GREMLIN Database
SYK - Lysine--tRNA ligase
UniProt: P37477 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 499 (429)
Sequences: 9639 (4758)
Seq/√Len: 229.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_H292_N4.5641.00
121_T138_S3.9661.00
94_I136_A3.7941.00
195_D252_Y3.6931.00
60_E63_I3.6921.00
66_T121_T3.6211.00
64_E121_T3.5881.00
193_Y292_N3.5281.00
188_Q192_R3.5041.00
192_R196_D3.3281.00
64_E137_T3.2921.00
188_Q195_D3.2381.00
240_L251_V2.9871.00
119_G140_E2.9451.00
189_A300_E2.8461.00
189_A296_H2.8051.00
281_A285_D2.7801.00
423_T468_G2.6571.00
182_T482_T2.5031.00
331_E342_T2.4591.00
206_T258_F2.3611.00
348_E352_E2.3381.00
94_I120_V2.3301.00
244_I467_T2.3121.00
190_M274_I2.2851.00
387_G399_N2.2581.00
369_E373_Q2.2491.00
146_L461_E2.2221.00
68_A119_G2.2151.00
186_I478_V2.1821.00
92_I134_V2.1571.00
220_I229_P2.0631.00
206_T255_G2.0571.00
187_I474_I2.0551.00
191_R201_E2.0551.00
413_I418_H2.0521.00
64_E123_K2.0371.00
62_A123_K2.0021.00
123_K137_T1.9821.00
192_R195_D1.9821.00
184_S195_D1.9561.00
295_A318_P1.9531.00
65_V134_V1.9531.00
324_H327_D1.9451.00
296_H300_E1.9441.00
192_R300_E1.9391.00
179_T484_A1.9231.00
432_R436_E1.9221.00
193_Y296_H1.9181.00
278_E281_A1.9121.00
193_Y197_H1.9091.00
288_S292_N1.8781.00
348_E351_K1.8731.00
283_Y407_D1.8731.00
190_M293_L1.8661.00
433_E437_A1.8361.00
193_Y293_L1.8331.00
286_I468_G1.8271.00
384_F411_L1.8271.00
400_P407_D1.8231.00
276_L470_L1.8011.00
327_D331_E1.7871.00
189_A297_I1.7771.00
428_P432_R1.7761.00
324_H387_G1.7621.00
125_F135_K1.7511.00
196_D296_H1.7321.00
67_I92_I1.7261.00
399_N407_D1.7171.00
294_V411_L1.6921.00
202_V243_L1.6861.00
282_D285_D1.6821.00
177_K181_I1.6651.00
86_Q91_Q1.6411.00
376_E379_L1.6371.00
181_I200_L1.6351.00
433_E436_E1.6151.00
432_R457_V1.5881.00
199_Y278_E1.5871.00
66_T119_G1.5771.00
428_P461_E1.5671.00
178_H182_T1.5581.00
71_M112_S1.5501.00
71_M118_I1.5351.00
84_H91_Q1.5341.00
398_K427_D1.5151.00
81_G106_Y1.5061.00
323_I328_A1.5051.00
306_T315_D1.5041.00
123_K135_K1.4881.00
198_G250_K1.4861.00
437_A440_K1.4821.00
185_K188_Q1.4691.00
278_E289_L1.4591.00
71_M83_A1.4591.00
298_A481_L1.4401.00
162_R169_D1.4381.00
368_N372_E1.4381.00
423_T426_N1.4361.00
185_K300_E1.4281.00
345_Q348_E1.4261.00
398_K430_D1.4131.00
186_I297_I1.4131.00
326_V330_K1.4001.00
57_E60_E1.3961.00
136_A139_F1.3931.00
284_K288_S1.3891.00
257_V273_M1.3881.00
174_P178_H1.3861.00
284_K322_R1.3851.00
342_T345_Q1.3791.00
343_V347_R1.3761.00
61_K126_K1.3681.00
180_F248_L1.3631.00
175_D484_A1.3541.00
299_Q303_G1.3521.00
189_A192_R1.3491.00
327_D330_K1.3361.00
281_A468_G1.3311.00
112_S118_I1.3271.00
274_I474_I1.3191.00
458_E461_E1.3181.00
323_I385_I1.3171.00
103_D107_E1.3141.00
432_R454_E1.3021.00
