GREMLIN Database
YYAP - Uncharacterized protein YyaP
UniProt: P37508 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 188 (169)
Sequences: 5627 (3771)
Seq/√Len: 290.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_I182_I4.0381.00
54_R58_D3.5181.00
168_K185_H3.2061.00
134_I142_F3.0121.00
12_L130_I2.9521.00
170_V185_H2.6531.00
105_N108_E2.6091.00
84_K100_I2.4121.00
22_I127_A2.3431.00
141_E183_V2.3201.00
128_S132_T2.2931.00
112_K116_N2.2801.00
88_F129_L2.2611.00
8_R118_G2.2581.00
49_T86_Y2.1831.00
12_L139_V2.1821.00
107_L136_L2.1701.00
9_R141_E2.1561.00
109_E112_K2.0971.00
156_P159_I2.0571.00
19_D152_G2.0171.00
102_I109_E2.0131.00
11_I120_D1.9901.00
25_K153_E1.9671.00
9_R120_D1.9411.00
95_I101_F1.8861.00
141_E185_H1.8581.00
137_G186_W1.8501.00
8_R117_P1.8441.00
89_S101_F1.8131.00
171_N183_V1.7891.00
92_Q101_F1.7731.00
112_K115_K1.6481.00
46_Q120_D1.5871.00
24_G28_E1.5231.00
48_D119_K1.5151.00
167_L186_W1.5011.00
18_L167_L1.4971.00
89_S92_Q1.4201.00
143_R183_V1.4131.00
147_H179_V1.4021.00
139_V142_F1.3861.00
107_L111_N1.3671.00
23_E155_K1.3641.00
86_Y102_I1.3511.00
49_T84_K1.3451.00
56_S125_G1.3071.00
24_G164_R1.3071.00
104_D108_E1.2981.00
156_P160_D1.2941.00
111_N115_K1.2901.00
88_F109_E1.2831.00
169_M182_I1.2581.00
10_I110_V1.2471.00
78_K82_S1.2291.00
150_V167_L1.2251.00
93_N103_N1.2201.00
42_D45_N1.2081.00
84_K116_N1.2061.00
14_L22_I1.1791.00
55_K128_S1.1711.00
58_D62_Q1.1691.00
41_T45_N1.1501.00
95_I99_A1.1341.00
88_F102_I1.1301.00
9_R185_H1.1201.00
36_P39_G1.1151.00
169_M172_T1.1001.00
49_T121_I1.0891.00
21_F156_P1.0721.00
143_R181_Q1.0661.00
16_V146_I1.0641.00
28_E31_W1.0621.00
108_E112_K1.0581.00
108_E111_N1.0521.00
131_T135_N1.0451.00
59_L63_Y1.0401.00
142_F167_L1.0371.00
169_M180_V1.0361.00
54_R90_R1.0321.00
15_A147_H1.0211.00
145_S181_Q1.0171.00
90_R128_S1.0061.00
79_L83_K1.0001.00
142_F186_W0.9901.00
110_V133_F0.9901.00
10_I114_K0.9891.00
86_Y116_N0.9771.00
35_D39_G0.9761.00
16_V22_I0.9731.00
104_D112_K0.9721.00
17_T151_L0.9641.00
35_D38_M0.9621.00
171_N174_T0.9621.00
135_N161_V0.9511.00
170_V183_V0.9471.00
145_S179_V0.9451.00
134_I139_V0.9341.00
16_V144_L0.9331.00
153_E160_D0.9311.00
27_G55_K0.9291.00
14_L127_A0.9151.00
135_N162_K0.9131.00
42_D46_Q0.9111.00
11_I143_R0.9021.00
48_D120_D0.8981.00
129_L132_T0.8941.00
114_K121_I0.8871.00
123_L139_V0.8841.00
34_M166_N0.8791.00
131_T159_I0.8711.00
106_I136_L0.8601.00
51_L88_F0.8551.00
44_L83_K0.8551.00
51_L110_V0.8491.00
135_N160_D0.8391.00
52_Y60_W0.8371.00
12_L126_G0.8351.00
173_R181_Q0.8271.00
47_I122_W0.8271.00
175_F181_Q0.8251.00
57_F61_G0.8231.00
132_T136_L0.8201.00
137_G165_I0.8191.00
54_R92_Q0.8141.00
27_G155_K0.8091.00
180_V184_Y0.8071.00
86_Y100_I0.7970.99
127_A131_T0.7940.99
24_G30_D0.7920.99
23_E29_V0.7820.99
90_R132_T0.7780.99
24_G27_G0.7700.99
169_M184_Y0.7700.99
