GREMLIN Database
YYAM - Uncharacterized transporter YyaM
UniProt: P37511 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (276)
Sequences: 38723 (28214)
Seq/√Len: 1698.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_G159_I3.4391.00
9_M238_Q2.8861.00
96_N156_D2.7691.00
263_S268_T2.6181.00
238_Q242_E2.6021.00
45_A191_V2.5261.00
87_V158_I2.5161.00
127_G284_G2.5121.00
38_A198_I2.4931.00
84_L161_T2.4341.00
23_L223_F2.3451.00
107_L163_N2.2261.00
118_D174_R2.1901.00
238_Q241_K2.1821.00
63_L66_N2.1821.00
111_L171_V2.0961.00
84_L158_I2.0661.00
25_K268_T2.0261.00
113_R120_M1.9591.00
18_G258_V1.9561.00
43_L225_A1.9161.00
42_G194_A1.9091.00
98_A259_T1.9041.00
80_G165_C1.9021.00
24_A86_F1.8981.00
157_L161_T1.8931.00
10_L239_G1.8821.00
92_T156_D1.8691.00
215_I219_G1.8671.00
49_L187_T1.8421.00
112_A118_D1.8291.00
108_T249_S1.8061.00
109_A128_I1.7971.00
50_I53_I1.7891.00
225_A230_V1.7671.00
103_L107_L1.7661.00
92_T155_G1.7011.00
91_Y154_G1.6541.00
286_L290_G1.6521.00
195_V199_V1.6481.00
121_T124_Q1.6451.00
45_A194_A1.6441.00
18_G262_I1.6401.00
66_N179_D1.6291.00
84_L165_C1.6101.00
181_T184_S1.5891.00
19_A223_F1.5731.00
244_G247_K1.5731.00
107_L167_A1.5551.00
15_I258_V1.5511.00
214_P217_V1.5501.00
131_A253_N1.5441.00
199_V202_L1.5391.00
38_A194_A1.5311.00
111_L115_I1.4951.00
65_K69_S1.4941.00
127_G288_A1.4851.00
271_K274_Q1.4811.00
13_F239_G1.4761.00
272_V276_I1.4261.00
97_G159_I1.4261.00
153_S156_D1.4181.00
31_F217_V1.4091.00
49_L53_I1.4011.00
68_V72_V1.3841.00
107_L164_V1.3761.00
94_P263_S1.3721.00
92_T96_N1.3701.00
65_K68_V1.3621.00
275_V279_V1.3591.00
87_V91_Y1.3541.00
137_L280_L1.3511.00
112_A116_L1.3281.00
173_G237_N1.3281.00
16_F227_F1.3231.00
51_I55_T1.3181.00
64_R68_V1.3171.00
47_V230_V1.3151.00
71_I192_I1.2991.00
46_A50_I1.2981.00
22_N262_I1.2971.00
27_T36_S1.2901.00
9_M235_W1.2891.00
36_S224_M1.2871.00
50_I54_F1.2821.00
122_K126_L1.2671.00
95_V260_M1.2661.00
44_A190_M1.2661.00
93_S96_N1.2651.00
91_Y158_I1.2641.00
125_V129_F1.2631.00
17_T232_G1.2551.00
127_G287_T1.2491.00
279_V283_L1.2481.00
26_Y220_A1.2471.00
72_V172_L1.2441.00
137_L273_F1.2441.00
131_A284_G1.2391.00
87_V90_K1.2351.00
258_V262_I1.2301.00
216_G219_G1.2271.00
134_G277_G1.2211.00
99_L278_A1.2201.00
111_L168_L1.2171.00
30_Y217_V1.2141.00
215_I218_W1.2141.00
69_S172_L1.2111.00
64_R67_A1.2071.00
254_L258_V1.2051.00
167_A171_V1.1941.00
210_L213_I1.1921.00
129_F133_I1.1901.00
270_I275_V1.1891.00
138_V277_G1.1741.00
219_G223_F1.1701.00
196_S199_V1.1611.00
153_S157_L1.1601.00
38_A42_G1.1601.00
75_I196_S1.1491.00
174_R244_G1.1471.00
175_R178_K1.1441.00
45_A187_T1.1431.00
38_A201_S1.1431.00
123_K287_T1.1361.00
108_T245_A1.1261.00
7_Y251_F1.1231.00
32_S35_S1.1101.00
116_L171_V1.1061.00
25_K29_G1.1041.00
109_A120_M1.0951.00
8_I12_G1.0911.00
120_M125_V1.0901.00
91_Y155_G1.0891.00
79_F196_S1.0851.00
89_L97_G1.0751.00
154_G158_I1.0731.00
40_R229_S1.0711.00
174_R178_K1.0711.00
100_I163_N1.0591.00
