MFD - BACSU - GREMLIN Contacts

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MFD - Transcription-repair-coupling factor

UniProt:	P37474	Sequences: MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSALANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQRLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEVGYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETLTSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSEGQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLLEEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQMNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYIMEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVHINHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLYKLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQETEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTTILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKDVVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLVPDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKMGLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRDLTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAYIPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVYARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQTKGRSADEWLDTVLGMLKGLKDVKKQTISST	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	1177 (1106)
Sequences:	2558 (1543)
Seq/√Len:	46.4

ECOLI - MFD
BACSU - MFD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
852_I	861_V	8.675	1.00
607_S	671_D	7.139	1.00
142_I	201_V	6.608	1.00
721_G	726_T	6.545	1.00
669_I	729_I	5.929	1.00
879_S	884_E	5.331	1.00
735_R	740_D	5.164	1.00
712_R	716_N	5.084	1.00
194_I	201_V	4.927	1.00
837_F	909_F	4.680	1.00
673_K	745_D	4.535	1.00
749_L	765_I	4.525	1.00
639_M	668_A	4.515	1.00
723_K	742_V	4.475	1.00
1031_I	1076_V	4.469	1.00
143_Q	220_S	4.454	1.00
692_I	731_I	4.386	1.00
181_I	196_L	4.360	1.00
722_L	730_V	4.299	1.00
719_I	741_V	4.228	1.00
720_K	724_N	4.214	1.00
704_G	718_T	4.208	1.00
689_Y	693_K	4.188	1.00
309_L	315_I	4.124	1.00
42_T	308_I	3.984	1.00
717_E	721_G	3.980	1.00
721_G	730_V	3.975	1.00
704_G	727_V	3.883	1.00
669_I	701_I	3.862	1.00
862_A	885_S	3.762	1.00
848_K	909_F	3.635	1.00
413_L	453_G	3.630	1.00
389_F	399_E	3.597	1.00
677_L	692_I	3.545	1.00
56_I	125_I	3.469	1.00
54_F	307_L	3.459	1.00
713_K	717_E	3.398	1.00
825_I	856_V	3.394	1.00
593_K	597_E	3.392	1.00
716_N	720_K	3.363	1.00
54_F	120_A	3.362	1.00
132_V	295_A	3.334	1.00
1036_I	1045_M	3.220	1.00
192_V	218_L	3.182	1.00
517_L	535_H	3.152	1.00
143_Q	146_H	3.126	1.00
635_I	649_L	3.121	1.00
520_E	533_N	3.093	1.00
602_K	642_E	3.065	1.00
842_V	867_K	3.060	1.00
67_T	119_V	3.014	1.00
665_A	750_I	2.966	1.00
63_A	119_V	2.966	1.00
148_I	196_L	2.952	1.00
80_L	106_V	2.952	1.00
676_A	736_L	2.924	1.00
721_G	727_V	2.888	1.00
158_V	174_F	2.888	1.00
54_F	118_V	2.848	1.00
153_L	181_I	2.842	1.00
176_I	181_I	2.829	1.00
420_T	450_I	2.817	1.00
826_E	858_D	2.803	1.00
702_N	721_G	2.799	1.00
849_A	889_V	2.783	1.00
703_I	729_I	2.756	1.00
459_F	468_V	2.754	1.00
636_K	667_K	2.742	1.00
70_L	119_V	2.733	1.00
535_H	539_S	2.719	1.00
246_G	344_R	2.707	1.00
584_V	993_V	2.624	1.00
1089_A	1097_I	2.610	1.00
150_P	181_I	2.565	1.00
679_V	685_A	2.538	1.00
630_R	634_E	2.534	1.00
835_V	887_V	2.530	1.00
514_G	534_I	2.503	1.00
403_F	467_A	2.494	1.00
131_P	291_Y	2.473	1.00
713_K	716_N	2.444	1.00
837_F	848_K	2.439	1.00
55_L	66_V	2.430	1.00
818_G	851_E	2.417	1.00
195_E	205_R	2.414	1.00
141_L	220_S	2.410	1.00
120_A	297_L	2.374	1.00
816_Y	821_V	2.374	1.00
825_I	887_V	2.361	1.00
521_T	528_H	2.345	1.00
822_R	826_E	2.333	1.00
149_E	152_Q	2.327	1.00
875_T	879_S	2.294	1.00
839_Y	909_F	2.276	1.00
523_E	528_H	2.275	1.00
585_Q	760_T	2.255	1.00
296_S	299_D	2.249	1.00
432_I	448_V	2.234	1.00
59_N	62_Q	2.219	1.00
154_A	164_R	2.217	1.00
711_T	714_E	2.198	1.00
1062_Q	1077_E	2.196	1.00
348_S	351_K	2.185	1.00
717_E	720_K	2.181	1.00
718_T	727_V	2.157	1.00
408_F	465_K	2.151	1.00
706_L	715_A	2.149	1.00
70_L	117_I	2.144	1.00
665_A	675_V	2.140	1.00
1117_D	1120_K	2.132	1.00
149_E	196_L	2.129	1.00
715_A	735_R	2.118	1.00
816_Y	837_F	2.110	1.00
604_Y	673_K	2.109	1.00
566_Y	576_V	2.094	1.00
604_Y	671_D	2.092	1.00
63_A	81_L	2.091	1.00
604_Y	607_S	2.072	1.00
460_E	467_A	2.059	1.00
1062_Q	1080_F	2.053	0.99
624_E	629_L	2.030	0.99
738_S	1001_M	2.028	0.99
861_V	887_V	2.026	0.99
735_R	738_S	2.017	0.99
599_E	643_R	2.012	0.99
190_N	215_I	2.009	0.99
861_V	889_V	2.005	0.99
764_K	767_Q	1.995	0.99
910_D	940_R	1.985	0.99
238_R	242_K	1.981	0.99
1054_T	1057_E	1.980	0.99
1151_S	1154_E	1.976	0.99
67_T	81_L	1.966	0.99
