GREMLIN Database
YAAC - Uncharacterized protein YaaC
UniProt: P37526 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 315 (306)
Sequences: 119 (107)
Seq/√Len: 6.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_I271_A3.7820.92
56_Y296_F3.7810.92
191_M195_R3.3380.86
63_P270_I2.9710.78
109_Q270_I2.9640.78
181_V200_M2.9530.77
53_E67_K2.9350.77
65_E83_L2.8630.75
101_V262_L2.6570.69
129_F258_T2.5610.66
296_F300_S2.5430.65
156_L181_V2.5360.65
58_Q271_A2.4890.64
271_A279_Y2.4440.62
263_I268_G2.4030.61
102_T165_K2.3960.61
216_L259_I2.3850.60
181_V244_I2.3610.59
146_M266_N2.3330.58
51_H146_M2.3320.58
186_V196_F2.2880.57
72_F277_W2.2490.55
187_I192_S2.2280.55
65_E127_V2.1730.53
256_E303_K2.1690.53
51_H266_N2.1240.51
15_V43_E2.1090.50
87_D122_R2.0870.50
52_A130_M2.0510.48
108_K119_K2.0250.47
51_H82_C2.0040.47
113_F146_M1.9980.46
19_Q41_N1.9840.46
93_H249_E1.9320.44
153_I303_K1.9310.44
78_L262_L1.9100.43
12_F205_Q1.8960.43
196_F244_I1.8910.43
41_N48_F1.8380.41
98_A266_N1.8260.40
19_Q245_P1.8230.40
159_I292_L1.8100.40
83_L93_H1.8010.40
21_F42_S1.7940.39
67_K122_R1.7740.39
12_F87_D1.7680.38
44_R48_F1.7610.38
130_M308_A1.7510.38
39_F115_D1.7400.38
160_F235_F1.7230.37
266_N277_W1.7230.37
283_T287_S1.7110.37
52_A192_S1.6960.36
87_D128_H1.6920.36
134_F277_W1.6840.36
186_V192_S1.6840.36
113_F293_I1.6100.33
12_F195_R1.5900.33
98_A146_M1.5880.33
72_F265_Y1.5800.32
22_L26_Y1.5780.32
77_Q287_S1.5770.32
98_A277_W1.5740.32
113_F266_N1.5450.31
154_P289_D1.5300.31
191_M199_Y1.5160.30
76_A133_L1.4890.30
81_A125_L1.4630.29
12_F199_Y1.4590.29
108_K265_Y1.4540.29
43_E63_P1.4340.28
83_L282_L1.4330.28
86_R196_F1.4260.28
19_Q109_Q1.4110.27
56_Y300_S1.3950.27
58_Q63_P1.3860.27
151_M244_I1.3780.26
276_E280_E1.3720.26
37_N126_C1.3690.26
59_A192_S1.3600.26
43_E270_I1.3510.26
14_S101_V1.3510.26
262_L277_W1.3410.25
68_P104_R1.3310.25
172_V243_Y1.3070.24
51_H289_D1.3070.24
160_F292_L1.3020.24
119_K266_N1.2990.24
102_T142_E1.2860.24
263_I271_A1.2810.24
94_T109_Q1.2760.24
39_F76_A1.2720.24
158_D241_Q1.2680.23
85_T101_V1.2540.23
74_G121_Q1.2490.23
76_A114_S1.2470.23
130_M306_K1.2450.23
51_H77_Q1.2420.23
249_E309_S1.2350.23
98_A291_V1.2270.22
119_K265_Y1.2260.22
14_S265_Y1.2210.22
35_K50_K1.2210.22
134_F274_E1.2130.22
21_F31_I1.2110.22
54_S271_A1.2100.22
112_C308_A1.2030.22
27_I310_Q1.2020.22
133_L196_F1.1990.22
90_Y121_Q1.1890.21
74_G90_Y1.1890.21
11_L112_C1.1840.21
260_H305_P1.1820.21
