FTSH - BACSU - GREMLIN Contacts

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FTSH - ATP-dependent zinc metalloprotease FtsH

UniProt:	P37476	Sequences: MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNLDDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEPAQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKFKDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVIGREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDARDIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQAGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIARRMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYERAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNILTKTEEKKDDTKE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	637 (587)
Sequences:	4696 (2601)
Seq/√Len:	107.3

ECOLI - FTSH
BACSU - FTSH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
576_R	580_E	5.699	1.00
570_Q	574_E	5.168	1.00
337_E	356_K	4.016	1.00
559_R	563_E	3.919	1.00
548_Q	551_Y	3.752	1.00
43_N	48_K	3.714	1.00
488_I	576_R	3.560	1.00
337_E	341_K	3.542	1.00
519_K	552_E	3.464	1.00
475_I	564_C	3.423	1.00
344_A	374_L	3.416	1.00
386_K	393_D	3.397	1.00
330_R	366_S	3.393	1.00
347_K	389_I	3.198	1.00
580_E	584_Q	3.191	1.00
178_E	186_F	3.158	1.00
344_A	355_L	3.141	1.00
433_V	571_I	3.128	1.00
247_E	251_K	3.117	1.00
569_K	573_T	3.074	1.00
486_E	569_K	2.983	1.00
589_V	596_Q	2.972	1.00
188_E	387_K	2.903	1.00
575_N	578_K	2.867	1.00
433_V	575_N	2.846	1.00
386_K	390_D	2.844	1.00
340_L	370_L	2.838	1.00
487_I	572_L	2.809	1.00
78_T	81_P	2.776	1.00
430_I	476_V	2.774	1.00
511_V	560_I	2.726	1.00
374_L	394_I	2.717	1.00
476_V	564_C	2.704	1.00
519_K	556_E	2.673	1.00
488_I	579_L	2.639	1.00
436_E	473_D	2.624	1.00
478_L	502_R	2.620	1.00
519_K	555_Q	2.614	1.00
488_I	580_E	2.591	1.00
475_I	507_A	2.562	1.00
425_G	582_I	2.557	1.00
486_E	565_Y	2.549	1.00
418_N	584_Q	2.548	1.00
498_N	501_Q	2.545	1.00
566_E	570_Q	2.523	1.00
384_Q	396_E	2.410	1.00
431_G	457_M	2.398	1.00
558_Q	562_K	2.392	1.00
476_V	568_A	2.386	1.00
420_V	465_F	2.382	1.00
390_D	393_D	2.354	1.00
483_V	569_K	2.319	1.00
125_L	129_L	2.310	1.00
503_A	561_I	2.302	1.00
457_M	477_G	2.277	1.00
471_L	506_I	2.226	1.00
184_R	188_E	2.213	1.00
475_I	560_I	2.213	1.00
40_F	44_L	2.210	1.00
192_R	371_E	2.191	1.00
88_Q	91_N	2.140	1.00
469_P	491_E	2.120	1.00
432_L	598_K	2.100	1.00
509_R	513_E	2.092	1.00
494_T	514_F	2.091	1.00
509_R	514_F	2.075	1.00
498_N	502_R	2.061	1.00
36_S	39_T	2.049	1.00
487_I	573_T	2.046	1.00
472_L	563_E	2.044	1.00
351_E	388_K	2.007	1.00
76_F	81_P	1.962	1.00
431_G	477_G	1.962	1.00
223_F	252_N	1.956	1.00
463_R	470_E	1.947	1.00
585_T	592_L	1.944	1.00
444_T	591_T	1.925	1.00
384_Q	393_D	1.924	1.00