632_I	635_I	1.965	0.99
836_Y	900_I	1.963	0.99
739_K	764_K	1.958	0.99
997_L	1001_M	1.949	0.99
900_I	903_V	1.947	0.99
163_E	173_E	1.941	0.99
1049_F	1080_F	1.937	0.99
39_S	66_V	1.934	0.99
597_E	770_A	1.930	0.99
147_D	199_T	1.916	0.99
842_V	845_I	1.914	0.99
721_G	724_N	1.913	0.99
208_N	211_D	1.913	0.99
859_A	887_V	1.905	0.99
860_K	886_D	1.901	0.99
706_L	730_V	1.899	0.99
192_V	221_I	1.899	0.99
246_G	289_Y	1.891	0.99
718_T	730_V	1.889	0.99
1048_R	1064_E	1.888	0.99
720_K	723_K	1.887	0.99
470_T	473_E	1.879	0.99
322_L	326_E	1.870	0.99
42_T	55_L	1.867	0.99
908_V	937_F	1.859	0.99
179_G	195_E	1.857	0.99
589_D	1009_R	1.850	0.99
850_D	854_M	1.845	0.99
424_S	450_I	1.844	0.99
706_L	719_I	1.822	0.99
411_V	443_L	1.811	0.99
755_Q	917_S	1.811	0.99
437_T	449_Y	1.799	0.99
613_Q	636_K	1.798	0.99
864_A	876_V	1.797	0.99
132_V	136_K	1.797	0.99
412_F	427_L	1.794	0.99
662_I	691_T	1.793	0.99
662_I	692_I	1.771	0.98
853_S	861_V	1.766	0.98
906_L	926_V	1.765	0.98
147_D	198_D	1.761	0.98
906_L	937_F	1.750	0.98
601_S	771_N	1.750	0.98
118_V	301_T	1.749	0.98
82_Y	297_L	1.739	0.98
302_P	305_T	1.737	0.98
829_L	859_A	1.737	0.98
580_V	993_V	1.723	0.98
849_A	863_Y	1.716	0.98
614_R	618_S	1.716	0.98
233_P	277_G	1.715	0.98
238_R	292_E	1.713	0.98
693_K	703_I	1.704	0.98
1065_M	1080_F	1.699	0.98
176_I	196_L	1.695	0.98
852_I	856_V	1.694	0.98
244_D	275_S	1.694	0.98
852_I	887_V	1.683	0.98
665_A	729_I	1.682	0.98
145_G	200_E	1.672	0.98
848_K	851_E	1.672	0.98
408_F	467_A	1.667	0.98
631_S	649_L	1.667	0.98
704_G	710_R	1.665	0.98
624_E	632_I	1.662	0.98
610_H	670_G	1.659	0.98
296_S	347_F	1.657	0.98
1081_T	1160_L	1.656	0.98
1024_D	1098_K	1.656	0.98
239_A	290_F	1.653	0.98
122_V	319_E	1.652	0.98
533_N	541_K	1.651	0.98
126_R	319_E	1.650	0.98
606_F	673_K	1.646	0.98
722_L	727_V	1.643	0.98
590_D	767_Q	1.639	0.97
141_L	222_N	1.631	0.97
205_R	214_S	1.630	0.97
816_Y	909_F	1.623	0.97
585_Q	985_Q	1.615	0.97
636_K	640_E	1.614	0.97
838_L	898_V	1.606	0.97
609_D	613_Q	1.593	0.97
825_I	835_V	1.588	0.97
606_F	671_D	1.587	0.97
56_I	120_A	1.586	0.97
838_L	894_I	1.577	0.97
179_G	198_D	1.569	0.97
689_Y	705_L	1.568	0.97
849_A	853_S	1.565	0.97
66_V	119_V	1.563	0.97
846_E	853_S	1.562	0.97
585_Q	1008_E	1.560	0.97
318_M	322_L	1.552	0.96
384_R	460_E	1.548	0.96
719_I	735_R	1.548	0.96
1055_I	1084_E	1.543	0.96
676_A	743_Y	1.540	0.96
838_L	922_L	1.537	0.96
1062_Q	1072_Y	1.532	0.96
532_L	552_V	1.529	0.96
906_L	935_A	1.529	0.96
154_A	176_I	1.528	0.96
272_E	276_E	1.525	0.96
852_I	889_V	1.522	0.96
710_R	714_E	1.521	0.96
845_I	863_Y	1.521	0.96
662_I	731_I	1.514	0.96
839_Y	844_D	1.514	0.96
894_I	898_V	1.508	0.96
45_L	308_I	1.506	0.96
538_G	567_K	1.503	0.96
81_L	119_V	1.501	0.96
585_Q	984_A	1.499	0.96
43_S	74_L	1.498	0.96
701_I	768_I	1.492	0.96
513_I	566_Y	1.492	0.96
1031_I	1065_M	1.491	0.96
183_I	223_I	1.490	0.96
701_I	729_I	1.489	0.96
349_F	352_I	1.482	0.95
1045_M	1065_M	1.480	0.95
761_H	973_L	1.478	0.95
980_N	985_Q	1.477	0.95
864_A	873_L	1.477	0.95
196_L	201_V	1.467	0.95
273_R	278_Q	1.463	0.95
295_A	299_D	1.453	0.95
307_L	356_Q	1.452	0.95
361_L	366_F	1.448	0.95
51_K	304_N	1.447	0.95
39_S	69_D	1.444	0.95
120_A	124_A	1.437	0.95
1094_V	1097_I	1.431	0.94
1085_M	1097_I	1.431	0.94
847_R	851_E	1.420	0.94
692_I	729_I	1.420	0.94
567_K	570_G	1.419	0.94
838_L	901_P	1.418	0.94
677_L	750_I	1.418	0.94
133_E	137_S	1.417	0.94
718_T	721_G	1.416	0.94
1034_T	1075_E	1.408	0.94
576_V	580_V	1.403	0.94
612_M	670_G	1.402	0.94
129_L	297_L	1.402	0.94
730_V	736_L	1.397	0.94
82_Y	107_I	1.395	0.94
609_D	636_K	1.395	0.94
131_P	300_Y	1.393	0.94
188_S	206_S	1.390	0.94
192_V	206_S	1.390	0.94
634_E	649_L	1.387	0.93
125_I	298_L	1.376	0.93
188_S	192_V	1.371	0.93
580_V	584_V	1.370	0.93
881_L	900_I	1.368	0.93
824_A	907_I	1.365	0.93
401_E	405_K	1.363	0.93
604_Y	639_M	1.345	0.92
845_I	849_A	1.345	0.92
629_L	633_H	1.342	0.92
240_M	271_K	1.337	0.92
120_A	125_I	1.335	0.92
185_P	188_S	1.333	0.92
144_V	217_T	1.333	0.92
327_A	331_T	1.328	0.92
703_I	731_I	1.322	0.92
612_M	615_E	1.313	0.91
846_E	863_Y	1.313	0.91
1049_F	1058_K	1.309	0.91
363_Y	366_F	1.306	0.91
80_L	109_R	1.305	0.91
606_F	773_D	1.304	0.91
633_H	637_K	1.301	0.91
862_A	879_S	1.301	0.91
58_H	62_Q	1.300	0.91
1061_L	1065_M	1.296	0.91
324_K	328_E	1.295	0.91
1123_E	1127_Q	1.294	0.91
403_F	469_I	1.294	0.91
57_T	121_P	1.293	0.91
589_D	593_K	1.290	0.91
822_R	858_D	1.289	0.91
381_V	384_R	1.289	0.91
1081_T	1084_E	1.288	0.91
749_L	774_V	1.288	0.91
42_T	117_I	1.287	0.91
1058_K	1087_V	1.286	0.91
1004_E	1007_E	1.285	0.91
1074_K	1077_E	1.284	0.90
152_Q	156_R	1.282	0.90
789_S	793_V	1.278	0.90
144_V	219_T	1.277	0.90
