GREMLIN Database
SOJ - Sporulation initiation inhibitor protein Soj
UniProt: P37522 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 253 (236)
Sequences: 18209 (11606)
Seq/√Len: 755.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_S123_I3.7401.00
83_D119_Y3.7061.00
214_P241_V3.6521.00
32_K121_Y3.1371.00
30_I247_K3.0371.00
27_L121_Y2.9601.00
19_T242_Y2.7951.00
6_A141_S2.7821.00
149_Q185_M2.7091.00
3_K143_S2.7021.00
228_P231_L2.6601.00
35_L119_Y2.6191.00
36_L45_A2.5771.00
185_M215_R2.4251.00
21_V45_A2.3801.00
24_G36_L2.1371.00
143_S179_E2.1351.00
33_R120_D2.0731.00
48_G153_Y2.0361.00
218_R221_E1.9861.00
26_C230_I1.9781.00
29_Y243_L1.9391.00
20_S36_L1.9231.00
7_I23_L1.9111.00
187_D215_R1.8991.00
19_T182_L1.8621.00
26_C246_A1.8511.00
76_A83_D1.8201.00
192_L195_Q1.7931.00
182_L245_L1.7921.00
27_L123_I1.7791.00
198_E202_K1.7431.00
47_S156_E1.7181.00
21_V48_G1.7171.00
183_L197_I1.6751.00
200_V204_F1.6611.00
4_I124_I1.6571.00
32_K120_D1.6561.00
30_I243_L1.6391.00
211_T248_E1.6281.00
216_N238_G1.6251.00
59_C62_D1.6161.00
24_G123_I1.6161.00
39_I137_A1.6161.00
199_E203_Y1.6001.00
6_A126_C1.5981.00
71_I118_N1.5461.00
28_A82_L1.5261.00
143_S180_G1.5141.00
192_L196_V1.4841.00
21_V49_L1.4801.00
186_L212_V1.4731.00
106_V109_K1.4601.00
7_I145_V1.4421.00
211_T245_L1.4291.00
190_T193_G1.4261.00
134_T137_A1.4051.00
227_K232_Y1.3921.00
15_G184_T1.3741.00
217_V221_E1.3741.00
143_S177_M1.3651.00
39_I124_I1.3641.00
193_G196_V1.3551.00
3_K142_D1.3501.00
193_G197_I1.3481.00
180_G209_Y1.3411.00
39_I60_V1.3401.00
27_L34_V1.3371.00
49_L82_L1.3321.00
144_V165_V1.3251.00
198_E212_V1.3151.00
151_E154_A1.3101.00
145_V182_L1.3081.00
133_L137_A1.3051.00
150_C183_L1.3041.00
24_G45_A1.3021.00
23_L249_V1.3001.00
8_T161_L1.2911.00
44_N157_G1.2891.00
240_E243_L1.2881.00
192_L197_I1.2801.00
28_A81_N1.2741.00
61_Y65_V1.2311.00
19_T184_T1.2181.00
236_S239_A1.2171.00
218_R233_D1.2111.00
213_I238_G1.2031.00
89_I160_Q1.2021.00
23_L246_A1.1991.00
199_E202_K1.1961.00
7_I20_S1.1851.00
208_V212_V1.1821.00
221_E225_H1.1671.00
72_D75_K1.1341.00
35_L122_I1.1301.00
58_Q62_D1.1181.00
44_N153_Y1.1181.00
219_L238_G1.1071.00
26_C30_I1.1061.00
37_V124_I1.1041.00
24_G82_L1.1041.00
17_T45_A1.1031.00
8_T126_C1.0661.00
51_I84_V1.0581.00
17_T48_G1.0581.00
197_I201_K1.0561.00
243_L247_K1.0501.00
216_N236_S1.0481.00
25_A29_Y1.0471.00
227_K231_L1.0471.00
151_E220_S1.0441.00
58_Q68_A1.0431.00
244_D247_K1.0381.00
244_D248_E1.0381.00
93_G96_I1.0351.00
22_N25_A1.0341.00
5_I249_V1.0311.00
106_V110_R1.0201.00
159_S203_Y1.0181.00
