GREMLIN Database
HPRT - Hypoxanthine-guanine phosphoribosyltransferase
UniProt: P37472 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 180 (167)
Sequences: 3013 (1847)
Seq/√Len: 142.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_E143_F3.4091.00
124_K142_D3.3101.00
40_G49_M2.7831.00
19_K22_E2.7811.00
112_V116_R2.6971.00
94_D121_K2.6141.00
21_K55_H2.5051.00
12_S15_E2.4611.00
94_D122_S2.4341.00
91_E119_K2.4131.00
28_T57_D2.3721.00
38_A53_I2.3591.00
19_K146_F2.2741.00
28_T58_T2.1141.00
34_T94_D1.9531.00
41_V111_L1.9481.00
120_A123_I1.9361.00
72_N161_A1.9331.00
109_S113_E1.9301.00
13_E17_Q1.8851.00
29_S32_Q1.8821.00
24_G28_T1.8591.00
148_V153_V1.8111.00
51_D54_K1.7661.00
23_L145_G1.7511.00
34_T121_K1.7431.00
130_D135_R1.7261.00
106_L136_K1.7001.00
36_P96_L1.6881.00
51_D156_Y1.6591.00
102_I141_A1.6521.00
112_V125_I1.6391.00
36_P93_R1.6171.00
30_E124_K1.6111.00
61_E93_R1.6011.00
129_L153_V1.5901.00
129_L170_I1.5461.00
31_Y124_K1.5001.00
31_Y122_S1.4951.00
47_P53_I1.4671.00
38_A96_L1.4591.00
85_D118_R1.4551.00
130_D147_E1.4511.00
84_K87_D1.4501.00
114_L118_R1.4381.00
17_Q55_H1.4161.00
38_A56_I1.4051.00
46_L62_M1.3911.00
19_K26_E1.3901.00
40_G45_A1.3691.00
46_L50_A1.3551.00
41_V65_M1.3541.00
151_A172_V1.3381.00
13_E168_P1.3291.00
24_G56_I1.3251.00
26_E30_E1.3101.00
8_K151_A1.2961.00
27_L52_L1.2741.00
27_L56_I1.2491.00
50_A54_K1.2341.00
21_K25_A1.2221.00
92_G121_K1.1881.00
52_L98_I1.1861.00
129_L148_V1.1771.00
134_G150_D1.1460.99
20_V48_F1.1410.99
15_E18_K1.1400.99
8_K172_V1.1280.99
47_P50_A1.1230.99
14_E18_K1.1130.99
25_A29_S1.1110.99
133_S150_D1.1110.99
132_P147_E1.1100.99
22_E146_F1.0920.99
28_T56_I1.0860.99
63_D84_K1.0760.99
7_E174_K1.0660.99
133_S149_P1.0580.99
47_P54_K1.0460.99
13_E55_H1.0460.99
26_E29_S1.0350.99
90_V120_A1.0300.99
25_A28_T1.0270.99
141_A144_V1.0220.99
48_F126_V1.0140.99
17_Q51_D1.0070.99
113_E116_R1.0050.99
67_V107_T1.0000.99
31_Y96_L0.9940.98
37_L88_T0.9910.98
46_L64_F0.9870.98
23_L126_V0.9850.98
86_L90_V0.9780.98
110_Y113_E0.9610.98
31_Y94_D0.9570.98
35_F93_R0.9560.98
99_E127_T0.9440.98
153_V158_L0.9440.98
22_E26_E0.9350.98
37_L61_E0.9320.98
35_F61_E0.9220.98
102_I127_T0.9170.97
97_I112_V0.9140.97
37_L93_R0.8970.97
39_I86_L0.8940.97
66_D83_I0.8910.97
65_M82_I0.8870.97
46_L53_I0.8860.97
43_K162_E0.8860.97
18_K22_E0.8800.97
97_I115_F0.8680.96
27_L126_V0.8640.96
11_I148_V0.8610.96
27_L96_L0.8590.96
130_D134_G0.8520.96
61_E163_R0.8490.96
127_T144_V0.8420.96
73_S161_A0.8420.96
99_E125_I0.8340.95
8_K174_K0.8260.95
113_E117_Y0.8250.95
53_I62_M0.8180.95
9_V171_G0.8150.95
109_S137_A0.8130.95
71_G77_S0.8050.95
36_P58_T0.8000.94
125_I139_I0.7950.94
66_D84_K0.7950.94
60_L166_N0.7890.94
11_I146_F0.7870.94
97_I125_I0.7850.94
53_I60_L0.7800.94
99_E102_I0.7740.93
