YYAS - BACSU - GREMLIN Contacts

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YYAS - Uncharacterized protein YyaS

UniProt:	P37505	Sequences: MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLTVGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSKLICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLAIIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	201 (186)
Sequences:	1924 (1481)
Seq/√Len:	108.6

BACSU - YYAS YCZE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
44_T	84_D	4.672	1.00
50_V	80_G	4.512	1.00
114_G	181_L	3.643	1.00
99_L	169_I	2.677	1.00
115_L	185_F	2.627	1.00
43_L	51_L	2.606	1.00
44_T	47_S	2.578	1.00
18_S	86_W	2.560	1.00
32_A	160_A	2.534	1.00
14_S	82_G	2.509	1.00
20_T	109_G	2.501	1.00
37_L	48_W	2.460	1.00
15_L	86_W	2.312	1.00
99_L	168_G	2.261	1.00
21_I	45_V	2.114	1.00
19_L	108_I	2.112	1.00
12_I	116_G	2.107	1.00
35_V	166_P	2.031	1.00
99_L	103_L	2.014	1.00
81_I	85_L	1.951	1.00
144_T	147_F	1.951	1.00
184_V	188_I	1.935	1.00
16_G	112_L	1.915	1.00
154_A	175_V	1.901	1.00
53_S	76_A	1.841	1.00
9_G	116_G	1.834	1.00
11_L	86_W	1.723	1.00
18_S	87_L	1.708	1.00
146_L	183_H	1.701	1.00
127_S	135_L	1.694	1.00
45_V	83_I	1.673	1.00
24_G	102_K	1.662	1.00
110_L	173_L	1.644	1.00
143_R	147_F	1.624	1.00
16_G	113_I	1.613	1.00
11_L	82_G	1.608	1.00
7_G	74_I	1.581	1.00
113_I	174_T	1.527	1.00
158_V	162_I	1.521	1.00
9_G	123_T	1.473	1.00
36_G	164_K	1.459	1.00
31_D	34_L	1.453	1.00
138_R	141_S	1.430	1.00
181_L	185_F	1.422	1.00
115_L	119_I	1.419	1.00
43_L	48_W	1.415	1.00
75_T	126_A	1.397	1.00
17_I	31_D	1.391	1.00
173_L	177_L	1.390	1.00
47_S	51_L	1.379	1.00
106_F	170_G	1.378	1.00
56_L	133_L	1.367	1.00
59_C	133_L	1.340	1.00
100_L	104_I	1.322	0.99
149_R	153_Y	1.304	0.99
30_F	156_F	1.292	0.99
17_I	83_I	1.275	0.99
22_Q	87_L	1.254	0.99
14_S	18_S	1.249	0.99
8_I	119_I	1.248	0.99
30_F	153_Y	1.246	0.99
71_L	126_A	1.246	0.99
111_V	181_L	1.239	0.99
47_S	81_I	1.218	0.99
106_F	110_L	1.211	0.99
16_G	116_G	1.208	0.99
96_L	102_K	1.200	0.99
154_A	158_V	1.187	0.99
118_A	185_F	1.183	0.99
77_F	81_I	1.180	0.99
84_D	88_F	1.176	0.99
21_I	35_V	1.175	0.99
8_I	12_I	1.162	0.99
36_G	160_A	1.155	0.99
148_S	152_V	1.128	0.98
34_L	52_I	1.121	0.98
65_R	140_L	1.115	0.98
53_S	153_Y	1.110	0.98
13_L	116_G	1.109	0.98
85_L	88_F	1.101	0.98
104_I	108_I	1.086	0.98
28_S	33_L	1.075	0.98
14_S	86_W	1.071	0.98
23_S	109_G	1.071	0.98
151_L	155_L	1.063	0.98
30_F	130_I	1.062	0.98