338_A	341_K	1.922	1.00
468_K	472_L	1.921	1.00
350_D	388_K	1.911	1.00
476_V	567_R	1.907	1.00
517_S	556_E	1.902	1.00
434_L	473_D	1.887	1.00
472_L	564_C	1.879	1.00
565_Y	569_K	1.849	1.00
419_I	489_F	1.834	1.00
381_A	393_D	1.833	1.00
523_L	561_I	1.831	1.00
185_K	385_N	1.804	1.00
44_L	49_V	1.780	1.00
173_L	214_C	1.774	1.00
93_L	96_T	1.761	1.00
86_A	93_L	1.728	1.00
593_D	596_Q	1.720	1.00
562_K	566_E	1.708	1.00
417_R	587_L	1.703	1.00
40_F	52_V	1.702	1.00
334_I	337_E	1.683	1.00
468_K	518_E	1.683	1.00
114_T	118_P	1.680	1.00
83_G	86_A	1.647	1.00
415_K	418_N	1.639	1.00
47_G	96_T	1.633	1.00
39_T	43_N	1.631	1.00
585_T	589_V	1.623	1.00
452_G	465_F	1.619	1.00
573_T	576_R	1.619	1.00
419_I	493_S	1.616	1.00
473_D	567_R	1.615	1.00
422_Y	580_E	1.614	1.00
350_D	390_D	1.614	1.00
551_Y	555_Q	1.612	1.00
120_V	124_I	1.609	1.00
347_K	374_L	1.606	1.00
119_F	123_F	1.606	1.00
566_E	569_K	1.603	1.00
266_G	316_L	1.594	1.00
344_A	394_I	1.593	1.00
176_V	197_V	1.587	1.00
51_S	99_K	1.554	1.00
123_F	127_F	1.550	1.00
567_R	570_Q	1.550	1.00
42_K	46_D	1.545	1.00
89_I	93_L	1.544	1.00
594_A	598_K	1.542	1.00
471_L	494_T	1.526	1.00
210_L	328_V	1.521	1.00
437_A	477_G	1.504	1.00
584_Q	588_K	1.504	1.00
483_V	565_Y	1.493	1.00
422_Y	584_Q	1.492	1.00
39_T	42_K	1.490	1.00
474_K	502_R	1.490	1.00
392_R	396_E	1.481	1.00
61_Y	65_G	1.480	1.00
124_I	128_F	1.478	1.00
250_K	297_N	1.472	1.00
552_E	555_Q	1.466	1.00
525_F	553_I	1.463	1.00
505_N	509_R	1.453	1.00
93_L	98_V	1.449	1.00
487_I	569_K	1.447	1.00
443_V	455_A	1.447	1.00
578_K	581_L	1.440	1.00
440_V	455_A	1.435	1.00
108_G	112_F	1.434	1.00
487_I	576_R	1.423	1.00
354_N	357_S	1.413	1.00
478_L	506_I	1.404	1.00
418_N	489_F	1.399	1.00
82_E	86_A	1.393	1.00
585_T	599_H	1.387	1.00
451_A	454_Y	1.387	1.00
556_E	559_R	1.383	1.00
415_K	461_E	1.380	1.00
437_A	457_M	1.374	1.00
437_A	473_D	1.373	1.00
489_F	493_S	1.361	1.00
167_D	335_G	1.349	1.00
507_A	560_I	1.340	1.00
91_N	95_K	1.333	0.99
433_V	578_K	1.321	0.99
578_K	601_I	1.317	0.99
429_V	582_I	1.310	0.99
202_P	329_D	1.307	0.99
86_A	90_F	1.305	0.99
581_L	603_H	1.304	0.99
429_V	579_L	1.297	0.99
249_A	257_I	1.294	0.99
548_Q	552_E	1.287	0.99
86_A	89_I	1.285	0.99
117_I	120_V	1.280	0.99
520_L	525_F	1.278	0.99
430_I	568_A	1.273	0.99
140_V	143_F	1.273	0.99
334_I	338_A	1.272	0.99
248_N	251_K	1.266	0.99
93_L	97_D	1.265	0.99
146_S	244_D	1.263	0.99
472_L	476_V	1.260	0.99
116_I	120_V	1.250	0.99
81_P	84_K	1.250	0.99
500_F	524_Q	1.247	0.99
66_Q	69_N	1.233	0.99
472_L	567_R	1.232	0.99
581_L	585_T	1.232	0.99
361_R	398_T	1.221	0.99
441_H	458_L	1.220	0.99
399_D	442_K	1.214	0.99
255_C	300_I	1.209	0.99
158_V	212_K	1.205	0.99
596_Q	599_H	1.200	0.99
438_D	474_K	1.197	0.99
395_D	441_H	1.189	0.99