189_A301_V1.2991.00
450_H458_E1.2991.00
219_F225_A1.2991.00
427_D430_D1.2991.00
402_D405_F1.2951.00
375_I379_L1.2941.00
390_V434_R1.2891.00
67_I85_L1.2851.00
185_K305_T1.2841.00
194_L274_I1.2761.00
250_K278_E1.2741.00
321_K381_Q1.2711.00
411_L419_A1.2671.00
363_V367_I1.2651.00
54_T57_E1.2641.00
119_G142_L1.2401.00
120_V136_A1.2381.00
124_V132_L1.2361.00
192_R296_H1.2321.00
180_F492_L1.2281.00
181_I185_K1.2271.00
165_Q458_E1.2231.00
332_A378_T1.2221.00
321_K331_E1.2191.00
79_K98_K1.2181.00
236_I257_V1.2011.00
441_E451_L1.1981.00
288_S340_E1.1971.00
178_H181_I1.1961.00
326_V405_F1.1941.00
434_R437_A1.1871.00
194_L276_L1.1871.00
80_A95_Y1.1761.00
430_D433_E1.1681.00
182_T301_V1.1661.00
396_A422_F1.1611.00
124_V134_V1.1591.00
73_T84_H1.1501.00
152_K155_G1.1491.00
190_M474_I1.1361.00
177_K248_L1.1361.00
432_R450_H1.1311.00
222_H227_D1.1301.00
96_V136_A1.1291.00
194_L293_L1.1251.00
112_S139_F1.1241.00
222_H229_P1.1211.00
399_N405_F1.1161.00
83_A94_I1.1151.00
186_I481_L1.1101.00
364_G367_I1.1061.00
202_V248_L1.1051.00
190_M297_I1.0981.00
151_D155_G1.0941.00
290_T472_I1.0931.00
236_I273_M1.0881.00
207_M221_T1.0861.00
201_E252_Y1.0861.00
390_V398_K1.0821.00
262_G497_R1.0801.00
291_E295_A1.0791.00
113_D116_D1.0731.00
224_N227_D1.0711.00
151_D154_H1.0691.00
72_M86_Q1.0671.00
67_I134_V1.0641.00
185_K195_D1.0631.00
52_D89_E1.0551.00
197_H289_L1.0551.00
441_E450_H1.0531.00
362_T365_H1.0531.00
294_V477_L1.0521.00
238_L455_D1.0481.00
292_N295_A1.0481.00
297_I301_V1.0461.00
87_D90_G1.0461.00
328_A385_I1.0461.00
186_I474_I1.0441.00
85_L118_I1.0441.00
89_E92_I1.0441.00
97_R100_S1.0381.00
86_Q115_G1.0381.00
49_A63_I1.0311.00
382_P413_I1.0301.00
170_L180_F1.0281.00
299_Q305_T1.0251.00
291_E340_E1.0251.00
203_E256_R1.0201.00
441_E452_M1.0161.00
191_R252_Y1.0151.00
97_R135_K1.0131.00
107_E110_K1.0111.00
432_R461_E1.0111.00
434_R438_Q1.0091.00
112_S141_L1.0091.00
83_A118_I1.0051.00
207_M230_L1.0021.00
484_A489_D0.9901.00
182_T186_I0.9901.00
56_E60_E0.9891.00
105_Q108_I0.9891.00
332_A342_T0.9851.00
281_A286_I0.9831.00
245_V464_M0.9831.00
484_A490_V0.9771.00
111_S144_K0.9741.00
236_I255_G0.9701.00
287_M322_R0.9691.00
346_A350_A0.9681.00
149_L153_Y0.9671.00
182_T185_K0.9661.00
236_I239_H0.9651.00
293_L297_I0.9611.00
143_T464_M0.9611.00
89_E249_E0.9601.00
319_E322_R0.9581.00
266_R416_R0.9571.00
368_N392_I0.9561.00
329_V367_I0.9541.00
100_S137_T0.9521.00
292_N296_H0.9521.00
295_A317_K0.9491.00
158_D161_Q0.9491.00
290_T470_L0.9461.00
187_I201_E0.9411.00
285_D288_S0.9351.00
184_S188_Q0.9331.00
387_G405_F0.9311.00
100_S135_K0.9281.00
193_Y289_L0.9241.00
362_T391_E0.9241.00
67_I120_V0.9211.00
92_I124_V0.9191.00
464_M467_T0.9191.00
300_E304_T0.9181.00
242_R493_F0.9151.00
428_P457_V0.9141.00
