GREMLIN Database
YYAR - Uncharacterized protein YyaR
UniProt: P37506 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 173 (137)
Sequences: 3545 (2885)
Seq/√Len: 246.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_Y106_V3.4781.00
108_T143_K3.4281.00
115_I146_F2.9251.00
69_L76_C2.5261.00
108_T144_H2.5091.00
113_K116_E2.4311.00
80_I114_A2.3671.00
115_I171_Y2.3361.00
115_I126_L2.2291.00
133_I164_E2.1971.00
125_G170_Y2.1391.00
132_D165_I2.1351.00
148_I167_I2.1251.00
142_A148_I2.0811.00
77_I101_Y2.0191.00
67_A81_K1.9961.00
102_R136_S1.9301.00
112_H144_H1.9071.00
149_G170_Y1.8941.00
36_T54_D1.8551.00
139_H142_A1.8281.00
111_L144_H1.8161.00
71_Y76_C1.7541.00
148_I151_V1.7531.00
103_K136_S1.7511.00
78_G97_V1.7231.00
97_V106_V1.7131.00
117_W120_E1.6621.00
149_G168_F1.6271.00
80_I92_I1.6251.00
138_C142_A1.5651.00
117_W121_N1.5191.00
132_D167_I1.4981.00
38_T41_R1.4901.00
68_F113_K1.4891.00
72_L77_I1.4781.00
159_F164_E1.4731.00
72_L101_Y1.4331.00
71_Y74_N1.4081.00
151_V165_I1.3671.00
82_I114_A1.3631.00
135_I138_C1.3621.00
129_E166_A1.3091.00
90_A118_A1.2901.00
156_Y166_A1.2751.00
127_M170_Y1.2511.00
119_K171_Y1.2341.00
101_Y104_K1.2131.00
75_N98_A1.1931.00
66_A117_W1.1291.00
129_E156_Y1.1191.00
128_L141_Y1.0811.00
75_N100_D1.0681.00
70_Y78_G1.0511.00
83_R91_L1.0511.00
127_M149_G1.0451.00
53_D56_D1.0371.00
105_G108_T1.0321.00
118_A126_L1.0311.00
108_T112_H1.0271.00
34_V38_T1.0181.00
155_L166_A1.0181.00
88_G124_C1.0041.00
42_F46_Y1.0001.00
81_K93_E0.9971.00
46_Y99_K0.9961.00
91_L127_M0.9871.00
80_I110_L0.9861.00
137_A141_Y0.9811.00
72_L104_K0.9801.00
82_I118_A0.9791.00
132_D151_V0.9671.00
66_A121_N0.9571.00
113_K117_W0.9561.00
130_T134_N0.9551.00
77_I106_V0.9531.00
138_C148_I0.9361.00
126_L146_F0.9301.00
148_I169_W0.9171.00
79_R94_D0.9091.00
152_D168_F0.9051.00
109_A112_H0.9041.00
38_T42_F0.9041.00
72_L75_N0.9001.00
89_Y127_M0.8991.00
37_Y40_E0.8991.00
89_Y152_D0.8951.00
68_F117_W0.8931.00
111_L146_F0.8891.00
34_V37_Y0.8871.00
140_F144_H0.8841.00
135_I139_H0.8710.99
39_E42_F0.8610.99
142_A169_W0.8580.99
59_Y81_K0.8570.99
115_I144_H0.8500.99
79_R96_A0.8440.99
82_I90_A0.8270.99
97_V107_G0.8240.99
83_R93_E0.8160.99
103_K107_G0.8150.99
57_V79_R0.8000.99
130_T137_A0.7940.99
70_Y77_I0.7880.99
75_N101_Y0.7850.99
47_F96_A0.7830.99
118_A123_F0.7810.99
130_T141_Y0.7740.99
89_Y125_G0.7730.99
129_E155_L0.7660.99
116_E120_E0.7650.99
142_A147_I0.7640.99
47_F102_R0.7620.99
131_Q164_E0.7610.99
151_V167_I0.7590.99
85_N88_G0.7500.98
40_E45_P0.7430.98
99_K102_R0.7400.98
59_Y65_K0.7340.98
109_A113_K0.7310.98
154_M160_P0.7270.98
81_K94_D0.7270.98
46_Y98_A0.7260.98
102_R107_G0.7220.98
91_L94_D0.7210.98
34_V71_Y0.7170.98
138_C167_I0.7160.98
147_I170_Y0.7150.98
130_T169_W0.7120.98
46_Y50_Y0.7100.98
129_E152_D0.7090.98
70_Y110_L0.7040.98
68_F80_I0.7020.98
50_Y157_S0.7000.98
70_Y109_A0.6970.97
44_K47_F0.6950.97
37_Y76_C0.6900.97
138_C169_W0.6880.97
125_G149_G0.6880.97
67_A93_E0.6810.97
43_S47_F0.6700.97
135_I142_A0.6690.97
44_K48_K0.6690.97
95_I111_L0.6650.97
103_K139_H0.6650.97
32_N61_E0.6540.96
153_T165_I0.6490.96
31_E34_V0.6480.96
140_F143_K0.6360.96
157_S160_P0.6340.96
45_P99_K0.6330.96
153_T156_Y0.6240.95
112_H116_E0.6220.95
131_Q156_Y0.6220.95
103_K108_T0.6200.95
70_Y97_V0.6190.95
91_L152_D0.6160.95
134_N137_A0.6150.95
40_E43_S0.6150.95
65_K83_R0.6140.95
107_G115_I0.6100.95
110_L114_A0.6050.94
132_D138_C0.6010.94
85_N121_N0.6010.94
128_L137_A0.5920.94
85_N123_F0.5870.93
116_E119_K0.5820.93
90_A123_F0.5810.93
34_V39_E0.5780.93
79_R130_T0.5780.93
39_E43_S0.5780.93
101_Y106_V0.5710.93
47_F51_E0.5700.92
129_E164_E0.5690.92
80_I118_A0.5680.92
56_D93_E0.5670.92
88_G150_A0.5660.92
115_I140_F0.5640.92
168_F171_Y0.5610.92
90_A126_L0.5570.92
68_F71_Y0.5570.92
86_W168_F0.5540.91
154_M165_I0.5520.91
51_E57_V0.5510.91
35_W39_E0.5480.91
82_I126_L0.5430.91
98_A101_Y0.5370.90
57_V81_K0.5370.90
57_V62_E0.5340.90
152_D166_A0.5250.89
45_P48_K0.5240.89
127_M168_F0.5220.89
59_Y67_A0.5190.89
77_I98_A0.5180.88
81_K92_I0.5140.88
45_P50_Y0.5130.88
158_N164_E0.5130.88
160_P164_E0.5130.88
152_D156_Y0.5100.88
131_Q158_N0.5070.87
71_Y75_N0.5060.87
116_E124_C0.5050.87
80_I111_L0.5050.87
136_S139_H0.5010.87
50_Y159_F0.5010.87
34_V42_F0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2reeA 1 0.8728 99.9 0.388 Contact Map
3dr6A 2 0.8613 99.9 0.406 Contact Map
2ob0A 1 0.8671 99.9 0.407 Contact Map
2cntA 1 0.8439 99.9 0.408 Contact Map
4kvxA 1 0.8266 99.9 0.409 Contact Map
4h89A 2 0.8844 99.9 0.41 Contact Map
4pv6C 3 0.8555 99.9 0.411 Contact Map
2j8mA 2 0.8613 99.9 0.413 Contact Map
4l8aA 1 0.8613 99.9 0.421 Contact Map
4ua3A 1 0.9769 99.9 0.424 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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