356_K	360_M	1.179	0.99
118_P	121_I	1.169	0.99
94_K	100_V	1.168	0.99
45_D	92_A	1.167	0.99
214_C	303_I	1.162	0.99
414_K	418_N	1.154	0.98
478_L	503_A	1.146	0.98
79_H	82_E	1.143	0.98
349_L	355_L	1.142	0.98
18_V	22_V	1.135	0.98
92_A	95_K	1.132	0.98
543_Q	547_D	1.131	0.98
344_A	349_L	1.128	0.98
153_E	156_K	1.127	0.98
595_E	599_H	1.125	0.98
478_L	498_N	1.116	0.98
124_I	127_F	1.114	0.98
545_Y	550_A	1.114	0.98
467_T	493_S	1.112	0.98
35_M	43_N	1.111	0.98
90_F	100_V	1.111	0.98
519_K	559_R	1.110	0.98
97_D	100_V	1.105	0.98
119_F	125_L	1.104	0.98
122_I	126_F	1.102	0.98
434_L	437_A	1.102	0.98
96_T	100_V	1.102	0.98
148_A	151_Y	1.101	0.98
126_F	130_L	1.095	0.98
466_Q	470_E	1.093	0.98
380_V	393_D	1.086	0.98
59_G	65_G	1.086	0.98
396_E	406_A	1.083	0.98
582_I	600_L	1.082	0.98
599_H	604_G	1.076	0.98
141_M	144_G	1.071	0.98
271_A	536_G	1.070	0.98
430_I	480_G	1.066	0.97
167_D	338_A	1.064	0.97
484_A	579_L	1.064	0.97
428_T	592_L	1.063	0.97
43_N	63_V	1.060	0.97
483_V	573_T	1.060	0.97
443_V	597_I	1.060	0.97
56_P	59_G	1.056	0.97
502_R	505_N	1.055	0.97
570_Q	573_T	1.052	0.97
76_F	79_H	1.049	0.97
127_F	131_N	1.045	0.97
273_L	535_L	1.041	0.97
88_Q	92_A	1.040	0.97
581_L	600_L	1.040	0.97
19_I	23_S	1.039	0.97
59_G	66_Q	1.037	0.97
599_H	603_H	1.034	0.97
171_Q	174_V	1.033	0.97
90_F	93_L	1.029	0.97
536_G	539_F	1.028	0.97
422_Y	488_I	1.027	0.97
61_Y	69_N	1.026	0.97
268_Q	537_R	1.026	0.97
482_R	496_A	1.025	0.97
92_A	96_T	1.021	0.97
169_E	329_D	1.018	0.97
85_G	88_Q	1.017	0.97
373_L	398_T	1.014	0.97
121_I	125_L	1.013	0.97
470_E	474_K	1.010	0.97
212_K	296_A	1.009	0.96
568_A	571_I	1.008	0.96
21_V	25_F	1.004	0.96
51_S	62_E	1.001	0.96
422_Y	583_A	1.000	0.96
457_M	478_L	0.999	0.96
78_T	83_G	0.998	0.96
419_I	465_F	0.997	0.96
398_T	403_A	0.996	0.96
49_V	63_V	0.991	0.96
423_H	427_H	0.991	0.96
128_F	132_Q	0.989	0.96
13_L	20_G	0.988	0.96
432_L	597_I	0.987	0.96
123_F	126_F	0.985	0.96
581_L	584_Q	0.983	0.96
427_H	495_G	0.981	0.96
365_F	373_L	0.980	0.96
340_L	358_I	0.980	0.96
403_A	410_R	0.978	0.96
337_E	355_L	0.977	0.96
572_L	579_L	0.976	0.96
59_G	64_K	0.970	0.96
444_T	454_Y	0.969	0.96
16_L	20_G	0.968	0.96
118_P	122_I	0.968	0.96
108_G	114_T	0.967	0.96
20_G	24_Y	0.964	0.95
119_F	124_I	0.959	0.95
197_V	301_I	0.959	0.95
430_I	571_I	0.959	0.95
421_A	587_L	0.958	0.95
63_V	67_L	0.957	0.95
564_C	567_R	0.957	0.95
87_D	90_F	0.955	0.95
582_I	592_L	0.953	0.95
585_T	596_Q	0.953	0.95
229_D	286_Q	0.947	0.95
117_I	124_I	0.946	0.95
416_E	465_F	0.945	0.95
440_V	443_V	0.945	0.95
63_V	66_Q	0.944	0.95
86_A	96_T	0.944	0.95
547_D	551_Y	0.941	0.95
189_L	382_A	0.938	0.95
61_Y	64_K	0.937	0.95
357_S	391_A	0.933	0.95
264_A	289_V	0.932	0.95
17_V	21_V	0.927	0.94
35_M	40_F	0.927	0.94