161_I	167_I	1.059	0.97
14_S	79_T	1.053	0.97
46_G	84_D	1.045	0.97
66_K	139_D	1.036	0.97
13_L	117_T	1.012	0.97
82_G	85_L	1.009	0.97
150_T	154_A	1.005	0.97
178_G	182_L	1.002	0.96
29_P	175_V	1.000	0.96
158_V	161_I	0.975	0.96
6_Y	69_I	0.972	0.96
71_L	74_I	0.969	0.96
69_I	75_T	0.967	0.96
12_I	119_I	0.958	0.95
50_V	81_I	0.942	0.95
117_T	182_L	0.940	0.95
137_I	141_S	0.927	0.95
53_S	129_P	0.927	0.95
43_L	47_S	0.918	0.94
35_V	39_K	0.912	0.94
118_A	186_M	0.904	0.94
49_E	83_I	0.898	0.94
47_S	84_D	0.892	0.93
75_T	128_T	0.884	0.93
32_A	36_G	0.882	0.93
126_A	160_A	0.882	0.93
157_L	167_I	0.880	0.93
19_L	86_W	0.871	0.93
107_G	111_V	0.870	0.92
121_L	127_S	0.864	0.92
61_A	68_P	0.862	0.92
73_L	111_V	0.860	0.92
118_A	122_Q	0.855	0.92
122_Q	189_V	0.852	0.92
5_Y	122_Q	0.851	0.92
151_L	154_A	0.849	0.92
20_T	174_T	0.848	0.91
173_L	176_C	0.847	0.91
8_I	70_L	0.834	0.91
114_G	118_A	0.834	0.91
137_I	148_S	0.825	0.90
34_L	49_E	0.821	0.90
188_I	191_R	0.820	0.90
130_I	153_Y	0.815	0.90
76_A	129_P	0.814	0.90
6_Y	123_T	0.814	0.90
23_S	106_F	0.810	0.90
51_L	55_I	0.806	0.89
98_S	101_S	0.806	0.89
104_I	184_V	0.803	0.89
33_L	159_L	0.802	0.89
127_S	132_H	0.798	0.89
141_S	148_S	0.790	0.88
13_L	174_T	0.785	0.88
56_L	156_F	0.784	0.88
71_L	75_T	0.783	0.88
22_Q	90_V	0.780	0.88
118_A	189_V	0.778	0.88
50_V	76_A	0.775	0.87
57_L	76_A	0.774	0.87
5_Y	119_I	0.771	0.87
19_L	105_C	0.771	0.87
36_G	168_G	0.770	0.87
52_I	56_L	0.755	0.86
37_L	51_L	0.743	0.85
73_L	77_F	0.743	0.85
134_T	145_I	0.742	0.85
159_L	162_I	0.740	0.85
148_S	151_L	0.739	0.85
97_N	101_S	0.737	0.85
100_L	103_L	0.734	0.84
181_L	184_V	0.731	0.84
153_Y	156_F	0.729	0.84
175_V	179_G	0.729	0.84
29_P	178_G	0.727	0.84
99_L	102_K	0.726	0.84
13_L	113_I	0.721	0.83
110_L	181_L	0.720	0.83
144_T	183_H	0.718	0.83
25_L	102_K	0.716	0.83
50_V	77_F	0.714	0.83
7_G	70_L	0.714	0.83
67_K	139_D	0.712	0.83
53_S	128_T	0.711	0.82
134_T	153_Y	0.710	0.82
35_V	165_G	0.708	0.82
69_I	132_H	0.699	0.81
58_I	62_I	0.698	0.81
27_T	157_L	0.698	0.81
17_I	79_T	0.694	0.81
119_I	189_V	0.694	0.81
49_E	178_G	0.693	0.81
75_T	130_I	0.692	0.81
154_A	157_L	0.689	0.80
115_L	189_V	0.682	0.80
16_G	109_G	0.680	0.80
27_T	35_V	0.671	0.79
28_S	31_D	0.670	0.79
30_F	131_D	0.668	0.78
23_S	76_A	0.664	0.78
72_G	130_I	0.661	0.78
63_L	136_I	0.659	0.77
121_L	182_L	0.655	0.77
174_T	178_G	0.655	0.77
36_G	165_G	0.649	0.76
33_L	52_I	0.649	0.76
72_G	126_A	0.646	0.76