41_V110_Y0.7680.93
36_P94_D0.7640.93
114_L117_Y0.7590.93
167_L171_G0.7540.92
76_S106_L0.7530.92
35_F163_R0.7450.92
130_D144_V0.7400.92
152_F160_Y0.7350.91
95_I123_I0.7310.91
13_E169_Y0.7280.91
133_S147_E0.7270.91
112_V139_I0.7210.91
126_V143_F0.7190.91
10_L172_V0.7190.91
39_I115_F0.7160.90
9_V12_S0.7160.90
16_I128_L0.7160.90
24_G55_H0.7110.90
25_A57_D0.7110.90
55_H168_P0.7020.89
17_Q54_K0.7000.89
128_L170_I0.6970.89
164_Y171_G0.6940.89
49_M62_M0.6850.88
116_R123_I0.6780.88
42_L64_F0.6780.88
71_G161_A0.6770.88
49_M98_I0.6730.87
90_V115_F0.6700.87
79_E89_S0.6680.87
38_A98_I0.6670.87
41_V45_A0.6660.87
20_V156_Y0.6570.86
7_E171_G0.6570.86
17_Q21_K0.6530.86
56_I60_L0.6520.86
73_S77_S0.6430.85
26_E143_F0.6400.85
20_V55_H0.6390.85
67_V111_L0.6390.85
96_L143_F0.6380.84
20_V128_L0.6350.84
69_S103_D0.6290.84
72_N77_S0.6280.84
39_I63_D0.6280.84
128_L146_F0.6240.83
35_F59_Y0.6230.83
37_L90_V0.6230.83
34_T122_S0.6190.83
79_E110_Y0.6170.82
130_D141_A0.6160.82
127_T130_D0.6150.82
90_V95_I0.6140.82
63_D88_T0.6120.82
51_D55_H0.6060.81
61_E88_T0.6050.81
106_L137_A0.6050.81
115_F120_A0.6030.81
67_V83_I0.6020.81
75_V79_E0.5950.80
81_K87_D0.5950.80
24_G107_T0.5930.80
69_S104_S0.5890.80
109_S116_R0.5890.80
69_S76_S0.5880.79
52_L56_I0.5830.79
71_G152_F0.5830.79
110_Y114_L0.5830.79
7_E173_L0.5790.78
82_I114_L0.5750.78
119_K123_I0.5750.78
159_D162_E0.5730.78
124_K143_F0.5720.78
102_I137_A0.5720.78
82_I85_D0.5700.77
163_R166_N0.5660.77
38_A49_M0.5630.76
72_N162_E0.5620.76
59_Y62_M0.5570.76
76_S80_V0.5560.76
10_L153_V0.5550.75
52_L126_V0.5540.75
27_L30_E0.5540.75
20_V51_D0.5530.75
101_I148_V0.5530.75
82_I110_Y0.5530.75
107_T110_Y0.5510.75
128_L158_L0.5490.75
108_L125_I0.5470.74
158_L173_L0.5460.74
43_K66_D0.5450.74
67_V80_V0.5450.74
59_Y163_R0.5420.74
81_K114_L0.5380.73
67_V82_I0.5360.73
65_M111_L0.5350.73
11_I19_K0.5340.73
30_E122_S0.5310.72
48_F156_Y0.5300.72
77_S80_V0.5230.71
9_V169_Y0.5230.71
27_L143_F0.5200.71
109_S138_D0.5200.71
112_V140_K0.5170.70
154_V164_Y0.5170.70
90_V123_I0.5140.70
49_M108_L0.5140.70
46_L166_N0.5130.70
22_E145_G0.5090.69
107_T111_L0.5080.69
160_Y163_R0.5060.69
160_Y164_Y0.5050.68
71_G75_V0.5030.68
101_I153_V0.5030.68
23_L143_F0.5030.68
15_E19_K0.5000.68
88_T92_G0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ozfA 4 0.9944 100 0.366 Contact Map
2jbhA 4 0.9833 100 0.366 Contact Map
4qyiA 3 0.9556 100 0.367 Contact Map
4raoA 4 0.9556 100 0.367 Contact Map
1fsgA 4 0.9944 100 0.374 Contact Map
1pzmA 2 0.8944 100 0.384 Contact Map
4rhxA 3 0.9722 100 0.387 Contact Map
1hgxA 2 0.9222 100 0.388 Contact Map
4rqaA 3 0.9611 100 0.389 Contact Map
4pfqA 4 1 100 0.391 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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