GREMLIN Database
YYBC - Uncharacterized protein YybC
UniProt: P37501 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 159 (148)
Sequences: 369 (276)
Seq/√Len: 22.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_C49_F3.1051.00
145_G149_K2.8900.99
14_M146_V2.4940.98
25_I41_T2.4930.98
17_F42_V2.4700.98
55_L96_C2.3520.97
62_P66_K2.2660.97
68_A84_A2.2140.96
56_D89_M1.9760.93
64_A68_A1.9610.93
53_L57_L1.9450.92
135_Q140_G1.8920.91
22_V134_L1.8820.91
143_V147_F1.8740.91
147_F151_V1.8680.91
19_M23_M1.8440.90
90_V132_Y1.8430.90
19_M140_G1.8350.90
61_G65_K1.8320.90
94_V101_G1.7760.88
18_G143_V1.7740.88
49_F53_L1.7550.88
15_M19_M1.7360.87
56_D65_K1.7330.87
84_A88_C1.6730.85
5_K58_L1.6550.84
67_I137_L1.6520.84
68_A85_M1.6410.84
122_M126_K1.6240.83
57_L62_P1.6080.83
21_C25_I1.6060.83
6_K151_V1.6010.82
16_C61_G1.5970.82
21_C38_S1.5640.81
16_C53_L1.5600.81
4_N10_I1.5210.79
60_V96_C1.4420.75
60_V92_G1.4290.74
60_V89_M1.4220.74
140_G144_R1.3850.72
82_I89_M1.3410.69
10_I151_V1.3340.69
95_L120_Y1.3160.68
36_D40_M1.3130.68
59_L145_G1.2780.66
86_S140_G1.2760.66
9_L84_A1.2690.65
77_K80_Y1.2650.65
56_D86_S1.2480.64
20_V52_A1.2430.63
93_M97_M1.2290.63
16_C24_S1.2110.61
23_M27_N1.2070.61
83_L99_V1.1860.60
68_A98_S1.1750.59
94_V100_F1.1740.59
42_V46_V1.1740.59
16_C52_A1.1540.58
5_K9_L1.1380.56
148_M151_V1.1340.56
24_S46_V1.1340.56
50_M82_I1.1300.56
120_Y139_M1.1240.56
20_V86_S1.1230.55
51_I96_C1.0930.53
91_I136_L1.0910.53
2_P53_L1.0860.53
4_N14_M1.0810.53
94_V129_I1.0720.52
133_P137_L1.0650.51
52_A97_M1.0590.51
21_C41_T1.0580.51
96_C99_V1.0500.50
129_I133_P1.0430.50
9_L57_L1.0370.50
12_G19_M1.0330.49
94_V133_P1.0290.49
134_L139_M1.0280.49
95_L124_V1.0230.49
65_K69_F1.0190.48
15_M140_G1.0120.48
14_M143_V1.0070.47
26_Y135_Q1.0000.47
29_I41_T0.9980.47
20_V45_M0.9960.47
43_F46_V0.9900.46
101_G137_L0.9890.46
44_E48_G0.9870.46
52_A60_V0.9830.46
107_L117_F0.9770.45
11_F102_L0.9720.45
67_I88_C0.9690.45
83_L136_L0.9660.45
18_G142_L0.9640.45
5_K93_M0.9580.44
19_M86_S0.9510.44
26_Y30_I0.9500.44
5_K10_I0.9470.43
46_V148_M0.9450.43
15_M143_V0.9450.43
20_V64_A0.9430.43
87_T136_L0.9400.43
79_I82_I0.9300.42
68_A88_C0.9130.41
11_F134_L0.9120.41
40_M43_F0.9060.41
6_K16_C0.8820.39
10_I37_F0.8710.38
95_L129_I0.8690.38
23_M132_Y0.8550.37
13_V111_L0.8510.37
15_M23_M0.8510.37
56_D67_I0.8500.37
82_I111_L0.8480.37
100_F120_Y0.8440.37
33_A151_V0.8350.36
8_G143_V0.8340.36
67_I146_V0.8310.36
8_G56_D0.8160.35
