.24
14_A18_K0.8010.24
116_L121_Y0.7940.23
203_G260_D0.7920.23
176_A180_D0.7910.23
36_E262_K0.7890.23
230_D283_L0.7850.23
169_A178_S0.7840.23
161_V223_L0.7790.23
174_V177_M0.7770.23
67_V290_Q0.7740.23
243_N287_Q0.7700.22
28_A96_M0.7630.22
253_E267_L0.7610.22
196_L200_K0.7570.22
177_M200_K0.7570.22
172_R191_A0.7560.22
26_I148_T0.7520.22
136_T191_A0.7520.22
247_F276_K0.7460.21
10_K16_M0.7460.21
36_E257_H0.7450.21
11_R17_Q0.7440.21
50_A226_Q0.7430.21
114_F190_G0.7400.21
211_A225_M0.7370.21
184_T190_G0.7370.21
23_M45_L0.7360.21
157_I247_F0.7360.21
58_V154_T0.7340.21
11_R208_V0.7320.21
196_L281_S0.7310.21
173_K189_L0.7310.21
226_Q258_F0.7310.21
7_E10_K0.7310.21
82_A265_A0.7300.21
266_E269_K0.7300.21
173_K176_A0.7280.21
276_K281_S0.7270.21
211_A230_D0.7240.21
229_A288_R0.7230.21
232_V245_A0.7190.21
7_E12_G0.7180.20
242_D270_E0.7140.20
71_M257_H0.7110.20
183_M191_A0.7090.20
55_A289_M0.7060.20
15_E68_E0.7050.20
154_T157_I0.7030.20
11_R119_N0.6990.20
204_K253_E0.6990.20
170_Q173_K0.6960.20
152_P167_V0.6950.20
91_R261_Y0.6940.20
23_M43_M0.6920.20
68_E198_Q0.6880.19
69_E287_Q0.6870.19
130_R211_A0.6870.19
88_V230_D0.6870.19
185_E229_A0.6870.19
156_N282_N0.6850.19
184_T191_A0.6820.19
44_A48_V0.6790.19
108_T287_Q0.6740.19
26_I209_N0.6710.19
50_A215_V0.6700.19
73_A82_A0.6650.19
140_A178_S0.6630.19
178_S183_M0.6630.19
164_M215_V0.6620.19
10_K14_A0.6600.18
5_G12_G0.6600.18
130_R152_P0.6550.18
40_V256_T0.6530.18
19_G22_I0.6520.18
47_R52_I0.6520.18
44_A52_I0.6510.18
183_M190_G0.6500.18
75_S280_I0.6470.18
245_A249_K0.6470.18
187_K191_A0.6470.18
140_A190_G0.6460.18
225_M230_D0.6460.18
32_K75_S0.6460.18
177_M189_L0.6450.18
55_A280_I0.6440.18
269_K286_E0.6430.18
82_A130_R0.6430.18
187_K190_G0.6420.18
172_R203_G0.6420.18
280_I289_M0.6420.18
55_A152_P0.6400.18
156_N167_V0.6400.18
50_A114_F0.6390.18
91_R116_L0.6390.18
91_R258_F0.6340.18
127_C268_S0.6340.18
215_V221_A0.6310.18
174_V189_L0.6300.18
7_E13_M0.6290.17
164_M167_V0.6290.17
11_R231_G0.6280.17
157_I224_M0.6240.17
32_K245_A0.6240.17
174_V182_L0.6220.17
21_V221_A0.6210.17
9_V16_M0.6200.17
59_A108_T0.6190.17
8_R12_G0.6180.17
282_N291_E0.6170.17
46_E127_C0.6160.17
136_T192_P0.6140.17
165_R191_A0.6130.17
8_R190_G0.6110.17
97_G262_K0.6060.17
26_I286_E0.6060.17
177_M204_K0.6050.17
32_K246_K0.6050.17
161_V211_A0.6050.17
6_T75_S0.6030.17
193_Y196_L0.6020.17
26_I62_A0.6010.17
52_I274_A0.5990.17
215_V245_A0.5990.17
215_V222_A0.5990.17
11_R198_Q0.5980.17
24_D45_L0.5970.17
175_V199_I0.5970.17
71_M96_M0.5960.16
112_E192_P0.5950.16
112_E195_L0.5940.16
59_A156_N0.5900.16
13_M204_K0.5900.16