704_G	714_E	1.270	0.90
613_Q	617_E	1.268	0.90
710_R	715_A	1.261	0.90
118_V	297_L	1.259	0.90
749_L	769_K	1.258	0.90
314_R	317_E	1.254	0.89
912_D	943_K	1.253	0.89
705_L	730_V	1.244	0.89
587_I	984_A	1.239	0.89
649_L	660_V	1.236	0.89
862_A	876_V	1.231	0.89
153_L	196_L	1.225	0.88
640_E	667_K	1.215	0.88
53_I	308_I	1.210	0.88
856_V	887_V	1.207	0.88
103_R	228_E	1.205	0.87
715_A	719_I	1.203	0.87
169_S	173_E	1.201	0.87
809_V	1156_L	1.195	0.87
52_P	305_T	1.192	0.87
148_I	153_L	1.192	0.87
910_D	913_K	1.185	0.87
821_V	852_I	1.184	0.86
236_K	277_G	1.184	0.86
776_T	799_I	1.184	0.86
879_S	885_S	1.179	0.86
40_V	461_L	1.176	0.86
231_I	236_K	1.175	0.86
856_V	859_A	1.174	0.86
439_S	442_A	1.172	0.86
1118_G	1122_F	1.170	0.86
270_D	286_Y	1.169	0.86
417_K	421_Q	1.166	0.86
78_S	109_R	1.166	0.86
69_D	456_Q	1.164	0.86
704_G	721_G	1.162	0.85
214_S	1025_V	1.158	0.85
431_D	1010_K	1.157	0.85
1052_V	1061_L	1.157	0.85
726_T	730_V	1.154	0.85
818_G	854_M	1.150	0.85
38_R	310_D	1.150	0.85
57_T	120_A	1.144	0.85
1066_I	1071_N	1.142	0.84
67_T	79_V	1.141	0.84
849_A	861_V	1.139	0.84
392_Q	396_L	1.137	0.84
323_Q	348_S	1.133	0.84
425_S	429_D	1.133	0.84
696_F	729_I	1.131	0.84
789_S	795_D	1.129	0.84
502_I	516_Y	1.127	0.84
46_A	117_I	1.124	0.83
510_N	548_Q	1.123	0.83
1061_L	1080_F	1.116	0.83
147_D	200_E	1.114	0.83
56_I	298_L	1.109	0.83
1032_P	1076_V	1.109	0.83
192_V	204_I	1.109	0.83
106_V	110_L	1.106	0.82
839_Y	848_K	1.106	0.82
197_F	202_D	1.106	0.82
821_V	938_T	1.104	0.82
42_T	66_V	1.101	0.82
637_K	641_R	1.099	0.82
171_P	184_Y	1.095	0.82
403_F	408_F	1.095	0.82
404_K	410_V	1.093	0.82
1150_R	1154_E	1.092	0.82
634_E	637_K	1.090	0.82
1052_V	1057_E	1.085	0.81
52_P	302_P	1.085	0.81
1060_E	1063_D	1.083	0.81
33_L	37_A	1.083	0.81
57_T	66_V	1.081	0.81
322_L	329_F	1.081	0.81
749_L	772_V	1.080	0.81
150_P	154_A	1.080	0.81
602_K	908_V	1.078	0.81
955_A	968_I	1.078	0.81
600_A	1006_I	1.078	0.81
1036_I	1065_M	1.078	0.81
387_Q	396_L	1.077	0.81
36_S	73_L	1.076	0.81
1055_I	1059_N	1.076	0.81
505_Y	515_K	1.076	0.81
36_S	69_D	1.072	0.80
351_K	355_E	1.069	0.80
107_I	297_L	1.065	0.80
174_F	809_V	1.065	0.80
153_L	183_I	1.064	0.80
815_E	957_K	1.062	0.80
148_I	181_I	1.062	0.80
902_N	931_R	1.061	0.80
129_L	300_Y	1.055	0.79
574_K	578_K	1.053	0.79
150_P	196_L	1.052	0.79
1049_F	1083_A	1.052	0.79
534_I	772_V	1.052	0.79
128_M	351_K	1.051	0.79
690_E	693_K	1.048	0.79
670_G	701_I	1.043	0.79
375_P	378_I	1.041	0.78
509_I	1000_Q	1.040	0.78
900_I	914_M	1.040	0.78
586_D	589_D	1.036	0.78
85_N	89_S	1.034	0.78
1059_N	1062_Q	1.034	0.78
596_A	799_I	1.033	0.78
609_D	667_K	1.033	0.78
44_A	47_N	1.031	0.78
587_I	980_N	1.031	0.78
973_L	978_A	1.029	0.78
712_R	715_A	1.028	0.78
85_N	127_R	1.027	0.77
923_R	1068_R	1.027	0.77
609_D	788_M	1.024	0.77
190_N	206_S	1.022	0.77
686_Q	705_L	1.021	0.77
597_E	601_S	1.021	0.77
668_A	675_V	1.021	0.77
133_E	293_K	1.021	0.77
593_K	1008_E	1.016	0.77
206_S	216_E	1.016	0.77
168_V	207_F	1.016	0.77
53_I	306_L	1.012	0.76
119_V	891_T	1.010	0.76
1053_A	1057_E	1.009	0.76
413_L	451_M	1.008	0.76
949_A	975_I	1.008	0.76
685_A	705_L	1.007	0.76
662_I	703_I	1.007	0.76
617_E	636_K	1.006	0.76
1003_K	1007_E	1.006	0.76
677_L	731_I	1.003	0.76
1058_K	1084_E	1.002	0.76
419_R	475_F	1.002	0.76
823_E	827_R	1.001	0.76
205_R	874_E	1.000	0.76
1114_A	1117_D	0.998	0.75
908_V	922_L	0.995	0.75
400_M	410_V	0.993	0.75
675_V	750_I	0.992	0.75
142_I	194_I	0.992	0.75
411_V	451_M	0.991	0.75
611_E	615_E	0.991	0.75
308_I	361_L	0.988	0.75
809_V	839_Y	0.988	0.75
82_Y	129_L	0.987	0.75
148_I	201_V	0.987	0.75
727_V	730_V	0.985	0.74
191_P	207_F	0.984	0.74
349_F	353_V	0.984	0.74
714_E	717_E	0.982	0.74
802_P	981_L	0.980	0.74
704_G	730_V	0.979	0.74
169_S	655_Y	0.978	0.74
655_Y	802_P	0.976	0.74
1001_M	1004_E	0.975	0.74
721_G	731_I	0.975	0.74
650_C	877_M	0.974	0.74
1072_Y	1076_V	0.972	0.73
202_D	1066_I	0.970	0.73
595_Y	773_D	0.968	0.73
212_Q	1068_R	0.968	0.73
402_R	406_S	0.968	0.73
807_F	932_V	0.966	0.73
548_Q	970_M	0.963	0.73
702_N	726_T	0.958	0.72
180_I	767_Q	0.958	0.72
320_E	350_Q	0.957	0.72
890_S	896_T	0.955	0.72
396_L	469_I	0.955	0.72
459_F	473_E	0.955	0.72
908_V	956_I	0.955	0.72
760_T	764_K	0.952	0.72
631_S	634_E	0.950	0.72
33_L	41_F	0.950	0.72
814_V	820_L	0.950	0.72
1058_K	1080_F	0.948	0.72
30_L	41_F	0.946	0.71
613_Q	667_K	0.946	0.71
622_Y	809_V	0.946	0.71
234_E	237_A	0.945	0.71
662_I	770_A	0.944	0.71
648_L	1001_M	0.943	0.71
75_E	79_V	0.943	0.71
399_E	403_F	0.943	0.71
619_A	698_D	0.943	0.71
152_Q	155_S	0.941	0.71
849_A	852_I	0.940	0.71
848_K	889_V	0.939	0.71
631_S	692_I	0.938	0.71
90_S	974_T	0.937	0.71
197_F	696_F	0.937	0.71
