GREMLIN Database
YYAS - Uncharacterized protein YyaS
UniProt: P37505 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 201 (186)
Sequences: 1924 (1481)
Seq/√Len: 108.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_T84_D4.6721.00
50_V80_G4.5121.00
114_G181_L3.6431.00
99_L169_I2.6771.00
115_L185_F2.6271.00
43_L51_L2.6061.00
44_T47_S2.5781.00
18_S86_W2.5601.00
32_A160_A2.5341.00
14_S82_G2.5091.00
20_T109_G2.5011.00
37_L48_W2.4601.00
15_L86_W2.3121.00
99_L168_G2.2611.00
21_I45_V2.1141.00
19_L108_I2.1121.00
12_I116_G2.1071.00
35_V166_P2.0311.00
99_L103_L2.0141.00
81_I85_L1.9511.00
144_T147_F1.9511.00
184_V188_I1.9351.00
16_G112_L1.9151.00
154_A175_V1.9011.00
53_S76_A1.8411.00
9_G116_G1.8341.00
11_L86_W1.7231.00
18_S87_L1.7081.00
146_L183_H1.7011.00
127_S135_L1.6941.00
45_V83_I1.6731.00
24_G102_K1.6621.00
110_L173_L1.6441.00
143_R147_F1.6241.00
16_G113_I1.6131.00
11_L82_G1.6081.00
7_G74_I1.5811.00
113_I174_T1.5271.00
158_V162_I1.5211.00
9_G123_T1.4731.00
36_G164_K1.4591.00
31_D34_L1.4531.00
138_R141_S1.4301.00
181_L185_F1.4221.00
115_L119_I1.4191.00
43_L48_W1.4151.00
75_T126_A1.3971.00
17_I31_D1.3911.00
173_L177_L1.3901.00
47_S51_L1.3791.00
106_F170_G1.3781.00
56_L133_L1.3671.00
59_C133_L1.3401.00
100_L104_I1.3220.99
149_R153_Y1.3040.99
30_F156_F1.2920.99
17_I83_I1.2750.99
22_Q87_L1.2540.99
14_S18_S1.2490.99
8_I119_I1.2480.99
30_F153_Y1.2460.99
71_L126_A1.2460.99
111_V181_L1.2390.99
47_S81_I1.2180.99
106_F110_L1.2110.99
16_G116_G1.2080.99
96_L102_K1.2000.99
154_A158_V1.1870.99
118_A185_F1.1830.99
77_F81_I1.1800.99
84_D88_F1.1760.99
21_I35_V1.1750.99
8_I12_I1.1620.99
36_G160_A1.1550.99
148_S152_V1.1280.98
34_L52_I1.1210.98
65_R140_L1.1150.98
53_S153_Y1.1100.98
13_L116_G1.1090.98
85_L88_F1.1010.98
104_I108_I1.0860.98
28_S33_L1.0750.98
14_S86_W1.0710.98
23_S109_G1.0710.98
151_L155_L1.0630.98
30_F130_I1.0620.98
161_I167_I1.0590.97
14_S79_T1.0530.97
46_G84_D1.0450.97
66_K139_D1.0360.97
13_L117_T1.0120.97
82_G85_L1.0090.97
150_T154_A1.0050.97
178_G182_L1.0020.96
29_P175_V1.0000.96
158_V161_I0.9750.96
6_Y69_I0.9720.96
71_L74_I0.9690.96
69_I75_T0.9670.96
12_I119_I0.9580.95
50_V81_I0.9420.95
117_T182_L0.9400.95
137_I141_S0.9270.95
53_S129_P0.9270.95
43_L47_S0.9180.94
35_V39_K0.9120.94
118_A186_M0.9040.94
49_E83_I0.8980.94
47_S84_D0.8920.93
75_T128_T0.8840.93
32_A36_G0.8820.93
126_A160_A0.8820.93
157_L167_I0.8800.93
19_L86_W0.8710.93
107_G111_V0.8700.92
121_L127_S0.8640.92
61_A68_P0.8620.92
73_L111_V0.8600.92
118_A122_Q0.8550.92
122_Q189_V0.8520.92
5_Y122_Q0.8510.92
151_L154_A0.8490.92
20_T174_T0.8480.91
173_L176_C0.8470.91
8_I70_L0.8340.91
114_G118_A0.8340.91
137_I148_S0.8250.90
34_L49_E0.8210.90
188_I191_R0.8200.90
130_I153_Y0.8150.90
76_A129_P0.8140.90
6_Y123_T0.8140.90
23_S106_F0.8100.90
51_L55_I0.8060.89
98_S101_S0.8060.89
104_I184_V0.8030.89
33_L159_L0.8020.89
127_S132_H0.7980.89
141_S148_S0.7900.88
13_L174_T0.7850.88
56_L156_F0.7840.88
71_L75_T0.7830.88
22_Q90_V0.7800.88
118_A189_V0.7780.88
50_V76_A0.7750.87
57_L76_A0.7740.87
5_Y119_I0.7710.87
