GREMLIN Database
NOC - Nucleoid occlusion protein
UniProt: P37524 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 283 (243)
Sequences: 5662 (4106)
Seq/√Len: 263.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_E100_K4.2201.00
39_V80_Q3.8521.00
137_A141_E3.4131.00
173_P201_V3.2311.00
58_A95_S3.1671.00
206_E210_K3.0341.00
83_L90_W3.0201.00
109_S112_E3.0051.00
207_I217_T2.8831.00
70_I101_I2.6691.00
38_I83_L2.6411.00
66_I93_V2.5651.00
134_H175_Q2.5021.00
37_A80_Q2.4381.00
177_A204_L2.4061.00
34_P37_A2.3991.00
55_K95_S2.3211.00
33_I103_A2.3121.00
53_K125_E2.2941.00
33_I72_V2.2491.00
72_V103_A2.2271.00
147_Q162_A2.1191.00
157_G160_T2.1091.00
55_K59_M2.0841.00
176_E180_E1.9991.00
54_I58_A1.9951.00
73_R82_E1.9801.00
212_L220_R1.9651.00
138_R142_L1.9411.00
66_I102_P1.9371.00
51_D95_S1.9351.00
54_I95_S1.9261.00
90_W94_Q1.9161.00
108_F116_V1.8881.00
140_L150_L1.8631.00
70_I83_L1.8541.00
130_I175_Q1.8501.00
149_A152_Q1.7741.00
216_Q219_D1.7241.00
51_D55_K1.7061.00
93_V98_W1.7051.00
59_M62_H1.6951.00
38_I72_V1.6771.00
39_V82_E1.6751.00
35_V90_W1.6731.00
73_R110_D1.6651.00
85_A120_E1.6261.00
70_I103_A1.6131.00
134_H179_M1.6131.00
187_H214_V1.5851.00
45_P117_A1.5701.00
199_L202_T1.5521.00
39_V75_T1.5441.00
203_L220_R1.5261.00
41_N113_T1.5201.00
171_P200_Q1.5181.00
178_I188_A1.4931.00
159_S162_A1.4851.00
34_P100_K1.4851.00
136_Y154_L1.4811.00
75_T82_E1.4441.00
67_I71_V1.4401.00
50_S53_K1.4241.00
93_V96_L1.4131.00
132_E164_K1.4081.00
206_E220_R1.4061.00
171_P201_V1.3851.00
132_E156_K1.3671.00
205_T209_E1.3631.00
177_A208_I1.3611.00
61_I66_I1.3541.00
55_K58_A1.3461.00
87_E91_R1.3381.00
148_E152_Q1.3351.00
128_S179_M1.3321.00
74_H107_D1.3071.00
73_R113_T1.2991.00
164_K185_E1.2931.00
115_S153_R1.2921.00
37_A79_G1.2911.00
243_T251_R1.2731.00
172_Q175_Q1.2671.00
41_N117_A1.2461.00
42_R82_E1.2371.00
204_L208_I1.2321.00
174_V204_L1.2321.00
136_Y150_L1.2231.00
201_V205_T1.2141.00
66_I101_I1.2051.00
31_L105_I1.2031.00
61_I93_V1.2011.00
64_H112_E1.1831.00
35_V93_V1.1821.00
40_P90_W1.1811.00
58_A96_L1.1731.00
75_T78_E1.1621.00
53_K56_E1.1581.00
249_T253_S1.1491.00
58_A62_H1.1451.00
150_L161_I1.1341.00
32_E102_P1.1221.00
190_A217_T1.1151.00
47_T134_H1.1031.00
176_E179_M1.0921.00
64_H115_S1.0821.00
75_T80_Q1.0811.00
59_M63_T1.0541.00
196_Q199_L1.0431.00
136_Y156_K1.0411.00
137_A169_K1.0401.00
118_L135_A1.0341.00
36_N94_Q1.0331.00
84_I108_F1.0251.00
74_H79_G1.0201.00
217_T220_R1.0181.00
60_T119_I1.0141.00
160_T164_K1.0111.00
140_L165_L1.0051.00
207_I212_L1.0031.00
93_V101_I1.0011.00
49_F87_E0.9871.00
173_P205_T0.9841.00
194_L203_L0.9821.00
212_L217_T0.9821.00
