GREMLIN Database
YYBG - Uncharacterized protein YybG
UniProt: P37497 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 279 (263)
Sequences: 502 (364)
Seq/√Len: 22.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
218_A238_D6.3921.00
143_I162_H5.6451.00
83_V106_V4.4891.00
23_F84_S4.3921.00
40_F49_R3.9901.00
243_G263_D3.9341.00
167_N232_I3.9161.00
92_D95_N3.8051.00
40_F68_F3.6551.00
82_K147_T3.6001.00
142_K165_E3.5401.00
62_D66_K3.3811.00
88_Y102_Q3.0841.00
211_L231_F2.7650.99
150_S153_R2.6400.99
204_L224_A2.6290.99
174_S230_D2.3600.97
254_Q258_N2.3240.97
33_A39_A2.2980.97
257_V268_L2.2670.97
112_Q163_R2.2200.96
30_L218_A2.2030.96
221_L241_L2.1470.95
174_S178_R2.1400.95
87_T110_M2.0670.94
121_H140_F2.0340.94
17_A75_E1.8990.91
82_K86_I1.8480.90
149_L153_R1.8210.89
46_T49_R1.8150.89
102_Q152_E1.8070.89
59_I66_K1.7960.89
37_D108_P1.7870.88
240_D261_N1.7620.88
129_A132_I1.7470.87
31_P218_A1.7440.87
82_K144_E1.7390.87
173_T177_V1.7190.86
88_Y155_L1.7170.86
135_E172_K1.6890.85
253_T258_N1.6700.85
197_I215_L1.6670.85
222_R242_S1.6350.83
204_L227_R1.6020.82
129_A176_L1.5950.82
242_S263_D1.5930.82
129_A133_H1.5830.81
200_K224_A1.5550.80
30_L258_N1.5470.80
200_K227_R1.5390.79
43_D46_T1.5300.79
31_P37_D1.5260.79
124_L133_H1.5170.78
167_N171_L1.5170.78
200_K220_D1.5140.78
133_H137_R1.4980.77
75_E111_Q1.4920.77
124_L137_R1.4860.77
222_R240_D1.4860.77
39_A49_R1.4770.76
74_Y88_Y1.4350.74
124_L140_F1.4310.74
110_M151_K1.3970.72
122_E126_I1.3750.71
200_K204_L1.3720.71
139_T169_W1.3710.71
110_M147_T1.3450.69
33_A37_D1.3030.67
30_L40_F1.3010.67
231_F236_M1.2920.66
110_M222_R1.2880.66
171_L232_I1.2800.65
37_D68_F1.2770.65
30_L238_D1.2650.64
241_L260_A1.2540.64
142_K145_R1.2520.64
136_L169_W1.2510.64
201_L211_L1.2440.63
123_A136_L1.2420.63
49_R68_F1.2350.63
31_P255_A1.2190.61
275_P278_W1.2150.61
14_D21_H1.2080.61
229_T232_I1.2010.60
30_L43_D1.1980.60
224_A227_R1.1970.60
111_Q116_M1.1940.60
61_K153_R1.1940.60
194_S214_A1.1940.60
209_A229_T1.1700.58
201_L221_L1.1660.58
74_Y110_M1.1650.58
22_C26_C1.1600.58
39_A68_F1.1420.56
31_P40_F1.1250.55
112_Q253_T1.1240.55
29_A218_A1.1200.55
34_K215_L1.1160.55
17_A44_G1.1130.54
74_Y108_P1.0950.53
14_D82_K1.0920.53
69_R238_D1.0910.53
34_K125_S1.0850.52
262_G278_W1.0830.52
65_E249_S1.0800.52
262_G275_P1.0770.52
199_A231_F1.0690.51
167_N210_N1.0630.51
109_I132_I1.0590.51
19_C27_C1.0450.50
36_A73_A1.0390.49
135_E257_V1.0380.49
91_K96_S1.0370.49
210_N232_I1.0330.49
122_E252_L1.0240.48
55_Y97_P1.0200.48
126_I177_V1.0200.48
36_A255_A1.0150.48
13_Y16_S1.0150.48
178_R225_D1.0060.47
254_Q262_G0.9900.46
24_G29_A0.9790.45
82_K148_R0.9770.45
64_R72_S0.9730.45
197_I270_L0.9720.45
93_W104_F0.9710.45
33_A210_N0.9690.45
89_E96_S0.9500.43
96_S99_T0.9500.43
139_T167_N0.9450.43
46_T95_N0.9380.42
245_D267_K0.9370.42
