GREMLIN Database
YYBI - Uncharacterized protein YybI
UniProt: P37495 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 262 (227)
Sequences: 176 (152)
Seq/√Len: 10.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
200_N229_N6.5351.00
41_G97_L3.4260.97
209_D213_D3.2540.95
99_D103_D3.1870.95
198_W225_A2.9140.92
114_T122_Y2.7590.89
202_L220_A2.6480.87
209_D214_G2.6440.87
119_G230_A2.5820.86
209_D217_E2.5650.86
125_V135_R2.5160.84
242_W247_F2.3740.81
114_T119_G2.3560.80
200_N203_S2.3310.79
186_N190_V2.3170.79
142_L238_T2.3130.79
223_R232_S2.2900.78
72_I83_I2.2570.77
146_L173_L2.2540.77
93_P184_I2.2390.76
36_I78_H2.2260.76
99_D102_G2.2200.76
236_V254_V2.1950.75
150_V197_G2.1230.72
240_L247_F2.1100.72
62_S102_G2.0970.71
223_R229_N2.0960.71
52_V97_L2.0780.71
118_G230_A2.0670.70
226_G231_D2.0400.69
42_D46_D1.9630.66
117_S230_A1.9240.64
153_Q159_S1.9150.64
200_N225_A1.9030.64
181_L240_L1.8020.59
116_G230_A1.8010.59
131_R158_A1.7880.59
202_L205_L1.7240.56
107_D118_G1.6950.54
52_V154_N1.6690.53
50_D161_I1.6260.51
43_V50_D1.6180.51
102_G214_G1.5750.49
102_G209_D1.5650.48
42_D45_G1.5370.47
156_Y181_L1.5150.46
120_A201_P1.5040.46
83_I154_N1.4970.45
137_F142_L1.4760.44
35_I136_I1.4690.44
180_Y231_D1.4680.44
48_V75_G1.4640.44
44_T72_I1.4630.44
189_G218_L1.4380.43
116_G229_N1.4360.42
113_D121_I1.4140.41
142_L152_Y1.4090.41
208_V239_V1.3940.41
44_T131_R1.3830.40
228_Y232_S1.3550.39
144_D159_S1.3480.39
148_Y233_L1.3370.38
114_T117_S1.3340.38
183_E227_R1.3300.38
37_V223_R1.3240.37
66_R171_L1.3070.37
168_T178_R1.3010.36
156_Y173_L1.2980.36
115_G230_A1.2770.35
111_V123_A1.2310.34
137_F152_Y1.2130.33
64_L89_M1.2090.33
118_G228_Y1.2080.33
50_D174_T1.2020.32
142_L181_L1.2010.32
192_K197_G1.2010.32
177_G192_K1.1990.32
202_L234_G1.1880.32
115_G118_G1.1850.32
38_S95_L1.1750.31
125_V245_Q1.1680.31
195_I227_R1.1350.30
165_Q239_V1.1320.30
209_D215_V1.1280.29
131_R184_I1.1050.29
220_A238_T1.1030.29
158_A231_D1.0990.28
118_G216_Y1.0870.28
85_L206_Y1.0640.27
49_I155_Q1.0630.27
36_I221_Y1.0580.27
64_L200_N1.0550.27
225_A229_N1.0320.26
112_M150_V1.0300.26
85_L136_I1.0190.25
213_D241_K1.0160.25
65_W158_A1.0130.25
137_F181_L1.0070.25
74_D131_R1.0040.25
36_I112_M1.0030.25
158_A197_G1.0010.25
213_D217_E1.0010.25
83_I126_F0.9960.25
124_Y194_P0.9870.24
42_D48_V0.9850.24
144_D236_V0.9840.24
36_I203_S0.9780.24
158_A173_L0.9770.24
50_D84_Q0.9740.24
141_V179_E0.9710.24
64_L120_A0.9690.24
119_G205_L0.9610.23
207_P216_Y0.9600.23
42_D47_G0.9570.23