351_K362_T0.9131.00
65_V124_V0.9121.00
106_Y110_K0.9111.00
117_L143_T0.9070.99
72_M91_Q0.9060.99
299_Q315_D0.9000.99
398_K426_N0.8980.99
454_E458_E0.8970.99
344_E348_E0.8960.99
351_K357_I0.8960.99
96_V109_F0.8920.99
338_W381_Q0.8910.99
187_I274_I0.8870.99
440_K449_A0.8870.99
305_T317_K0.8860.99
88_L181_I0.8790.99
243_L492_L0.8780.99
116_D144_K0.8780.99
167_Y458_E0.8770.99
286_I470_L0.8740.99
290_T419_A0.8720.99
122_G134_V0.8660.99
283_Y287_M0.8640.99
276_L290_T0.8630.99
323_I383_T0.8630.99
295_A305_T0.8530.99
175_D179_T0.8510.99
182_T302_L0.8500.99
436_E450_H0.8490.99
113_D144_K0.8440.99
211_P451_L0.8440.99
53_L56_E0.8430.99
435_F453_D0.8430.99
441_E448_E0.8420.99
70_R280_Y0.8390.99
77_K80_A0.8380.99
199_Y250_K0.8380.99
244_I464_M0.8380.99
328_A331_E0.8350.99
291_E322_R0.8330.99
50_Y63_I0.8330.99
425_L430_D0.8290.99
245_V460_L0.8250.99
472_I477_L0.8240.99
76_G81_G0.8180.99
242_R459_A0.8170.99
479_M487_I0.8170.99
342_T386_Y0.8160.99
440_K453_D0.8140.99
357_I361_M0.8130.99
209_S239_H0.8130.99
67_I94_I0.8120.99
220_I231_Y0.8100.99
341_V368_N0.8080.99
418_H477_L0.8060.99
300_E303_G0.8050.99
297_I300_E0.8040.99
206_T236_I0.8020.99
358_K361_M0.7970.99
416_R480_L0.7960.99
184_S252_Y0.7940.99
281_A289_L0.7910.99
76_G79_K0.7890.99
197_H250_K0.7880.99
126_K131_E0.7860.99
179_T482_T0.7850.99
223_H230_L0.7840.99
276_L286_I0.7830.99
356_E360_S0.7830.99
349_Y352_E0.7820.98
120_V134_V0.7800.98
150_P153_Y0.7780.98
429_I432_R0.7780.98
189_A193_Y0.7770.98
186_I301_V0.7760.98
104_D107_E0.7740.98
117_L465_P0.7740.98
387_G407_D0.7740.98
83_A96_V0.7730.98
390_V406_T0.7710.98
330_K334_G0.7680.98
393_S408_R0.7680.98
108_I111_S0.7670.98
320_W411_L0.7670.98
361_M365_H0.7650.98
74_K81_G0.7630.98
349_Y353_H0.7600.98
330_K345_Q0.7600.98
283_Y387_G0.7600.98
429_I433_E0.7580.98
375_I378_T0.7570.98
108_I139_F0.7560.98
287_M386_Y0.7550.98
397_K426_N0.7500.98
370_F374_K0.7470.98
320_W382_P0.7450.98
296_H299_Q0.7430.98
127_T131_E0.7410.98
52_D92_I0.7380.98
385_I412_F0.7370.98
397_K400_P0.7370.98
425_L434_R0.7350.98
350_A366_I0.7350.98
364_G368_N0.7340.98
86_Q174_P0.7330.98
211_P235_A0.7330.98
173_N176_S0.7330.98
388_H412_F0.7330.98
83_A136_A0.7330.98
107_E111_S0.7260.98
334_G364_G0.7220.97
281_A423_T0.7220.97
343_V363_V0.7200.97
409_F421_A0.7190.97
449_A457_V0.7180.97
368_N371_F0.7150.97
345_Q349_Y0.7130.97
408_R420_N0.7110.97
73_T114_L0.7100.97
397_K407_D0.7100.97
355_V378_T0.7100.97
454_E457_V0.7090.97
141_L144_K0.7070.97
298_A316_L0.7070.97
301_V481_L0.7060.97
314_I414_V0.7060.97
254_I474_I0.7050.97
206_T256_R0.7050.97
318_P322_R0.7050.97
287_M384_F0.7050.97
276_L289_L0.7020.97
56_E132_L0.7020.97
482_T490_V0.6970.97
94_I118_I0.6960.97
347_R351_K0.6940.97
