GREMLIN Database
YYAK - Uncharacterized protein YyaK
UniProt: P37513 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (252)
Sequences: 3574 (3128)
Seq/√Len: 197.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_G212_L5.3771.00
183_T219_T4.8501.00
222_T231_S4.3351.00
157_T236_A4.0201.00
169_L223_I3.6831.00
188_G212_L3.4061.00
221_Y234_A3.2031.00
191_G211_Y3.1981.00
183_T223_I3.1191.00
214_F218_W3.0231.00
191_G215_G2.9541.00
207_A211_Y2.8981.00
238_N242_L2.8441.00
187_G212_L2.6971.00
187_G216_F2.4611.00
228_I232_L2.4431.00
227_S230_I2.4261.00
164_F193_L2.3231.00
169_L219_T2.2941.00
158_S232_L2.2901.00
111_I115_L2.2581.00
186_V219_T2.2551.00
153_V240_M2.2021.00
187_G219_T2.1781.00
173_G223_I2.0771.00
183_T216_F2.0441.00
282_A286_L2.0421.00
81_L85_F2.0071.00
157_T239_N1.9621.00
179_P183_T1.9411.00
222_T225_T1.9251.00
153_V156_Q1.9091.00
107_S111_I1.9071.00
181_F185_I1.8831.00
196_A207_A1.8721.00
236_A240_M1.8681.00
232_L236_A1.8231.00
122_L126_V1.8091.00
170_Q173_G1.7811.00
220_Y224_K1.7481.00
207_A210_E1.7411.00
177_K181_F1.7411.00
154_P236_A1.7381.00
156_Q236_A1.7231.00
169_L182_L1.7051.00
153_V157_T1.6921.00
80_W84_R1.6651.00
221_Y230_I1.6031.00
172_F185_I1.5561.00
221_Y231_S1.5531.00
179_P223_I1.5431.00
216_F219_T1.5351.00
218_W234_A1.5301.00
164_F190_F1.5221.00
180_L184_L1.4941.00
166_G227_S1.4871.00
169_L186_V1.4811.00
166_G228_I1.4791.00
233_G237_A1.4641.00
229_E232_L1.4221.00
191_G208_G1.4091.00
194_H239_N1.4021.00
104_R108_F1.3941.00
283_G286_L1.3851.00
194_H235_H1.3841.00
82_A86_I1.3771.00
170_Q222_T1.3181.00
227_S231_S1.2931.00
170_Q174_R1.2831.00
169_L173_G1.2781.00
222_T227_S1.2651.00
173_G182_L1.2621.00
182_L186_V1.2551.00
265_G268_M1.2451.00
206_W210_E1.2251.00
211_Y215_G1.1961.00
176_T181_F1.1901.00
22_L26_G1.1841.00
154_P229_E1.1831.00
173_G226_G1.1791.00
204_A207_A1.1741.00
196_A211_Y1.1681.00
273_F277_V1.1631.00
156_Q239_N1.1631.00
277_V280_V1.1561.00
187_G191_G1.1521.00
76_I162_L1.1461.00
168_L186_V1.1411.00
128_H131_S1.1401.00
219_T223_I1.1301.00
28_Y32_N1.1251.00
169_L222_T1.1231.00
210_E238_N1.1191.00
215_G219_T1.1041.00
113_Y237_A1.0991.00
210_E242_L1.0991.00
30_L33_I1.0951.00
164_F189_L1.0921.00
20_A24_M1.0751.00
79_V82_A1.0721.00
222_T230_I1.0691.00
24_M28_Y1.0691.00
162_L232_L1.0531.00
210_E213_T1.0501.00
100_K104_R1.0451.00
152_L156_Q1.0391.00
176_T185_I1.0371.00
279_L283_G1.0201.00
270_E273_F1.0191.00
184_L216_F1.0181.00
118_I246_I1.0151.00
190_F194_H1.0141.00
154_P157_T1.0061.00
159_A163_F0.9991.00
110_F114_F0.9981.00
206_W209_I0.9931.00
209_I213_T0.9931.00
76_I80_W0.9901.00
74_F77_P0.9871.00
142_F146_L0.9851.00
166_G222_T0.9730.99
156_Q232_L0.9730.99
208_G211_Y0.9700.99
190_F211_Y0.9690.99
80_W83_V0.9660.99
89_R93_T0.9650.99