145_K	148_A	0.925	0.94
585_T	588_K	0.919	0.94
552_E	558_Q	0.918	0.94
425_G	429_V	0.918	0.94
475_I	503_A	0.917	0.94
465_F	493_S	0.916	0.94
413_S	461_E	0.915	0.94
231_V	279_E	0.914	0.94
41_I	45_D	0.914	0.94
512_T	553_I	0.912	0.94
414_K	417_R	0.911	0.94
577_D	581_L	0.910	0.94
457_M	474_K	0.910	0.94
80_V	84_K	0.903	0.94
255_C	299_G	0.901	0.93
80_V	83_G	0.899	0.93
598_K	602_D	0.895	0.93
172_E	405_P	0.894	0.93
113_L	117_I	0.894	0.93
473_D	476_V	0.891	0.93
21_V	24_Y	0.891	0.93
61_Y	66_Q	0.890	0.93
501_Q	505_N	0.889	0.93
520_L	553_I	0.889	0.93
418_N	422_Y	0.887	0.93
160_F	177_V	0.885	0.93
476_V	571_I	0.882	0.93
64_K	68_K	0.882	0.93
582_I	597_I	0.882	0.93
361_R	399_D	0.881	0.93
176_V	214_C	0.879	0.93
436_E	469_P	0.876	0.92
500_F	523_L	0.876	0.92
112_F	116_I	0.873	0.92
119_F	122_I	0.872	0.92
107_S	111_T	0.871	0.92
358_I	370_L	0.870	0.92
223_F	248_N	0.870	0.92
87_D	93_L	0.867	0.92
483_V	568_A	0.867	0.92
81_P	86_A	0.866	0.92
527_Q	544_N	0.865	0.92
91_N	94_K	0.863	0.92
474_K	506_I	0.862	0.92
56_P	61_Y	0.861	0.92
193_I	301_I	0.856	0.92
144_G	240_S	0.855	0.92
22_V	26_Q	0.854	0.92
116_I	119_F	0.853	0.91
36_S	99_K	0.851	0.91
425_G	583_A	0.850	0.91
520_L	549_I	0.849	0.91
253_A	299_G	0.847	0.91
267_R	311_I	0.846	0.91
166_A	169_E	0.845	0.91
109_W	113_L	0.845	0.91
45_D	94_K	0.844	0.91
361_R	400_R	0.842	0.91
399_D	454_Y	0.841	0.91
415_K	419_I	0.839	0.91
65_G	69_N	0.839	0.91
56_P	63_V	0.834	0.91
603_H	606_L	0.833	0.90
83_G	87_D	0.832	0.90
560_I	564_C	0.832	0.90
189_L	381_A	0.830	0.90
249_A	300_I	0.829	0.90
184_R	187_A	0.829	0.90
357_S	395_D	0.828	0.90
178_E	182_D	0.826	0.90
520_L	552_E	0.826	0.90
432_L	601_I	0.826	0.90
197_V	326_I	0.826	0.90
62_E	66_Q	0.825	0.90
104_Q	107_S	0.825	0.90
469_P	473_D	0.821	0.90
17_V	20_G	0.820	0.90
252_N	255_C	0.820	0.90
419_I	452_G	0.819	0.90
122_I	129_L	0.817	0.90
209_L	367_G	0.815	0.90
37_Y	40_F	0.815	0.90
141_M	145_K	0.815	0.90
76_F	80_V	0.814	0.89
602_D	605_T	0.813	0.89
332_D	335_G	0.812	0.89
599_H	607_P	0.811	0.89
102_P	106_T	0.811	0.89
108_G	111_T	0.811	0.89
87_D	91_N	0.810	0.89
412_I	452_G	0.810	0.89
555_Q	559_R	0.809	0.89
118_P	131_N	0.806	0.89
423_H	495_G	0.806	0.89
172_E	400_R	0.805	0.89
173_L	176_V	0.805	0.89
49_V	52_V	0.803	0.89
579_L	583_A	0.801	0.89
37_Y	41_I	0.799	0.89
412_I	420_V	0.799	0.89
333_V	356_K	0.799	0.89
479_L	503_A	0.794	0.88
82_E	85_G	0.792	0.88
399_D	456_V	0.792	0.88
63_V	69_N	0.790	0.88
56_P	68_K	0.790	0.88
139_R	142_N	0.787	0.88
428_T	443_V	0.786	0.88
43_N	46_D	0.785	0.88
35_M	39_T	0.784	0.88
511_V	557_I	0.783	0.88
538_D	541_N	0.783	0.88
573_T	577_D	0.782	0.88
547_D	550_A	0.781	0.87
357_S	360_M	0.780	0.87
80_V	86_A	0.780	0.87
570_Q	575_N	0.777	0.87
