GREMLIN Database
CCPB - Catabolite control protein B
UniProt: P37517 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (298)
Sequences: 36063 (25996)
Seq/√Len: 1505.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_K200_A3.4211.00
174_H235_T3.3161.00
10_L42_E3.1741.00
271_R274_G2.8691.00
165_S262_I2.6301.00
118_G293_F2.6021.00
266_N279_D2.5981.00
174_H260_E2.5571.00
195_A199_K2.5531.00
152_P296_D2.4671.00
163_A204_R2.3851.00
221_E254_K2.2621.00
30_E34_K2.2471.00
84_A87_Q2.2191.00
38_Q42_E2.2071.00
34_K38_Q2.2001.00
84_A291_S2.1891.00
225_E255_N2.1341.00
163_A200_A2.1261.00
288_A291_S2.0751.00
160_T164_E2.0581.00
163_A201_V2.0201.00
167_R201_V1.9991.00
162_Y166_F1.9921.00
85_A290_F1.9901.00
21_V36_V1.9641.00
225_E251_F1.9491.00
161_A264_E1.9421.00
80_G286_G1.9311.00
159_K196_A1.9201.00
295_Q300_D1.9151.00
33_R37_H1.9111.00
252_A259_V1.8871.00
22_L40_M1.8591.00
229_M255_N1.8581.00
169_L236_A1.8521.00
5_K15_V1.8421.00
84_A287_I1.8391.00
220_G247_G1.8221.00
162_Y238_Y1.8051.00
167_R171_S1.8041.00
83_K283_E1.7871.00
166_F198_Y1.7631.00
168_Y172_R1.7521.00
11_A39_V1.6971.00
63_G116_I1.6931.00
163_A167_R1.6821.00
221_E251_F1.6661.00
281_N284_Q1.6631.00
179_F240_N1.6561.00
224_A248_I1.6481.00
10_L39_V1.6471.00
239_A248_I1.6191.00
80_G283_E1.6091.00
178_A234_P1.6011.00
84_A88_H1.5861.00
251_F255_N1.5671.00
143_C289_A1.5411.00
37_H41_K1.5411.00
206_E209_H1.5341.00
160_T163_A1.5301.00
196_A200_A1.5231.00
176_N233_V1.5171.00
88_H294_L1.5051.00
21_V40_M1.4861.00
170_K201_V1.4841.00
284_Q288_A1.4761.00
253_K274_G1.4751.00
168_Y171_S1.4601.00
193_D196_A1.4481.00
7_I39_V1.4411.00
166_F170_K1.4411.00
251_F254_K1.4341.00
37_H40_M1.4251.00
199_K203_G1.4111.00
157_D160_T1.4091.00
284_Q287_I1.4091.00
60_H117_D1.4001.00
84_A290_F1.3961.00
178_A227_F1.3531.00
214_C219_D1.3421.00
166_F197_A1.3421.00
224_A237_I1.3231.00
225_E254_K1.3221.00
176_N235_T1.3221.00
221_E250_L1.3071.00
221_E225_E1.3061.00
174_H236_A1.3031.00
5_K9_R1.3031.00
201_V204_R1.3011.00
10_L43_L1.2931.00
166_F201_V1.2921.00
224_A252_A1.2851.00
132_L136_E1.2851.00
162_Y197_A1.2821.00
6_E9_R1.2811.00
60_H90_Y1.2811.00
291_S295_Q1.2761.00
20_R25_H1.2701.00
30_E33_R1.2671.00
197_A201_V1.2551.00
294_L298_P1.2531.00
225_E229_M1.2511.00
29_S32_K1.2511.00
167_R204_R1.2451.00
35_L39_V1.2441.00
62_V85_A1.2411.00
164_E167_R1.2391.00
176_N209_H1.2391.00
7_I11_A1.2331.00