55_Y100_A0.9370.42
39_A50_N0.9360.42
88_Y152_E0.9340.42
30_L112_Q0.9320.42
134_S239_A0.9310.42
135_E145_R0.9230.41
193_G196_L0.9190.41
135_E140_F0.9170.41
43_D156_T0.9150.41
208_G215_L0.9090.40
31_P36_A0.9070.40
13_Y101_N0.9020.40
134_S150_S0.9020.40
30_L253_T0.9010.40
175_E210_N0.9000.40
153_R273_R0.8980.40
172_K247_T0.8870.39
183_H188_K0.8700.38
199_A224_A0.8700.38
83_V107_F0.8610.37
204_L257_V0.8580.37
44_G121_H0.8510.37
86_I228_M0.8490.37
74_Y107_F0.8470.36
150_S180_Q0.8440.36
154_L157_L0.8380.36
127_D189_K0.8350.36
16_S62_D0.8290.35
142_K172_K0.8240.35
125_S128_I0.8210.35
124_L136_L0.8180.35
98_E138_T0.8180.35
69_R228_M0.8120.34
98_E239_A0.8110.34
41_D222_R0.8060.34
204_L248_G0.8030.34
34_K95_N0.8030.34
102_Q106_V0.8030.34
46_T156_T0.8010.34
70_G76_C0.7990.33
171_L210_N0.7950.33
140_F143_I0.7930.33
71_C76_C0.7910.33
23_F103_M0.7910.33
115_E213_G0.7900.33
64_R198_G0.7840.33
174_S177_V0.7810.32
41_D215_L0.7800.32
92_D104_F0.7760.32
194_S274_T0.7750.32
145_R273_R0.7750.32
83_V110_M0.7700.32
36_A276_A0.7700.32
36_A39_A0.7650.31
14_D271_S0.7630.31
181_A188_K0.7620.31
179_A208_G0.7620.31
151_K182_R0.7610.31
95_N276_A0.7610.31
23_F99_T0.7600.31
223_N231_F0.7590.31
134_S138_T0.7560.31
32_Y111_Q0.7540.31
257_V267_K0.7540.31
17_A241_L0.7510.31
30_L47_P0.7500.31
105_D187_P0.7470.30
20_Q61_K0.7410.30
191_S245_D0.7410.30
99_T273_R0.7400.30
178_R200_K0.7400.30
237_R256_Q0.7370.30
13_Y228_M0.7330.30
46_T150_S0.7310.29
39_A108_P0.7290.29
154_L215_L0.7270.29
17_A31_P0.7200.29
265_N276_A0.7170.29
47_P218_A0.7160.29
21_H180_Q0.7110.28
95_N188_K0.7090.28
46_T149_L0.7080.28
37_D203_G0.7080.28
164_A181_A0.7020.28
65_E83_V0.6980.28
155_L276_A0.6930.27
130_K176_L0.6930.27
73_A108_P0.6920.27
24_G136_L0.6920.27
201_L239_A0.6830.27
89_E97_P0.6830.27
63_L80_G0.6820.27
16_S148_R0.6800.27
188_K208_G0.6780.26
122_E251_F0.6770.26
48_C63_L0.6770.26
138_T152_E0.6770.26
46_T270_L0.6750.26
126_I250_I0.6740.26
16_S274_T0.6730.26
19_C22_C0.6720.26
34_K276_A0.6690.26
261_N270_L0.6680.26
36_A248_G0.6650.26
42_K48_C0.6650.26
43_D130_K0.6640.26
216_L234_A0.6630.26
13_Y53_S0.6620.26
52_Q58_S0.6610.26
24_G30_L0.6580.25
19_C26_C0.6570.25
54_N194_S0.6560.25
66_K223_N0.6560.25
224_A248_G0.6550.25
241_L247_T0.6550.25
62_D132_I0.6550.25
60_H114_H0.6500.25
231_F252_L0.6490.25
217_I232_I0.6490.25
17_A255_A0.6480.25
13_Y157_L0.6470.25
53_S159_V0.6440.25
132_I145_R0.6430.25
249_S265_N0.6410.25
86_I99_T0.6400.25
70_G80_G0.6360.24
67_G115_E0.6350.24
142_K157_L0.6330.24
91_K95_N0.6310.24
119_Y167_N0.6300.24
29_A104_F0.6280.24
123_A173_T0.6240.24
238_D254_Q0.6230.24
41_D191_S0.6230.24
172_K204_L0.6230.24
76_C80_G0.6200.24
107_F262_G0.6190.23
187_P202_K0.6180.23
218_A254_Q0.6170.23
157_L162_H0.6160.23
177_V210_N0.6160.23
112_Q157_L0.6140.23
91_K207_R0.6120.23
112_Q258_N0.6110.23