443_V	592_L	0.777	0.87
121_I	124_I	0.777	0.87
119_F	126_F	0.775	0.87
349_L	353_V	0.773	0.87
119_F	129_L	0.773	0.87
86_A	91_N	0.772	0.87
374_L	377_A	0.769	0.87
244_D	248_N	0.768	0.87
340_L	355_L	0.768	0.87
211_A	367_G	0.765	0.86
418_N	587_L	0.765	0.86
166_A	335_G	0.765	0.86
35_M	61_Y	0.763	0.86
380_V	396_E	0.763	0.86
273_L	537_R	0.762	0.86
118_P	128_F	0.761	0.86
517_S	559_R	0.760	0.86
59_G	63_V	0.759	0.86
86_A	98_V	0.759	0.86
452_G	464_Y	0.756	0.86
578_K	600_L	0.756	0.86
81_P	87_D	0.754	0.86
474_K	478_L	0.753	0.85
146_S	149_K	0.752	0.85
513_E	524_Q	0.752	0.85
580_E	583_A	0.748	0.85
166_A	214_C	0.747	0.85
89_I	98_V	0.746	0.85
442_K	591_T	0.746	0.85
139_R	143_F	0.746	0.85
578_K	603_H	0.743	0.85
179_F	193_I	0.739	0.84
89_I	96_T	0.734	0.84
435_D	473_D	0.733	0.84
595_E	598_K	0.733	0.84
15_L	23_S	0.732	0.84
116_I	122_I	0.731	0.84
507_A	557_I	0.731	0.84
122_I	125_L	0.729	0.84
144_G	148_A	0.727	0.83
433_V	601_I	0.727	0.83
174_V	178_E	0.725	0.83
267_R	278_D	0.725	0.83
90_F	94_K	0.724	0.83
429_V	433_V	0.723	0.83
114_T	119_F	0.722	0.83
449_G	454_Y	0.720	0.83
81_P	93_L	0.720	0.83
41_I	49_V	0.720	0.83
41_I	92_A	0.719	0.83
503_A	568_A	0.717	0.83
500_F	503_A	0.717	0.83
53_S	62_E	0.717	0.83
116_I	125_L	0.716	0.82
107_S	110_V	0.714	0.82
16_L	19_I	0.714	0.82
258_F	305_A	0.712	0.82
94_K	97_D	0.711	0.82
178_E	185_K	0.711	0.82
489_F	492_V	0.710	0.82
475_I	561_I	0.709	0.82
347_K	394_I	0.705	0.82
200_V	326_I	0.704	0.81
471_L	514_F	0.704	0.81
377_A	394_I	0.704	0.81
271_A	537_R	0.703	0.81
65_G	68_K	0.702	0.81
489_F	587_L	0.701	0.81
522_P	562_K	0.700	0.81
518_E	559_R	0.700	0.81
23_S	27_T	0.698	0.81
507_A	511_V	0.697	0.81
419_I	491_E	0.696	0.81
84_K	87_D	0.696	0.81
400_R	403_A	0.695	0.81
489_F	583_A	0.694	0.81
406_A	454_Y	0.693	0.80
77_L	81_P	0.693	0.80
86_A	92_A	0.693	0.80
83_G	89_I	0.693	0.80
277_H	280_R	0.692	0.80
469_P	490_G	0.691	0.80
12_L	17_V	0.689	0.80
15_L	25_F	0.689	0.80
151_Y	154_E	0.689	0.80
37_Y	86_A	0.688	0.80
562_K	565_Y	0.688	0.80
49_V	54_V	0.687	0.80
434_L	476_V	0.687	0.80
103_A	106_T	0.686	0.80
175_E	383_R	0.685	0.80
430_I	433_V	0.683	0.79
102_P	107_S	0.680	0.79
273_L	539_F	0.679	0.79
143_F	237_V	0.679	0.79
13_L	16_L	0.679	0.79
443_V	454_Y	0.677	0.79
602_D	606_L	0.677	0.79
62_E	65_G	0.677	0.79
563_E	567_R	0.677	0.79
552_E	556_E	0.675	0.79
365_F	402_I	0.674	0.79
231_V	278_D	0.674	0.79
51_S	101_E	0.673	0.78
479_L	502_R	0.671	0.78
578_K	604_G	0.671	0.78
563_E	566_E	0.670	0.78
135_G	140_V	0.670	0.78
93_L	100_V	0.669	0.78
33_E	39_T	0.669	0.78
111_T	115_T	0.669	0.78
114_T	117_I	0.666	0.78
95_K	98_V	0.666	0.78
563_E	570_Q	0.666	0.78
231_V	280_R	0.663	0.77
412_I	417_R	0.663	0.77
56_P	64_K	0.663	0.77
78_T	86_A	0.662	0.77
