GREMLIN Database
YYAN - Uncharacterized HTH-type transcriptional regulator YyaN
UniProt: P37510 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 138 (113)
Sequences: 12836 (8986)
Seq/√Len: 845.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_T46_D3.9651.00
18_Y25_K3.1211.00
100_T110_K3.0321.00
22_Y26_I2.9651.00
17_S21_R2.5021.00
96_I100_T2.3051.00
103_L107_E2.1311.00
35_K41_F2.1261.00
57_K63_L2.0131.00
54_K57_K1.9851.00
7_S11_E1.9311.00
26_I67_N1.8491.00
95_R98_I1.8451.00
9_A50_M1.7961.00
9_A47_I1.7841.00
93_N117_I1.7611.00
49_F70_V1.7291.00
89_S93_N1.7001.00
89_S107_E1.6931.00
4_Y41_F1.6921.00
88_L91_S1.6791.00
62_S65_D1.6331.00
110_K114_E1.5381.00
8_K11_E1.4971.00
107_E110_K1.4561.00
5_S41_F1.4531.00
6_I21_R1.4481.00
93_N103_L1.4121.00
28_L53_L1.4011.00
5_S8_K1.3951.00
99_L103_L1.3921.00
102_H105_K1.2961.00
98_I102_H1.2951.00
13_T50_M1.2941.00
100_T103_L1.2941.00
9_A46_D1.2881.00
24_E30_P1.2651.00
101_K105_K1.1941.00
96_I114_E1.1941.00
65_D68_E1.1871.00
67_N71_K1.1711.00
96_I99_L1.1571.00
87_Q90_P1.1571.00
10_A17_S1.1421.00
97_E100_T1.1371.00
16_S19_T1.1251.00
23_Y50_M1.1051.00
33_K43_T1.1011.00
54_K58_E1.0861.00
104_E107_E1.0851.00
53_L66_I1.0831.00
20_L42_Y1.0791.00
26_I64_E1.0651.00
33_K41_F1.0601.00
12_K47_I1.0601.00
32_P46_D1.0401.00
5_S39_R1.0371.00
13_T47_I1.0301.00
93_N97_E1.0251.00
19_T22_Y1.0041.00
97_E101_K0.9821.00
20_L50_M0.9681.00
24_E29_L0.9661.00
22_Y63_L0.9481.00
29_L53_L0.9481.00
8_K12_K0.9471.00
92_I117_I0.9461.00
93_N96_I0.9441.00
61_M69_F0.9181.00
109_K112_E0.9141.00
98_I101_K0.9011.00
4_Y12_K0.9001.00
90_P94_K0.8871.00
64_E67_N0.8721.00
85_S88_L0.8701.00
104_E108_I0.8641.00
89_S103_L0.8641.00
13_T20_L0.8421.00
47_I51_L0.8401.00
4_Y44_E0.8331.00
101_K104_E0.8321.00
44_E48_Q0.8251.00
49_F77_E0.8211.00
52_F56_L0.8161.00
29_L46_D0.8061.00
12_K51_L0.7921.00
6_I10_A0.7871.00
94_K97_E0.7871.00
12_K44_E0.7791.00
50_M57_K0.7781.00
94_K98_I0.7771.00
34_R37_S0.7731.00
33_K46_D0.7691.00
86_A110_K0.7581.00
20_L24_E0.7571.00
108_I112_E0.7561.00
80_N83_V0.7541.00
10_A20_L0.7451.00
93_N107_E0.7441.00
115_E119_T0.7441.00
91_S94_K0.7401.00
48_Q51_L0.7391.00
106_M110_K0.7261.00
51_L55_S0.7241.00
35_K39_R0.7201.00
15_I50_M0.7181.00
88_L92_I0.7111.00
100_T114_E0.7061.00
68_E71_K0.7001.00
7_S17_S0.6991.00
31_P34_R0.6981.00
27_G30_P0.6981.00
19_T57_K0.6971.00
100_T104_E0.6951.00
114_E118_S0.6871.00
15_I54_K0.6781.00
58_E105_K0.6721.00
103_L110_K0.6621.00
65_D95_R0.6581.00
115_E118_S0.6571.00
16_S22_Y0.6501.00
24_E31_P0.6381.00
60_G102_H0.6351.00
56_L61_M0.6331.00
60_G95_R0.6321.00
37_S41_F0.6311.00
102_H109_K0.6271.00
107_E111_R0.6231.00
9_A29_L0.6191.00
95_R102_H0.6181.00
24_E42_Y0.6101.00
24_E32_P0.6101.00
57_K62_S0.6071.00
90_P93_N0.6071.00
88_L95_R0.6061.00
86_A89_S0.6041.00
84_K87_Q0.6011.00
6_I17_S0.6011.00
22_Y25_K0.6011.00
82_D86_A0.6001.00
26_I63_L0.5991.00
86_A114_E0.5991.00
15_I19_T0.5911.00
9_A13_T0.5901.00
116_V119_T0.5841.00
58_E102_H0.5831.00
111_R115_E0.5801.00
19_T63_L0.5771.00
112_E115_E0.5741.00
63_L66_I0.5731.00
18_Y52_F0.5681.00
88_L102_H0.5651.00
51_L54_K0.5621.00
13_T17_S0.5621.00
91_S95_R0.5581.00
18_Y22_Y0.5551.00
46_D49_F0.5531.00
96_I103_L0.5451.00
96_I110_K0.5431.00
112_E116_V0.5431.00
45_T48_Q0.5381.00
96_I117_I0.5361.00
87_Q91_S0.5311.00
35_K38_G0.5291.00
81_S85_S0.5271.00
102_H106_M0.5171.00
4_Y47_I0.5141.00
89_S92_I0.5131.00
95_R99_L0.5101.00
84_K88_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qaoA 2 0.942 99.9 0.223 Contact Map
3gp4A 4 0.9275 99.9 0.224 Contact Map
3hh0A 4 0.971 99.9 0.233 Contact Map
3gpvA 2 0.8406 99.9 0.246 Contact Map
2vz4A 2 0.7246 99.9 0.275 Contact Map
2dg6A 2 0.8768 99.9 0.277 Contact Map
1q06A 2 0.8986 99.9 0.277 Contact Map
1r8dA 2 0.7899 99.9 0.278 Contact Map
4ua1A 2 0.9058 99.9 0.295 Contact Map
2zhgA 2 0.8333 99.9 0.296 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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