249_H261_I1.2301.00
63_G111_L1.2281.00
211_L226_H1.2271.00
159_K163_A1.2201.00
120_I289_A1.2181.00
95_L111_L1.2161.00
95_L107_Y1.2051.00
176_N206_E1.2031.00
81_I120_I1.2021.00
262_I276_P1.2021.00
81_I290_F1.1961.00
175_E235_T1.1931.00
39_V43_L1.1921.00
39_V42_E1.1901.00
85_A92_T1.1871.00
231_G234_P1.1831.00
64_V81_I1.1781.00
4_I15_V1.1771.00
7_I43_L1.1731.00
159_K193_D1.1641.00
32_K35_L1.1561.00
226_H230_S1.1511.00
198_Y202_C1.1471.00
109_E133_A1.1411.00
218_N222_L1.1391.00
64_V92_T1.1301.00
283_E287_I1.1291.00
247_G251_F1.1271.00
88_H291_S1.1261.00
180_T248_I1.1241.00
207_D210_M1.1211.00
177_I202_C1.1151.00
159_K197_A1.1131.00
200_A204_R1.1101.00
21_V28_V1.1011.00
242_D277_S1.1011.00
38_Q41_K1.0931.00
288_A292_L1.0921.00
4_I18_V1.0861.00
179_F195_A1.0841.00
61_T91_A1.0821.00
48_N54_L1.0821.00
82_T86_F1.0751.00
242_D263_G1.0661.00
165_S238_Y1.0631.00
205_L208_R1.0581.00
61_T93_T1.0521.00
34_K37_H1.0481.00
237_I248_I1.0481.00
105_I109_E1.0461.00
176_N232_R1.0421.00
216_D219_D1.0401.00
286_G290_F1.0361.00
24_H33_R1.0341.00
196_A199_K1.0331.00
86_F103_I1.0291.00
223_A226_H1.0281.00
222_L226_H1.0261.00
198_Y238_Y1.0251.00
50_T53_D1.0251.00
168_Y276_P1.0181.00
40_M43_L1.0131.00
239_A245_A1.0091.00
293_F297_E1.0071.00
220_G224_A1.0061.00
88_H298_P0.9981.00
217_M250_L0.9981.00
287_I291_S0.9871.00
172_R260_E0.9751.00
224_A228_Y0.9731.00
156_N281_N0.9721.00
239_A244_V0.9701.00
48_N51_A0.9691.00
103_I106_K0.9671.00
177_I236_A0.9641.00
219_D222_L0.9631.00
11_A18_V0.9581.00
90_Y294_L0.9561.00
165_S278_L0.9471.00
87_Q287_I0.9471.00
189_P193_D0.9421.00
192_A196_A0.9391.00
152_P292_L0.9391.00
170_K175_E0.9331.00
166_F202_C0.9331.00
51_A54_L0.9271.00
109_E113_T0.9101.00
83_K287_I0.9101.00
120_I293_F0.9071.00
182_V215_N0.9031.00
47_P52_I0.9031.00
154_A292_L0.8971.00
112_R137_Y0.8951.00
79_N83_K0.8941.00
184_E212_S0.8921.00
128_W132_L0.8871.00
62_V120_I0.8851.00
187_R192_A0.8821.00
24_H37_H0.8821.00
205_L209_H0.8701.00
222_L225_E0.8561.00
242_D266_N0.8541.00
237_I259_V0.8541.00
64_V78_V0.8481.00
21_V37_H0.8481.00
178_A237_I0.8451.00
78_V82_T0.8431.00
81_I286_G0.8431.00
213_G244_V0.8421.00
31_E34_K0.8411.00
252_A261_I0.8361.00
266_N270_S0.8351.00
263_G277_S0.8351.00
118_G297_E0.8311.00
169_L262_I0.8311.00
228_Y251_F0.8301.00
17_T20_R0.8221.00
156_N280_L0.8181.00
181_C195_A0.8161.00
81_I92_T0.8131.00
170_K202_C0.8131.00