131_K137_S1.1790.21
184_E263_I1.1780.21
153_I287_S1.1740.21
62_S225_K1.1730.21
77_Q295_Q1.1720.21
44_R141_D1.1590.21
44_R53_E1.1520.21
95_S102_T1.1510.21
283_T286_I1.1460.20
37_N143_R1.1450.20
111_Y297_L1.1440.20
172_V181_V1.1400.20
141_D156_L1.1340.20
160_F280_E1.1280.20
143_R265_Y1.1260.20
138_D280_E1.1210.20
15_V270_I1.1120.20
218_F299_V1.1090.20
143_R190_K1.1010.19
249_E308_A1.0970.19
77_Q283_T1.0890.19
72_F266_N1.0880.19
275_T296_F1.0810.19
77_Q285_H1.0810.19
114_S268_G1.0790.19
17_S39_F1.0730.19
34_A133_L1.0700.19
67_K130_M1.0700.19
265_Y276_E1.0700.19
72_F262_L1.0690.19
19_Q94_T1.0650.19
76_A279_Y1.0620.19
172_V298_L1.0580.18
232_S291_V1.0520.18
55_F140_V1.0500.18
8_D309_S1.0430.18
233_L259_I1.0420.18
120_I235_F1.0410.18
48_F94_T1.0380.18
265_Y281_L1.0310.18
72_F98_A1.0260.18
76_A118_V1.0250.18
33_D290_Y1.0220.18
15_V109_Q1.0210.18
11_L17_S1.0200.18
6_W53_E1.0190.18
21_F25_V1.0190.18
102_T280_E1.0140.18
195_R199_Y1.0140.18
34_A165_K1.0130.18
102_T243_Y1.0050.17
59_A71_L1.0030.17
72_F276_E1.0030.17
23_E79_I1.0010.17
41_N258_T0.9980.17
156_L172_V0.9970.17
19_Q303_K0.9950.17
16_E141_D0.9920.17
232_S236_D0.9910.17
6_W12_F0.9890.17
51_H92_S0.9850.17
62_S219_E0.9790.17
196_F200_M0.9760.17
90_Y269_M0.9730.17
78_L82_C0.9720.17
19_Q95_S0.9690.17
8_D271_A0.9670.17
67_K156_L0.9620.16
38_S172_V0.9610.16
191_M270_I0.9610.16
245_P289_D0.9600.16
92_S192_S0.9600.16
14_S134_F0.9590.16
158_D167_R0.9570.16
123_N142_E0.9540.16
49_L125_L0.9530.16
72_F108_K0.9520.16
167_R216_L0.9470.16
139_I308_A0.9430.16
192_S233_L0.9390.16
29_N208_F0.9390.16
75_M234_L0.9340.16
59_A87_D0.9330.16
226_E233_L0.9230.16
21_F206_W0.9220.16
93_H299_V0.9210.16
64_L158_D0.9200.16
66_I144_Y0.9190.16
75_M304_F0.9160.16
103_T193_D0.9130.16
102_T286_I0.9040.15
127_V136_Q0.9040.15
122_R141_D0.9020.15
48_F187_I0.8970.15
11_L39_F0.8960.15
79_I129_F0.8910.15
43_E47_Y0.8870.15
62_S201_S0.8860.15
110_N255_P0.8790.15
74_G269_M0.8740.15
121_Q269_M0.8740.15
77_Q234_L0.8680.15
171_K235_F0.8630.15
114_S168_F0.8600.15
122_R248_R0.8530.14
49_L81_A0.8510.14
15_V283_T0.8480.14
66_I242_Y0.8480.14
186_V268_G0.8430.14
195_R270_I0.8420.14
97_L111_Y0.8410.14
7_K167_R0.8380.14
98_A143_R0.8320.14
21_F60_A0.8320.14
243_Y248_R0.8240.14
58_Q270_I0.8220.14
115_D258_T0.8090.14
79_I123_N0.8080.14
77_Q144_Y0.8070.14
45_F105_K0.8060.14
50_K109_Q0.8040.14
39_F268_G0.8020.14
255_P270_I0.7990.14
76_A129_F0.7970.13