410_R	514_F	0.662	0.77
427_H	499_D	0.661	0.77
418_N	580_E	0.661	0.77
13_L	19_I	0.659	0.77
402_I	456_V	0.659	0.77
14_I	23_S	0.658	0.77
319_P	401_V	0.658	0.77
327_T	450_Q	0.657	0.77
295_S	298_E	0.655	0.77
349_L	374_L	0.654	0.76
159_K	209_L	0.653	0.76
85_G	89_I	0.652	0.76
395_D	399_D	0.652	0.76
420_V	464_Y	0.652	0.76
20_G	26_Q	0.651	0.76
521_G	558_Q	0.650	0.76
142_N	148_A	0.649	0.76
434_L	571_I	0.649	0.76
389_I	394_I	0.645	0.75
479_L	568_A	0.644	0.75
44_L	52_V	0.644	0.75
110_V	113_L	0.644	0.75
197_V	303_I	0.642	0.75
549_I	552_E	0.640	0.75
200_V	309_A	0.639	0.75
118_P	126_F	0.639	0.75
69_N	76_F	0.638	0.75
358_I	394_I	0.638	0.75
543_Q	550_A	0.637	0.75
521_G	565_Y	0.637	0.75
226_S	289_V	0.637	0.75
363_P	458_L	0.637	0.75
189_L	592_L	0.636	0.74
472_L	560_I	0.634	0.74
431_G	456_V	0.634	0.74
50_D	64_K	0.633	0.74
127_F	130_L	0.633	0.74
535_L	539_F	0.633	0.74
497_H	500_F	0.633	0.74
407_K	410_R	0.632	0.74
47_G	97_D	0.632	0.74
500_F	522_P	0.631	0.74
44_L	96_T	0.629	0.74
535_L	538_D	0.628	0.74
358_I	395_D	0.627	0.73
16_L	24_Y	0.626	0.73
272_G	275_G	0.626	0.73
111_T	116_I	0.625	0.73
187_A	299_G	0.625	0.73
58_R	64_K	0.625	0.73
110_V	114_T	0.625	0.73
584_Q	587_L	0.624	0.73
407_K	420_V	0.623	0.73
273_L	536_G	0.623	0.73
548_Q	555_Q	0.623	0.73
14_I	18_V	0.622	0.73
106_T	111_T	0.622	0.73
239_A	282_Q	0.622	0.73
28_S	50_D	0.622	0.73
410_R	454_Y	0.622	0.73
44_L	93_L	0.622	0.73
54_V	59_G	0.622	0.73
93_L	99_K	0.622	0.73
535_L	541_N	0.621	0.73
115_T	118_P	0.618	0.72
179_F	294_F	0.618	0.72
82_E	93_L	0.618	0.72
91_N	96_T	0.618	0.72
16_L	25_F	0.618	0.72
495_G	499_D	0.616	0.72
133_A	136_G	0.616	0.72
146_S	150_L	0.615	0.72
22_V	25_F	0.614	0.72
396_E	448_R	0.614	0.72
430_I	440_V	0.613	0.72
28_S	31_K	0.613	0.72
309_A	535_L	0.613	0.72
60_V	63_V	0.613	0.72
85_G	90_F	0.613	0.72
104_Q	109_W	0.612	0.72
335_G	366_S	0.612	0.72
42_K	95_K	0.612	0.72
61_Y	68_K	0.610	0.71
58_R	61_Y	0.610	0.71
89_I	92_A	0.609	0.71
479_L	561_I	0.609	0.71
466_Q	506_I	0.608	0.71
386_K	392_R	0.607	0.71
594_A	597_I	0.606	0.71
546_S	551_Y	0.604	0.71
325_Q	450_Q	0.604	0.71
61_Y	67_L	0.602	0.70
76_F	82_E	0.602	0.70
471_L	509_R	0.602	0.70
14_I	25_F	0.601	0.70
187_A	195_K	0.600	0.70
333_V	337_E	0.600	0.70
605_T	608_E	0.600	0.70
407_K	454_Y	0.599	0.70
14_I	17_V	0.598	0.70
522_P	565_Y	0.598	0.70
115_T	123_F	0.597	0.70
484_A	488_I	0.596	0.70
34_N	39_T	0.595	0.69
120_V	123_F	0.595	0.69
41_I	94_K	0.595	0.69
233_M	237_V	0.595	0.69
51_S	56_P	0.594	0.69
84_K	93_L	0.594	0.69
589_V	603_H	0.594	0.69
51_S	63_V	0.594	0.69
59_G	69_N	0.593	0.69
537_R	544_N	0.593	0.69
494_T	498_N	0.593	0.69
132_Q	135_G	0.592	0.69
456_V	466_Q	0.592	0.69
507_A	561_I	0.591	0.69
382_A	385_N	0.591	0.69
