GREMLIN Database
DIVIC - Cell division protein DivIC
UniProt: P37471 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 125 (117)
Sequences: 373 (311)
Seq/√Len: 28.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_S117_I8.0421.00
103_L106_R3.9741.00
14_N17_K2.7271.00
95_K100_V2.4390.99
36_R63_L2.2950.99
58_S108_L2.1080.98
29_R33_G1.9580.96
107_D118_F1.9200.96
111_S116_I1.8910.95
31_R34_L1.8290.94
20_V23_Q1.8170.94
94_L111_S1.8140.94
34_L118_F1.7700.93
35_Y39_T1.7670.93
55_S118_F1.7430.93
68_E72_Q1.6840.91
97_E117_I1.6540.91
89_E93_K1.6500.91
107_D110_M1.6000.89
12_I19_Q1.5560.88
41_F45_V1.5530.88
59_Q118_F1.5420.87
100_V110_M1.5220.87
12_I25_Q1.5220.87
37_R87_L1.4970.86
104_A109_F1.4950.86
11_E14_N1.4520.84
48_T111_S1.4470.84
77_L100_V1.4350.83
11_E17_K1.4230.83
105_R115_E1.4010.82
43_A71_E1.3820.81
77_L81_K1.3800.81
105_R112_G1.3490.79
70_K101_T1.3480.79
88_K92_S1.3470.79
19_Q29_R1.2590.74
7_R117_I1.2500.74
8_T18_E1.2370.73
48_T102_E1.2290.72
42_G47_L1.1920.70
26_L93_K1.1720.69
16_Y111_S1.1400.66
99_Y112_G1.1310.66
6_E52_L1.1230.65
73_L80_L1.1230.65
40_V109_F1.1140.65
83_K86_D1.1030.64
82_T101_T1.0970.63
41_F47_L1.0680.61
101_T121_E1.0660.61
80_L84_Q1.0540.60
47_L78_K1.0510.60
100_V107_D1.0470.60
8_T15_D1.0150.57
54_S93_K1.0080.57
114_G119_N1.0010.56
63_L85_T0.9860.55
59_Q107_D0.9850.55
104_A110_M0.9780.54
76_E79_S0.9740.54
21_E102_E0.9540.53
7_R10_T0.9490.52
56_V81_K0.9430.52
8_T13_Q0.9290.51
66_K83_K0.9260.50
34_L109_F0.9240.50
68_E71_E0.9170.50
96_D122_K0.9130.49
41_F106_R0.9130.49
18_E76_E0.9050.49
45_V52_L0.8980.48
17_K49_A0.8880.47
22_R83_K0.8880.47
57_W68_E0.8850.47
85_T114_G0.8800.47
9_I57_W0.8790.47
36_R43_A0.8760.47
33_G106_R0.8760.47
65_A82_T0.8660.46
119_N122_K0.8580.45
8_T62_S0.8580.45
42_G119_N0.8470.44
100_V104_A0.8390.44
31_R69_K0.8330.43
41_F85_T0.8140.42
23_Q108_L0.8010.41
70_K93_K0.7940.40
34_L38_L0.7880.40
77_L107_D0.7870.40
15_D18_E0.7870.40
101_T104_A0.7840.40
55_S60_T0.7800.39
103_L107_D0.7780.39
54_S83_K0.7720.39
28_K51_V0.7660.38
58_S95_K0.7650.38
15_D20_V0.7590.38
105_R111_S0.7460.37
39_T50_I0.7450.37
69_K78_K0.7440.37
9_I15_D0.7420.36
11_E21_E0.7400.36
94_L102_E0.7250.35
30_R35_Y0.7230.35
49_A95_K0.7120.34
32_K74_E0.7060.34
59_Q110_M0.7050.34
110_M117_I0.7010.34
26_L30_R0.6840.32
52_L121_E0.6840.32
63_L103_L0.6820.32
62_S117_I0.6820.32
93_K116_I0.6820.32
8_T39_T0.6810.32
85_T89_E0.6790.32
42_G118_F0.6750.32
56_V98_D0.6680.31
66_K79_S0.6560.31
75_K95_K0.6560.31
57_W120_V0.6540.30
74_E113_D0.6540.30
57_W113_D0.6430.30
65_A85_T0.6410.30
49_A118_F0.6390.29
6_E46_F0.6370.29
19_Q22_R0.6310.29
38_L45_V0.6300.29
9_I51_V0.6300.29
48_T52_L0.6280.29
44_L90_E0.6260.29
97_E100_V0.6220.28
24_N103_L0.6200.28
51_V55_S0.6190.28
26_L50_I0.6160.28
117_I121_E0.6160.28
6_E68_E0.6150.28
91_I95_K0.6090.28
101_T110_M0.6070.27
46_F83_K0.6060.27
37_R90_E0.5980.27
52_L111_S0.5970.27
35_Y49_A0.5970.27
6_E91_I0.5940.27
93_K103_L0.5930.27
36_R60_T0.5910.26
71_E75_K0.5900.26
61_S86_D0.5790.26
12_I62_S0.5750.25
19_Q45_V0.5720.25
85_T88_K0.5650.25
67_E118_F0.5650.25
93_K120_V0.5590.25
50_I53_A0.5580.24
62_S96_D0.5540.24
44_L67_E0.5530.24
23_Q68_E0.5520.24
18_E73_L0.5480.24
23_Q79_S0.5450.24
8_T44_L0.5450.24
38_L66_K0.5340.23
59_Q63_L0.5310.23
42_G63_L0.5300.23
28_K44_L0.5260.23
92_S107_D0.5260.23
33_G59_Q0.5260.23
24_N107_D0.5240.23
86_D100_V0.5130.22
7_R72_Q0.5110.22
19_Q48_T0.5100.22
75_K79_S0.5080.22
59_Q103_L0.5060.22
34_L107_D0.5060.22
84_Q88_K0.5050.22
11_E15_D0.5040.21
27_K88_K0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q4gX 1 0 78.3 0.885 Contact Map
1rz2A 1 0.536 69.5 0.892 Contact Map
4cgkA 3 0.44 69.3 0.892 Contact Map
4etpB 1 0.496 43 0.908 Contact Map
4dznA 3 0.256 40 0.91 Contact Map
3owqA 1 0.256 31.2 0.915 Contact Map
4e61A 2 0.48 24.6 0.919 Contact Map
2w3zA 1 0.304 24.4 0.919 Contact Map
2ap3A 1 0.664 22 0.921 Contact Map
1nlwA 1 0.6 20.3 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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