GREMLIN Database
YCHF - Ribosome-binding ATPase YchF
UniProt: P37518 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 366 (360)
Sequences: 3401 (1597)
Seq/√Len: 84.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_K123_D5.0791.00
354_V360_I4.6501.00
306_E316_E3.6461.00
53_K56_E3.5961.00
60_P293_V3.3511.00
55_T63_T3.0831.00
148_S166_S3.0231.00
335_G338_G2.9511.00
122_I228_Y2.8781.00
171_A181_V2.8231.00
347_L363_R2.8091.00
257_M261_E2.7521.00
209_S212_E2.7191.00
116_S127_T2.6781.00
125_I225_I2.6731.00
169_K173_E2.6181.00
167_K187_Q2.5671.00
144_I162_F2.5461.00
53_K331_L2.5401.00
137_M169_K2.4361.00
108_S221_N2.4251.00
298_F302_M2.3901.00
61_K290_E2.3631.00
267_S270_D2.3441.00
61_K291_Q2.3371.00
28_E35_C2.2311.00
283_A300_K2.2291.00
324_T360_I2.1741.00
18_L241_A2.1511.00
324_T354_V2.1351.00
333_G342_A2.0971.00
327_Y331_L2.0861.00
227_E231_G2.0851.00
325_V339_A2.0611.00
338_G342_A2.0291.00
299_K302_M2.0241.00
318_G364_F2.0211.00
5_A276_S2.0181.00
235_E278_S1.9971.00
168_L178_A1.9921.00
266_E274_K1.9871.00
288_A293_V1.9791.00
323_E363_R1.9781.00
340_K345_V1.9671.00
298_F307_C1.9671.00
170_E174_S1.9581.00
116_S123_D1.8941.00
178_A199_S1.8931.00
278_S300_K1.8871.00
53_K327_Y1.8681.00
101_C205_V1.8541.00
58_V288_A1.8531.00
78_K116_S1.8141.00
163_E166_S1.8131.00
120_D123_D1.8011.00
302_M306_E1.7991.00
338_G341_E1.7811.00
58_V293_V1.7651.00
102_H202_I1.7571.00
325_V336_M1.7461.00
120_D224_K1.7411.00
321_R363_R1.7331.00
235_E275_A1.7311.00
303_K353_V1.7311.00
3_L276_S1.7071.00
184_T187_Q1.6711.00
321_R347_L1.6591.00
24_Q255_K1.6491.00
328_E332_A1.6461.00
203_L279_L1.6401.00
333_G339_A1.6391.00
220_E223_A1.6361.00
135_A139_T1.6261.00
145_T148_S1.6131.00
166_S170_E1.6061.00
222_V238_V1.5971.00
56_E59_N1.5931.00
337_A340_K1.5811.00
221_N224_K1.5731.00
104_V125_I1.5671.00
227_E230_A1.5531.00
300_K355_Q1.5331.00
106_A225_I1.5261.00
329_D332_A1.5171.00
336_M345_V1.5120.99
140_V165_L1.5110.99
223_A226_R1.5070.99
159_V163_E1.4990.99
171_A180_S1.4980.99
224_K227_E1.4740.99
326_A355_Q1.4640.99
147_V162_F1.4620.99
281_G300_K1.4440.99
24_Q252_G1.4400.99
122_I224_K1.4390.99
223_A227_E1.4310.99
47_P273_I1.4190.99
205_V272_L1.4180.99
256_Q260_E1.4090.99
52_Q56_E1.4040.99
54_L359_V1.3960.99
332_A344_K1.3830.99
325_V345_V1.3790.99
109_D242_K1.3760.99
140_V169_K1.3750.99
339_A345_V1.3700.99
218_G222_V1.3650.99
333_G344_K1.3560.99
309_G316_E1.3480.99
334_G338_G1.3470.99
247_I258_F1.3280.99
143_R161_E1.3250.99
51_L65_P1.3240.99
130_L134_L1.3200.99
78_K127_T1.3190.99
274_K278_S1.3020.98
323_E361_H1.2990.98
178_A181_V1.2910.98
283_A302_M1.2880.98
170_E173_E1.2810.98
164_I190_L1.2740.98
283_A298_F1.2660.98
345_V361_H1.2630.98
176_K231_G1.2490.98
178_A196_L1.2490.98
226_R230_A1.2440.98
245_S249_E1.2260.98
258_F261_E1.2250.98
218_G223_A1.2180.98
58_V330_L1.2160.98
206_A225_I1.2070.97