222_T226_G0.9570.99
84_R87_L0.9570.99
24_M27_L0.9380.99
216_F220_Y0.9320.99
113_Y117_M0.9290.99
65_L68_S0.9280.99
179_P182_L0.9270.99
267_P270_E0.9270.99
160_E194_H0.9230.99
262_V270_E0.9230.99
274_T278_N0.8980.99
207_A242_L0.8980.99
172_F176_T0.8900.99
17_Y23_V0.8880.99
186_V215_G0.8850.99
155_I239_N0.8790.99
187_G215_G0.8720.99
79_V83_V0.8700.99
280_V284_I0.8680.99
147_A151_I0.8670.99
90_P93_T0.8630.99
157_T196_A0.8530.99
164_F168_L0.8490.99
17_Y20_A0.8470.99
271_A274_T0.8470.99
18_F22_L0.8460.99
156_Q159_A0.8440.98
174_R182_L0.8390.98
76_I79_V0.8380.98
18_F21_F0.8370.98
229_E233_G0.8370.98
166_G169_L0.8350.98
218_W231_S0.8340.98
109_G233_G0.8340.98
281_F285_A0.8230.98
167_F171_A0.8210.98
157_T232_L0.8200.98
37_F41_F0.8180.98
171_A222_T0.8170.98
131_S134_M0.8130.98
155_I159_A0.8130.98
272_F276_A0.8100.98
80_W85_F0.8100.98
129_P133_S0.8090.98
58_L62_L0.8090.98
263_T270_E0.8080.98
105_R227_S0.8050.98
182_L219_T0.8050.98
177_K182_L0.8040.98
180_L220_Y0.8040.98
112_A116_L0.8030.98
75_A78_G0.7960.98
71_I75_A0.7940.98
190_F193_L0.7920.98
281_F284_I0.7910.98
180_L183_T0.7900.98
208_G212_L0.7880.98
81_L84_R0.7870.98
37_F40_L0.7870.98
72_Y76_I0.7840.98
20_A23_V0.7820.98
176_T182_L0.7820.98
92_R95_I0.7780.97
85_F89_R0.7700.97
165_R190_F0.7700.97
105_R225_T0.7640.97
79_V84_R0.7630.97
263_T268_M0.7630.97
25_V29_V0.7620.97
23_V30_L0.7570.97
276_A279_L0.7560.97
260_F268_M0.7550.97
158_S229_E0.7530.97
160_E235_H0.7530.97
277_V281_F0.7520.97
206_W213_T0.7480.97
276_A280_V0.7450.97
27_L31_G0.7440.97
103_W107_S0.7440.97
118_I122_L0.7420.97
187_G193_L0.7380.96
60_D63_V0.7360.96
157_T204_A0.7350.96
44_I81_L0.7320.96
190_F235_H0.7310.96
211_Y238_N0.7270.96
263_T266_N0.7230.96
261_T266_N0.7230.96
129_P132_Y0.7200.96
171_A174_R0.7190.96
218_W222_T0.7190.96
275_I282_A0.7120.96
72_Y159_A0.7100.96
268_M272_F0.7050.95
266_N270_E0.6970.95
225_T230_I0.6970.95
212_L219_T0.6960.95
19_F22_L0.6930.95
166_G170_Q0.6920.95
233_G239_N0.6910.95
149_A243_C0.6870.95
31_G35_Y0.6860.95
153_V243_C0.6830.95
27_L33_I0.6790.94
133_S205_V0.6760.94
87_L167_F0.6740.94
226_G231_S0.6740.94
109_G238_N0.6710.94
195_F208_G0.6710.94
105_R113_Y0.6710.94
259_L262_V0.6670.94
261_T265_G0.6660.94
32_N39_I0.6660.94
42_T46_N0.6660.94
92_R97_P0.6610.94
146_L150_L0.6600.94
158_S236_A0.6560.93
184_L187_G0.6550.93
223_I227_S0.6550.93
163_F190_F0.6490.93
101_M104_R0.6480.93
114_F118_I0.6480.93
180_L216_F0.6450.93
26_G29_V0.6430.93
117_M120_V0.6420.93
274_T277_V0.6380.92
183_T220_Y0.6370.92
66_Y70_V0.6350.92
181_F184_L0.6340.92
186_V222_T0.6340.92
164_F207_A0.6330.92
237_A242_L0.6330.92
278_N281_F0.6320.92
193_L243_C0.6290.92
38_A59_S0.6280.92
61_P65_L0.6250.92
243_C250_N0.6250.92
59_S62_L0.6230.91
21_F28_Y0.6220.91
