GREMLIN Database
YYCE - Uncharacterized protein YycE
UniProt: P37479 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 139 (123)
Sequences: 365 (243)
Seq/√Len: 21.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_L81_L4.3071.00
28_F123_P2.9710.99
64_T78_D2.9700.99
37_R40_E2.8020.99
91_L131_M2.7690.99
20_G72_A2.6670.99
21_Q24_E2.4160.98
59_Y83_F2.3410.97
96_S100_H2.2640.96
88_A92_A2.2310.96
41_F49_G2.1900.96
28_F95_T2.1800.95
105_E118_V2.0920.94
45_N115_N2.0760.94
30_E52_F2.0540.94
51_M60_H1.9040.91
19_T25_I1.8620.90
36_K55_P1.7840.88
72_A79_S1.7690.87
35_L54_L1.7600.87
66_Y79_S1.7350.86
51_M111_P1.7310.86
98_L128_I1.7240.86
41_F44_H1.6940.85
27_R31_E1.6870.84
74_V79_S1.6060.81
26_I50_V1.4230.73
32_G119_T1.4220.73
31_E93_A1.3860.71
30_E37_R1.3820.70
18_P51_M1.3610.69
26_I30_E1.3500.68
28_F34_C1.3180.67
20_G70_S1.2990.65
80_L119_T1.2980.65
15_I76_H1.2870.65
71_T108_S1.2860.65
26_I37_R1.2810.64
20_G79_S1.2330.61
44_H64_T1.1960.59
44_H47_Y1.1950.59
59_Y79_S1.1910.59
108_S114_S1.1330.55
66_Y109_E1.1220.54
95_T120_I1.1190.54
109_E126_W1.1180.54
77_P121_E1.1110.53
97_K130_F1.1100.53
71_T114_S1.0940.52
44_H110_N1.0600.50
19_T79_S1.0600.50
121_E127_R1.0540.49
76_H79_S1.0530.49
14_R17_R1.0510.49
103_Y118_V1.0470.49
94_I132_N1.0380.48
69_G109_E1.0300.48
44_H49_G1.0160.47
57_A61_L1.0020.46
22_L25_I0.9850.45
45_N52_F0.9800.44
109_E114_S0.9760.44
28_F103_Y0.9750.44
19_T66_Y0.9740.44
42_S58_D0.9710.44
76_H130_F0.9690.44
33_L130_F0.9630.43
13_I83_F0.9450.42
42_S86_P0.9430.42
119_T127_R0.9320.41
84_Y113_W0.9100.40
30_E93_A0.9100.40
41_F63_F0.8920.39
117_G131_M0.8820.38
25_I63_F0.8780.38
106_V121_E0.8770.38
32_G75_P0.8770.38
23_D96_S0.8690.37
26_I40_E0.8580.36
12_Q73_P0.8570.36
31_E52_F0.8570.36
19_T70_S0.8510.36
35_L46_G0.8480.36
66_Y71_T0.8470.36
23_D26_I0.8470.36
43_Q96_S0.8430.35
20_G66_Y0.8340.35
47_Y131_M0.8340.35
66_Y69_G0.8220.34
43_Q111_P0.8200.34
45_N111_P0.8150.34
19_T28_F0.8030.33
35_L118_V0.8030.33
30_E90_E0.8000.33
35_L70_S0.7910.32
66_Y70_S0.7850.32
39_G44_H0.7830.32
68_G121_E0.7750.31
18_P76_H0.7660.31
17_R74_V0.7520.30
54_L83_F0.7470.30
99_K118_V0.7430.30
70_S73_P0.7410.29
22_L27_R0.7400.29
35_L73_P0.7380.29
80_L112_Y0.7320.29
64_T110_N0.7300.29
39_G51_M0.7270.29
76_H85_V0.7170.28
18_P102_G0.7160.28
95_T117_G0.7110.28
13_I92_A0.7100.28
34_C123_P0.7070.28
61_L76_H0.7060.27
110_N113_W0.7040.27
75_P80_L0.6980.27
14_R22_L0.6930.27
83_F121_E0.6880.27
27_R93_A0.6790.26
41_F64_T0.6770.26
60_H80_L0.6760.26
58_D88_A0.6760.26
44_H111_P0.6750.26
21_Q126_W0.6730.26
80_L127_R0.6730.26
80_L129_V0.6670.25
117_G120_I0.6620.25
79_S126_W0.6580.25
91_L120_I0.6540.25
94_I123_P0.6520.25
17_R61_L0.6490.24
93_A107_E0.6460.24
11_A59_Y0.6440.24
31_E45_N0.6410.24
91_L94_I0.6400.24
97_K123_P0.6380.24
97_K133_S0.6340.24
88_A115_N0.6300.24
130_F133_S0.6290.24
36_K93_A0.6210.23
37_R52_F0.6160.23
69_G72_A0.6110.23
87_N132_N0.6100.23
77_P116_G0.6080.22
30_E42_S0.6080.22
73_P76_H0.6010.22
41_F47_Y0.5990.22
31_E133_S0.5970.22
31_E34_C0.5840.21
46_G86_P0.5840.21
32_G98_L0.5830.21
114_S126_W0.5820.21
24_E27_R0.5770.21
78_D96_S0.5770.21
16_A117_G0.5760.21
42_S105_E0.5750.21
71_T78_D0.5670.21
24_E34_C0.5610.20
15_I127_R0.5580.20
93_A115_N0.5560.20
22_L82_V0.5540.20
101_M132_N0.5540.20
35_L51_M0.5520.20
84_Y110_N0.5490.20
36_K100_H0.5430.20
89_V92_A0.5380.19
68_G73_P0.5300.19
84_Y117_G0.5290.19
28_F57_A0.5220.19
91_L126_W0.5200.19
16_A82_V0.5200.19
39_G132_N0.5170.18
15_I38_I0.5170.18
37_R96_S0.5160.18
32_G127_R0.5110.18
24_E89_V0.5100.18
46_G95_T0.5080.18
37_R48_D0.5080.18
25_I79_S0.5070.18
88_A118_V0.5070.18
48_D94_I0.5050.18
18_P75_P0.5040.18
29_Y90_E0.5030.18
41_F46_G0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1twuA 2 0.9856 99.8 0.71 Contact Map
2qqzA 2 0.8849 99 0.811 Contact Map
3e5dA 2 0.8777 99 0.812 Contact Map
3ghjA 2 0.8273 99 0.813 Contact Map
1zswA 1 0.964 99 0.816 Contact Map
4nazA 2 0.8345 98.9 0.818 Contact Map
4jh2A 2 0.8921 98.9 0.82 Contact Map
4hc5A 2 0.9281 98.9 0.821 Contact Map
1r9cA 2 0.8777 98.9 0.821 Contact Map
2c21A 2 0.8921 98.9 0.821 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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