2_P7_E0.8130.35
100_F129_I0.8110.34
24_S94_V0.7860.33
37_F118_S0.7800.33
32_R37_F0.7780.32
55_L59_L0.7700.32
45_M99_V0.7660.32
128_F145_G0.7650.32
25_I28_A0.7600.31
59_L152_K0.7570.31
40_M75_K0.7440.30
56_D107_L0.7440.30
4_N24_S0.7430.30
50_M138_I0.7330.30
2_P9_L0.7320.30
16_C89_M0.7300.30
18_G115_S0.7220.29
30_I129_I0.7220.29
11_F131_A0.7210.29
74_D78_K0.7130.29
65_K77_K0.7090.28
4_N7_E0.7080.28
42_V123_I0.7060.28
125_L130_L0.7050.28
15_M147_F0.7050.28
63_L128_F0.7040.28
69_F81_V0.7020.28
22_V130_L0.6970.28
124_V151_V0.6950.28
12_G98_S0.6910.27
19_M27_N0.6900.27
30_I152_K0.6870.27
65_K89_M0.6840.27
32_R54_L0.6800.27
49_F52_A0.6670.26
16_C45_M0.6650.26
39_L43_F0.6630.26
56_D60_V0.6580.26
52_A86_S0.6570.26
7_E101_G0.6540.25
110_G121_L0.6520.25
72_P81_V0.6510.25
116_L149_K0.6510.25
117_F128_F0.6500.25
10_I150_F0.6480.25
79_I91_I0.6440.25
53_L58_L0.6400.25
32_R40_M0.6340.24
54_L117_F0.6290.24
77_K83_L0.6270.24
143_V151_V0.6220.24
15_M135_Q0.6180.24
4_N8_G0.6180.24
12_G23_M0.6170.24
80_Y84_A0.6160.23
56_D82_I0.6150.23
18_G145_G0.6120.23
8_G16_C0.6090.23
98_S123_I0.6050.23
69_F85_M0.6040.23
75_K81_V0.6030.23
12_G18_G0.5970.23
102_L123_I0.5960.22
15_M68_A0.5950.22
137_L142_L0.5940.22
24_S56_D0.5930.22
40_M136_L0.5920.22
47_I50_M0.5880.22
16_C88_C0.5830.22
39_L123_I0.5830.22
28_A133_P0.5820.22
56_D93_M0.5800.22
30_I109_N0.5760.22
58_L148_M0.5740.21
31_N51_I0.5710.21
34_I118_S0.5690.21
40_M90_V0.5630.21
23_M97_M0.5610.21
23_M140_G0.5590.21
51_I55_L0.5550.21
10_I33_A0.5510.20
10_I13_V0.5480.20
31_N109_N0.5480.20
30_I130_L0.5480.20
42_V128_F0.5440.20
26_Y98_S0.5440.20
6_K92_G0.5410.20
28_A66_K0.5390.20
54_L100_F0.5370.20
2_P148_M0.5360.20
66_K132_Y0.5270.19
11_F120_Y0.5220.19
12_G15_M0.5170.19
55_L58_L0.5150.19
66_K133_P0.5140.19
9_L13_V0.5120.19
72_P76_T0.5110.19
29_I46_V0.5100.19
19_M135_Q0.5090.19
127_N144_R0.5070.18
15_M86_S0.5040.18
50_M110_G0.5020.18
19_M131_A0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p6vB 1 0.3774 19.1 0.947 Contact Map
3rlbA 1 0.8931 13.6 0.951 Contact Map
4tnwA 3 0.6604 6.1 0.958 Contact Map
4tkrA 2 0.9057 4.2 0.961 Contact Map
3rqwA 4 0.5849 3.9 0.962 Contact Map
4gc0A 1 0.8931 3.2 0.963 Contact Map
4rfsS 1 0.8931 2.8 0.964 Contact Map
4p6vE 1 0.5912 2.7 0.964 Contact Map
4hfiA 3 0.6226 2.5 0.965 Contact Map
2lkgA 1 0.4214 2.5 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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