73_C282_L0.8121.00
200_A203_G0.8121.00
292_L295_Q0.8101.00
219_D223_A0.8041.00
193_D197_A0.8041.00
290_F294_L0.8001.00
83_K87_Q0.7981.00
76_K283_E0.7921.00
13_V36_V0.7921.00
59_T117_D0.7911.00
224_A227_F0.7871.00
242_D245_A0.7851.00
80_G287_I0.7851.00
158_R194_K0.7831.00
77_I143_C0.7821.00
100_N103_I0.7821.00
49_R52_I0.7781.00
235_T260_E0.7751.00
180_T239_A0.7741.00
265_G280_L0.7711.00
16_S20_R0.7641.00
31_E35_L0.7631.00
58_K298_P0.7621.00
67_P74_F0.7611.00
80_G84_A0.7571.00
61_T114_K0.7551.00
179_F238_Y0.7531.00
164_E278_L0.7531.00
82_T92_T0.7491.00
133_A136_E0.7481.00
20_R26_P0.7461.00
238_Y262_I0.7441.00
224_A251_F0.7431.00
46_T113_T0.7431.00
228_Y255_N0.7381.00
58_K117_D0.7371.00
134_Y140_V0.7361.00
78_V94_L0.7361.00
93_T116_I0.7351.00
63_G119_L0.7331.00
245_A263_G0.7291.00
98_N103_I0.7291.00
62_V290_F0.7291.00
79_N82_T0.7271.00
226_H229_M0.7261.00
132_L135_Q0.7201.00
250_L253_K0.7191.00
106_K109_E0.7171.00
213_G219_D0.7171.00
163_A197_A0.7121.00
118_G141_I0.7091.00
164_E168_Y0.7081.00
295_Q299_A0.7051.00
209_H230_S0.7041.00
103_I107_Y0.7031.00
230_S233_V0.7001.00
220_G223_A0.6931.00
102_D106_K0.6911.00
230_S234_P0.6861.00
299_A302_K0.6861.00
65_I107_Y0.6831.00
207_D211_L0.6821.00
241_S265_G0.6811.00
34_K41_K0.6811.00
120_I143_C0.6771.00
246_A269_I0.6761.00
191_T215_N0.6741.00
211_L223_A0.6731.00
135_Q151_V0.6721.00
21_V33_R0.6701.00
270_S277_S0.6701.00
82_T96_P0.6691.00
183_R187_R0.6681.00
224_A247_G0.6661.00
135_Q140_V0.6631.00
177_I235_T0.6621.00
118_G289_A0.6571.00
144_E190_S0.6541.00
141_I154_A0.6541.00
252_A255_N0.6481.00
108_L119_L0.6461.00
41_K44_D0.6421.00
140_V151_V0.6401.00
142_A151_V0.6391.00
20_R28_V0.6371.00
5_K55_I0.6371.00
46_T109_E0.6371.00
71_H243_E0.6361.00
249_H253_K0.6351.00
35_L38_Q0.6331.00
27_Y32_K0.6331.00
250_L254_K0.6311.00
177_I198_Y0.6301.00
141_I296_D0.6271.00
217_M269_I0.6271.00
205_L210_M0.6271.00
260_E276_P0.6241.00
76_K282_L0.6221.00
18_V21_V0.6221.00
7_I18_V0.6211.00
250_L274_G0.6211.00
163_A166_F0.6211.00
77_I282_L0.6181.00
283_E286_G0.6171.00
135_Q138_G0.6161.00
179_F198_Y0.6141.00
169_L238_Y0.6131.00
18_V40_M0.6111.00
93_T114_K0.6101.00
62_V90_Y0.6061.00
182_V191_T0.6061.00
264_E280_L0.6051.00
144_E158_R0.6041.00
218_N221_E0.6031.00
13_V32_K0.6031.00
141_I293_F0.6031.00
130_S133_A0.6021.00
211_L227_F0.6011.00
241_S244_V0.5981.00
59_T91_A0.5971.00
199_K205_L0.5961.00