34_S200_V1.0551.00
111_L167_A1.0531.00
13_F17_T1.0521.00
111_L164_V1.0521.00
19_A262_I1.0501.00
79_F197_L1.0501.00
23_L220_A1.0461.00
240_I248_T1.0401.00
24_A89_L1.0341.00
12_G235_W1.0301.00
174_R245_A1.0281.00
91_Y152_I1.0271.00
94_P266_V1.0241.00
74_G192_I1.0201.00
17_T236_W1.0201.00
13_F235_W1.0131.00
66_N180_G1.0041.00
240_I244_G1.0041.00
113_R119_N1.0031.00
30_Y214_P1.0021.00
118_D124_Q0.9991.00
16_F235_W0.9971.00
108_T170_G0.9941.00
134_G281_V0.9901.00
123_K291_V0.9861.00
122_K125_V0.9851.00
27_T217_V0.9831.00
216_G220_A0.9831.00
37_A86_F0.9821.00
33_P37_A0.9791.00
219_G222_A0.9771.00
114_I117_K0.9771.00
123_K290_G0.9721.00
119_N123_K0.9681.00
100_I156_D0.9651.00
222_A225_A0.9641.00
92_T159_I0.9621.00
121_T125_V0.9601.00
103_L135_V0.9541.00
35_S201_S0.9541.00
154_G157_L0.9541.00
133_I137_L0.9531.00
218_W222_A0.9481.00
94_P268_T0.9441.00
100_I159_I0.9431.00
69_S73_L0.9401.00
155_G159_I0.9401.00
34_S83_A0.9381.00
244_G248_T0.9371.00
163_N167_A0.9371.00
85_F89_L0.9291.00
68_V71_I0.9241.00
130_F284_G0.9201.00
47_V226_F0.9181.00
111_L114_I0.9071.00
99_L136_L0.9061.00
27_T220_A0.9021.00
69_S176_F0.9021.00
200_V204_T0.9021.00
140_T271_K0.9011.00
136_L140_T0.8981.00
243_I248_T0.8951.00
67_A192_I0.8921.00
272_V275_V0.8831.00
108_T167_A0.8771.00
41_F193_G0.8661.00
78_I169_Y0.8661.00
200_V203_F0.8641.00
22_N263_S0.8561.00
199_V203_F0.8551.00
119_N122_K0.8511.00
14_S18_G0.8511.00
76_I168_L0.8491.00
72_V75_I0.8401.00
14_S258_V0.8361.00
66_N69_S0.8321.00
76_I165_C0.8301.00
42_G198_I0.8301.00
56_E59_K0.8291.00
53_I56_E0.8291.00
49_L191_V0.8261.00
276_I280_L0.8241.00
11_L258_V0.8231.00
47_V50_I0.8231.00
243_I247_K0.8211.00
239_G248_T0.8211.00
107_L160_F0.8181.00
227_F231_L0.8121.00
254_L257_V0.8121.00
37_A197_L0.8061.00
257_V278_A0.8041.00
70_Y180_G0.8041.00
79_F83_A0.8031.00
192_I195_V0.7971.00
83_A87_V0.7951.00
175_R179_D0.7931.00
222_A226_F0.7931.00
106_L131_A0.7931.00
126_L130_F0.7931.00
260_M270_I0.7891.00
191_V195_V0.7841.00
214_P218_W0.7831.00
133_I280_L0.7831.00
137_L276_I0.7821.00
110_I114_I0.7771.00
168_L172_L0.7771.00
69_S175_R0.7731.00
63_L67_A0.7731.00
202_L205_S0.7691.00
284_G288_A0.7681.00
187_T191_V0.7671.00
135_V139_I0.7631.00
48_M230_V0.7601.00
278_A282_I0.7541.00
166_W170_G0.7521.00
88_G97_G0.7501.00
260_M278_A0.7501.00
273_F276_I0.7451.00
45_A49_L0.7441.00
100_I160_F0.7431.00
220_A223_F0.7421.00
140_T143_S0.7391.00
152_I156_D0.7381.00
113_R117_K0.7381.00
10_L251_F0.7301.00
283_L287_T0.7291.00
52_L187_T0.7271.00
14_S254_L0.7231.00
159_I163_N0.7211.00
71_I74_G0.7211.00
81_F165_C0.7191.00
109_A124_Q0.7171.00
70_Y74_G0.7101.00
203_F206_K0.7081.00
51_I183_L0.7071.00
270_I274_Q0.7051.00
47_V225_A0.7021.00
217_V220_A0.7011.00
22_N94_P0.7011.00
69_S72_V0.7001.00
108_T171_V0.6991.00
192_I196_S0.6951.00
209_S212_N0.6941.00
186_T237_N0.6901.00
151_S154_G0.6871.00
103_L106_L0.6821.00
130_F287_T0.6811.00
76_I172_L0.6801.00
231_L235_W0.6781.00