8_R48_D0.7660.99
13_D143_R0.7650.99
52_Y126_G0.7590.99
113_L117_P0.7580.99
123_L133_F0.7410.99
40_F43_F0.7350.99
89_S93_N0.7250.99
172_T180_V0.7240.99
8_R49_T0.7170.99
13_D43_F0.7150.99
10_I133_F0.7130.99
130_I139_V0.7070.99
144_L157_L0.7060.99
94_E101_F0.7040.99
40_F44_L0.6980.99
88_F106_I0.6930.98
102_I105_N0.6920.98
90_R104_D0.6860.98
61_G64_I0.6860.98
43_F46_Q0.6840.98
86_Y109_E0.6840.98
135_N163_Q0.6840.98
50_I83_K0.6810.98
55_K58_D0.6740.98
10_I123_L0.6740.98
43_F143_R0.6730.98
166_N169_M0.6720.98
51_L133_F0.6720.98
150_V165_I0.6710.98
109_E113_L0.6660.98
62_Q65_P0.6620.98
167_L184_Y0.6610.98
132_T135_N0.6610.98
141_E170_V0.6600.98
42_D173_R0.6580.98
48_D117_P0.6470.98
14_L130_I0.6470.98
54_R91_T0.6440.98
100_I109_E0.6360.97
14_L126_G0.6310.97
38_M179_V0.6310.97
91_T95_I0.6300.97
103_N109_E0.6290.97
102_I106_I0.6270.97
45_N79_L0.6270.97
134_I186_W0.6200.97
59_L62_Q0.6200.97
13_D124_Y0.6160.97
172_T182_I0.6150.97
161_V164_R0.6110.97
49_T118_G0.6100.97
15_A32_C0.6080.97
29_V59_L0.6070.97
14_L157_L0.6050.96
85_K98_Q0.6020.96
48_D121_I0.5980.96
174_T178_G0.5950.96
104_D109_E0.5940.96
18_L150_V0.5920.96
161_V165_I0.5890.96
106_I132_T0.5870.96
23_E28_E0.5870.96
15_A40_F0.5870.96
100_I116_N0.5830.96
102_I112_K0.5800.96
163_Q166_N0.5800.96
23_E27_G0.5780.95
58_D61_G0.5760.95
13_D122_W0.5690.95
111_N136_L0.5690.95
48_D118_G0.5690.95
21_F155_K0.5680.95
175_F178_G0.5680.95
52_Y79_L0.5670.95
61_G65_P0.5660.95
46_Q143_R0.5660.95
123_L126_G0.5650.95
174_T180_V0.5620.95
58_D92_Q0.5610.95
128_S155_K0.5610.95
105_N109_E0.5600.95
13_D40_F0.5590.95
133_F138_L0.5580.94
22_I155_K0.5580.94
127_A155_K0.5570.94
31_W34_M0.5560.94
41_T44_L0.5530.94
13_D145_S0.5510.94
50_I124_Y0.5500.94
105_N111_N0.5480.94
85_K99_A0.5460.94
85_K97_N0.5450.94
21_F153_E0.5450.94
13_D32_C0.5440.94
50_I122_W0.5420.94
43_F47_I0.5410.94
60_W85_K0.5410.94
78_K81_H0.5400.93
128_S131_T0.5400.93
35_D177_S0.5400.93
121_I125_G0.5380.93
91_T94_E0.5360.93
35_D176_S0.5320.93
56_S126_G0.5290.93
64_I97_N0.5200.92
146_I180_V0.5160.92
86_Y118_G0.5160.92
33_I147_H0.5150.92
39_G43_F0.5110.92
44_L79_L0.5110.92
60_W124_Y0.5100.91
15_A126_G0.5080.91
120_D123_L0.5060.91
36_P176_S0.5050.91
30_D34_M0.5050.91
106_I133_F0.5030.91
131_T134_I0.5010.91
53_G56_S0.5000.91
23_E127_A0.5000.91
11_I122_W0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gd9A 2 0.9521 100 0.31 Contact Map
3jtwA 2 0.9096 100 0.374 Contact Map
3ky8A 2 0.9309 100 0.39 Contact Map
3kgyA 2 0.9255 100 0.391 Contact Map
2xw7A 2 0.8777 100 0.393 Contact Map
3nrrA 2 0.8883 100 0.408 Contact Map
3qg2A 2 0.9149 100 0.413 Contact Map
1cz3A 2 0.867 100 0.417 Contact Map
3ix9A 2 0.8511 100 0.421 Contact Map
3zpgA 2 0.9787 100 0.425 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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