GREMLIN Database
YYAD - Uncharacterized protein YyaD
UniProt: P37520 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (329)
Sequences: 891 (730)
Seq/√Len: 40.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_L265_Y7.7551.00
14_L215_I5.5321.00
96_V309_L5.2011.00
36_S224_N4.8641.00
60_K202_L4.4401.00
26_Q30_Q3.8961.00
238_E307_S3.8411.00
83_D278_R3.6801.00
36_S39_A3.6591.00
44_T217_G3.4651.00
75_G79_A3.4271.00
13_I51_S3.3181.00
111_P114_W3.2561.00
209_S213_G2.9441.00
99_A305_G2.9151.00
48_I213_G2.7561.00
296_V300_P2.6501.00
10_M211_A2.6301.00
183_L187_S2.4551.00
37_G224_N2.3971.00
184_N216_F2.2651.00
6_G207_I2.2361.00
52_Y209_S2.1960.99
91_F95_M2.1750.99
15_G20_A2.1700.99
6_G211_A2.1370.99
111_P132_K2.0760.99
194_S263_A2.0540.99
148_G259_V1.8820.98
50_S325_L1.8640.98
26_Q29_W1.8590.98
24_S217_G1.8590.98
208_A212_S1.8090.98
51_S212_S1.8010.98
35_E38_L1.7980.98
13_I212_S1.7660.98
87_I279_L1.7480.97
207_I211_A1.7430.97
52_Y206_K1.7370.97
47_F184_N1.7360.97
15_G142_I1.7300.97
24_S71_E1.6990.97
124_V295_L1.6910.97
5_A8_K1.6630.96
91_F298_M1.6080.96
162_H165_T1.5830.95
31_F74_M1.5680.95
121_I326_V1.5660.95
157_Q258_A1.5470.95
118_L154_I1.5450.95
249_P252_L1.5310.94
226_T244_V1.5300.94
76_P80_K1.5250.94
151_Y255_C1.5160.94
259_V286_P1.5160.94
151_Y211_A1.5160.94
156_F160_H1.5130.94
302_T305_G1.5090.94
142_I266_T1.4720.93
78_L81_I1.4590.93
46_M181_T1.4430.92
103_V238_E1.4340.92
142_I263_A1.4320.92
120_C295_L1.4250.92
121_I125_C1.4140.91
28_I224_N1.4110.91
22_Y220_S1.3940.91
191_I194_S1.3730.90
13_I17_L1.3710.90
123_T268_T1.3690.90
105_L118_L1.3550.90
94_T272_L1.3540.90
263_A266_T1.3450.89
254_L296_V1.3420.89
7_M45_I1.3390.89
18_I263_A1.3320.89
83_D142_I1.3260.89
97_M264_I1.3260.89
24_S239_I1.3180.88
138_N263_A1.3090.88
65_H68_P1.3020.88
88_F284_H1.3010.88
206_K210_V1.2980.87
241_L256_M1.2970.87
71_E80_K1.2950.87
171_Q174_W1.2940.87
182_S322_L1.2930.87
89_Y183_L1.2930.87
40_I220_S1.2800.87
20_A143_P1.2730.86
125_C211_A1.2720.86
71_E178_I1.2690.86
12_L129_W1.2670.86
183_L273_L1.2590.86
104_T257_T1.2580.86
50_S181_T1.2500.85
218_V247_G1.2470.85
63_S270_A1.2400.85
102_G115_G1.2330.85
214_L292_L1.2290.84
26_Q100_G1.2280.84
28_I220_S1.2130.84
45_I54_V1.2080.83
177_S181_T1.2060.83
93_T101_G1.2050.83
10_M212_S1.1990.83
153_L157_Q1.1970.83
70_L145_L1.1880.82
152_A245_L1.1880.82
47_F181_T1.1870.82
16_S263_A1.1870.82
145_L224_N1.1820.82
101_G261_C1.1760.82
47_F216_F1.1740.82
237_F243_A1.1620.81
23_A269_V1.1590.81
101_G256_M1.1530.80
56_K206_K1.1350.79
110_L118_L1.1340.79
51_S208_A1.1240.79
125_C164_W1.1230.79
17_L216_F1.1180.78
