GREMLIN Database
MAA - Probable maltose O-acetyltransferase
UniProt: P37515 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 184 (155)
Sequences: 6468 (4645)
Seq/√Len: 373.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_I95_V4.0861.00
76_H96_R3.1731.00
86_D106_G3.0671.00
109_I131_V3.0351.00
80_H100_H2.8381.00
135_D153_D2.7871.00
134_G153_D2.7161.00
136_Q154_N2.5781.00
79_D99_C2.5651.00
132_T150_T2.3141.00
146_N159_S2.2801.00
78_G99_C2.2561.00
56_S76_H2.2401.00
25_E73_Y2.1751.00
110_Y141_G2.1091.00
42_D45_V1.9231.00
111_T130_P1.9131.00
34_R38_E1.8721.00
139_I145_I1.8261.00
58_G79_D1.8191.00
134_G150_T1.7611.00
81_T101_C1.7321.00
60_Q80_H1.6511.00
77_I81_T1.6471.00
96_R132_T1.5801.00
55_G58_G1.5791.00
76_H94_E1.5421.00
57_V61_V1.5411.00
64_L82_F1.5311.00
109_I112_A1.4811.00
112_A128_G1.4791.00
139_I143_A1.4681.00
81_T99_C1.4631.00
47_T51_K1.4631.00
74_H94_E1.4591.00
93_C128_G1.4401.00
83_V87_C1.4321.00
32_L52_E1.4131.00
109_I133_I1.4121.00
38_E58_G1.4011.00
116_L156_V1.3931.00
97_I103_I1.3311.00
100_H136_Q1.3291.00
103_I109_I1.3221.00
54_L63_I1.3211.00
28_H32_L1.2861.00
56_S77_I1.2521.00
75_I89_I1.2461.00
35_Q40_P1.2451.00
117_D120_E1.2211.00
98_G135_D1.2141.00
98_G116_L1.2141.00
137_V155_A1.2081.00
83_V89_I1.2001.00
144_V159_S1.1941.00
61_V77_I1.1801.00
56_S59_D1.1781.00
131_V149_V1.1731.00
133_I139_I1.1611.00
146_N164_T1.1431.00
133_I137_V1.1331.00
151_I155_A1.1291.00
29_A53_L1.1251.00
99_C135_D1.1031.00
72_G75_I1.0751.00
77_I97_I1.0661.00
143_A161_S1.0661.00
108_H142_R1.0601.00
45_V48_K1.0471.00
77_I83_V1.0461.00
78_G98_G1.0431.00
20_Q24_L1.0271.00
31_Q40_P1.0261.00
59_D79_D1.0241.00
137_V153_D1.0121.00
84_N102_L1.0121.00
49_L53_L0.9931.00
34_R41_E0.9921.00
99_C116_L0.9921.00
121_R138_W0.9831.00
29_A33_I0.9801.00
7_E11_A0.9801.00
88_V106_G0.9781.00
50_L54_L0.9771.00
21_Q25_E0.9611.00
14_L127_F0.9591.00
96_R113_G0.9561.00
103_I107_V0.9521.00
34_R40_P0.9321.00
69_C75_I0.9321.00
47_T67_F0.9281.00
60_Q79_D0.9261.00
106_G142_R0.9191.00
90_L110_Y0.9141.00
116_L135_D0.9121.00
108_H141_G0.8951.00
84_N90_L0.8941.00
105_P124_G0.8871.00
40_P58_G0.8861.00
97_I101_C0.8821.00
100_H117_D0.8781.00
61_V81_T0.8751.00
54_L57_V0.8621.00
158_A161_S0.8601.00
118_P153_D0.8551.00
136_Q153_D0.8551.00
36_Y50_L0.8491.00
82_F102_L0.8371.00
115_P135_D0.8251.00
31_Q41_E0.8231.00
35_Q45_V0.8171.00
137_V152_G0.8151.00
113_G129_K0.8131.00
103_I139_I0.8111.00
35_Q52_E0.8101.00
113_G132_T0.8091.00
113_G127_F0.8071.00
23_L26_R0.8061.00
101_C153_D0.7981.00
134_G155_A0.7961.00
106_G125_K0.7961.00
97_I109_I0.7921.00
43_D66_T0.7901.00