844_D	848_K	0.935	0.71
1049_F	1061_L	0.933	0.70
410_V	467_A	0.932	0.70
82_Y	124_A	0.932	0.70
606_F	639_M	0.931	0.70
763_E	774_V	0.931	0.70
859_A	886_D	0.930	0.70
816_Y	851_E	0.929	0.70
719_I	751_I	0.926	0.70
412_F	423_L	0.923	0.70
751_I	770_A	0.922	0.69
529_K	547_E	0.922	0.69
140_M	153_L	0.922	0.69
389_F	396_L	0.921	0.69
1154_E	1157_D	0.920	0.69
1097_I	1106_L	0.920	0.69
163_E	204_I	0.920	0.69
1056_E	1059_N	0.918	0.69
809_V	906_L	0.918	0.69
475_F	894_I	0.917	0.69
956_I	968_I	0.916	0.69
111_T	136_K	0.916	0.69
513_I	555_Y	0.915	0.69
102_Q	105_D	0.913	0.69
450_I	641_R	0.911	0.69
396_L	474_L	0.910	0.68
802_P	1086_K	0.909	0.68
1021_T	1090_R	0.909	0.68
579_K	991_D	0.908	0.68
111_T	132_V	0.907	0.68
1023_I	1085_M	0.905	0.68
863_Y	876_V	0.905	0.68
883_G	902_N	0.904	0.68
318_M	324_K	0.904	0.68
108_N	224_G	0.904	0.68
1084_E	1088_Y	0.902	0.68
750_I	1086_K	0.900	0.68
485_K	489_T	0.900	0.68
877_M	898_V	0.900	0.68
751_I	864_A	0.899	0.67
302_P	731_I	0.898	0.67
1088_Y	1091_Q	0.896	0.67
731_I	1154_E	0.895	0.67
143_Q	234_E	0.895	0.67
181_I	1145_I	0.895	0.67
54_F	301_T	0.895	0.67
361_L	364_S	0.892	0.67
1045_M	1052_V	0.892	0.67
799_I	867_K	0.891	0.67
610_H	613_Q	0.890	0.67
240_M	275_S	0.890	0.67
325_E	329_F	0.888	0.67
703_I	1076_V	0.887	0.66
1026_E	1099_Q	0.887	0.66
319_E	349_F	0.885	0.66
666_F	670_G	0.882	0.66
106_V	118_V	0.880	0.66
400_M	404_K	0.876	0.65
627_D	801_T	0.875	0.65
110_L	118_V	0.875	0.65
534_I	552_V	0.874	0.65
751_I	867_K	0.873	0.65
52_P	118_V	0.871	0.65
428_A	433_E	0.871	0.65
151_D	154_A	0.869	0.65
190_N	209_S	0.868	0.65
179_G	203_S	0.868	0.65
154_A	174_F	0.867	0.65
233_P	237_A	0.865	0.64
324_K	327_A	0.865	0.64
816_Y	848_K	0.864	0.64
299_D	1065_M	0.864	0.64
45_L	751_I	0.863	0.64
40_V	73_L	0.862	0.64
1005_A	1008_E	0.862	0.64
417_K	452_E	0.862	0.64
42_T	53_I	0.861	0.64
706_L	741_V	0.861	0.64
923_R	1067_D	0.859	0.64
609_D	1024_D	0.859	0.64
1049_F	1052_V	0.859	0.64
184_Y	191_P	0.855	0.64
1149_G	1158_T	0.854	0.63
826_E	852_I	0.854	0.63
689_Y	704_G	0.854	0.63
544_V	552_V	0.853	0.63
134_V	291_Y	0.853	0.63
326_E	329_F	0.850	0.63
208_N	215_I	0.849	0.63
299_D	355_E	0.849	0.63
1048_R	1061_L	0.849	0.63
801_T	962_L	0.848	0.63
89_S	801_T	0.846	0.63
1049_F	1087_V	0.845	0.63
453_G	723_K	0.845	0.63
52_P	304_N	0.845	0.63
505_Y	563_P	0.844	0.63
837_F	852_I	0.843	0.62
111_T	579_K	0.842	0.62
519_I	1042_K	0.842	0.62
617_E	667_K	0.841	0.62
506_V	835_V	0.839	0.62
420_T	436_M	0.838	0.62
143_Q	218_L	0.837	0.62
420_T	452_E	0.835	0.62
693_K	704_G	0.835	0.62
75_E	1001_M	0.833	0.62
254_L	421_Q	0.831	0.61
665_A	823_E	0.831	0.61
151_D	155_S	0.830	0.61
272_E	856_V	0.829	0.61
131_P	165_S	0.829	0.61
1083_A	1086_K	0.827	0.61
722_L	743_Y	0.826	0.61
1063_D	1071_N	0.826	0.61
1063_D	1066_I	0.825	0.61
1007_E	1011_G	0.825	0.61
1064_E	1069_F	0.824	0.61
537_Q	995_F	0.824	0.61
361_L	365_L	0.823	0.61
557_G	938_T	0.822	0.60
1128_Y	1131_Q	0.820	0.60
499_E	584_V	0.820	0.60
700_P	703_I	0.819	0.60
155_S	159_E	0.819	0.60
32_G	462_P	0.818	0.60
594_L	796_L	0.818	0.60
836_Y	903_V	0.818	0.60
54_F	305_T	0.817	0.60
813_V	956_I	0.816	0.60
847_R	850_D	0.816	0.60
516_Y	698_D	0.816	0.60
613_Q	971_R	0.816	0.60
491_A	582_T	0.815	0.60
322_L	325_E	0.815	0.60
907_I	938_T	0.815	0.60
127_R	346_S	0.814	0.60
1062_Q	1084_E	0.814	0.60
609_D	612_M	0.813	0.60
514_G	772_V	0.813	0.60
402_R	467_A	0.812	0.60
523_E	822_R	0.812	0.60
53_I	117_I	0.812	0.60
233_P	236_K	0.810	0.59
739_K	742_V	0.810	0.59
751_I	1011_G	0.807	0.59
605_A	649_L	0.806	0.59
896_T	901_P	0.803	0.59
485_K	546_V	0.802	0.59
75_E	604_Y	0.801	0.58
639_M	773_D	0.801	0.58
799_I	896_T	0.801	0.58
350_Q	354_A	0.800	0.58
85_N	95_A	0.800	0.58
301_T	305_T	0.799	0.58
417_K	438_D	0.798	0.58
59_N	122_V	0.797	0.58
179_G	655_Y	0.797	0.58
155_S	233_P	0.796	0.58
533_N	543_Y	0.796	0.58
481_K	484_R	0.795	0.58
787_H	920_Y	0.795	0.58
55_L	119_V	0.795	0.58
584_V	793_V	0.794	0.58
1157_D	1160_L	0.794	0.58
483_P	623_Q	0.794	0.58
233_P	643_R	0.793	0.58
603_G	773_D	0.793	0.58
112_N	894_I	0.793	0.58
57_T	63_A	0.792	0.58
599_E	641_R	0.791	0.58
1094_V	1106_L	0.791	0.58
242_K	292_E	0.790	0.57
686_Q	878_L	0.790	0.57
550_D	816_Y	0.789	0.57
742_V	745_D	0.788	0.57
774_V	946_T	0.787	0.57
683_I	917_S	0.787	0.57
624_E	743_Y	0.787	0.57
728_D	744_K	0.786	0.57
195_E	540_D	0.786	0.57
54_F	409_T	0.785	0.57
74_L	117_I	0.785	0.57
120_A	307_L	0.784	0.57
30_L	104_L	0.784	0.57
629_L	1004_E	0.783	0.57
83_P	102_Q	0.782	0.57
31_A	375_P	0.782	0.57
1011_G	1015_K	0.782	0.57
1097_I	1159_V	0.780	0.56
638_D	647_R	0.779	0.56
128_M	294_P	0.779	0.56
140_M	149_E	0.778	0.56
294_P	297_L	0.778	0.56