161_E207_R0.6110.23
72_S87_T0.6100.23
16_S34_K0.6100.23
16_S44_G0.6090.23
34_K145_R0.6080.23
210_N222_R0.6070.23
141_E145_R0.6060.23
136_L176_L0.6050.23
91_K223_N0.6050.23
18_D25_L0.6040.23
45_G51_L0.6040.23
37_D277_H0.6030.23
57_C63_L0.6010.23
71_C80_G0.5970.22
49_R191_S0.5960.22
193_G210_N0.5940.22
102_Q121_H0.5940.22
179_A255_A0.5930.22
76_C81_Q0.5930.22
167_N173_T0.5920.22
76_C79_A0.5920.22
160_D168_E0.5890.22
91_K270_L0.5880.22
77_F90_G0.5880.22
134_S249_S0.5870.22
262_G266_T0.5860.22
44_G55_Y0.5850.22
28_V43_D0.5850.22
266_T269_P0.5820.22
20_Q228_M0.5810.22
65_E145_R0.5810.22
60_H81_Q0.5800.22
142_K236_M0.5790.22
110_M249_S0.5770.21
46_T105_D0.5770.21
57_C60_H0.5760.21
85_Q90_G0.5750.21
112_Q251_F0.5740.21
74_Y197_I0.5710.21
28_V40_F0.5700.21
131_P176_L0.5670.21
38_F78_G0.5670.21
139_T143_I0.5640.21
28_V239_A0.5620.21
50_N82_K0.5620.21
212_R230_D0.5610.21
71_C81_Q0.5600.21
191_S200_K0.5600.21
39_A168_E0.5590.21
75_E84_S0.5570.21
173_T271_S0.5560.20
172_K175_E0.5560.20
131_P138_T0.5550.20
196_L216_L0.5530.20
84_S108_P0.5530.20
116_M193_G0.5520.20
57_C76_C0.5510.20
183_H208_G0.5510.20
57_C81_Q0.5510.20
24_G55_Y0.5510.20
142_K242_S0.5500.20
95_N179_A0.5490.20
82_K110_M0.5490.20
162_H231_F0.5490.20
85_Q103_M0.5490.20
70_G78_G0.5460.20
101_N153_R0.5460.20
22_C27_C0.5450.20
101_N265_N0.5450.20
21_H36_A0.5450.20
51_L57_C0.5440.20
116_M210_N0.5430.20
115_E230_D0.5410.20
17_A74_Y0.5370.20
52_Q110_M0.5360.20
203_G224_A0.5360.20
219_A231_F0.5360.20
20_Q46_T0.5360.20
153_R271_S0.5350.20
159_V172_K0.5350.20
134_S176_L0.5350.20
233_G237_R0.5340.20
138_T191_S0.5340.20
259_A277_H0.5340.20
236_M259_A0.5340.20
34_K44_G0.5330.19
62_D68_F0.5310.19
63_L76_C0.5300.19
30_L84_S0.5290.19
13_Y46_T0.5280.19
73_A224_A0.5270.19
36_A111_Q0.5210.19
82_K87_T0.5180.19
63_L78_G0.5180.19
195_V236_M0.5180.19
64_R67_G0.5170.19
218_A258_N0.5170.19
126_I241_L0.5160.19
36_A273_R0.5140.19
20_Q267_K0.5100.19
107_F254_Q0.5090.18
60_H235_D0.5090.18
194_S259_A0.5080.18
131_P169_W0.5070.18
14_D164_A0.5070.18
117_L211_L0.5060.18
71_C79_A0.5060.18
81_Q235_D0.5050.18
134_S141_E0.5040.18
60_H63_L0.5030.18
255_A268_L0.5030.18
16_S33_A0.5030.18
13_Y20_Q0.5010.18
20_Q69_R0.5010.18
16_S176_L0.5010.18
34_K163_R0.5000.18
33_A167_N0.5000.18
53_S121_H0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qyuA 1 0.5341 99.9 0.773 Contact Map
2o6wA 1 0.4803 99.8 0.792 Contact Map
3du1X 1 0.4624 99.8 0.796 Contact Map
3n90A 1 0.4122 99.8 0.798 Contact Map
3nb2A 2 0.5484 99.8 0.804 Contact Map
2j8kA 1 0.5233 99.7 0.807 Contact Map
2f3lA 1 0.3943 99.7 0.816 Contact Map
4jraC 1 0.3333 99.7 0.819 Contact Map
2w7zA 2 0.6022 99.6 0.823 Contact Map
3pssA 2 0.4552 99.6 0.832 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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