GREMLIN Database
YYAT - Uncharacterized protein YyaT
UniProt: P37504 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (130)
Sequences: 3359 (2583)
Seq/√Len: 226.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_E122_Y2.9611.00
60_G93_L2.9601.00
114_A124_I2.6391.00
108_H129_F2.4191.00
20_R34_E2.1161.00
92_G95_E2.1011.00
111_T128_E2.0581.00
128_E135_P2.0031.00
87_K120_L1.9581.00
18_I75_C1.9491.00
14_E51_Y1.8451.00
18_I77_L1.8321.00
90_V120_L1.7971.00
57_V80_Y1.7901.00
94_E141_K1.7801.00
49_L56_P1.7771.00
114_A137_V1.7681.00
50_V85_L1.7431.00
63_R72_E1.7351.00
125_S138_L1.6981.00
21_G77_L1.6691.00
12_L16_L1.6651.00
71_L90_V1.6311.00
51_Y56_P1.6221.00
58_G76_I1.5991.00
21_G25_E1.5881.00
50_V58_G1.5821.00
125_S140_T1.5671.00
59_T75_C1.5271.00
118_Q124_I1.5201.00
87_K119_K1.5071.00
114_A118_Q1.4781.00
96_I100_K1.4701.00
94_E105_Y1.4531.00
129_F138_L1.4351.00
130_M133_G1.3951.00
87_K91_S1.3721.00
115_G118_Q1.3481.00
130_M135_P1.3441.00
65_V70_K1.3311.00
17_K21_G1.3301.00
15_A49_L1.3081.00
108_H138_L1.3041.00
60_G74_I1.2961.00
29_V132_D1.2951.00
27_Q110_Q1.2851.00
33_D132_D1.2841.00
74_I90_V1.2831.00
126_S138_L1.2751.00
29_V134_I1.2721.00
68_T106_K1.2711.00
20_R31_E1.2581.00
48_I96_I1.2521.00
48_I93_L1.2481.00
96_I99_E1.2421.00
55_Q79_P1.2401.00
108_H131_E1.2381.00
46_Q96_I1.2271.00
106_K138_L1.2261.00
16_L35_F1.1991.00
124_I137_V1.1731.00
88_I92_G1.1621.00
15_A59_T1.1221.00
52_H80_Y1.1091.00
20_R24_I1.1081.00
104_S140_T1.0981.00
21_G33_D1.0781.00
64_I102_L1.0591.00
62_A97_M1.0471.00
70_K106_K1.0371.00
98_K141_K1.0341.00
46_Q100_K1.0231.00
111_T114_A1.0111.00
106_K140_T1.0001.00
71_L74_I0.9901.00
80_Y83_Y0.9891.00
26_E81_R0.9861.00
20_R35_F0.9811.00
110_Q136_H0.9761.00
20_R25_E0.9671.00
24_I31_E0.9411.00
10_A14_E0.9371.00
14_E17_K0.9261.00
13_H16_L0.9211.00
91_S95_E0.9161.00
92_G96_I0.9070.99
97_M105_Y0.9050.99
52_H57_V0.8940.99
69_A102_L0.8890.99
38_F63_R0.8850.99
60_G89_I0.8770.99
58_G89_I0.8680.99
95_E99_E0.8650.99
86_G116_F0.8610.99
109_G139_M0.8520.99
37_E43_E0.8500.99
113_A116_F0.8420.99
68_T104_S0.8380.99
63_R70_K0.8370.99
71_L93_L0.8320.99
48_I60_G0.8220.99
57_V85_L0.8180.99
9_E13_H0.8180.99
70_K107_L0.8070.99
30_S33_D0.8020.99
51_Y54_N0.7970.99
88_I91_S0.7960.99
25_E30_S0.7940.99
45_C63_R0.7910.99
111_T135_P0.7780.98
58_G85_L0.7700.98
70_K108_H0.7590.98
52_H83_Y0.7570.98
11_D49_L0.7570.98
77_L80_Y0.7560.98
17_K37_E0.7530.98
55_Q77_L0.7530.98
16_L20_R0.7510.98
91_S120_L0.7470.98
18_I56_P0.7440.98
21_G79_P0.7340.98
62_A96_I0.7150.97
97_M102_L0.7060.97
122_Y141_K0.7050.97
45_C64_I0.6930.97
84_G87_K0.6920.97
123_Q142_E0.6850.96
111_T137_V0.6810.96
105_Y122_Y0.6790.96
114_A128_E0.6680.96
23_F26_E0.6670.96
85_L88_I0.6670.96
71_L122_Y0.6600.96
18_I59_T0.6560.95
30_S34_E0.6520.95
29_V131_E0.6500.95
11_D15_A0.6500.95
23_F110_Q0.6420.95
71_L105_Y0.6420.95
26_E78_K0.6390.95
124_I128_E0.6390.95
50_V88_I0.6370.95
24_I34_E0.6360.95
107_L117_Y0.6340.94
47_H59_T0.6320.94
39_D72_E0.6250.94
20_R30_S0.6230.94
95_E98_K0.6230.94
48_I92_G0.6190.94
94_E120_L0.6150.94
22_V81_R0.6100.93
71_L107_L0.6100.93
36_D61_R0.6070.93
23_F27_Q0.5960.92
50_V57_V0.5960.92
61_R73_R0.5910.92
89_I92_G0.5880.92
83_Y86_G0.5800.91
13_H35_F0.5800.91
48_I62_A0.5800.91
72_E110_Q0.5790.91
69_A97_M0.5770.91
131_E134_I0.5760.91
127_Q137_V0.5690.91
118_Q123_Q0.5680.91
33_D131_E0.5650.90
104_S142_E0.5650.90
128_E137_V0.5640.90
58_G86_G0.5600.90
82_K87_K0.5590.90
76_I85_L0.5570.90
37_E44_Q0.5560.90
80_Y85_L0.5530.89
13_H37_E0.5480.89
27_Q136_H0.5430.89
13_H17_K0.5410.88
10_A43_E0.5400.88
63_R69_A0.5360.88
112_Q134_I0.5350.88
69_A101_G0.5250.87
38_F44_Q0.5240.87
26_E110_Q0.5230.87
107_L139_M0.5200.86
66_G70_K0.5180.86
52_H55_Q0.5110.85
26_E73_R0.5100.85
26_E132_D0.5100.85
12_L39_D0.5090.85
65_V72_E0.5060.85
107_L113_A0.5060.85
27_Q73_R0.5060.85
23_F73_R0.5050.85
24_I30_S0.5040.85
74_I120_L0.5010.84
21_G78_K0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2g0bA 4 0.9865 99.9 0.404 Contact Map
1q2yA 1 0.9392 99.9 0.416 Contact Map
1kzfA 1 0.9054 99.9 0.429 Contact Map
3p2hA 1 0.9324 99.9 0.434 Contact Map
2jdcA 1 0.9257 99.9 0.439 Contact Map
1ro5A 5 0.9865 99.9 0.447 Contact Map
1xebA 2 0.9459 99.9 0.448 Contact Map
3efaA 2 0.9527 99.9 0.449 Contact Map
1y9wA 2 0.9324 99.8 0.564 Contact Map
1yvkA 3 0.9189 99.7 0.585 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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