GREMLIN Database
YYBB - Probable metallo-hydrolase YybB
UniProt: P37502 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 220 (181)
Sequences: 19616 (13984)
Seq/√Len: 1039.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_T145_V4.3451.00
35_D61_K3.9751.00
65_L76_A3.5331.00
121_L124_Q3.2531.00
62_A88_F3.0921.00
132_K149_K2.9111.00
131_L148_H2.6281.00
64_L146_Y2.5011.00
37_Y62_A2.3701.00
133_Y144_V2.3671.00
125_T130_P2.3511.00
51_I82_R2.3351.00
153_T197_C2.0891.00
148_H151_D2.0681.00
62_A86_P2.0611.00
93_E142_G2.0601.00
28_W197_C2.0531.00
133_Y146_Y1.9901.00
120_P124_Q1.9851.00
118_V121_L1.9501.00
35_D59_N1.9241.00
152_R194_T1.9231.00
177_D180_E1.8921.00
39_V66_T1.8771.00
53_A57_I1.8131.00
90_H135_L1.8041.00
132_K147_Y1.6811.00
90_H144_V1.6771.00
53_A56_A1.6671.00
39_V155_L1.6231.00
28_W155_L1.5821.00
91_Q122_T1.5791.00
37_Y64_L1.4941.00
78_K82_R1.4921.00
94_L98_N1.4801.00
76_A87_I1.4791.00
145_V154_L1.4471.00
51_I55_L1.4351.00
183_D186_S1.4301.00
134_Y147_Y1.4081.00
60_P85_I1.4001.00
88_F119_Q1.3941.00
147_Y152_R1.3801.00
35_D62_A1.3521.00
36_V60_P1.3521.00
147_Y154_L1.3441.00
134_Y187_I1.3011.00
86_P119_Q1.2931.00
77_S81_E1.2841.00
129_L148_H1.2761.00
138_G184_S1.2711.00
143_H157_G1.2711.00
187_I190_Q1.2681.00
31_K36_V1.2651.00
48_D52_R1.2541.00
180_E183_D1.2481.00
51_I83_F1.2381.00
52_R56_A1.2341.00
55_L82_R1.2321.00
60_P83_F1.2051.00
80_L118_V1.1911.00
126_L129_L1.1901.00
32_D128_H1.1661.00
118_V124_Q1.1371.00
38_I60_P1.1371.00
92_K135_L1.1351.00
206_Y209_E1.1351.00
145_V188_I1.1331.00
77_S80_L1.1321.00
54_A60_P1.1291.00
127_A130_P1.1231.00
66_T157_G1.1191.00
153_T195_L1.0991.00
80_L87_I1.0981.00
39_V146_Y1.0961.00
52_R55_L1.0891.00
88_F121_L1.0861.00
195_L203_E1.0851.00
140_S143_H1.0731.00
41_T63_I1.0691.00
136_T184_S1.0621.00
196_I204_I1.0481.00
89_A93_E1.0431.00
129_L151_D1.0301.00
36_V61_K1.0201.00
123_E132_K1.0201.00
120_P123_E1.0171.00
123_E187_I1.0061.00
186_S190_Q0.9981.00
27_T50_Q0.9971.00
63_I85_I0.9871.00
178_I182_I0.9861.00
121_L144_V0.9841.00
179_N183_D0.9731.00
37_Y131_L0.9721.00
145_V159_L0.9591.00
167_L170_P0.9511.00
91_Q120_P0.9471.00
30_I39_V0.9431.00
182_I186_S0.9411.00
68_G89_A0.9391.00
147_Y191_I0.9311.00
49_A53_A0.9311.00
159_L188_I0.9271.00
47_A75_G0.9261.00
149_K152_R0.9231.00
66_T146_Y0.9231.00
186_S189_D0.9171.00
141_P180_E0.9041.00
65_L87_I0.9031.00
49_A52_R0.9011.00
178_I181_N0.9011.00
70_S74_G0.8981.00
119_Q124_Q0.8951.00
41_T76_A0.8931.00
125_T128_H0.8931.00
29_F36_V0.8861.00
120_P187_I0.8831.00
156_T196_I0.8831.00
123_E130_P0.8801.00
93_E140_S0.8721.00
132_K191_I0.8691.00
27_T42_G0.8651.00
91_Q94_L0.8621.00
47_A78_K0.8561.00
63_I76_A0.8551.00
94_L120_P0.8501.00
29_F53_A0.8501.00
92_K95_K0.8491.00
36_V59_N0.8471.00
136_T143_H0.8421.00
154_L191_I0.8341.00
26_H201_G0.8331.00
64_L131_L0.8281.00
134_Y145_V0.8271.00
37_Y126_L0.8251.00
168_H181_N0.8221.00
136_T159_L0.8221.00
95_K99_G0.8211.00
38_I41_T0.8191.00
72_H158_D0.8041.00
147_Y193_P0.7981.00
39_V64_L0.7921.00
162_T202_E0.7871.00