109_I145_I0.7851.00
117_D136_Q0.7781.00
81_T98_G0.7711.00
145_I151_I0.7601.00
83_V103_I0.7601.00
151_I157_I0.7601.00
40_P55_G0.7571.00
78_G116_L0.7541.00
7_E14_L0.7541.00
39_T42_D0.7501.00
81_T97_I0.7501.00
78_G81_T0.7391.00
36_Y45_V0.7381.00
108_H144_V0.7381.00
51_K55_G0.7341.00
14_L125_K0.7331.00
107_V143_A0.7301.00
27_K30_R0.7281.00
143_A159_S0.7251.00
13_E16_N0.7241.00
143_A157_I0.7131.00
51_K67_F0.7090.99
55_G76_H0.7080.99
110_Y129_K0.7050.99
81_T135_D0.7010.99
22_L26_R0.6970.99
134_G152_G0.6970.99
36_Y65_P0.6950.99
21_Q24_L0.6920.99
48_K52_E0.6910.99
150_T153_D0.6900.99
68_R86_D0.6860.99
133_I145_I0.6840.99
46_R50_L0.6830.99
32_L53_L0.6780.99
51_K57_V0.6740.99
97_I133_I0.6710.99
78_G101_C0.6660.99
113_G116_L0.6640.99
32_L49_L0.6610.99
118_P137_V0.6570.99
39_T62_T0.6520.99
118_P121_R0.6520.99
44_A47_T0.6520.99
63_I83_V0.6520.99
161_S164_T0.6460.99
28_H52_E0.6450.99
58_G61_V0.6450.99
39_T45_V0.6320.99
75_I95_V0.6320.99
98_G101_C0.6320.99
125_K142_R0.6310.99
88_V108_H0.6290.99
68_R85_F0.6270.99
30_R33_I0.6230.99
127_F142_R0.6200.99
67_F75_I0.6180.99
27_K31_Q0.6150.99
31_Q34_R0.6130.99
128_G131_V0.6090.98
46_R49_L0.6070.98
22_L25_E0.6040.98
64_L85_F0.6030.98
36_Y49_L0.6000.98
131_V148_G0.5970.98
53_L71_Y0.5960.98
72_G90_L0.5880.98
32_L35_Q0.5860.98
19_D22_L0.5850.98
81_T116_L0.5850.98
90_L108_H0.5840.98
43_D47_T0.5820.98
144_V160_G0.5820.98
53_L56_S0.5800.98
54_L69_C0.5770.98
47_T50_L0.5750.98
119_I138_W0.5740.98
62_T82_F0.5720.98
57_V79_D0.5680.98
10_A93_C0.5680.98
39_T49_L0.5650.98
88_V105_P0.5560.97
34_R44_A0.5560.97
115_P132_T0.5550.97
24_L27_K0.5530.97
87_C107_V0.5510.97
129_K148_G0.5500.97
158_A164_T0.5490.97
138_W156_V0.5490.97
145_I149_V0.5470.97
31_Q35_Q0.5460.97
33_I69_C0.5370.97
101_C135_D0.5340.97
110_Y144_V0.5300.96
86_D108_H0.5300.96
149_V165_K0.5290.96
25_E28_H0.5280.96
130_P148_G0.5230.96
118_P154_N0.5210.96
94_E130_P0.5200.96
38_E41_E0.5200.96
144_V162_V0.5200.96
94_E111_T0.5160.96
87_C103_I0.5150.96
30_R64_L0.5090.95
15_Y112_A0.5070.95
70_D86_D0.5060.95
28_H31_Q0.5040.95
141_G144_V0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3srtA 3 1 100 0.201 Contact Map
3hjjA 3 1 100 0.204 Contact Map
2p2oA 3 0.9891 100 0.207 Contact Map
1krrA 3 0.9946 100 0.209 Contact Map
3nz2A 4 0.9946 100 0.211 Contact Map
3fttA 3 0.9891 100 0.211 Contact Map
1ocxA 3 0.9837 100 0.24 Contact Map
2v0hA 3 0.9728 100 0.433 Contact Map
4g3qA 3 0.9891 100 0.433 Contact Map
3vbiA 3 0.7772 99.9 0.44 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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