101_S	104_I	0.645	0.76
91_K	95_Y	0.641	0.75
155_L	159_L	0.639	0.75
69_I	126_A	0.638	0.75
42_G	107_G	0.637	0.75
61_A	69_I	0.631	0.74
55_I	59_C	0.630	0.74
48_W	51_L	0.629	0.74
64_T	67_K	0.627	0.74
110_L	120_Y	0.625	0.74
30_F	34_L	0.624	0.73
59_C	104_I	0.622	0.73
105_C	108_I	0.621	0.73
36_G	163_F	0.619	0.73
143_R	148_S	0.619	0.73
69_I	72_G	0.616	0.73
129_P	132_H	0.616	0.73
23_S	178_G	0.615	0.72
30_F	134_T	0.614	0.72
6_Y	71_L	0.612	0.72
44_T	48_W	0.612	0.72
7_G	78_I	0.611	0.72
74_I	78_I	0.610	0.72
103_L	158_V	0.608	0.72
83_I	87_L	0.607	0.71
86_W	90_V	0.605	0.71
27_T	106_F	0.604	0.71
133_L	137_I	0.600	0.71
126_A	165_G	0.598	0.70
10_I	29_P	0.596	0.70
147_F	150_T	0.594	0.70
53_S	83_I	0.593	0.70
101_S	137_I	0.593	0.70
30_F	129_P	0.589	0.69
184_V	187_P	0.587	0.69
141_S	151_L	0.586	0.69
124_K	190_E	0.580	0.68
34_L	130_I	0.573	0.67
15_L	19_L	0.569	0.67
134_T	152_V	0.568	0.66
24_G	112_L	0.567	0.66
20_T	53_S	0.566	0.66
38_S	45_V	0.565	0.66
33_L	156_F	0.564	0.66
143_R	151_L	0.563	0.66
39_K	97_N	0.561	0.65
17_I	80_G	0.559	0.65
82_G	86_W	0.556	0.65
37_L	42_G	0.549	0.64
4_M	7_G	0.549	0.64
4_M	108_I	0.546	0.63
53_S	134_T	0.546	0.63
32_A	167_I	0.545	0.63
47_S	50_V	0.545	0.63
120_Y	134_T	0.544	0.63
17_I	113_I	0.543	0.63
120_Y	128_T	0.543	0.63
62_I	103_L	0.542	0.63
64_T	136_I	0.542	0.63
177_L	181_L	0.541	0.63
134_T	182_L	0.537	0.62
160_A	164_K	0.536	0.62
113_I	117_T	0.532	0.61
160_A	163_F	0.530	0.61
114_G	183_H	0.530	0.61
36_G	126_A	0.526	0.61
177_L	180_M	0.526	0.61
112_L	115_L	0.525	0.60
114_G	185_F	0.523	0.60
24_G	52_I	0.523	0.60
110_L	177_L	0.522	0.60
54_V	58_I	0.521	0.60
4_M	155_L	0.518	0.59
101_S	108_I	0.517	0.59
6_Y	74_I	0.517	0.59
32_A	165_G	0.513	0.59
53_S	145_I	0.512	0.58
108_I	112_L	0.509	0.58
67_K	140_L	0.507	0.58
142_K	187_P	0.506	0.58
79_T	153_Y	0.505	0.57
7_G	11_L	0.505	0.57
131_D	145_I	0.504	0.57
78_I	82_G	0.503	0.57
187_P	191_R	0.501	0.57
85_L	89_V	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tx3A	2	0.7512	11.6	0.945	Contact Map
2kv5A	1	0.1642	6.1	0.951	Contact Map
4ma7A	1	0.194	3.1	0.958	Contact Map
4mt1A	3	0.8607	3	0.958	Contact Map
5a63C	1	0.4229	2.8	0.959	Contact Map
4av3A	2	0.4726	2.8	0.959	Contact Map
4dx5A	3	0.8856	2.7	0.959	Contact Map
2ra8A	2	0.3184	2.6	0.96	Contact Map
4b19A	1	0.1493	2.5	0.96	Contact Map
2k1eA	3	0.4876	2.3	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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