GREMLIN Database
YYBS - Uncharacterized protein YybS
UniProt: P37485 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 309 (286)
Sequences: 948 (804)
Seq/√Len: 47.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_T54_G5.8291.00
209_R266_H4.5941.00
43_I191_A3.2601.00
217_V253_I3.2141.00
40_L43_I3.1831.00
262_F279_V3.0401.00
224_I242_A3.0141.00
84_G88_G2.9801.00
299_D303_H2.9101.00
89_H93_R2.7851.00
262_F275_A2.7641.00
173_P244_N2.7631.00
45_Y57_M2.5861.00
273_A276_V2.5771.00
23_L27_V2.5551.00
14_I18_A2.5081.00
11_A14_I2.3831.00
258_L282_G2.3421.00
63_P74_L2.3031.00
48_R200_P2.1601.00
125_N128_D2.1451.00
63_P113_F2.1451.00
40_L191_A2.1421.00
252_L256_Q2.1191.00
303_H306_N2.0651.00
91_F188_Y2.0080.99
259_S305_R1.9990.99
276_V280_I1.9820.99
39_P81_A1.9510.99
215_Q222_L1.9390.99
212_K303_H1.9210.99
135_R139_D1.9110.99
261_I292_I1.8990.99
140_I143_T1.8770.99
95_E98_H1.8620.99
90_F99_A1.8520.99
216_S220_L1.8160.99
265_C275_A1.8120.99
188_Y262_F1.7880.99
14_I27_V1.7770.99
104_A181_V1.7630.99
108_M180_G1.7580.99
159_K163_E1.7000.98
113_F199_S1.6870.98
83_A253_I1.6800.98
109_L266_H1.6790.98
295_L304_I1.6510.98
87_M103_G1.6460.98
50_G54_G1.6350.98
58_G81_A1.6340.98
11_A15_S1.6310.98
111_I183_F1.5720.97
274_A277_I1.5630.97
44_L195_L1.5510.97
219_V295_L1.5480.97
16_L23_L1.5400.97
192_K205_L1.5340.96
23_L283_F1.5280.96
221_Y297_V1.4760.96
90_F95_E1.4420.95
253_I300_M1.4420.95
186_L304_I1.4170.95
26_Y291_A1.4130.94
41_P45_Y1.4090.94
128_D132_T1.3930.94
207_P211_L1.3920.94
134_Y258_L1.3920.94
135_R162_E1.3850.94
79_M143_T1.3770.94
41_P44_L1.3560.93
136_Q186_L1.3530.93
94_K201_D1.3460.93
279_V282_G1.3340.93
18_A27_V1.3250.92
45_Y203_P1.3130.92
294_I298_L1.2940.91
31_G300_M1.2810.91
78_F194_L1.2810.91
132_T135_R1.2750.91
128_D288_F1.2660.90
211_L278_A1.2490.90
237_M241_I1.2450.90
268_K291_A1.2430.90
40_L53_L1.2420.90
214_P297_V1.2350.89
145_A222_L1.2290.89
23_L34_L1.2260.89
195_L200_P1.2070.88
50_G92_K1.1870.87
193_P196_R1.1830.87
89_H95_E1.1780.87
36_F43_I1.1770.87
171_L208_F1.1700.86
174_T247_F1.1640.86
100_I112_V1.1570.86
224_I227_L1.1500.86
173_P199_S1.1500.86
276_V302_F1.1300.85
44_L55_I1.1270.84
178_M251_F1.1230.84
45_Y50_G1.1210.84
91_F204_N1.1170.84
260_F295_L1.1120.84
174_T248_I1.1110.83
214_P256_Q1.1050.83
61_S204_N1.1020.83
220_L249_L1.1010.83
107_Y295_L1.0910.82
188_Y205_L1.0890.82
227_L242_A1.0880.82
167_I194_L1.0850.82
297_V304_I1.0810.82
97_G205_L1.0790.82
258_L295_L1.0780.82
20_I109_L1.0720.81
47_I91_F1.0720.81
15_S21_T1.0700.81
126_I211_L1.0690.81
251_F280_I1.0630.81
299_D305_R1.0630.81
253_I260_F1.0620.81
43_I84_G1.0560.80
117_I259_S1.0530.80
200_P203_P1.0520.80
132_T136_Q1.0470.80
11_A24_V1.0460.80
11_A17_F1.0450.80
11_A18_A1.0350.79
218_V297_V1.0270.78
163_E167_I1.0270.78
20_I30_I1.0260.78
43_I90_F1.0240.78
64_V68_V1.0230.78
256_Q296_G1.0200.78
224_I249_L1.0120.77
51_L89_H1.0070.77
38_L47_I1.0040.77
158_L162_E1.0030.77
23_L186_L1.0010.77
192_K196_R0.9990.76
13_L24_V0.9980.76
50_G190_I0.9870.76
57_M83_A0.9840.75
40_L47_I0.9820.75