299_V303_S1.1150.78
25_G32_F1.1150.78
137_I286_P1.1140.78
143_P306_F1.1040.77
176_A291_V1.1020.77
51_S213_G1.1010.77
16_S138_N1.0990.77
111_P155_S1.0960.77
134_I192_L1.0920.77
15_G241_L1.0860.76
127_F291_V1.0820.76
223_Y245_L1.0790.76
38_L42_L1.0780.76
11_L16_S1.0750.75
227_L239_I1.0700.75
76_P312_F1.0690.75
17_L184_N1.0660.75
9_W152_A1.0660.75
88_F326_V1.0630.75
12_L139_S1.0600.74
11_L273_L1.0550.74
275_L294_L1.0460.73
118_L165_T1.0420.73
172_Y316_I1.0400.73
153_L222_V1.0390.73
165_T214_L1.0360.73
75_G213_G1.0350.73
56_K59_F1.0340.73
31_F315_P1.0340.73
157_Q293_I1.0210.72
223_Y241_L1.0130.71
150_L222_V1.0070.71
152_A316_I1.0060.70
41_V150_L1.0000.70
97_M143_P0.9990.70
31_F317_Y0.9990.70
100_G143_P0.9930.69
47_F226_T0.9880.69
190_A301_F0.9870.69
251_F316_I0.9830.69
5_A225_E0.9770.68
20_A142_I0.9740.68
69_V272_L0.9650.67
168_L297_L0.9650.67
280_M290_I0.9630.67
142_I273_L0.9600.67
49_F332_P0.9560.66
23_A267_T0.9540.66
12_L16_S0.9520.66
58_S63_S0.9510.66
22_Y219_I0.9490.66
262_L292_L0.9480.66
121_I161_H0.9480.66
96_V310_I0.9430.65
308_D312_F0.9410.65
26_Q306_F0.9390.65
217_G310_I0.9370.65
153_L297_L0.9340.65
42_L106_Q0.9340.65
222_V329_L0.9320.64
143_P315_P0.9280.64
88_F154_I0.9260.64
179_T188_V0.9240.64
66_F278_R0.9230.64
22_Y47_F0.9190.63
24_S219_I0.9160.63
41_V326_V0.9160.63
178_I239_I0.9140.63
59_F201_G0.9080.62
99_A144_V0.9060.62
163_T218_V0.9040.62
203_G206_K0.9020.62
81_I157_Q0.9010.62
58_S69_V0.8970.61
97_M268_T0.8950.61
163_T201_G0.8850.60
187_S275_L0.8830.60
51_S188_V0.8760.60
58_S196_G0.8750.60
97_M306_F0.8740.59
322_L326_V0.8740.59
63_S219_I0.8690.59
134_I137_I0.8650.59
48_I182_S0.8640.59
99_A294_L0.8640.59
219_I317_Y0.8610.58
262_L266_T0.8590.58
157_Q296_V0.8580.58
142_I191_I0.8570.58
251_F258_A0.8560.58
306_F315_P0.8550.58
22_Y180_F0.8500.57
27_E184_N0.8400.56
127_F269_V0.8350.56
143_P265_Y0.8290.55
260_L301_F0.8250.55
194_S205_A0.8250.55
211_A215_I0.8230.55
246_E253_F0.8220.55
215_I219_I0.8200.55
196_G267_T0.8180.54
27_E97_M0.8180.54
24_S331_Y0.8080.53
280_M286_P0.8080.53
39_A325_L0.8080.53
62_Q161_H0.8070.53
72_H331_Y0.7980.53
167_D170_Q0.7970.52
42_L178_I0.7950.52
177_S252_L0.7950.52
79_A189_V0.7900.52
42_L199_M0.7900.52
151_Y235_S0.7880.52
134_I276_S0.7870.52
116_I120_C0.7860.51
15_G273_L0.7860.51
6_G220_S0.7840.51
87_I233_S0.7830.51
83_D277_S0.7830.51
101_G171_Q0.7820.51
98_I123_T0.7820.51
266_T316_I0.7800.51
285_M300_P0.7770.51
186_L324_L0.7760.51
255_C285_M0.7740.50
8_K145_L0.7730.50
201_G204_E0.7710.50
74_M183_L0.7700.50
81_I222_V0.7680.50
5_A85_L0.7660.50
171_Q175_P0.7650.50
263_A271_G0.7640.49
31_F179_T0.7630.49