796_L	990_I	0.778	0.56
705_L	710_R	0.778	0.56
720_K	742_V	0.777	0.56
322_L	328_E	0.777	0.56
863_Y	889_V	0.777	0.56
286_Y	411_V	0.776	0.56
1007_E	1012_D	0.775	0.56
768_I	913_K	0.775	0.56
385_Q	396_L	0.774	0.56
685_A	707_S	0.774	0.56
644_P	799_I	0.773	0.56
27_E	362_Y	0.772	0.56
523_E	526_G	0.772	0.56
1064_E	1068_R	0.772	0.56
164_R	176_I	0.771	0.56
677_L	693_K	0.770	0.55
956_I	1001_M	0.770	0.55
457_S	703_I	0.769	0.55
49_T	306_L	0.768	0.55
874_E	878_L	0.767	0.55
200_E	842_V	0.767	0.55
402_R	405_K	0.767	0.55
326_E	346_S	0.767	0.55
292_E	703_I	0.767	0.55
1008_E	1011_G	0.766	0.55
157_L	174_F	0.766	0.55
731_I	808_P	0.765	0.55
1045_M	1069_F	0.765	0.55
173_E	962_L	0.765	0.55
414_G	423_L	0.765	0.55
760_T	767_Q	0.765	0.55
111_T	118_V	0.762	0.55
409_T	449_Y	0.760	0.54
678_L	773_D	0.760	0.54
132_V	1061_L	0.760	0.54
319_E	322_L	0.758	0.54
1030_Y	1042_K	0.758	0.54
818_G	855_L	0.758	0.54
373_T	378_I	0.757	0.54
214_S	997_L	0.756	0.54
902_N	947_E	0.756	0.54
424_S	428_A	0.756	0.54
516_Y	1048_R	0.756	0.54
73_L	455_L	0.754	0.54
1101_K	1147_T	0.754	0.54
609_D	617_E	0.754	0.54
709_F	873_L	0.753	0.54
575_R	836_Y	0.753	0.54
79_V	119_V	0.752	0.54
894_I	964_S	0.752	0.54
64_Q	81_L	0.752	0.54
771_N	799_I	0.751	0.54
566_Y	896_T	0.751	0.54
585_Q	593_K	0.751	0.54
276_E	751_I	0.751	0.54
128_M	296_S	0.749	0.53
37_A	383_G	0.748	0.53
142_I	223_I	0.748	0.53
146_H	196_L	0.748	0.53
669_I	692_I	0.747	0.53
528_H	1028_D	0.746	0.53
796_L	974_T	0.746	0.53
615_E	618_S	0.745	0.53
142_I	153_L	0.744	0.53
278_Q	830_A	0.743	0.53
130_P	914_M	0.742	0.53
468_V	850_D	0.741	0.53
603_G	788_M	0.741	0.53
805_N	1043_I	0.741	0.53
829_L	887_V	0.740	0.53
590_D	593_K	0.740	0.53
175_S	294_P	0.740	0.53
1045_M	1048_R	0.740	0.53
575_R	579_K	0.739	0.52
702_N	724_N	0.739	0.52
380_N	579_K	0.739	0.52
174_F	211_D	0.738	0.52
96_S	807_F	0.735	0.52
505_Y	562_E	0.735	0.52
195_E	701_I	0.735	0.52
410_V	1105_R	0.734	0.52
471_E	532_L	0.734	0.52
144_V	176_I	0.733	0.52
596_A	867_K	0.733	0.52
715_A	946_T	0.732	0.52
494_I	1047_K	0.732	0.52
631_S	790_M	0.732	0.52
883_G	1010_K	0.732	0.52
869_T	872_E	0.730	0.52
426_V	430_Y	0.729	0.51
296_S	1056_E	0.728	0.51
407_N	703_I	0.728	0.51
104_L	181_I	0.728	0.51
648_L	774_V	0.728	0.51
751_I	772_V	0.727	0.51
396_L	404_K	0.727	0.51
361_L	368_R	0.725	0.51
231_I	279_T	0.725	0.51
1133_G	1146_Q	0.725	0.51
195_E	719_I	0.724	0.51
765_I	772_V	0.723	0.51
711_T	821_V	0.722	0.51
587_I	985_Q	0.722	0.51
1009_R	1054_T	0.722	0.51
548_Q	551_Q	0.721	0.51
406_S	448_V	0.721	0.51
515_K	535_H	0.720	0.51
524_I	1027_L	0.720	0.51
419_R	471_E	0.720	0.51
567_K	571_S	0.719	0.50
838_L	848_K	0.718	0.50
677_L	729_I	0.717	0.50
709_F	769_K	0.717	0.50
613_Q	939_Y	0.716	0.50
270_D	285_K	0.716	0.50
211_D	298_L	0.715	0.50
99_L	290_F	0.715	0.50
826_E	855_L	0.714	0.50
244_D	271_K	0.714	0.50
955_A	975_I	0.713	0.50
455_L	1001_M	0.712	0.50
587_I	962_L	0.712	0.50
458_G	534_I	0.712	0.50
144_V	720_K	0.712	0.50
155_S	158_V	0.712	0.50
60_L	121_P	0.711	0.50
33_L	516_Y	0.711	0.50
553_Q	1047_K	0.710	0.50
755_Q	805_N	0.709	0.49
729_I	853_S	0.708	0.49
851_E	854_M	0.708	0.49
606_F	641_R	0.707	0.49
78_S	116_P	0.707	0.49
1125_G	1132_I	0.707	0.49
143_Q	713_K	0.706	0.49
553_Q	920_Y	0.706	0.49
401_E	432_I	0.706	0.49
700_P	728_D	0.706	0.49
470_T	534_I	0.706	0.49
119_V	304_N	0.705	0.49
668_A	673_K	0.705	0.49
204_I	650_C	0.705	0.49
524_I	847_R	0.704	0.49
81_L	120_A	0.704	0.49
60_L	272_E	0.703	0.49
1056_E	1101_K	0.703	0.49
118_V	731_I	0.701	0.49
202_D	1071_N	0.701	0.49
397_A	432_I	0.700	0.49
711_T	1088_Y	0.699	0.48
827_R	943_K	0.699	0.48
385_Q	392_Q	0.698	0.48
119_V	466_L	0.697	0.48
851_E	908_V	0.696	0.48
59_N	318_M	0.696	0.48
603_G	639_M	0.696	0.48
214_S	1067_D	0.695	0.48
322_L	330_I	0.694	0.48
323_Q	327_A	0.694	0.48
196_L	672_G	0.694	0.48
145_G	1054_T	0.694	0.48
846_E	850_D	0.693	0.48
403_F	460_E	0.693	0.48
793_V	987_H	0.692	0.48
104_L	1025_V	0.691	0.48
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363_Y	802_P	0.690	0.48
160_V	920_Y	0.689	0.48
860_K	884_E	0.689	0.48
254_L	271_K	0.689	0.48
494_I	679_V	0.688	0.47
155_S	731_I	0.688	0.47
886_D	906_L	0.688	0.47
697_Q	949_A	0.688	0.47
838_L	997_L	0.687	0.47
79_V	410_V	0.686	0.47
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130_P	524_I	0.686	0.47
153_L	917_S	0.686	0.47
397_A	401_E	0.685	0.47
408_F	460_E	0.684	0.47
129_L	423_L	0.682	0.47
548_Q	882_E	0.681	0.47
235_E	238_R	0.680	0.47
896_T	1028_D	0.680	0.47
816_Y	938_T	0.679	0.47
655_Y	964_S	0.679	0.47
616_F	662_I	0.679	0.47
1022_E	1096_L	0.679	0.47
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1043_I	1050_R	0.676	0.46