218_G238_V1.2030.97
329_D344_K1.1920.97
92_S96_Q1.1900.97
222_V226_R1.1840.97
275_A278_S1.1630.97
164_I167_K1.1590.97
229_A236_V1.1580.97
298_F310_I1.1460.97
324_T347_L1.1440.96
146_R150_L1.1440.96
328_E355_Q1.1440.96
162_F166_S1.1420.96
305_P316_E1.1340.96
59_N290_E1.1340.96
315_F362_F1.1280.96
168_L191_V1.1270.96
213_V222_V1.1250.96
326_A329_D1.1170.96
52_Q63_T1.1120.96
144_I165_L1.1040.96
208_V238_V1.1040.96
285_Y310_I1.0950.95
125_I228_Y1.0950.95
285_Y291_Q1.0880.95
328_E331_L1.0850.95
330_L335_G1.0810.95
313_S317_R1.0780.95
277_Y297_T1.0740.95
242_K245_S1.0730.95
141_E169_K1.0600.95
330_L359_V1.0530.94
284_T295_A1.0480.94
129_N232_E1.0470.94
336_M361_H1.0440.94
302_M310_I1.0360.94
243_I262_L1.0360.94
206_A236_V1.0310.94
27_A30_A1.0290.94
154_K157_D1.0270.94
106_A206_A1.0170.93
323_E347_L1.0140.93
247_I264_I1.0130.93
51_L63_T1.0120.93
51_L55_T1.0110.93
351_E363_R1.0060.93
53_K57_L1.0040.93
212_E219_N1.0000.93
5_A101_C0.9990.93
166_S169_K0.9960.93
60_P290_E0.9890.92
325_V330_L0.9870.92
245_S248_A0.9810.92
50_R286_F0.9800.92
144_I166_S0.9780.92
4_T69_E0.9780.92
30_A35_C0.9770.92
27_A40_N0.9730.92
154_K159_V0.9720.92
188_Q199_S0.9690.92
83_G87_G0.9610.91
318_G365_N0.9600.91
8_V100_I0.9530.91
186_E189_K0.9530.91
20_N29_S0.9510.91
176_K180_S0.9440.90
191_V194_L0.9410.90
347_L361_H0.9320.90
155_D158_A0.9320.90
20_N27_A0.9290.90
331_L335_G0.9290.90
78_K82_K0.9160.89
333_G338_G0.9150.89
242_K246_E0.9050.89
239_V272_L0.9040.88
326_A346_R0.9030.88
126_E175_E0.9030.88
175_E178_A0.9030.88
228_Y232_E0.8970.88
335_G339_A0.8960.88
55_T293_V0.8930.88
339_A359_V0.8880.88
260_E265_Q0.8810.87
171_A174_S0.8800.87
37_I74_A0.8780.87
183_F187_Q0.8780.87
330_L339_A0.8770.87
179_R232_E0.8760.87
37_I77_V0.8670.86
307_C354_V0.8670.86
49_D53_K0.8660.86
171_A176_K0.8620.86
168_L171_A0.8600.86
3_L68_F0.8570.86
317_R364_F0.8550.86
58_V291_Q0.8530.85
191_V199_S0.8510.85
164_I191_V0.8450.85
54_L288_A0.8450.85
93_H97_V0.8370.84
310_I315_F0.8310.84
43_I69_E0.8300.84
155_D159_V0.8280.84
68_F276_S0.8260.84
185_E188_Q0.8200.83
123_D127_T0.8190.83
230_A233_N0.8140.83
266_E270_D0.8140.83
159_V162_F0.8120.82
60_P63_T0.8100.82
160_F164_I0.8090.82
220_E224_K0.8090.82
167_K182_E0.8070.82
57_L331_L0.8010.82
144_I169_K0.7960.81
228_Y231_G0.7940.81
89_K142_K0.7940.81
303_K316_E0.7930.81
317_R365_N0.7930.81
17_T241_A0.7900.81
165_L169_K0.7890.81
167_K170_E0.7850.80
167_K183_F0.7850.80
208_V222_V0.7850.80
168_L172_F0.7850.80
18_L239_V0.7820.80
259_L264_I0.7780.80
226_R236_V0.7770.80
305_P315_F0.7760.80
32_Y35_C0.7750.79
58_V286_F0.7720.79
139_T142_K0.7710.79
303_K351_E0.7710.79
80_A85_G0.7700.79
4_T97_V0.7700.79
130_L173_E0.7690.79
58_V64_V0.7650.79
303_K306_E0.7610.78
291_Q361_H0.7610.78
60_P64_V0.7600.78
258_F262_L0.7600.78
164_I183_F0.7600.78
302_M307_C0.7590.78
222_V236_V0.7590.78
336_M340_K0.7580.78