82_A117_N0.5890.16
171_V199_I0.5830.16
19_G28_A0.5810.16
5_G13_M0.5810.16
58_V108_T0.5800.16
215_V251_I0.5790.16
282_N288_R0.5780.16
166_K195_L0.5760.16
50_A140_A0.5750.16
167_V229_A0.5730.16
55_A290_Q0.5730.16
17_Q91_R0.5730.16
30_Q54_A0.5710.16
54_A242_D0.5690.16
90_A244_P0.5680.16
63_D272_G0.5660.16
130_R161_V0.5660.16
88_V270_E0.5650.16
166_K192_P0.5630.16
159_E282_N0.5580.15
112_E130_R0.5580.15
270_E284_L0.5570.15
261_Y269_K0.5560.15
173_K185_E0.5540.15
157_I280_I0.5530.15
168_N202_D0.5520.15
5_G17_Q0.5520.15
55_A59_A0.5520.15
146_L205_L0.5500.15
226_Q261_Y0.5490.15
130_R279_E0.5490.15
148_T167_V0.5490.15
71_M101_I0.5480.15
74_V110_A0.5470.15
243_N272_G0.5460.15
66_I169_A0.5450.15
215_V281_S0.5440.15
21_V222_A0.5430.15
125_F133_G0.5420.15
100_Y246_K0.5400.15
165_R278_I0.5400.15
92_V255_T0.5400.15
14_A256_T0.5380.15
15_E229_A0.5380.15
32_K65_T0.5370.15
185_E190_G0.5370.15
50_A259_T0.5360.15
244_P271_L0.5340.15
48_V55_A0.5340.15
55_A71_M0.5330.15
283_L291_E0.5330.15
8_R100_Y0.5320.15
280_I288_R0.5290.15
240_K273_T0.5290.15
117_N245_A0.5280.15
157_I290_Q0.5280.15
160_A237_G0.5270.15
13_M122_T0.5250.14
62_A67_V0.5250.14
149_K160_A0.5250.14
108_T115_H0.5240.14
114_F178_S0.5230.14
224_M255_T0.5210.14
241_S248_A0.5200.14
15_E18_K0.5190.14
173_K177_M0.5190.14
21_V215_V0.5170.14
55_A66_I0.5170.14
204_K231_G0.5160.14
17_Q187_K0.5160.14
24_D84_I0.5150.14
24_D43_M0.5150.14
247_F278_I0.5150.14
9_V29_E0.5150.14
113_E192_P0.5140.14
82_A101_I0.5140.14
98_V123_V0.5140.14
282_N287_Q0.5130.14
196_L203_G0.5120.14
241_S271_L0.5110.14
48_V59_A0.5110.14
159_E244_P0.5110.14
131_D191_A0.5100.14
185_E188_N0.5090.14
82_A255_T0.5080.14
114_F180_D0.5080.14
159_E279_E0.5080.14
185_E196_L0.5070.14
21_V251_I0.5070.14
114_F184_T0.5070.14
27_N185_E0.5070.14
48_V62_A0.5050.14
36_E68_E0.5050.14
7_E100_Y0.5040.14
108_T156_N0.5040.14
190_G257_H0.5030.14
167_V224_M0.5020.14
109_P182_L0.5020.14
7_E119_N0.5020.14
149_K237_G0.5020.14
53_R56_G0.5010.14
65_T95_A0.5010.14
45_L149_K0.5010.14
81_K149_K0.5000.14
96_M129_C0.5000.14
27_N266_E0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yzrA 5 0.9286 100 0.697 Contact Map
2nv1A 5 0.881 100 0.76 Contact Map
2zbtA 5 0.9354 100 0.765 Contact Map
3o07A 3 0.8776 100 0.783 Contact Map
4adtA 5 0.9286 100 0.788 Contact Map
4qccA 6 0.7449 99.5 0.901 Contact Map
1xm3A 4 0.6973 99.5 0.901 Contact Map
2htmA 3 0.6701 99.5 0.901 Contact Map
3qjaA 1 0.7449 99.5 0.903 Contact Map
1wv2A 3 0.6565 99.5 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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