194_I	204_I	0.674	0.46
33_L	36_S	0.674	0.46
961_E	967_K	0.674	0.46
809_V	1090_R	0.674	0.46
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232_R	235_E	0.671	0.46
321_Q	325_E	0.671	0.46
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336_E	864_A	0.670	0.46
890_S	1001_M	0.670	0.46
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292_E	550_D	0.669	0.46
42_T	119_V	0.669	0.46
170_A	962_L	0.669	0.46
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815_E	941_R	0.669	0.46
317_E	320_E	0.668	0.45
352_I	355_E	0.668	0.45
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669_I	1010_K	0.667	0.45
1076_V	1079_L	0.667	0.45
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761_H	768_I	0.665	0.45
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241_E	245_S	0.665	0.45
480_K	808_P	0.664	0.45
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389_F	392_Q	0.662	0.45
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412_F	469_I	0.659	0.45
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773_D	840_N	0.658	0.44
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513_I	906_L	0.656	0.44
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461_L	464_M	0.653	0.44
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639_M	667_K	0.653	0.44
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1069_F	1106_L	0.651	0.44
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1032_P	1073_P	0.650	0.44
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142_I	176_I	0.650	0.44
299_D	702_N	0.650	0.44
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621_P	1023_I	0.648	0.43
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229_L	701_I	0.647	0.43
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743_Y	764_K	0.647	0.43
1006_I	1009_R	0.647	0.43
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648_L	822_R	0.645	0.43
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228_E	284_V	0.644	0.43
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788_M	995_F	0.643	0.43
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845_I	889_V	0.641	0.43
613_Q	640_E	0.641	0.43
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318_M	326_E	0.638	0.43
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379_V	383_G	0.635	0.42
630_R	778_T	0.635	0.42
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194_I	1116_I	0.630	0.42
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789_S	876_V	0.629	0.42
1102_D	1148_K	0.629	0.42
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411_V	691_T	0.627	0.41
641_R	751_I	0.627	0.41
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1084_E	1087_V	0.626	0.41
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636_K	971_R	0.623	0.41
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328_E	331_T	0.619	0.41
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616_F	619_A	0.617	0.41
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1031_I	1036_I	0.617	0.41
573_W	622_Y	0.616	0.40
822_R	883_G	0.616	0.40
80_L	110_L	0.616	0.40
401_E	431_D	0.616	0.40
201_V	453_G	0.616	0.40
787_H	999_S	0.616	0.40
186_L	198_D	0.615	0.40
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435_A	447_Q	0.614	0.40
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669_I	672_G	0.614	0.40
231_I	750_I	0.613	0.40
898_V	906_L	0.613	0.40
105_D	299_D	0.612	0.40
156_R	293_K	0.612	0.40
937_F	987_H	0.612	0.40
424_S	1057_E	0.612	0.40
673_K	1054_T	0.612	0.40
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1097_I	1156_L	0.611	0.40
522_L	525_N	0.610	0.40
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553_Q	789_S	0.610	0.40
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844_D	847_R	0.610	0.40
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239_A	289_Y	0.610	0.40
670_G	700_P	0.610	0.40
195_E	198_D	0.609	0.40
874_E	920_Y	0.609	0.40
315_I	464_M	0.609	0.40
330_I	333_L	0.609	0.40
574_K	743_Y	0.609	0.40
162_Y	184_Y	0.608	0.40
170_A	173_E	0.608	0.40
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558_S	1052_V	0.607	0.40
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829_L	832_G	0.607	0.40
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307_L	310_D	0.606	0.39
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432_I	761_H	0.602	0.39
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621_P	694_E	0.602	0.39
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494_I	616_F	0.601	0.39
513_I	678_L	0.600	0.39
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36_S	799_I	0.598	0.39