102_T254_L0.7960.13
153_I156_L0.7960.13
103_T235_F0.7830.13
15_V58_Q0.7820.13
75_M136_Q0.7750.13
261_Y265_Y0.7750.13
90_Y116_D0.7680.13
44_R279_Y0.7640.13
22_L45_F0.7640.13
26_Y45_F0.7640.13
215_G241_Q0.7590.13
51_H98_A0.7580.13
93_H263_I0.7500.13
13_Y136_Q0.7490.13
12_F122_R0.7470.13
81_A256_E0.7450.13
55_F285_H0.7430.13
108_K113_F0.7430.13
279_Y285_H0.7430.13
14_S42_S0.7420.13
113_F119_K0.7400.13
140_V270_I0.7340.12
66_I214_H0.7330.12
90_Y105_K0.7260.12
82_C312_L0.7250.12
153_I257_M0.7240.12
41_N94_T0.7240.12
256_E307_Y0.7230.12
159_I254_L0.7220.12
271_A290_Y0.7190.12
266_N291_V0.7120.12
50_K270_I0.7110.12
89_H102_T0.7080.12
233_L237_M0.7050.12
39_F93_H0.7050.12
297_L307_Y0.7050.12
157_S244_I0.7040.12
87_D199_Y0.7040.12
271_A285_H0.7030.12
116_D269_M0.7030.12
75_M299_V0.7020.12
181_V252_L0.6990.12
134_F262_L0.6990.12
82_C108_K0.6980.12
75_M182_P0.6970.12
266_N274_E0.6940.12
81_A105_K0.6940.12
47_Y143_R0.6920.12
49_L113_F0.6880.12
293_I303_K0.6860.12
39_F189_Y0.6820.12
83_L301_E0.6820.12
194_S240_N0.6810.12
220_I288_D0.6800.12
96_V244_I0.6800.12
52_A56_Y0.6780.12
85_T185_V0.6770.12
116_D121_Q0.6750.12
74_G116_D0.6750.12
48_F232_S0.6740.12
17_S63_P0.6710.12
136_Q283_T0.6710.12
51_H118_V0.6680.11
105_K269_M0.6650.11
118_V239_K0.6640.11
151_M263_I0.6620.11
131_K208_F0.6580.11
135_G190_K0.6560.11
92_S311_F0.6540.11
110_N287_S0.6540.11
237_M271_A0.6530.11
110_N150_L0.6530.11
38_S290_Y0.6510.11
56_Y101_V0.6470.11
181_V234_L0.6470.11
7_K32_N0.6460.11
67_K191_M0.6430.11
93_H120_I0.6430.11
17_S163_Q0.6420.11
98_A265_Y0.6420.11
39_F129_F0.6410.11
12_F218_F0.6410.11
189_Y284_Q0.6400.11
12_F163_Q0.6390.11
37_N92_S0.6350.11
118_V125_L0.6340.11
151_M184_E0.6340.11
143_R291_V0.6340.11
105_K121_Q0.6330.11
74_G105_K0.6330.11
132_H283_T0.6300.11
7_K29_N0.6290.11
9_L163_Q0.6270.11
9_L213_E0.6260.11
65_E77_Q0.6250.11
28_L216_L0.6220.11
14_S289_D0.6210.11
264_L277_W0.6200.11
185_V225_K0.6200.11
110_N259_I0.6140.11
13_Y150_L0.6140.11
16_E114_S0.6140.11
50_K94_T0.6130.11
62_S297_L0.6120.11
160_F271_A0.6120.11
66_I255_P0.6110.11
18_T289_D0.6080.11
194_S201_S0.6060.11
35_K242_Y0.6060.11
274_E277_W0.6040.11
63_P108_K0.6020.11
146_M289_D0.6010.11
18_T123_N0.5990.11
166_E214_H0.5980.10
43_E191_M0.5970.10
52_A200_M0.5880.10
10_A242_Y0.5870.10
15_V306_K0.5860.10
67_K110_N0.5830.10
25_V127_V0.5830.10
57_K169_M0.5820.10
56_Y261_Y0.5820.10
29_N224_D0.5810.10
233_L275_T0.5800.10