100_P104_R1.0161.00
19_T23_L1.0091.00
109_K113_E1.0031.00
153_Y223_P0.9991.00
71_I75_K0.9961.00
146_I158_L0.9901.00
241_V244_D0.9861.00
184_T242_Y0.9791.00
111_A114_A0.9711.00
69_D72_D0.9681.00
5_I121_Y0.9611.00
49_L84_V0.9581.00
41_P133_L0.9561.00
126_C137_A0.9491.00
22_N230_I0.9491.00
83_D117_Q0.9471.00
95_E131_G0.9461.00
84_V89_I0.9461.00
188_A197_I0.9451.00
237_R240_E0.9421.00
33_R118_N0.9371.00
26_C243_L0.9141.00
198_E201_K0.9131.00
136_N139_T0.9111.00
225_H232_Y0.8931.00
216_N237_R0.8891.00
34_V121_Y0.8881.00
70_V74_I0.8871.00
245_L249_V0.8831.00
147_P184_T0.8791.00
230_I243_L0.8781.00
29_Y231_L0.8761.00
237_R241_V0.8761.00
26_C29_Y0.8721.00
43_G46_T0.8711.00
72_D76_A0.8631.00
4_I116_K0.8631.00
68_A73_I0.8581.00
201_K212_V0.8521.00
70_V85_I0.8521.00
234_P239_A0.8511.00
70_V73_I0.8501.00
18_T219_L0.8501.00
238_G241_V0.8441.00
74_I83_D0.8431.00
7_I19_T0.8431.00
188_A191_N0.8421.00
208_V211_T0.8411.00
233_D236_S0.8391.00
107_R111_A0.8381.00
63_I73_I0.8381.00
37_V122_I0.8361.00
4_I122_I0.8341.00
27_L246_A0.8341.00
71_I74_I0.8271.00
203_Y206_D0.8241.00
43_G87_A0.8221.00
103_S106_V0.8211.00
195_Q198_E0.8191.00
18_T223_P0.8141.00
65_V68_A0.8121.00
229_I239_A0.8111.00
83_D86_P0.8031.00
163_N166_R0.7941.00
107_R110_R0.7911.00
146_I161_L0.7821.00
110_R114_A0.7811.00
213_I241_V0.7801.00
230_I239_A0.7801.00
146_I162_L0.7781.00
8_T134_T0.7741.00
7_I123_I0.7731.00
25_A231_L0.7721.00
73_I85_I0.7721.00
101_T105_E0.7701.00
150_C186_L0.7691.00
149_Q154_A0.7671.00
207_K248_E0.7651.00
14_V154_A0.7631.00
42_Q128_P0.7591.00
79_V231_L0.7511.00
19_T147_P0.7501.00
62_D67_D0.7491.00
25_A230_I0.7471.00
180_G207_K0.7471.00
78_T81_N0.7451.00
183_L186_L0.7441.00
63_I111_A0.7401.00
16_K128_P0.7401.00
34_V123_I0.7401.00
108_L111_A0.7391.00
5_I143_S0.7381.00
239_A243_L0.7361.00
101_T104_R0.7351.00
214_P237_R0.7301.00
240_E244_D0.7261.00
144_V176_L0.7231.00
119_Y122_I0.7201.00
25_A228_P0.7111.00
163_N167_L0.7111.00
235_R240_E0.7071.00
35_L74_I0.7021.00
47_S152_Y0.7021.00
109_K112_L0.6971.00
10_Q164_T0.6951.00
46_T86_P0.6921.00
22_N228_P0.6911.00
62_D66_D0.6911.00
9_N14_V0.6901.00
29_Y230_I0.6811.00
183_L212_V0.6801.00
169_Q177_M0.6791.00
5_I179_E0.6781.00
197_I212_V0.6741.00
34_V82_L0.6731.00
85_I89_I0.6731.00
152_Y156_E0.6731.00
150_C193_G0.6691.00
234_P240_E0.6681.00
60_V63_I0.6681.00
229_I238_G0.6681.00
134_T138_L0.6671.00
19_T213_I0.6661.00
42_Q46_T0.6661.00
135_I164_T0.6661.00
39_I133_L0.6581.00
61_Y97_E0.6581.00
66_D69_D0.6571.00
44_N156_E0.6561.00
162_L166_R0.6541.00
