GREMLIN Database
YYAC - Uncharacterized protein YyaC
UniProt: P37521 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (171)
Sequences: 535 (442)
Seq/√Len: 33.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_Y102_H5.9791.00
60_L178_L5.7081.00
67_K176_N4.1371.00
83_S169_N3.7111.00
47_V182_L3.5531.00
128_G147_H2.8981.00
70_Q176_N2.7301.00
126_G147_H2.6961.00
44_P102_H2.6761.00
52_T165_N2.4221.00
153_N166_T2.3440.99
95_I143_V2.2780.99
169_N173_N2.1790.99
84_D94_K2.1320.99
102_H105_P2.0340.98
86_V94_K2.0140.98
59_S66_M1.9880.98
156_G164_Q1.9390.98
124_Q151_I1.8580.97
83_S173_N1.8210.96
135_G170_L1.8120.96
18_V125_I1.8000.96
114_L153_N1.7650.96
79_Y98_I1.7350.95
56_T164_Q1.7140.95
159_E162_V1.7130.95
48_V86_V1.7120.95
133_G138_K1.6930.95
83_S125_I1.6150.93
52_T174_M1.6130.93
47_V108_I1.5740.92
53_D167_R1.5700.92
175_A179_A1.5580.92
67_K172_M1.5450.91
106_F145_D1.5430.91
17_Y21_T1.5370.91
125_I148_I1.5240.91
26_A30_Q1.4670.89
46_V102_H1.4580.89
131_K142_E1.4540.89
154_V162_V1.4460.88
184_L187_R1.4370.88
123_F177_V1.4150.87
29_I181_G1.3780.86
56_T166_T1.3600.85
27_K30_Q1.3430.84
56_T156_G1.3280.84
36_S127_D1.3150.83
54_R164_Q1.2560.80
55_S159_E1.2470.80
88_A140_L1.2410.79
95_I109_A1.2390.79
29_I125_I1.2250.78
77_H102_H1.2120.78
46_V105_P1.1920.76
18_V25_A1.1660.75
154_V157_F1.1640.75
94_K97_D1.1620.74
92_K96_N1.1430.73
89_V161_F1.1330.73
153_N163_L1.1310.72
95_I142_E1.1280.72
156_G159_E1.1250.72
136_V160_Y1.1180.72
33_L148_I1.1080.71
46_V79_Y1.0990.70
114_L166_T1.0950.70
47_V110_V1.0860.69
153_N164_Q1.0810.69
125_I181_G1.0810.69
148_I178_L1.0690.68
160_Y181_G1.0540.67
134_A158_M1.0520.67
156_G162_V1.0360.66
28_Q36_S1.0310.65
29_I173_N1.0310.65
98_I102_H1.0310.65
116_R147_H1.0210.64
25_A78_V1.0030.63
55_S160_Y1.0020.63
25_A181_G0.9930.62
44_P123_F0.9880.62
124_Q135_G0.9830.61
159_E167_R0.9780.61
135_G154_V0.9620.60
18_V145_D0.9350.58
134_A159_E0.9300.57
56_T171_V0.9290.57
55_S164_Q0.9180.56
55_S158_M0.9180.56
112_A136_V0.9170.56
90_N138_K0.9160.56
56_T149_N0.9060.55
89_V181_G0.9010.55
19_S66_M0.8950.54
17_Y119_S0.8940.54
23_A29_I0.8920.54
117_V120_V0.8850.53
53_D63_L0.8790.53
123_F174_M0.8770.53
71_M183_S0.8760.53
87_H167_R0.8690.52
68_L129_P0.8660.52
43_K125_I0.8610.51
78_V125_I0.8580.51
75_R110_V0.8520.51
21_T118_K0.8480.50
52_T134_A0.8460.50
17_Y20_H0.8370.49
104_N180_E0.8360.49
25_A135_G0.8340.49
75_R109_A0.8290.49
39_K127_D0.8280.49
44_P77_H0.8220.48
48_V143_V0.8190.48
157_F162_V0.7980.46
59_S104_N0.7940.46
137_Q147_H0.7920.46
103_K107_V0.7920.46
120_V154_V0.7840.45
154_V159_E0.7830.45
52_T66_M0.7770.44
152_V163_L0.7650.43
85_P168_L0.7640.43
64_V178_L0.7570.43
96_N108_I0.7570.43
156_G163_L0.7560.43
122_S151_I0.7560.43
45_I69_K0.7540.42
114_L164_Q0.7540.42
48_V130_L0.7530.42
153_N167_R0.7510.42
57_G168_L0.7510.42
56_T153_N0.7420.41
66_M116_R0.7410.41