177_A182_K0.9771.00
66_I70_I0.9751.00
49_F91_R0.9741.00
41_N82_E0.9711.00
187_H190_A0.9701.00
163_N189_R0.9671.00
114_A138_R0.9651.00
140_L147_Q0.9621.00
247_M266_T0.9431.00
203_L224_M0.9421.00
66_I96_L0.9411.00
243_T248_N0.9401.00
146_T149_A0.9381.00
248_N251_R0.9361.00
197_P200_Q0.9361.00
35_V94_Q0.9351.00
219_D223_K0.9351.00
40_P87_E0.9341.00
57_L88_R0.9331.00
33_I37_A0.9221.00
151_A161_I0.9201.00
219_D222_V0.9161.00
38_I103_A0.9141.00
70_I90_W0.9071.00
171_P174_V0.9051.00
221_V225_L0.8971.00
213_N216_Q0.8901.00
217_T221_V0.8801.00
156_K160_T0.8671.00
175_Q179_M0.8661.00
71_V85_A0.8621.00
156_K161_I0.8561.00
177_A205_T0.8551.00
199_L224_M0.8511.00
63_T153_R0.8511.00
120_E124_R0.8501.00
61_I98_W0.8501.00
147_Q158_Q0.8501.00
129_S167_L0.8481.00
172_Q176_E0.8410.99
203_L217_T0.8400.99
248_N252_Q0.8370.99
34_P99_E0.8340.99
244_R248_N0.8310.99
185_E189_R0.8240.99
177_A183_I0.8200.99
33_I38_I0.8190.99
108_F112_E0.8090.99
183_I188_A0.7990.99
220_R223_K0.7980.99
193_P225_L0.7970.99
64_H116_V0.7950.99
58_A61_I0.7900.99
190_A214_V0.7880.99
183_I204_L0.7880.99
119_I123_Q0.7810.99
69_P104_I0.7770.99
246_A249_T0.7750.99
243_T247_M0.7710.99
71_V104_I0.7710.99
245_I249_T0.7700.99
67_I116_V0.7650.99
88_R125_E0.7570.99
63_T152_Q0.7570.99
24_D27_K0.7530.99
158_Q162_A0.7470.99
184_T187_H0.7460.99
38_I101_I0.7420.99
197_P201_V0.7350.99
252_Q256_M0.7350.99
254_L262_V0.7210.98
82_E113_T0.7180.98
212_L216_Q0.7180.98
174_V200_Q0.7170.98
48_I179_M0.7160.98
185_E190_A0.7150.98
30_I103_A0.7090.98
40_P83_L0.7070.98
251_R255_S0.6980.98
170_L188_A0.6970.98
46_R120_E0.6940.98
166_R192_I0.6890.98
166_R193_P0.6870.98
93_V102_P0.6840.98
245_I248_N0.6840.98
266_T269_E0.6830.98
31_L74_H0.6760.98
171_P197_P0.6760.98
266_T270_E0.6720.97
76_E80_Q0.6700.97
75_T79_G0.6670.97
143_H150_L0.6660.97
187_H191_L0.6630.97
52_E55_K0.6610.97
83_L87_E0.6610.97
189_R192_I0.6590.97
214_V217_T0.6560.97
195_K225_L0.6550.97
261_G265_N0.6540.97
220_R224_M0.6520.97
62_H96_L0.6500.97
118_L139_L0.6490.97
111_T115_S0.6460.97
145_L153_R0.6460.97
194_L200_Q0.6450.97
215_K218_E0.6440.97
72_V81_Y0.6430.97
160_T185_E0.6420.97
108_F113_T0.6410.97
62_H97_E0.6380.97
151_A158_Q0.6360.96
252_Q260_S0.6350.96
202_T206_E0.6350.96
36_N99_E0.6350.96
40_P91_R0.6340.96
118_L122_L0.6330.96
62_H98_W0.6330.96
54_I61_I0.6320.96
246_A250_I0.6310.96
85_A116_V0.6310.96
178_I183_I0.6300.96
195_K199_L0.6300.96
57_L92_A0.6290.96
177_A180_E0.6280.96
81_Y105_I0.6280.96
147_Q151_A0.6270.96
54_I96_L0.6270.96
136_Y161_I0.6240.96
254_L258_E0.6240.96
221_V224_M0.6240.96
253_S257_V0.6200.96
265_N270_E0.6180.96
243_T246_A0.6170.96