167_R298_L0.5800.10
55_F265_Y0.5800.10
38_S191_M0.5780.10
63_P265_Y0.5760.10
67_K282_L0.5760.10
105_K276_E0.5760.10
178_E208_F0.5760.10
246_S254_L0.5740.10
39_F217_L0.5730.10
108_K270_I0.5720.10
28_L263_I0.5700.10
50_K63_P0.5690.10
86_R204_Y0.5670.10
79_I224_D0.5660.10
212_N302_K0.5650.10
79_I166_E0.5650.10
117_E121_Q0.5640.10
74_G117_E0.5640.10
133_L137_S0.5620.10
27_I184_E0.5610.10
141_D251_F0.5610.10
50_K143_R0.5600.10
181_V239_K0.5600.10
41_N109_Q0.5580.10
12_F179_I0.5580.10
98_A290_Y0.5570.10
234_L271_A0.5560.10
235_F308_A0.5540.10
56_Y182_P0.5510.10
62_S247_Q0.5500.10
82_C262_L0.5500.10
39_F228_W0.5490.10
96_V255_P0.5490.10
107_K273_Y0.5470.10
100_G272_R0.5470.10
100_G124_G0.5470.10
91_P99_H0.5470.10
99_H107_K0.5470.10
100_G107_K0.5470.10
99_H278_W0.5470.10
99_H273_Y0.5470.10
99_H272_R0.5470.10
99_H124_G0.5470.10
273_Y278_W0.5470.10
272_R278_W0.5470.10
100_G273_Y0.5470.10
107_K278_W0.5470.10
107_K272_R0.5470.10
91_P272_R0.5470.10
91_P124_G0.5470.10
91_P273_Y0.5470.10
91_P278_W0.5470.10
100_G278_W0.5470.10
91_P107_K0.5470.10
91_P100_G0.5470.10
107_K124_G0.5470.10
124_G278_W0.5470.10
73_Y272_R0.5470.10
73_Y91_P0.5470.10
73_Y100_G0.5470.10
73_Y124_G0.5470.10
73_Y278_W0.5470.10
124_G273_Y0.5470.10
124_G272_R0.5470.10
73_Y273_Y0.5470.10
73_Y107_K0.5470.10
73_Y99_H0.5470.10
163_Q263_I0.5460.10
102_T259_I0.5450.10
16_E259_I0.5450.10
40_K192_S0.5450.10
108_K293_I0.5430.10
229_T263_I0.5420.10
130_M258_T0.5410.10
20_K27_I0.5370.10
266_N289_D0.5370.10
153_I180_F0.5330.10
158_D219_E0.5310.10
26_Y74_G0.5310.10
187_I190_K0.5310.10
22_L74_G0.5310.10
22_L121_Q0.5310.10
26_Y121_Q0.5310.10
119_K245_P0.5270.10
177_N263_I0.5270.10
83_L243_Y0.5250.10
27_I178_E0.5220.10
78_L111_Y0.5180.09
13_Y279_Y0.5180.09
155_E303_K0.5140.09
150_L155_E0.5120.09
40_K310_Q0.5100.09
101_V182_P0.5100.09
84_I141_D0.5050.09
140_V289_D0.5050.09
92_S300_S0.5010.09
122_R301_E0.5000.09
113_F125_L0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kpaA 1 0.0794 11.4 0.98 Contact Map
1yfbA 2 0.1619 9.8 0.981 Contact Map
2fi0A 1 0.2444 9.3 0.981 Contact Map
2k53A 1 0.2222 6.1 0.982 Contact Map
2l9bB 1 0.0889 5.9 0.983 Contact Map
2k5eA 1 0.2317 5.4 0.983 Contact Map
4g9jC 1 0.0413 3.9 0.984 Contact Map
3o27A 2 0.1778 3.1 0.985 Contact Map
3te4A 1 0.1873 3 0.985 Contact Map
2lktA 1 0.1714 3 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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