219_V301_G0.9800.75
118_S122_L0.9800.75
203_P271_P0.9780.75
219_V297_V0.9770.75
62_L74_L0.9760.75
103_G256_Q0.9750.75
212_K259_S0.9740.75
143_T146_K0.9740.75
138_L141_V0.9710.74
178_M181_V0.9690.74
65_V73_G0.9620.74
126_I129_E0.9610.74
37_A132_T0.9580.73
36_F74_L0.9570.73
95_E99_A0.9560.73
207_P210_E0.9540.73
148_S159_K0.9540.73
136_Q140_I0.9530.73
45_Y53_L0.9510.73
18_A28_P0.9510.73
261_I278_A0.9500.73
192_K203_P0.9490.73
15_S264_Y0.9480.73
255_I266_H0.9420.72
242_A298_L0.9360.72
12_I18_A0.9270.71
43_I258_L0.9260.71
273_A284_V0.9230.70
241_I292_I0.9190.70
110_S208_F0.9150.70
110_S175_A0.9110.69
105_L138_L0.9090.69
40_L76_V0.9060.69
186_L189_L0.9030.69
205_L209_R0.9000.69
214_P244_N0.8920.68
213_F252_L0.8900.68
143_T269_Q0.8860.67
60_V180_G0.8840.67
256_Q260_F0.8830.67
270_Y303_H0.8800.67
212_K306_N0.8780.67
45_Y49_H0.8760.66
53_L271_P0.8750.66
264_Y268_K0.8730.66
128_D131_M0.8710.66
278_A292_I0.8710.66
82_C177_V0.8710.66
192_K201_D0.8700.66
48_R198_F0.8680.66
111_I130_A0.8670.66
60_V264_Y0.8660.66
21_T38_L0.8650.65
260_F304_I0.8650.65
47_I191_A0.8640.65
69_G80_S0.8620.65
96_P270_Y0.8600.65
109_L132_T0.8590.65
219_V300_M0.8580.65
44_L47_I0.8570.65
221_Y250_G0.8550.65
125_N171_L0.8520.64
104_A138_L0.8510.64
109_L149_G0.8480.64
285_H292_I0.8450.64
79_M107_Y0.8400.63
36_F39_P0.8390.63
72_N172_F0.8360.63
78_F282_G0.8360.63
31_G36_F0.8320.62
36_F41_P0.8240.62
115_F292_I0.8180.61
112_V115_F0.8070.60
293_R297_V0.8040.60
48_R54_G0.8030.60
249_L295_L0.8010.59
67_I143_T0.7990.59
88_G299_D0.7970.59
15_S18_A0.7940.59
91_F191_A0.7870.58
42_M84_G0.7850.58
240_S295_L0.7830.58
265_C270_Y0.7820.58
40_L64_V0.7800.57
93_R303_H0.7770.57
50_G212_K0.7750.57
40_L195_L0.7750.57
134_Y137_S0.7730.57
18_A23_L0.7730.57
217_V255_I0.7730.57
12_I15_S0.7730.57
89_H92_K0.7720.57
19_I71_F0.7700.56
222_L302_F0.7690.56
14_I243_L0.7680.56
122_L125_N0.7670.56
261_I279_V0.7640.56
41_P88_G0.7620.56
23_L223_I0.7610.56
176_I264_Y0.7580.55
82_C268_K0.7560.55
33_I81_A0.7540.55
99_A192_K0.7520.55
176_I247_F0.7510.55
217_V231_P0.7490.54
55_I82_C0.7470.54
118_S163_E0.7460.54
194_L198_F0.7460.54
86_A106_I0.7440.54
257_G292_I0.7430.54
191_A287_V0.7420.54
107_Y185_F0.7410.54
215_Q253_I0.7380.53
47_I58_G0.7370.53
91_F205_L0.7350.53
169_Q230_L0.7340.53
78_F134_Y0.7330.53
41_P49_H0.7330.53
172_F187_S0.7320.53
255_I279_V0.7290.52
55_I63_P0.7290.52
46_T57_M0.7260.52
45_Y211_L0.7240.52
252_L301_G0.7200.51
199_S202_I0.7190.51
181_V284_V0.7170.51
179_V183_F0.7150.51
44_L191_A0.7150.51
12_I45_Y0.7140.51
99_A102_S0.7120.51
136_Q139_D0.7110.51
59_A186_L0.7110.51
41_P195_L0.7060.50
108_M118_S0.7030.50
169_Q226_M0.7020.50
135_R138_L0.6990.49
14_I21_T0.6950.49
188_Y216_S0.6940.49
74_L261_I0.6920.49
42_M53_L0.6910.49
177_V202_I0.6910.49
12_I44_L0.6900.48
199_S225_V0.6890.48
145_A150_N0.6860.48
121_F227_L0.6840.48
263_F305_R0.6840.48
113_F144_V0.6830.48
196_R201_D0.6810.48
196_R199_S0.6780.47
74_L296_G0.6770.47
38_L42_M0.6750.47
19_I181_V0.6670.46
35_L285_H0.6600.45
60_V296_G0.6600.45
252_L300_M0.6580.45
47_I279_V0.6560.45