17_V	25_F	0.590	0.69
250_K	298_E	0.589	0.69
155_K	219_G	0.587	0.68
566_E	573_T	0.587	0.68
82_E	89_I	0.587	0.68
489_F	579_L	0.587	0.68
399_D	465_F	0.586	0.68
47_G	98_V	0.586	0.68
334_I	356_K	0.585	0.68
18_V	21_V	0.585	0.68
198_L	325_Q	0.585	0.68
199_L	596_Q	0.585	0.68
530_G	535_L	0.584	0.68
36_S	42_K	0.584	0.68
36_S	53_S	0.583	0.68
98_V	101_E	0.582	0.68
581_L	605_T	0.582	0.68
438_D	459_P	0.582	0.68
161_K	338_A	0.582	0.68
45_D	96_T	0.580	0.68
14_I	22_V	0.580	0.68
391_A	395_D	0.577	0.67
35_M	49_V	0.577	0.67
79_H	83_G	0.576	0.67
223_F	408_K	0.576	0.67
42_K	94_K	0.576	0.67
505_N	527_Q	0.576	0.67
268_Q	314_P	0.575	0.67
523_L	553_I	0.574	0.67
383_R	400_R	0.573	0.67
83_G	90_F	0.573	0.67
332_D	410_R	0.572	0.66
432_L	594_A	0.571	0.66
417_R	446_V	0.571	0.66
438_D	470_E	0.570	0.66
508_R	557_I	0.570	0.66
427_H	496_A	0.569	0.66
115_T	126_F	0.569	0.66
469_P	472_L	0.569	0.66
253_A	300_I	0.569	0.66
343_H	371_E	0.568	0.66
352_T	391_A	0.568	0.66
181_K	219_G	0.567	0.66
16_L	65_G	0.567	0.66
360_M	588_K	0.567	0.66
24_Y	28_S	0.566	0.66
166_A	338_A	0.566	0.66
523_L	557_I	0.565	0.66
384_Q	392_R	0.565	0.66
150_L	248_N	0.565	0.66
575_N	605_T	0.565	0.66
522_P	561_I	0.563	0.65
77_L	84_K	0.562	0.65
412_I	419_I	0.562	0.65
12_L	23_S	0.561	0.65
85_G	91_N	0.560	0.65
56_P	62_E	0.560	0.65
16_L	53_S	0.560	0.65
12_L	20_G	0.559	0.65
100_V	115_T	0.559	0.65
265_V	310_D	0.558	0.65
83_G	93_L	0.558	0.65
380_V	397_A	0.558	0.65
466_Q	514_F	0.558	0.65
357_S	441_H	0.557	0.64
20_G	25_F	0.556	0.64
600_L	603_H	0.556	0.64
118_P	125_L	0.555	0.64
16_L	26_Q	0.555	0.64
13_L	29_N	0.554	0.64
29_N	32_T	0.554	0.64
188_E	348_P	0.554	0.64
13_L	17_V	0.554	0.64
398_T	402_I	0.553	0.64
231_V	239_A	0.552	0.64
467_T	491_E	0.552	0.64
44_L	98_V	0.552	0.64
152_T	155_K	0.552	0.64
300_I	541_N	0.552	0.64
145_K	244_D	0.551	0.64
52_V	98_V	0.551	0.64
272_G	278_D	0.551	0.64
49_V	76_F	0.550	0.63
200_V	325_Q	0.550	0.63
81_P	91_N	0.550	0.63
471_L	560_I	0.549	0.63
199_L	379_L	0.549	0.63
143_F	146_S	0.548	0.63
330_R	450_Q	0.546	0.63
564_C	568_A	0.545	0.63
169_E	407_K	0.545	0.63
144_G	233_M	0.544	0.63
347_K	371_E	0.544	0.63
441_H	456_V	0.543	0.62
572_L	582_I	0.542	0.62
25_F	30_P	0.542	0.62
536_G	541_N	0.542	0.62
403_A	470_E	0.542	0.62
40_F	61_Y	0.541	0.62
80_V	85_G	0.540	0.62
161_K	345_R	0.540	0.62
35_M	392_R	0.540	0.62
162_D	345_R	0.540	0.62
468_K	491_E	0.539	0.62
328_V	514_F	0.539	0.62
19_I	58_R	0.539	0.62
116_I	127_F	0.538	0.62
81_P	90_F	0.538	0.62
152_T	157_R	0.537	0.62
18_V	23_S	0.537	0.62
277_H	537_R	0.537	0.62
361_R	395_D	0.537	0.62
402_I	466_Q	0.537	0.62
277_H	311_I	0.537	0.62
465_F	514_F	0.536	0.62
144_G	244_D	0.536	0.62
195_K	299_G	0.536	0.62
13_L	23_S	0.536	0.62
415_K	436_E	0.536	0.62