291_E319_E0.6910.97
440_K452_M0.6900.97
323_I331_E0.6890.97
53_L57_E0.6890.97
265_T486_S0.6880.97
167_Y462_Y0.6860.97
62_A126_K0.6860.97
105_Q139_F0.6830.96
365_H368_N0.6830.96
290_T409_F0.6820.96
184_S200_L0.6800.96
88_L249_E0.6790.96
333_T337_F0.6790.96
85_L94_I0.6780.96
283_Y399_N0.6780.96
163_Y489_D0.6780.96
182_T478_V0.6770.96
194_L289_L0.6760.96
116_D141_L0.6760.96
176_S489_D0.6740.96
478_V482_T0.6730.96
117_L280_Y0.6710.96
244_I279_A0.6710.96
430_D434_R0.6700.96
295_A319_E0.6700.96
204_T253_E0.6690.96
166_R170_L0.6690.96
144_K427_D0.6670.96
185_K304_T0.6660.96
317_K321_K0.6660.96
344_E363_V0.6660.96
154_H175_D0.6660.96
439_L452_M0.6660.96
168_L458_E0.6640.96
378_T483_N0.6630.96
71_M74_K0.6610.96
391_E404_R0.6580.96
176_S179_T0.6570.96
411_L472_I0.6550.96
263_V496_M0.6530.95
407_D423_T0.6500.95
121_T137_T0.6490.95
169_D173_N0.6490.95
161_Q165_Q0.6480.95
299_Q302_L0.6480.95
144_K429_I0.6470.95
187_I203_E0.6460.95
393_S422_F0.6460.95
314_I380_I0.6460.95
289_L292_N0.6450.95
183_R203_E0.6450.95
100_S123_K0.6450.95
127_T130_G0.6440.95
298_A380_I0.6440.95
353_H370_F0.6420.95
74_K114_L0.6420.95
83_A109_F0.6420.95
97_R125_F0.6400.95
174_P177_K0.6390.95
51_Q55_K0.6370.95
284_K287_M0.6370.95
224_N229_P0.6370.95
398_K425_L0.6370.95
52_D55_K0.6360.95
369_E372_E0.6350.95
51_Q60_E0.6340.95
74_K83_A0.6330.95
96_V139_F0.6280.94
282_D423_T0.6260.94
98_K106_Y0.6250.94
61_K132_L0.6240.94
192_R304_T0.6240.94
200_L248_L0.6240.94
373_Q377_E0.6240.94
342_T387_G0.6230.94
295_A299_Q0.6220.94
286_I290_T0.6220.94
330_K336_D0.6210.94
338_W341_V0.6210.94
328_A332_A0.6210.94
401_E404_R0.6180.94
109_F139_F0.6180.94
349_Y379_L0.6170.94
325_M329_V0.6160.94
355_V358_K0.6150.94
286_I289_L0.6150.94
419_A472_I0.6140.94
426_N464_M0.6140.94
295_A320_W0.6130.94
197_H296_H0.6120.94
294_V472_I0.6090.93
63_I124_V0.6080.93
294_V320_W0.6070.93
149_L152_K0.6050.93
448_E452_M0.6050.93
318_P324_H0.6040.93
203_E272_T0.6030.93
416_R486_S0.6020.93
278_E285_D0.6020.93
194_L470_L0.6010.93
175_D489_D0.6010.93
410_E420_N0.5970.93
399_N402_D0.5950.93
204_T240_L0.5950.93
323_I327_D0.5940.93
302_L314_I0.5940.93
147_R461_E0.5930.93
370_F373_Q0.5910.92
330_K333_T0.5910.92
149_L155_G0.5900.92
399_N404_R0.5880.92
328_A375_I0.5870.92
204_T236_I0.5850.92
89_E181_I0.5850.92
399_N403_P0.5840.92
98_K103_D0.5840.92
75_R84_H0.5830.92
371_F385_I0.5820.92
283_Y386_Y0.5810.92
81_G109_F0.5810.92
175_D178_H0.5800.92
69_G94_I0.5790.92
286_I409_F0.5790.92
384_F409_F0.5790.92
148_P153_Y0.5780.92
159_V163_Y0.5780.92
80_A125_F0.5780.92
484_A487_I0.5760.91
436_E440_K0.5760.91
77_K128_N0.5760.91
323_I332_A0.5750.91
183_R475_D0.5720.91
343_V366_I0.5720.91
302_L481_L0.5710.91
199_Y236_I0.5710.91
236_I254_I0.5690.91
361_M369_E0.5690.91