79_F200_V0.6761.00
166_W236_W0.6761.00
221_I225_A0.6751.00
10_L243_I0.6751.00
120_M124_Q0.6741.00
43_L47_V0.6741.00
62_Q66_N0.6741.00
78_I233_Y0.6731.00
21_F85_F0.6721.00
20_T228_T0.6671.00
42_G46_A0.6661.00
31_F36_S0.6661.00
74_G79_F0.6651.00
223_F227_F0.6591.00
26_Y266_V0.6591.00
35_S39_W0.6591.00
51_I54_F0.6571.00
81_F169_Y0.6571.00
92_T97_G0.6551.00
115_I168_L0.6551.00
24_A28_V0.6521.00
80_G84_L0.6521.00
85_F97_G0.6501.00
105_P253_N0.6501.00
118_D246_S0.6481.00
39_W43_L0.6471.00
191_V194_A0.6411.00
102_G135_V0.6401.00
188_Y192_I0.6381.00
16_F232_G0.6361.00
134_G284_G0.6351.00
67_A188_Y0.6341.00
116_L174_R0.6311.00
84_L162_G0.6301.00
7_Y247_K0.6241.00
78_I193_G0.6221.00
85_F162_G0.6191.00
67_A71_I0.6161.00
193_G197_L0.6141.00
99_L139_I0.6141.00
262_I265_A0.6141.00
250_L288_A0.6131.00
186_T189_T0.6111.00
21_F98_A0.6111.00
184_S188_Y0.6101.00
158_I161_T0.6091.00
71_I75_I0.6081.00
194_A198_I0.6081.00
182_P186_T0.6071.00
274_Q278_A0.6071.00
234_L238_Q0.6041.00
208_V211_S0.6031.00
170_G236_W0.6021.00
180_G185_T0.5991.00
52_L56_E0.5981.00
44_A230_V0.5931.00
12_G16_F0.5911.00
109_A113_R0.5861.00
139_I156_D0.5841.00
71_I196_S0.5841.00
103_L163_N0.5841.00
34_S197_L0.5831.00
195_V198_I0.5731.00
14_S255_V0.5731.00
63_L68_V0.5731.00
70_Y185_T0.5721.00
169_Y237_N0.5721.00
16_F228_T0.5711.00
67_A70_Y0.5711.00
102_G105_P0.5691.00
263_S266_V0.5691.00
88_G155_G0.5671.00
78_I189_T0.5671.00
269_P273_F0.5661.00
55_T181_T0.5651.00
28_V89_L0.5621.00
282_I286_L0.5621.00
170_G249_S0.5601.00
22_N259_T0.5601.00
214_P219_G0.5591.00
124_Q244_G0.5591.00
21_F25_K0.5581.00
102_G163_N0.5571.00
18_G255_V0.5551.00
99_L138_V0.5551.00
112_A246_S0.5551.00
253_N285_V0.5541.00
116_L175_R0.5531.00
271_K275_V0.5521.00
188_Y191_V0.5511.00
110_I128_I0.5481.00
66_N70_Y0.5471.00
269_P274_Q0.5461.00
7_Y11_L0.5431.00
81_F166_W0.5411.00
285_V288_A0.5401.00
20_T86_F0.5341.00
34_S204_T0.5341.00
164_V168_L0.5321.00
239_G243_I0.5321.00
202_L206_K0.5311.00
126_L133_I0.5261.00
52_L184_S0.5261.00
103_L131_A0.5241.00
86_F90_K0.5221.00
78_I82_N0.5221.00
37_A83_A0.5181.00
39_W221_I0.5181.00
11_L14_S0.5181.00
132_F136_L0.5161.00
32_S205_S0.5161.00
235_W238_Q0.5141.00
50_I55_T0.5131.00
141_Q273_F0.5111.00
46_A49_L0.5111.00
31_F35_S0.5111.00
201_S205_S0.5101.00
169_Y189_T0.5091.00
252_F255_V0.5071.00
121_T291_V0.5051.00
106_L132_F0.5051.00
19_A228_T0.5051.00
55_T59_K0.5041.00
40_R82_N0.5031.00
81_F85_F0.5001.00
17_T255_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2492 98.4 0.787 Contact Map
3b5dA 2 0.3311 98.3 0.792 Contact Map
1pw4A 1 0.9705 57 0.917 Contact Map
4j05A 3 0.9377 52 0.92 Contact Map
4tphA 2 0.8885 41.6 0.924 Contact Map
3wdoA 1 0.9443 38.8 0.926 Contact Map
4pypA 1 0.918 38.3 0.926 Contact Map
4he8J 1 0.5082 35.3 0.928 Contact Map
1u7gA 3 0.7672 28.2 0.931 Contact Map
4ldsA 2 0.5607 23.8 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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