151_A162_F0.7580.78
99_A279_L0.7580.78
141_E173_E0.7580.78
325_V361_H0.7570.78
257_M260_E0.7500.77
68_F97_V0.7500.77
54_L58_V0.7480.77
147_V161_E0.7470.77
285_Y299_K0.7470.77
147_V165_L0.7460.77
94_I100_I0.7460.77
43_I67_A0.7450.77
283_A307_C0.7430.77
291_Q313_S0.7410.76
327_Y359_V0.7390.76
137_M140_V0.7370.76
63_T291_Q0.7330.76
177_P198_T0.7280.75
306_E309_G0.7280.75
326_A333_G0.7270.75
337_A341_E0.7270.75
58_V361_H0.7260.75
208_V213_V0.7250.75
104_V128_I0.7250.75
61_K64_V0.7220.74
80_A83_G0.7210.74
140_V144_I0.7210.74
298_F306_E0.7210.74
336_M344_K0.7200.74
122_I126_E0.7190.74
9_G14_G0.7160.74
58_V325_V0.7130.74
62_K291_Q0.7130.74
139_T195_H0.7090.73
275_A279_L0.7070.73
205_V239_V0.7060.73
290_E336_M0.7050.73
102_H124_D0.7050.73
193_Q196_L0.7050.73
55_T60_P0.7040.73
87_G90_F0.7030.72
66_T277_Y0.7020.72
108_S220_E0.7000.72
27_A35_C0.6990.72
26_G249_E0.6980.72
304_A319_F0.6980.72
315_F361_H0.6950.72
285_Y315_F0.6940.72
329_D336_M0.6930.71
309_G313_S0.6920.71
29_S35_C0.6910.71
147_V150_L0.6880.71
122_I125_I0.6850.71
18_L103_V0.6840.70
4_T71_T0.6830.70
57_L330_L0.6810.70
256_Q261_E0.6800.70
60_P286_F0.6790.70
89_K138_E0.6780.70
150_L155_D0.6750.69
183_F191_V0.6730.69
72_D75_G0.6720.69
12_N16_S0.6720.69
164_I181_V0.6720.69
70_F101_C0.6710.69
288_A359_V0.6690.69
326_A339_A0.6670.69
252_G256_Q0.6670.69
140_V196_L0.6650.68
154_K158_A0.6630.68
101_C203_L0.6620.68
168_L183_F0.6610.68
5_A161_E0.6590.68
333_G336_M0.6590.68
73_I94_I0.6590.68
240_C243_I0.6580.67
71_T154_K0.6570.67
157_D160_F0.6560.67
49_D265_Q0.6540.67
106_A219_N0.6540.67
57_L335_G0.6530.67
122_I225_I0.6520.67
285_Y290_E0.6510.67
114_H119_V0.6460.66
167_K181_V0.6450.66
25_A43_I0.6430.66
28_E32_Y0.6430.66
145_T150_L0.6420.66
235_E238_V0.6410.65
64_V294_R0.6390.65
38_D89_K0.6390.65
164_I194_L0.6390.65
183_F193_Q0.6390.65
5_A68_F0.6380.65
80_A90_F0.6350.65
49_D274_K0.6340.65
113_T117_G0.6330.64
191_V195_H0.6310.64
140_V172_F0.6310.64
71_T98_D0.6300.64
12_N36_T0.6300.64
80_A87_G0.6290.64
4_T96_Q0.6290.64
150_L157_D0.6290.64
104_V129_N0.6290.64
113_T213_V0.6270.64
283_A356_D0.6270.64
148_S162_F0.6240.63
204_Y232_E0.6210.63
34_F77_V0.6200.63
46_V273_I0.6190.63
41_V69_E0.6190.63
330_L338_G0.6190.63
16_S36_T0.6170.63
277_Y284_T0.6160.62
58_V61_K0.6110.62
20_N25_A0.6100.62
112_I115_V0.6100.62
133_I172_F0.6090.61
213_V238_V0.6090.61
134_L173_E0.6060.61
102_H129_N0.6050.61
30_A33_P0.6040.61
213_V271_Q0.6020.61
114_H117_G0.6020.61
177_P180_S0.6000.60
33_P36_T0.6000.60
205_V212_E0.6000.60
21_A32_Y0.5990.60
86_L89_K0.5980.60
20_N26_G0.5980.60
324_T361_H0.5970.60
51_L291_Q0.5960.60
89_K96_Q0.5940.60
61_K293_V0.5920.59
93_H197_L0.5920.59
213_V240_C0.5890.59
44_V70_F0.5890.59
60_P288_A0.5880.59
64_V290_E0.5870.59
13_V16_S0.5860.59
56_E334_G0.5850.58
79_G82_K0.5830.58
70_F269_L0.5820.58
219_N222_V0.5820.58
12_N31_N0.5810.58