142_N	145_K	0.535	0.61
13_L	22_V	0.535	0.61
77_L	83_G	0.535	0.61
585_T	600_L	0.535	0.61
403_A	441_H	0.535	0.61
58_R	62_E	0.533	0.61
89_I	97_D	0.532	0.61
492_V	565_Y	0.532	0.61
106_T	110_V	0.532	0.61
131_N	140_V	0.532	0.61
423_H	499_D	0.531	0.61
229_D	289_V	0.531	0.61
23_S	26_Q	0.530	0.61
60_V	64_K	0.530	0.61
341_K	356_K	0.530	0.61
12_L	15_L	0.529	0.61
17_V	27_T	0.529	0.61
43_N	253_A	0.528	0.60
538_D	544_N	0.528	0.60
182_D	185_K	0.528	0.60
229_D	399_D	0.527	0.60
14_I	29_N	0.527	0.60
63_V	68_K	0.526	0.60
342_V	593_D	0.526	0.60
77_L	85_G	0.524	0.60
53_S	101_E	0.524	0.60
118_P	124_I	0.524	0.60
333_V	360_M	0.523	0.60
148_A	244_D	0.522	0.59
107_S	114_T	0.522	0.59
126_F	493_S	0.520	0.59
416_E	464_Y	0.520	0.59
90_F	96_T	0.520	0.59
496_A	499_D	0.520	0.59
527_Q	542_E	0.519	0.59
421_A	511_V	0.519	0.59
44_L	63_V	0.518	0.59
543_Q	549_I	0.518	0.59
348_P	388_K	0.517	0.59
327_T	535_L	0.517	0.59
82_E	90_F	0.516	0.59
466_Q	474_K	0.515	0.58
17_V	105_E	0.515	0.58
374_L	389_I	0.515	0.58
446_V	592_L	0.515	0.58
22_V	116_I	0.514	0.58
395_D	600_L	0.514	0.58
508_R	544_N	0.513	0.58
526_G	544_N	0.513	0.58
195_K	302_I	0.513	0.58
115_T	122_I	0.513	0.58
347_K	452_G	0.512	0.58
249_A	512_T	0.511	0.58
352_T	390_D	0.511	0.58
145_K	149_K	0.511	0.58
530_G	540_N	0.511	0.58
380_V	405_P	0.510	0.58
107_S	115_T	0.510	0.58
286_Q	290_E	0.510	0.58
20_G	23_S	0.510	0.58
272_G	310_D	0.509	0.58
309_A	328_V	0.508	0.57
453_G	515_G	0.508	0.57
365_F	458_L	0.507	0.57
398_T	454_Y	0.507	0.57
523_L	558_Q	0.507	0.57
15_L	19_I	0.506	0.57
168_E	332_D	0.506	0.57
342_V	371_E	0.506	0.57
383_R	405_P	0.506	0.57
268_Q	271_A	0.506	0.57
152_T	500_F	0.505	0.57
64_K	67_L	0.505	0.57
270_G	277_H	0.505	0.57
202_P	330_R	0.505	0.57
219_G	589_V	0.505	0.57
379_L	383_R	0.505	0.57
16_L	42_K	0.504	0.57
333_V	411_V	0.504	0.57
40_F	78_T	0.504	0.57
416_E	463_R	0.504	0.57
405_P	444_T	0.503	0.57
508_R	512_T	0.502	0.57
449_G	480_G	0.502	0.57
460_R	463_R	0.502	0.57
226_S	278_D	0.502	0.57
156_K	159_K	0.501	0.56
197_V	462_D	0.501	0.56
330_R	335_G	0.501	0.56
535_L	540_N	0.500	0.56
46_D	66_Q	0.500	0.56
187_A	191_A	0.500	0.56
139_R	197_V	0.500	0.56
159_K	162_D	0.500	0.56
48_K	65_G	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ce7A	3	0.6735	100	0.395	Contact Map
4ww0A	4	0.6766	100	0.405	Contact Map
2dhrA	5	0.719	100	0.439	Contact Map
4cr2J	1	0.5761	100	0.663	Contact Map
4cr2I	1	0.5651	100	0.683	Contact Map
4cr2K	1	0.5918	100	0.696	Contact Map
4cr2L	1	0.5636	100	0.696	Contact Map
4cr2M	1	0.5636	100	0.701	Contact Map
4cr2H	1	0.551	100	0.705	Contact Map
3cf2A	3	0.5243	100	0.708	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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