111_A115_V0.6511.00
3_K179_E0.6501.00
159_S163_N0.6461.00
36_L49_L0.6441.00
101_T107_R0.6431.00
218_R236_S0.6421.00
116_K142_D0.6421.00
105_E136_N0.6381.00
62_D65_V0.6361.00
200_V203_Y0.6251.00
133_L139_T0.6241.00
134_T139_T0.6231.00
62_D68_A0.6231.00
92_A95_E0.6221.00
126_C134_T0.6211.00
183_L200_V0.6201.00
74_I85_I0.6181.00
11_K153_Y0.6151.00
100_P103_S0.6131.00
187_D217_V0.6091.00
209_Y248_E0.6081.00
80_E83_D0.6081.00
93_G97_E0.6071.00
34_V120_D0.6031.00
11_K14_V0.6021.00
23_L245_L0.6011.00
71_I114_A0.5991.00
116_K122_I0.5981.00
148_V181_V0.5971.00
222_A232_Y0.5961.00
3_K32_K0.5931.00
31_G81_N0.5921.00
96_I99_V0.5921.00
91_L97_E0.5901.00
194_I198_E0.5861.00
195_Q199_E0.5861.00
4_I142_D0.5861.00
26_C242_Y0.5861.00
25_A80_E0.5851.00
33_R119_Y0.5851.00
217_V220_S0.5841.00
222_A227_K0.5831.00
20_S45_A0.5821.00
66_D70_V0.5791.00
35_L115_V0.5781.00
96_I132_L0.5771.00
131_G134_T0.5771.00
222_A229_I0.5771.00
113_E116_K0.5741.00
46_T88_T0.5721.00
59_C88_T0.5701.00
94_A97_E0.5691.00
91_L94_A0.5671.00
28_A34_V0.5631.00
190_T217_V0.5631.00
220_S224_S0.5631.00
3_K121_Y0.5631.00
164_T167_L0.5621.00
63_I85_I0.5611.00
21_V36_L0.5611.00
73_I76_A0.5591.00
43_G88_T0.5581.00
179_E209_Y0.5561.00
106_V139_T0.5551.00
63_I66_D0.5511.00
112_L140_A0.5511.00
25_A82_L0.5501.00
194_I197_I0.5491.00
68_A72_D0.5481.00
66_D72_D0.5471.00
78_T83_D0.5461.00
26_C239_A0.5441.00
201_K206_D0.5441.00
33_R83_D0.5431.00
166_R169_Q0.5421.00
5_I123_I0.5421.00
138_L144_V0.5391.00
33_R81_N0.5371.00
145_V249_V0.5371.00
44_N47_S0.5361.00
238_G242_Y0.5311.00
222_A228_P0.5271.00
152_Y224_S0.5261.00
45_A84_V0.5251.00
202_K205_R0.5241.00
219_L223_P0.5231.00
229_I242_Y0.5221.00
63_I70_V0.5191.00
22_N229_I0.5191.00
242_Y245_L0.5191.00
108_L112_L0.5171.00
221_E232_Y0.5171.00
63_I68_A0.5161.00
145_V179_E0.5161.00
137_A141_S0.5131.00
11_K16_K0.5131.00
215_R220_S0.5121.00
19_T145_V0.5061.00
8_T138_L0.5051.00
15_G19_T0.5051.00
196_V200_V0.5031.00
213_I245_L0.5031.00
183_L208_V0.5021.00
90_Q93_G0.5001.00
193_G203_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pfsA 1 0.9249 100 0.222 Contact Map
1wcv1 2 0.9565 100 0.256 Contact Map
3pg5A 2 0.8854 100 0.258 Contact Map
1g3qA 1 0.9328 100 0.266 Contact Map
1hyqA 1 0.913 100 0.269 Contact Map
4rz3A 2 0.9368 100 0.286 Contact Map
3ea0A 2 0.9249 100 0.286 Contact Map
4v03A 2 0.8972 100 0.293 Contact Map
3q9lA 2 0.9565 100 0.294 Contact Map
3ez2A 2 0.9881 100 0.296 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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