137_M141_E0.5800.58
33_P37_I0.5800.58
334_G339_A0.5800.58
13_V31_N0.5800.58
9_G15_K0.5800.58
213_V218_G0.5790.58
31_N37_I0.5780.58
183_F188_Q0.5770.57
305_P350_K0.5770.57
16_S37_I0.5750.57
298_F353_V0.5740.57
76_I85_G0.5730.57
161_E193_Q0.5710.57
247_I255_K0.5710.57
151_A158_A0.5710.57
330_L334_G0.5690.56
125_I204_Y0.5690.56
27_A240_C0.5690.56
11_P15_K0.5690.56
286_F354_V0.5680.56
160_F190_L0.5670.56
285_Y298_F0.5670.56
126_E130_L0.5660.56
93_H100_I0.5640.56
5_A99_A0.5640.56
165_L194_L0.5640.56
322_A360_I0.5630.56
348_E351_E0.5620.55
224_K228_Y0.5620.55
203_L208_V0.5620.55
203_L264_I0.5610.55
79_G85_G0.5600.55
267_S274_K0.5600.55
77_V80_A0.5580.55
66_T284_T0.5580.55
254_E258_F0.5580.55
82_K89_K0.5570.55
226_R238_V0.5540.54
192_K195_H0.5540.54
125_I229_A0.5530.54
148_S152_K0.5520.54
330_L333_G0.5520.54
162_F165_L0.5520.54
161_E190_L0.5520.54
22_I26_G0.5500.54
238_V271_Q0.5480.54
5_A284_T0.5480.54
336_M342_A0.5470.53
331_L334_G0.5450.53
221_N225_I0.5450.53
253_E257_M0.5440.53
330_L345_V0.5440.53
23_T32_Y0.5420.53
177_P202_I0.5410.53
203_L235_E0.5410.53
129_N228_Y0.5400.53
298_F354_V0.5390.52
34_F37_I0.5380.52
53_K60_P0.5380.52
130_L133_I0.5370.52
59_N293_V0.5370.52
46_V277_Y0.5360.52
83_G88_N0.5340.52
68_F341_E0.5340.52
163_E167_K0.5340.52
5_A71_T0.5330.52
80_A88_N0.5320.51
95_R135_A0.5320.51
53_K334_G0.5320.51
58_V336_M0.5310.51
26_G67_A0.5300.51
58_V63_T0.5300.51
119_V124_D0.5280.51
217_S226_R0.5280.51
49_D52_Q0.5270.51
210_E242_K0.5260.51
168_L181_V0.5250.51
35_C101_C0.5250.51
281_G299_K0.5220.50
172_F177_P0.5210.50
103_V205_V0.5210.50
330_L336_M0.5210.50
57_L334_G0.5180.50
246_E250_L0.5170.49
178_A183_F0.5170.49
242_K247_I0.5160.49
247_I250_L0.5140.49
175_E179_R0.5130.49
171_A178_A0.5130.49
138_E142_K0.5130.49
157_D161_E0.5130.49
230_A235_E0.5110.49
77_V87_G0.5110.49
160_F186_E0.5100.49
352_Y358_D0.5100.49
290_E293_V0.5100.49
18_L22_I0.5100.49
217_S238_V0.5080.48
21_A44_V0.5080.48
23_T135_A0.5070.48
195_H199_S0.5050.48
183_F190_L0.5050.48
50_R357_G0.5040.48
75_G85_G0.5040.48
68_F283_A0.5040.48
66_T295_A0.5040.48
229_A233_N0.5030.48
25_A28_E0.5030.48
261_E341_E0.5030.48
165_L196_L0.5030.48
43_I286_F0.5020.47
129_N202_I0.5020.47
269_L276_S0.5020.47
160_F163_E0.5020.47
243_I261_E0.5020.47
101_C276_S0.5010.47
39_P74_A0.5010.47
12_N34_F0.5000.47
288_A361_H0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jalA 1 0.9508 100 0.199 Contact Map
2dbyA 1 0.959 100 0.224 Contact Map
1ni3A 1 0.9863 100 0.26 Contact Map
2ohfA 1 0.8716 100 0.362 Contact Map
1wxqA 1 0.8197 100 0.381 Contact Map
4a9aA 1 0.7787 100 0.59 Contact Map
1lnzA 1 0.5055 99.9 0.779 Contact Map
1udxA 1 0.6776 99.9 0.785 Contact Map
4csu9 1 0.4809 99.9 0.791 Contact Map
3ievA 1 0.7978 99.9 0.815 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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