GREMLIN Database
YYAH - Uncharacterized protein YyaH
UniProt: P37516 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 126 (125)
Sequences: 469 (343)
Seq/√Len: 30.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_G44_I4.5621.00
88_T112_S4.4111.00
23_Y94_D4.1421.00
10_V118_E3.7741.00
81_R104_T3.6411.00
78_V124_I3.0921.00
85_D110_Y2.8231.00
31_L40_K2.5100.99
92_K101_G2.3380.99
83_K86_E2.1670.98
77_S125_T2.1480.98
115_E121_L2.0870.98
4_E51_R2.0820.98
40_K56_K2.0340.98
89_D93_A1.9670.97
116_D120_N1.9500.97
20_Y116_D1.9170.96
18_S21_E1.9170.96
20_Y117_D1.8390.95
17_K28_A1.8180.95
89_D92_K1.7320.94
90_R94_D1.7150.93
56_K60_V1.7150.93
11_N62_D1.6830.93
12_D15_R1.6410.92
16_M118_E1.6010.91
92_K98_V1.5670.90
12_D118_E1.5400.89
46_F52_L1.5350.89
87_L112_S1.4560.86
51_R109_Y1.3770.83
26_G76_F1.3700.82
6_T74_I1.3410.81
9_W20_Y1.2970.79
91_L112_S1.2590.77
10_V16_M1.2420.76
17_K42_Y1.2270.75
7_A29_N1.2250.75
22_S94_D1.2230.75
88_T91_L1.2170.74
72_A116_D1.2040.73
43_F75_A1.1980.73
16_M20_Y1.1940.73
98_V101_G1.1800.72
85_D104_T1.1410.69
38_D58_G1.0990.66
25_N47_D1.0930.66
57_K121_L1.0840.65
61_T66_Q1.0780.65
23_Y96_F1.0690.64
2_Q48_S1.0690.64
57_K67_T1.0610.63
4_E75_A1.0540.63
2_Q15_R1.0530.63
87_L91_L1.0390.62
10_V13_L1.0370.62
67_T121_L1.0350.62
82_E86_E1.0250.61
20_Y113_V1.0240.61
81_R85_D1.0140.60
11_N69_T1.0100.60
9_W37_K0.9730.57
71_W74_I0.9560.55
30_D83_K0.9330.54
83_K90_R0.9260.53
16_M117_D0.9130.52
115_E119_G0.9070.51
15_R118_E0.9030.51
24_F117_D0.9030.51
4_E49_G0.8570.47
62_D82_E0.8390.46
24_F74_I0.8320.45
89_D101_G0.8220.45
105_T125_T0.8100.44
39_F75_A0.8070.43
109_Y118_E0.8030.43
61_T72_A0.7970.43
16_M54_I0.7910.42
77_S80_S0.7860.42
9_W116_D0.7820.41
100_N113_V0.7810.41
98_V124_I0.7800.41
9_W60_V0.7800.41
97_A115_E0.7710.41
8_V71_W0.7670.40
99_V115_E0.7600.40
80_S83_K0.7500.39
37_K100_N0.7460.39
33_H40_K0.7430.38
86_E124_I0.7390.38
9_W113_V0.7350.38
4_E109_Y0.7290.37
14_E42_Y0.7250.37
17_K92_K0.7150.36
52_L114_I0.7140.36
100_N121_L0.7140.36
18_S22_S0.7030.35
3_I6_T0.6970.35
61_T65_S0.6970.35
56_K78_V0.6970.35
32_Y106_G0.6940.35
91_L96_F0.6920.35
20_Y34_N0.6910.35
24_F31_L0.6900.35
20_Y37_K0.6850.34
8_V72_A0.6790.34
54_I100_N0.6780.34
16_M116_D0.6750.33
21_E44_I0.6720.33
41_S57_K0.6710.33
28_A52_L0.6700.33
61_T67_T0.6610.32
9_W39_F0.6600.32
19_F114_I0.6560.32
9_W41_S0.6550.32
24_F115_E0.6540.32
9_W121_L0.6530.32
20_Y120_N0.6520.32
33_H101_G0.6520.32
22_S47_D0.6500.32
9_W72_A0.6500.32
4_E50_A0.6480.32
33_H37_K0.6450.31
34_N46_F0.6450.31
86_E90_R0.6450.31
99_V121_L0.6450.31
113_V116_D0.6420.31
27_E47_D0.6400.31
8_V93_A0.6370.31
9_W117_D0.6340.31
39_F57_K0.6290.30
42_Y54_I0.6180.29
56_K74_I0.6170.29
84_V103_R0.6130.29
23_Y91_L0.6110.29
22_S65_S0.6100.29
29_N87_L0.6070.29
82_E104_T0.6030.29
7_A88_T0.5990.28
37_K57_K0.5970.28
5_H107_D0.5940.28
8_V74_I0.5930.28
64_P76_F0.5900.28
72_A120_N0.5900.28
34_N37_K0.5880.28
91_L94_D0.5850.27
6_T104_T0.5830.27
63_P86_E0.5790.27
27_E82_E0.5780.27
35_E56_K0.5780.27
26_G40_K0.5770.27
68_M121_L0.5760.27
21_E28_A0.5760.27
58_G86_E0.5620.26
19_F113_V0.5590.26
29_N76_F0.5570.26
72_A122_I0.5570.26
5_H84_V0.5570.26
105_T110_Y0.5550.25
4_E39_F0.5530.25
9_W56_K0.5520.25
39_F43_F0.5490.25
22_S62_D0.5430.25
27_E86_E0.5430.25
24_F30_D0.5340.24
67_T81_R0.5320.24
22_S90_R0.5310.24
63_P74_I0.5290.24
76_F101_G0.5280.24
38_D68_M0.5270.24
24_F63_P0.5240.24
56_K118_E0.5230.24
75_A109_Y0.5160.23
84_V107_D0.5160.23
103_R107_D0.5150.23
47_D81_R0.5140.23
36_K60_V0.5130.23
77_S105_T0.5130.23
44_I74_I0.5130.23
101_G110_Y0.5120.23
37_K58_G0.5100.23
57_K69_T0.5080.23
19_F112_S0.5050.23
20_Y31_L0.5050.23
8_V31_L0.5040.22
87_L124_I0.5020.22
55_M115_E0.5020.22
56_K125_T0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e5dA 2 1 99.9 0.628 Contact Map
2rbbA 2 0.9444 99.8 0.683 Contact Map
1xqaA 2 0.881 99.8 0.696 Contact Map
3kolA 2 0.9683 99.8 0.697 Contact Map
4mtsA 2 0.9603 99.8 0.7 Contact Map
1f9zA 2 0.9603 99.8 0.7 Contact Map
3w0tA 2 0.9683 99.7 0.705 Contact Map
1ss4A 4 0.9683 99.7 0.714 Contact Map
3rheA 2 0.8889 99.7 0.714 Contact Map
2rk0A 4 0.9603 99.7 0.715 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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