176_N234_P0.5931.00
80_G282_L0.5901.00
211_L230_S0.5881.00
239_A263_G0.5881.00
79_N283_E0.5871.00
135_Q150_D0.5871.00
62_V118_G0.5861.00
215_N240_N0.5861.00
73_C77_I0.5851.00
165_S236_A0.5841.00
158_R193_D0.5831.00
141_I292_L0.5821.00
129_D132_L0.5821.00
90_Y117_D0.5821.00
246_A267_T0.5771.00
238_Y264_E0.5771.00
217_M247_G0.5771.00
202_C205_L0.5761.00
46_T50_T0.5761.00
105_I130_S0.5751.00
52_I56_R0.5741.00
228_Y252_A0.5731.00
242_D267_T0.5721.00
195_A210_M0.5711.00
168_Y262_I0.5711.00
178_A209_H0.5681.00
270_S275_F0.5681.00
141_I289_A0.5611.00
101_P105_I0.5611.00
95_L110_L0.5601.00
142_A153_C0.5601.00
221_E224_A0.5601.00
248_I252_A0.5591.00
249_H273_L0.5591.00
18_V36_V0.5591.00
90_Y297_E0.5581.00
154_A288_A0.5571.00
191_T240_N0.5571.00
223_A227_F0.5561.00
292_L296_D0.5561.00
85_A294_L0.5561.00
13_V18_V0.5551.00
11_A21_V0.5521.00
62_V297_E0.5501.00
156_N161_A0.5451.00
213_G220_G0.5441.00
84_A294_L0.5441.00
161_A164_E0.5401.00
205_L211_L0.5361.00
61_T117_D0.5361.00
167_R170_K0.5351.00
215_N244_V0.5351.00
116_I119_L0.5341.00
221_E247_G0.5331.00
85_A90_Y0.5321.00
25_H28_V0.5311.00
234_P237_I0.5301.00
79_N98_N0.5281.00
109_E112_R0.5271.00
118_G139_P0.5271.00
142_A146_T0.5271.00
111_L116_I0.5251.00
72_P243_E0.5211.00
208_R211_L0.5211.00
172_R235_T0.5201.00
159_K162_Y0.5191.00
24_H27_Y0.5181.00
81_I85_A0.5161.00
170_K205_L0.5161.00
53_D56_R0.5151.00
76_K268_S0.5151.00
59_T90_Y0.5151.00
233_V258_D0.5121.00
180_T223_A0.5111.00
176_N231_G0.5111.00
188_S191_T0.5111.00
28_V33_R0.5101.00
71_H74_F0.5101.00
236_A260_E0.5091.00
158_R190_S0.5091.00
296_D302_K0.5081.00
266_N277_S0.5081.00
26_P33_R0.5051.00
242_D270_S0.5041.00
74_F122_T0.5041.00
16_S25_H0.5011.00
133_A137_Y0.5011.00
6_E10_L0.5011.00
288_A295_Q0.5011.00
105_I133_A0.5011.00
110_L113_T0.5011.00
102_D105_I0.5001.00
219_D244_V0.5001.00
208_R230_S0.5001.00
281_N285_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dbiA 2 0.8135 100 0.122 Contact Map
2hsgA 1 0.9839 100 0.124 Contact Map
4o5aA 2 0.8006 100 0.133 Contact Map
3h5oA 2 0.8006 100 0.134 Contact Map
3bilA 2 0.7556 100 0.134 Contact Map
2o20A 2 0.8167 100 0.135 Contact Map
1qpzA 2 0.9904 100 0.136 Contact Map
3kjxA 2 0.9968 100 0.136 Contact Map
3ctpA 2 0.791 100 0.137 Contact Map
1jyeA 2 0.8039 100 0.142 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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