154_L196_I0.7851.00
99_G102_P0.7781.00
32_D35_D0.7761.00
152_R192_K0.7731.00
137_P184_S0.7721.00
78_K81_E0.7701.00
159_L181_N0.7681.00
25_V42_G0.7671.00
174_F177_D0.7581.00
195_L205_L0.7581.00
68_G93_E0.7521.00
159_L184_S0.7481.00
63_I87_I0.7461.00
131_L146_Y0.7391.00
181_N185_G0.7361.00
75_G78_K0.7341.00
161_I164_K0.7311.00
48_D51_I0.7301.00
161_I166_D0.7291.00
193_P207_N0.7291.00
29_F38_I0.7251.00
90_H93_E0.7231.00
185_G189_D0.7201.00
95_K98_N0.7201.00
168_H178_I0.7181.00
130_P150_I0.7181.00
25_V199_S0.7181.00
110_E117_I0.7161.00
129_L150_I0.7151.00
93_E96_Y0.7051.00
69_H72_H0.6941.00
193_P210_L0.6931.00
124_Q132_K0.6921.00
117_I120_P0.6911.00
61_K86_P0.6861.00
88_F118_V0.6851.00
197_C203_E0.6831.00
188_I206_Y0.6821.00
102_P105_N0.6811.00
100_E103_Y0.6781.00
134_Y191_I0.6761.00
183_D187_I0.6751.00
89_A97_I0.6751.00
156_T198_S0.6751.00
79_W83_F0.6731.00
163_S207_N0.6731.00
117_I121_L0.6681.00
64_L144_V0.6661.00
101_E104_P0.6641.00
143_H159_L0.6631.00
47_A51_I0.6631.00
104_P108_E0.6621.00
28_W199_S0.6591.00
33_G128_H0.6591.00
36_V54_A0.6501.00
30_I148_H0.6501.00
163_S208_E0.6491.00
89_A94_L0.6441.00
38_I54_A0.6431.00
76_A80_L0.6421.00
65_L73_I0.6421.00
29_F54_A0.6381.00
48_D78_K0.6371.00
119_Q122_T0.6361.00
141_P175_S0.6331.00
103_Y106_K0.6331.00
71_D200_H0.6301.00
67_H158_D0.6181.00
54_A58_G0.6141.00
35_D127_A0.6141.00
106_K109_V0.6101.00
40_D67_H0.6101.00
105_N108_E0.6061.00
134_Y154_L0.6051.00
148_H155_L0.6051.00
80_L84_D0.6031.00
148_H153_T0.6031.00
91_Q95_K0.6021.00
198_S201_G0.6021.00
118_V123_E0.6011.00
96_Y141_P0.5991.00
135_L144_V0.5991.00
103_Y107_N0.5971.00
155_L197_C0.5891.00
159_L166_D0.5891.00
147_Y192_K0.5871.00
38_I50_Q0.5851.00
44_E75_G0.5841.00
68_G142_G0.5831.00
193_P196_I0.5801.00
130_P149_K0.5801.00
38_I79_W0.5771.00
196_I206_Y0.5701.00
21_L27_T0.5691.00
67_H71_D0.5661.00
138_G168_H0.5661.00
55_L58_G0.5631.00
34_D58_G0.5631.00
26_H199_S0.5551.00
182_I189_D0.5541.00
148_H152_R0.5531.00
73_I76_A0.5521.00
161_I165_E0.5491.00
46_F49_A0.5471.00
63_I79_W0.5461.00
86_P118_V0.5421.00
118_V122_T0.5391.00
96_Y101_E0.5381.00
41_T65_L0.5361.00
96_Y99_G0.5361.00
31_K34_D0.5361.00
53_A58_G0.5331.00
119_Q123_E0.5321.00
165_E168_H0.5311.00
60_P79_W0.5291.00
103_Y109_V0.5281.00
66_T69_H0.5261.00
179_N182_I0.5211.00
123_E135_L0.5211.00
105_N109_V0.5201.00
90_H94_L0.5171.00
69_H140_S0.5171.00
67_H72_H0.5141.00
92_K141_P0.5131.00
207_N210_L0.5101.00
40_D158_D0.5081.00
135_L187_I0.5031.00
175_S181_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zo4A 1 0.9727 100 0.263 Contact Map
2yheA 3 0.9682 100 0.298 Contact Map
2cfuA 2 0.9545 100 0.311 Contact Map
4nurA 2 0.9682 100 0.313 Contact Map
4pdxA 2 0.95 100 0.319 Contact Map
4ad9A 4 0.9318 100 0.33 Contact Map
2fhxA 2 0.9409 100 0.335 Contact Map
3iogA 1 0.9455 100 0.346 Contact Map
3vpeA 1 0.9636 100 0.347 Contact Map
4fekA 1 0.9636 100 0.351 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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