38_S51_E0.9520.23
56_G172_D0.9480.23
112_M199_V0.9460.23
179_E224_I0.9410.23
149_S178_R0.9370.23
132_Q190_V0.9370.23
211_D249_F0.9350.23
76_R166_N0.9270.22
50_D75_G0.9270.22
154_N186_N0.9060.22
185_Y189_G0.9050.22
79_Q173_L0.9000.22
210_F237_Q0.8970.21
227_R232_S0.8970.21
102_G217_E0.8940.21
39_T237_Q0.8930.21
54_L238_T0.8890.21
148_Y181_L0.8860.21
50_D172_D0.8820.21
41_G52_V0.8810.21
36_I57_N0.8800.21
37_V110_V0.8760.21
116_G119_G0.8750.21
176_K247_F0.8730.21
160_V189_G0.8670.21
73_R105_I0.8670.21
184_I195_I0.8670.21
212_R251_R0.8670.21
93_P210_F0.8630.20
177_G240_L0.8630.20
45_G191_L0.8610.20
176_K231_D0.8610.20
114_T221_Y0.8600.20
152_Y181_L0.8590.20
78_H239_V0.8500.20
109_A125_V0.8480.20
56_G229_N0.8450.20
52_V100_M0.8420.20
125_V137_F0.8420.20
43_V111_V0.8380.20
113_D220_A0.8380.20
160_V219_L0.8340.20
168_T203_S0.8330.20
100_M108_V0.8200.19
120_A200_N0.8200.19
116_G224_I0.8190.19
51_E163_H0.8180.19
78_H106_E0.8170.19
142_L240_L0.8160.19
83_I156_Y0.8160.19
68_I184_I0.8160.19
100_M131_R0.8150.19
107_D131_R0.8100.19
76_R246_R0.8100.19
117_S229_N0.8080.19
34_A128_Y0.8050.19
78_H146_L0.8030.19
155_Q163_H0.8000.19
150_V247_F0.7990.19
81_Q128_Y0.7930.18
157_K231_D0.7920.18
148_Y199_V0.7890.18
154_N190_V0.7860.18
73_R104_K0.7850.18
47_G103_D0.7850.18
61_G66_R0.7820.18
62_S214_G0.7820.18
178_R208_V0.7810.18
156_Y254_V0.7800.18
154_N171_L0.7770.18
143_N247_F0.7760.18
52_V76_R0.7750.18
224_I236_V0.7710.18
95_L132_Q0.7710.18
138_N247_F0.7680.18
98_G110_V0.7670.18
102_G203_S0.7650.18
195_I201_P0.7650.18
202_L253_T0.7650.18
145_E176_K0.7640.18
93_P228_Y0.7560.17
39_T97_L0.7550.17
118_G226_G0.7470.17
171_L245_Q0.7470.17
184_I244_G0.7390.17
56_G189_G0.7370.17
77_T242_W0.7330.17
35_I125_V0.7310.17
188_Q213_D0.7260.17
169_Y203_S0.7220.16
50_D53_F0.7220.16
101_T193_M0.7220.16
201_P204_G0.7210.16
53_F208_V0.7210.16
33_R238_T0.7200.16
175_Y234_G0.7130.16
91_Y117_S0.7120.16
94_S244_G0.7120.16
152_Y183_E0.7090.16
61_G132_Q0.7080.16
55_T221_Y0.7070.16
120_A225_A0.7030.16
172_D189_G0.7020.16
119_G222_Q0.7020.16
143_N224_I0.6990.16
193_M196_E0.6980.16
125_V217_E0.6980.16
50_D145_E0.6930.16
74_D97_L0.6870.16
62_S91_Y0.6850.16
97_L244_G0.6810.15
183_E225_A0.6730.15
52_V149_S0.6670.15
34_A249_F0.6590.15
93_P191_L0.6590.15
110_V215_V0.6570.15
96_F216_Y0.6510.15
64_L224_I0.6470.15
219_L237_Q0.6460.15
206_Y219_L0.6450.15
117_S228_Y0.6440.15
162_S203_S0.6430.15
208_V249_F0.6380.14
99_D107_D0.6370.14
93_P172_D0.6350.14
192_K240_L0.6350.14
32_S193_M0.6330.14