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626_E	629_L	0.598	0.39
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571_S	574_K	0.597	0.39
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577_K	887_V	0.596	0.39
959_F	967_K	0.595	0.38
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119_V	299_D	0.595	0.38
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142_I	146_H	0.594	0.38
1008_E	1013_T	0.594	0.38
194_I	535_H	0.594	0.38
496_S	896_T	0.594	0.38
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1057_E	1060_E	0.594	0.38
957_K	971_R	0.593	0.38
967_K	970_M	0.593	0.38
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540_D	804_E	0.593	0.38
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1123_E	1126_N	0.589	0.38
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298_L	347_F	0.587	0.38
104_L	975_I	0.587	0.38
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731_I	1097_I	0.585	0.37
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835_V	859_A	0.581	0.37
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157_L	181_I	0.558	0.35
53_I	751_I	0.557	0.35
96_S	460_E	0.557	0.35
543_Y	683_I	0.557	0.35
289_Y	471_E	0.557	0.35
206_S	218_L	0.557	0.35
534_I	1021_T	0.557	0.35
233_P	433_E	0.556	0.35
505_Y	564_K	0.556	0.35
1119_Q	1123_E	0.555	0.35
153_L	478_R	0.555	0.35
530_D	869_T	0.555	0.35
230_I	701_I	0.554	0.35
118_V	457_S	0.554	0.35
120_A	318_M	0.554	0.35
201_V	825_I	0.554	0.35
801_T	995_F	0.554	0.35
320_E	468_V	0.554	0.35
469_I	519_I	0.554	0.35
613_Q	666_F	0.554	0.35
546_V	799_I	0.554	0.35
807_F	930_N	0.553	0.35
282_E	338_K	0.553	0.35
151_D	324_K	0.553	0.35
531_Y	636_K	0.553	0.35
350_Q	357_K	0.553	0.35
550_D	1098_K	0.553	0.35
57_T	836_Y	0.553	0.35
332_N	335_E	0.552	0.34
835_V	886_D	0.552	0.34
231_I	450_I	0.551	0.34
610_H	617_E	0.551	0.34
909_F	938_T	0.551	0.34
639_M	673_K	0.551	0.34
744_K	907_I	0.550	0.34
940_R	944_V	0.550	0.34
932_V	1042_K	0.550	0.34
211_D	587_I	0.550	0.34
245_S	429_D	0.550	0.34
364_S	829_L	0.549	0.34
842_V	944_V	0.549	0.34
672_G	938_T	0.549	0.34
30_L	703_I	0.549	0.34
291_Y	800_E	0.549	0.34
517_L	741_V	0.548	0.34
30_L	750_I	0.548	0.34
543_Y	623_Q	0.548	0.34
550_D	1083_A	0.547	0.34
155_S	428_A	0.547	0.34
405_K	1085_M	0.547	0.34
517_L	533_N	0.547	0.34
699_Y	937_F	0.547	0.34
409_T	446_G	0.547	0.34
744_K	1095_E	0.547	0.34
607_S	610_H	0.546	0.34
197_F	200_E	0.546	0.34
180_I	218_L	0.546	0.34
543_Y	889_V	0.546	0.34
990_I	1009_R	0.546	0.34
1146_Q	1149_G	0.546	0.34
230_I	751_I	0.546	0.34
853_S	887_V	0.546	0.34
575_R	1001_M	0.546	0.34
1033_E	1042_K	0.546	0.34
356_Q	487_K	0.545	0.34
134_V	552_V	0.545	0.34
292_E	769_K	0.545	0.34
292_E	356_Q	0.545	0.34
540_D	547_E	0.544	0.34
807_F	1086_K	0.544	0.34
118_V	219_T	0.544	0.34
475_F	817_N	0.544	0.34
380_N	723_K	0.543	0.34
743_Y	765_I	0.543	0.34
548_Q	1042_K	0.543	0.34
124_A	131_P	0.543	0.34
1001_M	1005_A	0.543	0.34
411_V	468_V	0.543	0.34
207_F	534_I	0.543	0.34
142_I	1071_N	0.543	0.34
472_E	1094_V	0.542	0.34
814_V	817_N	0.542	0.34
566_Y	956_I	0.542	0.34
623_Q	933_A	0.542	0.34
743_Y	912_D	0.542	0.34
89_S	93_A	0.542	0.34
306_L	358_R	0.542	0.34
455_L	468_V	0.542	0.34
1044_D	1048_R	0.542	0.34
1146_Q	1150_R	0.541	0.34
214_S	553_Q	0.541	0.34
552_V	740_D	0.541	0.34
229_L	1123_E	0.541	0.34
1055_I	1087_V	0.540	0.33
621_P	686_Q	0.540	0.33
400_M	403_F	0.539	0.33
586_D	896_T	0.539	0.33
522_L	778_T	0.539	0.33
736_L	1106_L	0.538	0.33
636_K	902_N	0.538	0.33
162_Y	1049_F	0.538	0.33
911_A	1059_N	0.538	0.33
424_S	436_M	0.538	0.33
596_A	689_Y	0.538	0.33
525_N	1003_K	0.538	0.33
373_T	376_Q	0.538	0.33
587_I	755_Q	0.538	0.33
679_V	997_L	0.538	0.33
875_T	884_E	0.538	0.33
35_G	954_Q	0.538	0.33
749_L	771_N	0.538	0.33
121_P	126_R	0.537	0.33
832_G	883_G	0.537	0.33
855_L	858_D	0.537	0.33
204_I	1153_D	0.537	0.33
119_V	900_I	0.536	0.33
540_D	594_L	0.536	0.33
325_E	495_K	0.536	0.33
627_D	800_E	0.536	0.33
894_I	940_R	0.536	0.33
824_A	922_L	0.536	0.33
104_L	513_I	0.536	0.33
626_E	736_L	0.536	0.33
543_Y	937_F	0.536	0.33
706_L	946_T	0.535	0.33
609_D	815_E	0.535	0.33
525_N	537_Q	0.535	0.33
543_Y	836_Y	0.535	0.33
217_T	1071_N	0.535	0.33
1118_G	1121_L	0.535	0.33
719_I	722_L	0.534	0.33
790_M	1156_L	0.534	0.33
791_L	929_S	0.534	0.33
667_K	902_N	0.534	0.33
594_L	765_I	0.533	0.33
1075_E	1089_A	0.533	0.33
722_L	741_V	0.533	0.33
437_T	443_L	0.533	0.33
686_Q	922_L	0.532	0.33
391_G	396_L	0.532	0.33
94_V	284_V	0.532	0.33
1040_K	1044_D	0.532	0.33
1062_Q	1066_I	0.532	0.33
410_V	933_A	0.531	0.33
150_P	176_I	0.531	0.33
285_K	1043_I	0.531	0.33
605_A	644_P	0.531	0.33
89_S	932_V	0.531	0.33
181_I	908_V	0.531	0.33