19_L105_C0.7710.87
36_G168_G0.7700.87
52_I56_L0.7550.86
37_L51_L0.7430.85
73_L77_F0.7430.85
134_T145_I0.7420.85
159_L162_I0.7400.85
148_S151_L0.7390.85
97_N101_S0.7370.85
100_L103_L0.7340.84
181_L184_V0.7310.84
153_Y156_F0.7290.84
175_V179_G0.7290.84
29_P178_G0.7270.84
99_L102_K0.7260.84
13_L113_I0.7210.83
110_L181_L0.7200.83
144_T183_H0.7180.83
25_L102_K0.7160.83
50_V77_F0.7140.83
7_G70_L0.7140.83
67_K139_D0.7120.83
53_S128_T0.7110.82
134_T153_Y0.7100.82
35_V165_G0.7080.82
69_I132_H0.6990.81
58_I62_I0.6980.81
27_T157_L0.6980.81
17_I79_T0.6940.81
119_I189_V0.6940.81
49_E178_G0.6930.81
75_T130_I0.6920.81
154_A157_L0.6890.80
115_L189_V0.6820.80
16_G109_G0.6800.80
27_T35_V0.6710.79
28_S31_D0.6700.79
30_F131_D0.6680.78
23_S76_A0.6640.78
72_G130_I0.6610.78
63_L136_I0.6590.77
121_L182_L0.6550.77
174_T178_G0.6550.77
36_G165_G0.6490.76
33_L52_I0.6490.76
72_G126_A0.6460.76
101_S104_I0.6450.76
91_K95_Y0.6410.75
155_L159_L0.6390.75
69_I126_A0.6380.75
42_G107_G0.6370.75
61_A69_I0.6310.74
55_I59_C0.6300.74
48_W51_L0.6290.74
64_T67_K0.6270.74
110_L120_Y0.6250.74
30_F34_L0.6240.73
59_C104_I0.6220.73
105_C108_I0.6210.73
36_G163_F0.6190.73
143_R148_S0.6190.73
69_I72_G0.6160.73
129_P132_H0.6160.73
23_S178_G0.6150.72
30_F134_T0.6140.72
6_Y71_L0.6120.72
44_T48_W0.6120.72
7_G78_I0.6110.72
74_I78_I0.6100.72
103_L158_V0.6080.72
83_I87_L0.6070.71
86_W90_V0.6050.71
27_T106_F0.6040.71
133_L137_I0.6000.71
126_A165_G0.5980.70
10_I29_P0.5960.70
147_F150_T0.5940.70
53_S83_I0.5930.70
101_S137_I0.5930.70
30_F129_P0.5890.69
184_V187_P0.5870.69
141_S151_L0.5860.69
124_K190_E0.5800.68
34_L130_I0.5730.67
15_L19_L0.5690.67
134_T152_V0.5680.66
24_G112_L0.5670.66
20_T53_S0.5660.66
38_S45_V0.5650.66
33_L156_F0.5640.66
143_R151_L0.5630.66
39_K97_N0.5610.65
17_I80_G0.5590.65
82_G86_W0.5560.65
37_L42_G0.5490.64
4_M7_G0.5490.64
4_M108_I0.5460.63
53_S134_T0.5460.63
32_A167_I0.5450.63
47_S50_V0.5450.63
120_Y134_T0.5440.63
17_I113_I0.5430.63
120_Y128_T0.5430.63
62_I103_L0.5420.63
64_T136_I0.5420.63
177_L181_L0.5410.63
134_T182_L0.5370.62
160_A164_K0.5360.62
113_I117_T0.5320.61
160_A163_F0.5300.61
114_G183_H0.5300.61
36_G126_A0.5260.61
177_L180_M0.5260.61
112_L115_L0.5250.60
114_G185_F0.5230.60
24_G52_I0.5230.60
110_L177_L0.5220.60
54_V58_I0.5210.60
4_M155_L0.5180.59
101_S108_I0.5170.59
6_Y74_I0.5170.59
32_A165_G0.5130.59
53_S145_I0.5120.58
108_I112_L0.5090.58
67_K140_L0.5070.58
142_K187_P0.5060.58
79_T153_Y0.5050.57
7_G11_L0.5050.57
131_D145_I0.5040.57
78_I82_G0.5030.57
187_P191_R0.5010.57
85_L89_V0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tx3A 2 0.7512 11.6 0.945 Contact Map
2kv5A 1 0.1642 6.1 0.951 Contact Map
4ma7A 1 0.194 3.1 0.958 Contact Map
4mt1A 3 0.8607 3 0.958 Contact Map
5a63C 1 0.4229 2.8 0.959 Contact Map
4av3A 2 0.4726 2.8 0.959 Contact Map
4dx5A 3 0.8856 2.7 0.959 Contact Map
2ra8A 2 0.3184 2.6 0.96 Contact Map
4b19A 1 0.1493 2.5 0.96 Contact Map
2k1eA 3 0.4876 2.3 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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