105_Q138_S0.5670.91
452_M457_V0.5660.91
346_A349_Y0.5660.91
117_L142_L0.5650.91
187_I254_I0.5640.91
194_L252_Y0.5640.91
315_D318_P0.5630.91
376_E381_Q0.5630.91
49_A53_L0.5630.91
190_M254_I0.5620.90
124_V133_S0.5620.90
361_M364_G0.5610.90
240_L253_E0.5610.90
391_E394_P0.5600.90
257_V274_I0.5600.90
419_A470_L0.5590.90
460_L464_M0.5580.90
431_Q460_L0.5550.90
55_K60_E0.5550.90
76_G110_K0.5540.90
287_M290_T0.5510.90
57_E61_K0.5500.90
353_H378_T0.5490.89
194_L197_H0.5470.89
228_I495_Q0.5470.89
151_D168_L0.5460.89
367_I370_F0.5460.89
287_M420_N0.5460.89
170_L246_G0.5450.89
50_Y66_T0.5450.89
77_K81_G0.5450.89
333_T374_K0.5450.89
341_V385_I0.5430.89
186_I477_L0.5420.89
180_F243_L0.5420.89
145_A462_Y0.5420.89
432_R452_M0.5420.89
211_P231_Y0.5410.89
112_S116_D0.5400.89
242_R455_D0.5400.89
316_L382_P0.5400.89
353_H374_K0.5390.89
209_S212_G0.5380.88
149_L171_I0.5380.88
104_D108_I0.5360.88
399_N430_D0.5350.88
321_K324_H0.5350.88
263_V495_Q0.5350.88
268_N491_L0.5340.88
223_H226_L0.5340.88
284_K340_E0.5330.88
57_E131_E0.5330.88
456_F460_L0.5330.88
148_P151_D0.5330.88
297_I477_L0.5320.88
287_M291_E0.5320.88
421_A470_L0.5310.88
283_Y423_T0.5300.88
185_K189_A0.5290.88
330_K356_E0.5280.88
195_D198_G0.5280.88
246_G465_P0.5280.88
284_K386_Y0.5280.88
100_S105_Q0.5260.87
393_S396_A0.5260.87
287_M409_F0.5260.87
55_K128_N0.5250.87
365_H441_E0.5240.87
63_I123_K0.5240.87
458_E462_Y0.5240.87
209_S228_I0.5230.87
439_L451_L0.5220.87
99_D135_K0.5210.87
116_D145_A0.5200.87
386_Y399_N0.5200.87
56_E61_K0.5190.87
95_Y133_S0.5180.87
157_K161_Q0.5170.86
181_I248_L0.5170.86
238_L456_F0.5160.86
344_E402_D0.5150.86
170_L247_G0.5140.86
237_E424_E0.5130.86
286_I421_A0.5110.86
208_H213_G0.5110.86
193_Y297_I0.5110.86
364_G372_E0.5100.86
245_V456_F0.5100.86
183_R272_T0.5090.86
220_I224_N0.5080.86
397_K430_D0.5080.86
403_P430_D0.5080.86
363_V404_R0.5070.85
92_I132_L0.5070.85
383_T411_L0.5070.85
116_D143_T0.5070.85
278_E286_I0.5070.85
70_R247_G0.5060.85
450_H454_E0.5050.85
96_V100_S0.5050.85
179_T489_D0.5040.85
249_E279_A0.5040.85
168_L462_Y0.5040.85
203_E475_D0.5040.85
151_D157_K0.5020.85
341_V346_A0.5020.85
364_G371_F0.5020.85
74_K113_D0.5010.85
371_F412_F0.5000.85
149_L161_Q0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ex5A 2 0.9639 100 0.103 Contact Map
4pg3A 2 0.9419 100 0.112 Contact Map
4ycuA 3 0.98 100 0.116 Contact Map
4up7A 2 0.986 100 0.116 Contact Map
3a74A 4 0.9699 100 0.133 Contact Map
1e1oA 2 0.9659 100 0.134 Contact Map
3i7fA 2 0.8898 100 0.225 Contact Map
1l0wA 2 0.8637 100 0.236 Contact Map
1eovA 2 0.9058 100 0.236 Contact Map
1c0aA 1 0.8637 100 0.241 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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