707_S	836_Y	0.530	0.33
648_L	710_R	0.530	0.33
933_A	956_I	0.530	0.33
882_E	1106_L	0.529	0.32
73_L	79_V	0.529	0.32
138_S	809_V	0.529	0.32
769_K	789_S	0.529	0.32
89_S	974_T	0.529	0.32
87_L	285_K	0.528	0.32
142_I	196_L	0.528	0.32
385_Q	631_S	0.528	0.32
858_D	886_D	0.528	0.32
1027_L	1078_Y	0.528	0.32
609_D	640_E	0.528	0.32
540_D	679_V	0.528	0.32
149_E	854_M	0.527	0.32
836_Y	1075_E	0.527	0.32
113_G	116_P	0.527	0.32
120_A	1088_Y	0.527	0.32
811_T	1067_D	0.527	0.32
612_M	796_L	0.527	0.32
487_K	750_I	0.527	0.32
686_Q	999_S	0.527	0.32
791_L	989_F	0.527	0.32
374_S	400_M	0.526	0.32
808_P	960_T	0.526	0.32
1054_T	1087_V	0.526	0.32
610_H	667_K	0.526	0.32
195_E	679_V	0.526	0.32
1116_I	1120_K	0.525	0.32
116_P	802_P	0.525	0.32
842_V	876_V	0.525	0.32
526_G	677_L	0.525	0.32
171_P	186_L	0.524	0.32
183_I	584_V	0.524	0.32
1001_M	1036_I	0.524	0.32
412_F	990_I	0.524	0.32
105_D	222_N	0.523	0.32
814_V	938_T	0.523	0.32
72_S	937_F	0.523	0.32
202_D	711_T	0.523	0.32
933_A	1094_V	0.523	0.32
492_E	906_L	0.523	0.32
543_Y	765_I	0.523	0.32
94_V	1042_K	0.522	0.32
296_S	1094_V	0.522	0.32
929_S	1047_K	0.522	0.32
298_L	1054_T	0.522	0.32
345_L	400_M	0.522	0.32
736_L	951_K	0.521	0.32
141_L	144_V	0.521	0.32
566_Y	898_V	0.521	0.32
181_I	706_L	0.521	0.32
286_Y	826_E	0.521	0.32
195_E	796_L	0.520	0.32
461_L	777_L	0.520	0.32
307_L	469_I	0.520	0.32
1093_R	1143_I	0.520	0.32
177_R	1068_R	0.520	0.32
595_Y	648_L	0.520	0.32
609_D	971_R	0.519	0.32
93_A	995_F	0.519	0.32
39_S	55_L	0.519	0.32
649_L	796_L	0.519	0.32
596_A	914_M	0.519	0.32
1100_D	1103_A	0.519	0.32
27_E	1134_L	0.519	0.32
316_H	320_E	0.518	0.32
226_A	1017_E	0.518	0.32
662_I	951_K	0.518	0.32
878_L	882_E	0.518	0.32
179_G	533_N	0.518	0.32
48_E	54_F	0.518	0.32
655_Y	966_F	0.518	0.32
85_N	228_E	0.518	0.32
345_L	966_F	0.517	0.31
730_V	820_L	0.517	0.31
756_R	842_V	0.517	0.31
181_I	618_S	0.517	0.31
945_L	969_A	0.517	0.31
582_T	760_T	0.516	0.31
91_E	123_A	0.516	0.31
46_A	55_L	0.516	0.31
154_A	202_D	0.515	0.31
188_S	221_I	0.515	0.31
939_Y	1042_K	0.515	0.31
917_S	1044_D	0.514	0.31
142_I	789_S	0.514	0.31
303_D	1006_I	0.514	0.31
472_E	1023_I	0.514	0.31
284_V	288_S	0.514	0.31
891_T	913_K	0.513	0.31
414_G	622_Y	0.513	0.31
151_D	176_I	0.513	0.31
174_F	298_L	0.513	0.31
143_Q	215_I	0.513	0.31
610_H	993_V	0.513	0.31
592_I	1005_A	0.512	0.31
896_T	902_N	0.512	0.31
85_N	284_V	0.512	0.31
513_I	743_Y	0.512	0.31
729_I	1063_D	0.511	0.31
731_I	871_N	0.511	0.31
622_Y	634_E	0.511	0.31
432_I	641_R	0.511	0.31
617_E	640_E	0.511	0.31
95_A	284_V	0.511	0.31
837_F	938_T	0.511	0.31
557_G	984_A	0.511	0.31
353_V	896_T	0.510	0.31
543_Y	1038_D	0.510	0.31
496_S	553_Q	0.510	0.31
85_N	94_V	0.510	0.31
697_Q	701_I	0.510	0.31
450_I	614_R	0.510	0.31
152_Q	719_I	0.510	0.31
547_E	737_L	0.510	0.31
861_V	949_A	0.510	0.31
777_L	1001_M	0.509	0.31
749_L	862_A	0.509	0.31
303_D	361_L	0.509	0.31
968_I	1028_D	0.509	0.31
616_F	951_K	0.509	0.31
448_V	852_I	0.509	0.31
702_N	718_T	0.509	0.31
698_D	702_N	0.509	0.31
280_D	597_E	0.508	0.31
697_Q	1031_I	0.508	0.31
865_H	926_V	0.508	0.31
715_A	731_I	0.508	0.31
631_S	737_L	0.508	0.31
662_I	669_I	0.507	0.31
190_N	216_E	0.507	0.31
527_I	883_G	0.507	0.31
974_T	991_D	0.507	0.31
195_E	430_Y	0.506	0.31
198_D	286_Y	0.506	0.31
565_L	632_I	0.506	0.31
159_E	821_V	0.506	0.31
790_M	903_V	0.506	0.31
604_Y	773_D	0.506	0.31
875_T	949_A	0.505	0.30
454_E	459_F	0.505	0.30
89_S	95_A	0.504	0.30
89_S	282_E	0.504	0.30
668_A	773_D	0.504	0.30
66_V	590_D	0.504	0.30
537_Q	778_T	0.504	0.30
274_L	280_D	0.504	0.30
43_S	703_I	0.503	0.30
320_E	349_F	0.503	0.30
228_E	816_Y	0.503	0.30
100_R	844_D	0.503	0.30
296_S	352_I	0.503	0.30
315_I	901_P	0.503	0.30
70_L	599_E	0.503	0.30
167_M	1069_F	0.503	0.30
548_Q	961_E	0.503	0.30
543_Y	697_Q	0.502	0.30
163_E	170_A	0.502	0.30
52_P	113_G	0.502	0.30
773_D	839_Y	0.502	0.30
789_S	837_F	0.501	0.30
713_K	943_K	0.501	0.30
494_I	966_F	0.501	0.30
157_L	199_T	0.501	0.30
56_I	1061_L	0.501	0.30
578_K	581_E	0.501	0.30
307_L	360_L	0.501	0.30
711_T	917_S	0.501	0.30
603_G	756_R	0.501	0.30
995_F	1004_E	0.501	0.30
52_P	116_P	0.500	0.30
70_L	997_L	0.500	0.30
787_H	995_F	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hjhA	1	0.3738	100	0.793	Contact Map
1gm5A	1	0.5879	100	0.801	Contact Map
2d7dA	2	0.497	100	0.813	Contact Map
1c4oA	1	0.3874	100	0.822	Contact Map
4cbhA	1	0.2838	100	0.875	Contact Map
4q2cA	1	0.6134	100	0.879	Contact Map
4u4cA	1	0.4401	100	0.881	Contact Map
2fwrA	1	0.3067	100	0.884	Contact Map
4w7sA	2	0.3526	100	0.886	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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