141_R145_L0.6210.91
107_S205_V0.6200.91
224_K230_I0.6200.91
102_N227_S0.6200.91
260_F270_E0.6200.91
163_F211_Y0.6190.91
109_G113_Y0.6150.91
70_V73_L0.6140.91
68_S71_I0.6140.91
128_H271_A0.6140.91
148_A152_L0.6120.91
154_P158_S0.6100.91
279_L282_A0.6060.90
139_A148_A0.6040.90
33_I37_F0.6040.90
82_A167_F0.6030.90
204_A211_Y0.6030.90
18_F26_G0.6000.90
277_V285_A0.5980.90
238_N241_F0.5980.90
262_V271_A0.5960.90
190_F239_N0.5950.89
240_M244_M0.5940.89
17_Y28_Y0.5910.89
220_Y230_I0.5890.89
115_L118_I0.5880.89
192_V208_G0.5860.89
33_I36_L0.5860.89
95_I162_L0.5830.89
108_F115_L0.5830.89
259_L263_T0.5820.88
192_V195_F0.5820.88
111_I118_I0.5820.88
196_A220_Y0.5800.88
271_A280_V0.5800.88
208_G213_T0.5780.88
116_L234_A0.5780.88
72_Y79_V0.5770.88
245_F248_E0.5770.88
38_A42_T0.5760.88
175_L178_N0.5750.88
145_L244_M0.5740.88
160_E215_G0.5730.88
92_R96_T0.5720.88
153_V242_L0.5690.87
280_V283_G0.5670.87
153_V164_F0.5670.87
36_L40_L0.5670.87
151_I228_I0.5660.87
220_Y281_F0.5650.87
259_L271_A0.5650.87
156_Q222_T0.5640.87
146_L244_M0.5590.86
42_T48_N0.5560.86
72_Y77_P0.5540.86
79_V159_A0.5520.86
275_I278_N0.5510.86
234_A240_M0.5490.85
260_F263_T0.5490.85
169_L183_T0.5480.85
234_A237_A0.5470.85
262_V266_N0.5460.85
172_F177_K0.5460.85
116_L120_V0.5450.85
275_I279_L0.5450.85
153_V236_A0.5420.85
266_N269_W0.5400.84
271_A277_V0.5380.84
75_A79_V0.5380.84
164_F187_G0.5370.84
279_L285_A0.5370.84
104_R184_L0.5360.84
19_F23_V0.5350.84
139_A146_L0.5350.84
60_D64_D0.5340.84
149_A240_M0.5340.84
64_D67_L0.5330.84
76_I83_V0.5320.84
78_G237_A0.5320.84
73_L206_W0.5310.83
71_I78_G0.5300.83
211_Y239_N0.5260.83
118_I121_Q0.5260.83
153_V244_M0.5250.83
24_M36_L0.5250.83
228_I231_S0.5240.83
220_Y223_I0.5220.82
36_L42_T0.5180.82
43_V49_I0.5170.82
81_L107_S0.5160.82
21_F25_V0.5160.82
172_F182_L0.5140.81
187_G208_G0.5140.81
69_H76_I0.5110.81
91_F96_T0.5090.81
78_G85_F0.5090.81
62_L254_G0.5080.81
262_V268_M0.5080.81
243_C246_I0.5070.81
115_L267_P0.5070.81
282_A285_A0.5070.81
175_L191_G0.5060.80
35_Y77_P0.5050.80
73_L132_Y0.5050.80
191_G207_A0.5040.80
264_R269_W0.5040.80
18_F25_V0.5030.80
172_F208_G0.5020.80
32_N35_Y0.5010.80
272_F283_G0.5010.80
171_A186_V0.5010.80
230_I233_G0.5000.80
151_I156_Q0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cadC 1 0.796 99.9 0.523 Contact Map
3kcuA 3 0.806 52.8 0.926 Contact Map
2onkC 2 0.8127 34.2 0.934 Contact Map
4lz6A 1 0.9431 27.5 0.937 Contact Map
3klyA 3 0.8094 26.8 0.937 Contact Map
2m20A 2 0.1237 23.4 0.939 Contact Map
2ks1B 1 0.1438 22.5 0.939 Contact Map
3d31C 2 0.8094 20.6 0.94 Contact Map
2kluA 1 0.1472 18.4 0.942 Contact Map
2jwaA 2 0.1438 18.1 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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