23_L80_S0.6560.45
271_P307_K0.6560.45
215_Q256_Q0.6550.45
59_A105_L0.6530.45
44_L48_R0.6530.45
260_F301_G0.6510.45
25_V295_L0.6510.45
63_P178_M0.6510.45
90_F96_P0.6500.44
236_Q267_K0.6490.44
22_L121_F0.6480.44
260_F268_K0.6470.44
163_E166_G0.6470.44
34_L47_I0.6460.44
62_L290_A0.6460.44
63_P78_F0.6420.44
87_M146_K0.6410.44
106_I276_V0.6410.44
54_G68_V0.6350.43
21_T33_I0.6320.43
165_L176_I0.6310.43
227_L258_L0.6300.43
97_G188_Y0.6260.42
91_F206_K0.6260.42
15_S22_L0.6250.42
180_G195_L0.6240.42
27_V77_A0.6230.42
212_K299_D0.6210.42
137_S146_K0.6200.42
141_V148_S0.6200.42
132_T229_F0.6180.41
195_L207_P0.6170.41
38_L43_I0.6170.41
254_F292_I0.6170.41
42_M58_G0.6160.41
241_I272_K0.6150.41
16_L56_W0.6130.41
129_E132_T0.6100.41
15_S26_Y0.6080.40
50_G257_G0.6060.40
222_L249_L0.6010.40
171_L289_M0.6000.40
39_P55_I0.6000.40
142_E158_L0.5990.40
55_I266_H0.5960.39
30_I175_A0.5950.39
222_L260_F0.5900.39
52_K106_I0.5880.38
123_G177_V0.5850.38
73_G176_I0.5840.38
217_V252_L0.5830.38
37_A65_V0.5830.38
211_L217_V0.5820.38
69_G282_G0.5800.38
219_V244_N0.5800.38
201_D207_P0.5800.38
241_I296_G0.5790.38
55_I283_F0.5780.38
66_F223_I0.5780.38
260_F303_H0.5770.37
215_Q218_V0.5770.37
91_F97_G0.5760.37
19_I30_I0.5760.37
17_F45_Y0.5760.37
59_A168_V0.5740.37
107_Y208_F0.5720.37
91_F192_K0.5710.37
62_L229_F0.5710.37
71_F138_L0.5700.37
52_K264_Y0.5690.37
195_L198_F0.5680.37
258_L277_I0.5670.37
167_I255_I0.5660.36
216_S256_Q0.5650.36
37_A76_V0.5630.36
62_L136_Q0.5620.36
208_F258_L0.5610.36
43_I47_I0.5610.36
267_K306_N0.5580.36
58_G105_L0.5580.36
128_D225_V0.5570.36
110_S223_I0.5530.35
221_Y236_Q0.5510.35
37_A191_A0.5510.35
278_A302_F0.5500.35
11_A27_V0.5490.35
226_M270_Y0.5490.35
27_V30_I0.5460.35
105_L135_R0.5450.34
272_K276_V0.5430.34
31_G256_Q0.5430.34
62_L71_F0.5410.34
227_L238_L0.5380.34
11_A23_L0.5360.34
17_F78_F0.5350.34
186_L295_L0.5350.34
27_V242_A0.5330.33
79_M137_S0.5300.33
106_I110_S0.5300.33
190_I200_P0.5300.33
254_F289_M0.5290.33
22_L55_I0.5270.33
211_L255_I0.5250.33
203_P211_L0.5250.33
43_I46_T0.5240.33
37_A74_L0.5240.33
194_L204_N0.5240.33
201_D204_N0.5230.33
87_M226_M0.5230.33
86_A103_G0.5190.32
43_I112_V0.5180.32
53_L57_M0.5180.32
251_F281_L0.5170.32
118_S297_V0.5160.32
217_V295_L0.5160.32
77_A182_I0.5150.32
298_L304_I0.5120.32
101_I131_M0.5120.32
31_G40_L0.5120.32
220_L239_Y0.5080.31
112_V288_F0.5080.31
141_V298_L0.5080.31
60_V101_I0.5070.31
202_I274_A0.5010.31
88_G92_K0.5010.31
214_P285_H0.5000.31
165_L230_L0.5000.31
238_L242_A0.5000.31
286_P289_M0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tkrA 2 0.5372 96.6 0.882 Contact Map
3rlbA 1 0.5437 96.4 0.885 Contact Map
4rfsS 1 0.521 95.6 0.892 Contact Map
3p5nA 2 0.5146 94.5 0.899 Contact Map
4hzuS 1 0.5113 94.2 0.9 Contact Map
4z7fA 2 0.4725 94 0.901 Contact Map
4huqS 1 0.521 93.9 0.902 Contact Map
4dveA 3 0.5372 88.2 0.915 Contact Map
2ksfA 1 0.3107 28.7 0.945 Contact Map
3qnqA 2 0.4013 10 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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