266_T272_L0.7630.49
128_L154_I0.7620.49
245_L306_F0.7610.49
121_I284_H0.7610.49
129_W133_G0.7560.49
124_V128_L0.7550.49
286_P289_M0.7550.49
15_G270_A0.7540.49
53_I193_S0.7500.48
13_I119_I0.7490.48
109_K239_I0.7480.48
15_G138_N0.7480.48
9_W208_A0.7460.48
45_I84_V0.7450.48
318_G321_N0.7450.48
90_L119_I0.7440.48
220_S260_L0.7410.47
93_T260_L0.7380.47
137_I291_V0.7370.47
289_M329_L0.7350.47
179_T182_S0.7320.46
183_L322_L0.7310.46
200_K258_A0.7300.46
150_L157_Q0.7300.46
71_E203_G0.7300.46
315_P318_G0.7280.46
294_L304_F0.7250.46
255_C290_I0.7240.46
83_D267_T0.7220.46
96_V261_C0.7210.45
81_I163_T0.7210.45
15_G263_A0.7180.45
127_F148_G0.7180.45
131_V256_M0.7170.45
26_Q307_S0.7170.45
84_V214_L0.7170.45
38_L296_V0.7140.45
12_L253_F0.7130.45
125_C225_E0.7120.45
131_V193_S0.7050.44
96_V213_G0.7040.44
300_P304_F0.7040.44
151_Y168_L0.7020.44
45_I121_I0.7000.44
69_V81_I0.7000.44
204_E207_I0.6990.43
121_I297_L0.6990.43
82_Y86_I0.6980.43
66_F138_N0.6980.43
18_I23_A0.6970.43
19_G25_G0.6970.43
143_P318_G0.6970.43
152_A226_T0.6950.43
121_I330_L0.6940.43
41_V45_I0.6930.43
260_L268_T0.6930.43
139_S253_F0.6920.43
258_A281_A0.6900.43
20_A306_F0.6890.43
101_G183_L0.6890.43
6_G234_L0.6820.42
35_E214_L0.6810.42
77_W81_I0.6800.42
82_Y104_T0.6790.42
272_L298_M0.6780.42
179_T239_I0.6760.41
56_K60_K0.6730.41
94_T271_G0.6730.41
85_L320_L0.6730.41
40_I48_I0.6720.41
41_V84_V0.6720.41
138_N271_G0.6670.41
157_Q161_H0.6670.41
16_S23_A0.6660.41
162_H166_I0.6640.40
42_L175_P0.6620.40
26_Q245_L0.6620.40
179_T245_L0.6610.40
276_S287_R0.6600.40
20_A315_P0.6590.40
113_W303_S0.6590.40
268_T278_R0.6580.40
279_L290_I0.6570.40
203_G211_A0.6570.40
42_L236_Q0.6530.39
153_L176_A0.6530.39
121_I289_M0.6530.39
7_M326_V0.6520.39
62_Q203_G0.6510.39
60_K151_Y0.6500.39
136_S288_W0.6490.39
110_L225_E0.6470.39
172_Y210_V0.6460.39
121_I203_G0.6460.39
181_T217_G0.6440.39
161_H164_W0.6430.39
124_V292_L0.6380.38
93_T183_L0.6380.38
133_G216_F0.6380.38
105_L241_L0.6370.38
133_G191_I0.6360.38
89_Y186_L0.6360.38
114_W163_T0.6360.38
135_L146_V0.6350.38
144_V296_V0.6330.38
178_I182_S0.6320.38
66_F317_Y0.6300.37
17_L136_S0.6300.37
13_I213_G0.6290.37
155_S162_H0.6290.37
13_I97_M0.6290.37
181_T184_N0.6280.37
89_Y220_S0.6270.37
67_L183_L0.6260.37
239_I266_T0.6260.37
292_L333_I0.6260.37
264_I328_L0.6250.37
120_C206_K0.6230.37
66_F83_D0.6200.37
273_L321_N0.6160.36
145_L269_V0.6150.36
117_T251_F0.6110.36
224_N310_I0.6100.36
11_L274_G0.6100.36
261_C275_L0.6050.35
14_L35_E0.6050.35
119_I261_C0.6040.35
78_L166_I0.6020.35
77_W80_K0.6010.35
255_C312_F0.5980.35
293_I297_L0.5980.35
254_L258_A0.5960.35