171_P196_Q0.6160.96
49_F88_R0.6160.96
140_L143_H0.6150.96
43_F110_D0.6150.96
38_I90_W0.6150.96
136_Y160_T0.6140.96
214_V218_E0.6140.96
158_Q186_R0.6120.96
267_E270_E0.6120.96
133_A168_L0.6090.95
163_N166_R0.6060.95
111_T142_L0.6030.95
58_A92_A0.6000.95
200_Q204_L0.5990.95
167_L175_Q0.5980.95
243_T263_K0.5970.95
166_R189_R0.5970.95
32_E103_A0.5960.95
148_E158_Q0.5950.95
53_K88_R0.5940.95
59_M152_Q0.5890.95
189_R193_P0.5880.95
121_N124_R0.5870.95
119_I139_L0.5860.94
35_V101_I0.5850.94
87_E90_W0.5840.94
31_L81_Y0.5830.94
43_F113_T0.5820.94
224_M228_G0.5820.94
187_H217_T0.5790.94
68_Q120_E0.5780.94
186_R190_A0.5780.94
140_L162_A0.5770.94
56_E59_M0.5770.94
169_K195_K0.5760.94
210_K216_Q0.5750.94
203_L206_E0.5750.94
127_L131_E0.5700.94
48_I51_D0.5660.93
183_I207_I0.5640.93
202_T205_T0.5630.93
255_S267_E0.5630.93
66_I98_W0.5630.93
54_I125_E0.5600.93
252_Q255_S0.5590.93
263_K266_T0.5590.93
186_R215_K0.5560.93
67_I119_I0.5560.93
66_I116_V0.5560.93
258_E264_L0.5530.93
226_E231_K0.5530.93
213_N217_T0.5500.92
255_S259_D0.5500.92
223_K226_E0.5500.92
229_Q232_P0.5490.92
28_E106_K0.5490.92
73_R84_I0.5470.92
71_V108_F0.5460.92
244_R266_T0.5450.92
242_D245_I0.5450.92
44_Q49_F0.5430.92
167_L185_E0.5420.92
44_Q117_A0.5420.92
86_G89_R0.5410.92
151_A157_G0.5410.92
136_Y164_K0.5410.92
145_L149_A0.5390.92
44_Q87_E0.5380.92
168_L213_N0.5380.92
71_V116_V0.5380.92
132_E136_Y0.5370.91
173_P200_Q0.5370.91
130_I168_L0.5360.91
46_R117_A0.5350.91
67_I106_K0.5350.91
192_I200_Q0.5340.91
114_A143_H0.5330.91
122_L135_A0.5330.91
128_S131_E0.5320.91
130_I134_H0.5320.91
43_F82_E0.5290.91
112_E116_V0.5260.91
186_R189_R0.5260.91
47_T131_E0.5250.91
225_L228_G0.5230.90
147_Q150_L0.5200.90
228_G232_P0.5190.90
23_H26_N0.5180.90
230_R240_S0.5160.90
139_L150_L0.5150.90
54_I57_L0.5140.90
49_F54_I0.5130.90
150_L160_T0.5130.90
251_R259_D0.5110.89
249_T256_M0.5100.89
248_N256_M0.5100.89
222_V225_L0.5100.89
248_N253_S0.5090.89
182_K208_I0.5090.89
244_R249_T0.5080.89
246_A260_S0.5080.89
132_E160_T0.5050.89
242_D248_N0.5040.89
259_D264_L0.5010.88
39_V42_R0.5010.88
45_P118_L0.5010.88
92_A121_N0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4umkA 2 0.682 100 0.265 Contact Map
1vz0A 3 0.6784 100 0.277 Contact Map
1r71A 2 0.3922 99.9 0.589 Contact Map
1vk1A 1 0.6396 99.9 0.632 Contact Map
1yzsA 1 0.4064 99.8 0.633 Contact Map
1xw3A 1 0.3675 99.8 0.634 Contact Map
3mkyB 2 0.3852 99.6 0.712 Contact Map
1zx4A 2 0.5512 98.2 0.839 Contact Map
2hwjA 5 0.6537 97.4 0.864 Contact Map
3vwbA 1 0.4064 93.4 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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