GREMLIN Database
YYAQ - Uncharacterized protein YyaQ
UniProt: P37507 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 118 (114)
Sequences: 409 (333)
Seq/√Len: 31.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_T41_Y7.4781.00
11_V32_L4.2661.00
34_H117_T3.8261.00
26_Y29_Y3.3451.00
21_Y30_A3.0571.00
8_F32_L2.8501.00
15_Y111_E2.5321.00
10_H111_E2.4700.99
42_G63_L2.1920.99
12_K18_S2.1160.98
78_G105_E2.0800.98
73_D90_E2.0440.98
64_N94_S1.9930.97
7_I110_I1.8310.96
77_N80_N1.7770.95
47_V82_L1.7300.94
8_F11_V1.6000.91
8_F44_I1.5880.91
4_R61_D1.5750.90
11_V41_Y1.5630.90
81_I109_L1.5150.89
49_P56_G1.4980.88
31_S43_L1.4550.87
84_G89_K1.4530.86
22_P43_L1.3770.83
23_W29_Y1.3250.81
31_S84_G1.3150.80
67_C72_S1.3040.80
67_C112_Q1.2930.79
13_E110_I1.2460.77
88_D91_H1.2440.76
106_I110_I1.2390.76
6_D103_E1.2380.76
65_L93_I1.2150.75
98_E101_D1.2030.74
62_I84_G1.1870.73
23_W43_L1.1860.73
7_I63_L1.1830.73
19_P30_A1.1670.72
11_V42_G1.1410.70
25_K29_Y1.1270.69
52_L82_L1.1010.67
19_P32_L1.0820.66
65_L95_I1.0820.66
63_L94_S1.0540.64
108_N111_E1.0470.63
69_P91_H1.0330.62
29_Y45_M1.0200.61
20_D23_W1.0180.61
16_G106_I1.0120.60
55_D106_I1.0110.60
67_C93_I0.9810.58
29_Y46_N0.9780.58
48_L84_G0.9630.57
76_R90_E0.9590.56
34_H114_F0.9450.55
8_F51_K0.9450.55
49_P58_G0.9380.55
49_P60_I0.9310.54
32_L66_K0.9290.54
22_P64_N0.9150.53
69_P116_L0.9040.52
101_D105_E0.8990.51
64_N84_G0.8980.51
6_D9_K0.8810.50
10_H94_S0.8740.49
72_S76_R0.8720.49
18_S74_R0.8550.48
7_I83_P0.8550.48
103_E107_Y0.8400.47
23_W47_V0.8380.46
81_I93_I0.8360.46
10_H14_K0.8360.46
48_L51_K0.8160.45
98_E104_G0.8120.44
22_P27_P0.8110.44
25_K51_K0.8090.44
18_S52_L0.7960.43
8_F21_Y0.7960.43
83_P110_I0.7920.43
71_I112_Q0.7870.42
53_G56_G0.7840.42
9_K13_E0.7810.42
52_L116_L0.7720.41
57_H72_S0.7670.41
84_G110_I0.7660.41
23_W30_A0.7650.41
70_E73_D0.7310.38
67_C81_I0.7230.37
54_L110_I0.7190.37
73_D76_R0.7180.37
67_C71_I0.7150.37
48_L63_L0.7150.37
6_D107_Y0.7140.37
47_V62_I0.7040.36
46_N59_E0.7020.36
66_K117_T0.7010.36
28_N38_K0.6990.36
34_H80_N0.6970.35
11_V17_T0.6940.35
33_R117_T0.6920.35
10_H107_Y0.6910.35
15_Y72_S0.6890.35
19_P66_K0.6810.34
23_W94_S0.6800.34
36_S95_I0.6790.34
31_S37_N0.6780.34
79_E102_P0.6700.34
31_S88_D0.6650.33
48_L56_G0.6600.33
62_I111_E0.6570.33
7_I106_I0.6560.33
71_I74_R0.6550.32
50_E56_G0.6520.32
26_Y46_N0.6380.31
76_R116_L0.6370.31
55_D108_N0.6350.31
45_M109_L0.6310.31
42_G60_I0.6300.31
51_K89_K0.6290.31
38_K102_P0.6290.31
78_G114_F0.6210.30
17_T32_L0.6210.30
9_K78_G0.6190.30
7_I36_S0.6180.30
5_E44_I0.6140.30
8_F41_Y0.5990.29
28_N35_T0.5990.29
16_G64_N0.5960.28
70_E91_H0.5930.28
65_L78_G0.5910.28
68_P80_N0.5880.28
17_T117_T0.5880.28
24_E110_I0.5870.28
47_V64_N0.5860.28
58_G115_H0.5820.27
81_I103_E0.5740.27
34_H106_I0.5690.27
47_V52_L0.5660.26
15_Y102_P0.5650.26
28_N46_N0.5610.26
44_I108_N0.5600.26
63_L108_N0.5600.26
59_E79_E0.5540.26
67_C73_D0.5510.26
5_E109_L0.5470.25
35_T57_H0.5470.25
13_E57_H0.5420.25
20_D43_L0.5420.25
20_D33_R0.5410.25
47_V85_Y0.5410.25
4_R54_L0.5340.24
74_R90_E0.5340.24
67_C109_L0.5330.24
72_S89_K0.5330.24
34_H43_L0.5320.24
39_K51_K0.5320.24
13_E94_S0.5320.24
11_V116_L0.5290.24
26_Y64_N0.5270.24
38_K111_E0.5240.24
14_K110_I0.5210.24
68_P104_G0.5180.24
69_P115_H0.5170.23
80_N99_R0.5160.23
59_E63_L0.5090.23
81_I101_D0.5050.23
37_N49_P0.5040.23
87_M116_L0.5020.23
38_K57_H0.5000.23
16_G57_H0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kfpA 1 0.9915 100 0.34 Contact Map
2a1vA 1 0.8983 100 0.49 Contact Map
2fkiA 1 0.8729 99.9 0.524 Contact Map
2od0A 2 0.8051 95.8 0.878 Contact Map
1sc3B 2 0.6356 29.9 0.939 Contact Map
2i8dA 2 0.8136 20.4 0.943 Contact Map
3pvlA 1 0.8475 13.9 0.947 Contact Map
3rjmB 2 0.6356 13.1 0.948 Contact Map
2oc6A 1 0.822 11.5 0.949 Contact Map
2dkoB 2 0.678 10.6 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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