241_K254_V0.6310.14
36_I55_T0.6290.14
184_I227_R0.6260.14
111_V121_I0.6250.14
191_L194_P0.6240.14
56_G205_L0.6220.14
75_G100_M0.6210.14
125_V168_T0.6120.14
112_M122_Y0.6110.14
108_V216_Y0.6110.14
107_D221_Y0.6090.14
39_T215_V0.6030.14
108_V128_Y0.6030.14
175_Y244_G0.6030.14
208_V215_V0.6000.14
194_P197_G0.5990.14
181_L192_K0.5950.14
29_P187_S0.5920.13
167_E173_L0.5920.13
207_P218_L0.5920.13
170_I203_S0.5910.13
169_Y204_G0.5880.13
118_G229_N0.5880.13
103_D107_D0.5870.13
109_A216_Y0.5860.13
93_P252_Q0.5840.13
157_K172_D0.5830.13
45_G240_L0.5820.13
119_G228_Y0.5810.13
139_S212_R0.5800.13
144_D201_P0.5780.13
48_V166_N0.5770.13
51_E215_V0.5770.13
94_S217_E0.5770.13
106_E167_E0.5750.13
224_I234_G0.5740.13
43_V169_Y0.5740.13
79_Q186_N0.5730.13
70_L228_Y0.5730.13
121_I165_Q0.5730.13
75_G197_G0.5710.13
94_S151_R0.5710.13
126_F174_T0.5690.13
118_G188_Q0.5670.13
126_F234_G0.5670.13
110_V164_Q0.5670.13
150_V160_V0.5650.13
219_L224_I0.5650.13
92_N119_G0.5640.13
102_G107_D0.5610.13
101_T242_W0.5610.13
76_R136_I0.5550.13
103_D170_I0.5540.13
100_M217_E0.5520.13
158_A233_L0.5510.13
148_Y229_N0.5500.13
149_S190_V0.5460.12
104_K186_N0.5420.12
67_N193_M0.5410.12
143_N197_G0.5400.12
162_S197_G0.5370.12
146_L240_L0.5360.12
43_V173_L0.5330.12
194_P242_W0.5320.12
55_T162_S0.5320.12
116_G226_G0.5320.12
50_D117_S0.5310.12
145_E171_L0.5310.12
65_W193_M0.5310.12
136_I155_Q0.5300.12
104_K176_K0.5290.12
113_D130_N0.5290.12
77_T247_F0.5280.12
169_Y234_G0.5250.12
150_V199_V0.5240.12
163_H246_R0.5240.12
94_S154_N0.5230.12
115_G228_Y0.5230.12
151_R238_T0.5220.12
72_I106_E0.5220.12
83_I236_V0.5220.12
44_T100_M0.5180.12
159_S173_L0.5170.12
52_V238_T0.5170.12
43_V128_Y0.5170.12
234_G254_V0.5160.12
41_G181_L0.5150.12
35_I243_N0.5140.12
119_G172_D0.5140.12
178_R181_L0.5130.12
161_I188_Q0.5070.12
199_V223_R0.5050.12
54_L64_L0.5040.12
214_G217_E0.5040.12
35_I68_I0.5040.12
70_L110_V0.5040.12
146_L158_A0.5030.12
79_Q147_K0.5020.12
248_M254_V0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ijeA 1 0.7901 92.9 0.932 Contact Map
4o9xA 1 0.8321 92.2 0.934 Contact Map
2bwrA 1 0.6031 88.7 0.939 Contact Map
4iglA 1 0.7863 87.2 0.94 Contact Map
4um9A 1 0.8092 86.8 0.941 Contact Map
4a7kA 2 0.7061 82 0.944 Contact Map
3vi3A 1 0.7863 75.8 0.947 Contact Map
2zuxA 1 0.8206 72.7 0.949 Contact Map
4nehA 1 0.8053 65.6 0.951 Contact Map
4pj2A 1 0.4542 65 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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