159_E164_Q0.7400.41
43_K145_D0.7390.41
87_H133_G0.7360.41
86_V107_V0.7210.40
25_A125_I0.7180.39
133_G140_L0.7160.39
67_K71_M0.7130.39
84_D139_D0.7100.39
48_V113_C0.7050.38
100_K182_L0.7030.38
20_H174_M0.7030.38
17_Y66_M0.7010.38
96_N170_L0.7010.38
99_H104_N0.7000.38
154_V171_V0.7000.38
48_V95_I0.6980.38
113_C119_S0.6950.38
158_M162_V0.6910.37
81_T85_P0.6890.37
47_V183_S0.6890.37
88_A112_A0.6860.37
20_H66_M0.6830.37
54_R168_L0.6780.36
155_S164_Q0.6770.36
45_I143_V0.6760.36
56_T162_V0.6740.36
53_D164_Q0.6730.36
48_V98_I0.6700.36
61_G115_G0.6670.35
158_M174_M0.6660.35
36_S146_L0.6620.35
87_H138_K0.6590.35
64_V72_Q0.6530.34
71_M76_F0.6530.34
22_D123_F0.6500.34
137_Q149_N0.6470.34
138_K167_R0.6420.34
155_S159_E0.6400.33
29_I185_T0.6390.33
26_A177_V0.6390.33
56_T134_A0.6360.33
83_S185_T0.6350.33
43_K148_I0.6340.33
66_M75_R0.6320.33
131_K139_D0.6300.33
100_K179_A0.6300.33
35_S123_F0.6250.32
67_K75_R0.6230.32
46_V98_I0.6180.32
53_D112_A0.6160.32
38_R106_F0.6140.31
86_V160_Y0.6130.31
132_P138_K0.6110.31
77_H98_I0.6100.31
122_S126_G0.6100.31
20_H169_N0.6100.31
81_T113_C0.6100.31
106_F146_L0.6080.31
164_Q168_L0.6080.31
73_L182_L0.6080.31
113_C149_N0.6070.31
38_R180_E0.6060.31
40_A103_K0.6040.31
68_L174_M0.6010.31
116_R142_E0.6000.30
163_L171_V0.5980.30
93_D96_N0.5980.30
78_V152_V0.5950.30
138_K165_N0.5940.30
25_A177_V0.5900.30
158_M171_V0.5880.30
50_I63_L0.5860.29
64_V176_N0.5830.29
119_S122_S0.5830.29
134_A157_F0.5680.28
89_V183_S0.5680.28
118_K182_L0.5670.28
97_D169_N0.5670.28
87_H90_N0.5640.28
69_K74_T0.5620.28
96_N182_L0.5600.28
155_S185_T0.5580.28
29_I177_V0.5570.27
21_T173_N0.5560.27
38_R176_N0.5550.27
35_S145_D0.5540.27
53_D87_H0.5540.27
45_I186_D0.5480.27
73_L81_T0.5470.27
29_I123_F0.5470.27
140_L150_G0.5460.27
92_K142_E0.5440.27
69_K97_D0.5430.27
78_V118_K0.5420.26
27_K184_L0.5420.26
113_C162_V0.5390.26
75_R186_D0.5370.26
64_V179_A0.5340.26
140_L143_V0.5320.26
54_R165_N0.5280.26
30_Q181_G0.5260.25
34_S185_T0.5250.25
54_R138_K0.5250.25
126_G185_T0.5250.25
35_S76_F0.5240.25
86_V133_G0.5230.25
41_A99_H0.5210.25
52_T154_V0.5170.25
19_S22_D0.5170.25
23_A137_Q0.5130.25
134_A156_G0.5120.25
23_A27_K0.5110.24
57_G61_G0.5110.24
132_P140_L0.5110.24
113_C124_Q0.5100.24
160_Y165_N0.5060.24
100_K180_E0.5060.24
39_K42_G0.5030.24
49_C121_G0.5010.24
23_A97_D0.5000.24
57_G166_T0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1c8bA 3 0.922 100 0.552 Contact Map
1cfzA 1 0.6439 76.9 0.944 Contact Map
2e85A 2 0.6829 69 0.947 Contact Map
3pu6A 1 0.6244 60.5 0.95 Contact Map
2h54A 1 0.5171 59 0.95 Contact Map
4gicA 2 0.7415 42.7 0.955 Contact Map
1pyoA 2 0.5073 30.1 0.958 Contact Map
2fp3A 1 0.8 30 0.958 Contact Map
3p45A 3 0.439 29.6 0.959 Contact Map
8abpA 1 0.8927 27.9 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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