183_L223_Y0.5940.34
74_M77_W0.5930.34
112_F305_G0.5930.34
109_K319_M0.5910.34
40_I191_I0.5900.34
22_Y43_F0.5890.34
24_S325_L0.5880.34
182_S283_I0.5880.34
6_G62_Q0.5860.34
124_V190_A0.5840.34
102_G209_S0.5830.33
101_G105_L0.5830.33
261_C310_I0.5820.33
47_F260_L0.5810.33
90_L238_E0.5810.33
21_G180_F0.5810.33
6_G150_L0.5800.33
83_D324_L0.5770.33
57_I331_Y0.5770.33
243_A301_F0.5770.33
103_V199_M0.5740.33
52_Y205_A0.5740.33
21_G309_L0.5700.32
137_I140_I0.5700.32
40_I55_M0.5700.32
13_I47_F0.5690.32
91_F299_V0.5680.32
38_L255_C0.5670.32
69_V257_T0.5670.32
13_I32_F0.5670.32
18_I27_E0.5670.32
193_S263_A0.5660.32
83_D306_F0.5660.32
16_S66_F0.5640.32
137_I254_L0.5640.32
88_F297_L0.5630.32
139_S191_I0.5630.32
190_A266_T0.5620.32
309_L315_P0.5610.32
131_V184_N0.5570.31
16_S270_A0.5570.31
12_L131_V0.5530.31
79_A269_V0.5530.31
167_D210_V0.5530.31
28_I34_A0.5520.31
117_T157_Q0.5520.31
72_H203_G0.5510.31
7_M109_K0.5500.31
193_S262_L0.5500.31
11_L134_I0.5490.31
62_Q218_V0.5480.31
41_V169_S0.5480.31
99_A139_S0.5470.31
81_I169_S0.5470.31
239_I303_S0.5470.31
148_G215_I0.5460.30
117_T299_V0.5450.30
84_V255_C0.5450.30
27_E216_F0.5450.30
15_G219_I0.5440.30
192_L245_L0.5370.30
10_M39_A0.5370.30
16_S274_G0.5360.30
48_I292_L0.5350.30
53_I332_P0.5340.30
106_Q228_V0.5320.29
130_D203_G0.5320.29
94_T298_M0.5300.29
57_I73_L0.5300.29
56_K202_L0.5280.29
59_F124_V0.5280.29
10_M35_E0.5280.29
38_L244_V0.5270.29
19_G23_A0.5270.29
99_A178_I0.5270.29
238_E315_P0.5270.29
18_I208_A0.5270.29
64_T312_F0.5230.29
204_E333_I0.5230.29
54_V328_L0.5220.29
17_L322_L0.5210.29
24_S261_C0.5210.29
173_N255_C0.5210.29
133_G143_P0.5190.28
192_L272_L0.5180.28
141_L262_L0.5180.28
44_T310_I0.5170.28
153_L226_T0.5170.28
104_T248_A0.5160.28
63_S310_I0.5150.28
284_H289_M0.5140.28
293_I316_I0.5140.28
146_V215_I0.5140.28
256_M263_A0.5110.28
28_I184_N0.5110.28
41_V161_H0.5100.28
48_I225_E0.5080.28
266_T274_G0.5080.28
107_M264_I0.5070.28
272_L276_S0.5030.27
211_A276_S0.5030.27
50_S54_V0.5030.27
77_W292_L0.5030.27
34_A243_A0.5030.27
87_I297_L0.5030.27
77_W114_W0.5020.27
196_G306_F0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dh4A 3 0.9349 99.9 0.742 Contact Map
2xq2A 2 0.9379 99.8 0.758 Contact Map
3l1lA 2 0.9615 99.7 0.799 Contact Map
3giaA 1 0.9793 99.5 0.819 Contact Map
4djkA 2 0.9379 99.2 0.851 Contact Map
2jlnA 1 0.9763 98.7 0.876 Contact Map
4wgvA 2 0.9438 98.6 0.881 Contact Map
4us3A 1 0.9053 98.1 0.896 Contact Map
2a65A 2 0.9408 98 0.897 Contact Map
4xp4A 1 0.9734 97 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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