GREMLIN Database
PTH - Peptidyl-tRNA hydrolase
UniProt: P37470 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 188 (184)
Sequences: 4096 (2803)
Seq/√Len: 206.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_R77_D3.3251.00
118_I126_F3.1181.00
76_M86_L2.7971.00
90_Y114_I2.7041.00
27_D60_K2.6421.00
2_L85_D2.5961.00
17_T149_S2.4671.00
48_T55_K2.4401.00
72_L117_L2.4171.00
67_L70_E2.3631.00
93_L133_I2.3221.00
44_G59_V2.3061.00
59_V75_L2.2741.00
112_N115_K2.1851.00
43_N70_E2.1091.00
44_G71_C2.0811.00
35_I47_G2.0631.00
28_Q31_K2.0121.00
35_I49_G1.9791.00
93_L142_V1.9641.00
5_A72_L1.8541.00
26_I58_L1.8361.00
12_K15_E1.7671.00
32_E167_K1.7511.00
116_S120_H1.7291.00
16_N24_M1.6941.00
108_A115_K1.6911.00
32_E170_E1.6101.00
45_L62_L1.6081.00
30_A58_L1.6061.00
171_A180_V1.6031.00
108_A118_I1.5761.00
28_Q163_D1.5661.00
26_I37_L1.5621.00
87_T129_I1.5231.00
59_V71_C1.5061.00
37_L47_G1.5041.00
76_M121_L1.4391.00
88_V117_L1.4251.00
73_R120_H1.4121.00
21_V131_I1.3991.00
175_K179_E1.3811.00
176_P180_V1.3731.00
63_T71_C1.3641.00
176_P179_E1.3621.00
23_F60_K1.3521.00
104_T178_L1.3521.00
127_D177_F1.3381.00
33_W170_E1.3331.00
171_A184_F1.3281.00
67_L116_S1.3111.00
28_Q32_E1.3101.00
83_N123_T1.3061.00
97_T161_A1.2991.00
143_V148_G1.2761.00
171_A175_K1.2761.00
155_A159_E1.2741.00
25_V162_V1.2351.00
114_I126_F1.2351.00
82_D85_D1.2301.00
137_V140_M1.2291.00
116_S119_Q1.2261.00
87_T172_S1.2211.00
179_E183_E1.2181.00
152_K156_P1.2131.00
70_E120_H1.2041.00
25_V89_I1.1861.00
28_Q166_V1.1851.00
24_M155_A1.1791.00
157_E160_E1.1771.00
97_T134_G1.1731.00
135_R142_V1.1611.00
104_T127_D1.1471.00
33_W49_G1.1391.00
102_L177_F1.1371.00
175_K183_E1.1361.00
30_A37_L1.1331.00
3_V81_V1.1321.00
131_I161_A1.1261.00
10_P62_L1.1251.00
7_L65_M1.1251.00
151_T154_E1.1121.00
18_R154_E1.1081.00
16_N155_A1.0871.00
140_M144_D1.0851.00
25_V165_S1.0811.00
89_I169_C1.0711.00
94_D130_R1.0691.00
43_N74_P1.0671.00
25_V131_I1.0651.00
141_K144_D1.0601.00
32_E166_V1.0511.00
30_A47_G1.0411.00
3_V59_V1.0391.00
29_L169_C1.0341.00
37_L60_K1.0291.00
24_M150_F1.0181.00
76_M81_V1.0131.00
33_W51_V1.0131.00
4_I89_I1.0051.00
102_L129_I1.0041.00
28_Q162_V1.0011.00
96_P99_K0.9921.00
97_T157_E0.9841.00
50_F55_K0.9801.00
158_I162_V0.9781.00
94_D135_R0.9761.00
51_V56_V0.9681.00
87_T169_C0.9651.00
156_P159_E0.9651.00
171_A176_P0.9621.00
105_K125_E0.9490.99
30_A35_I0.9310.99
108_A124_S0.9260.99
136_P142_V0.9230.99
160_E163_D0.9220.99
168_A184_F0.9140.99
87_T127_D0.9120.99
160_E164_K0.9110.99
179_E182_N0.9050.99
153_E156_P0.9000.99
29_L33_W0.8990.99
28_Q159_E0.8990.99
24_M162_V0.8950.99
97_T158_I0.8940.99
52_S174_S0.8920.99
92_D109_G0.8910.99
156_P160_E0.8890.99
56_V173_L0.8850.99
65_M111_H0.8840.99
44_G62_L0.8760.99
23_F61_P0.8760.99
21_V24_M0.8700.99
115_K119_Q0.8670.99
18_R148_G0.8650.99
23_F62_L0.8570.99
42_F78_Y0.8560.99
32_E163_D0.8510.99
25_V169_C0.8480.99
5_A86_L0.8390.99
164_K167_K0.8390.99
161_A165_S0.8380.99
16_N149_S0.8320.99
95_L99_K0.8300.99
70_E116_S0.8250.98
74_P77_D0.8210.98
129_I172_S0.8180.98
170_E174_S0.8160.98
37_L46_Y0.8130.98
171_A183_E0.8110.98
167_K170_E0.8020.98
23_F27_D0.7900.98
169_C173_L0.7870.98
4_I169_C0.7850.98
6_G26_I0.7790.98
3_V75_L0.7780.98
154_E157_E0.7760.98
92_D130_R0.7750.98
21_V158_I0.7720.98
90_Y94_D0.7710.98
2_L54_K0.7700.98
168_A180_V0.7680.98
93_L135_R0.7550.97
46_Y75_L0.7520.97
118_I124_S0.7510.97
39_Q48_T0.7430.97
171_A174_S0.7400.97
103_R106_G0.7300.97
42_F74_P0.7300.97
97_T150_F0.7280.97
45_L60_K0.7250.97
90_Y130_R0.7240.97
14_Y17_T0.7220.97
2_L82_D0.7220.97
77_D120_H0.7220.97
89_I131_I0.7200.96
150_F158_I0.7130.96
86_L121_L0.7080.96
163_D167_K0.7080.96
41_K46_Y0.7060.96
152_K155_A0.7060.96
110_G114_I0.7050.96
95_L130_R0.7050.96
84_E125_E0.7020.96
51_V54_K0.7020.96
106_G128_R0.7010.96
72_L86_L0.6990.96
57_L75_L0.6970.96
84_E104_T0.6960.96
134_G145_Y0.6910.96
52_S170_E0.6880.95
102_L168_A0.6880.95
37_L45_L0.6830.95
159_E163_D0.6810.95
166_V170_E0.6760.95
110_G118_I0.6740.95
95_L101_R0.6740.95
106_G114_I0.6690.95
42_F59_V0.6680.95
166_V169_C0.6680.95
108_A114_I0.6670.95
46_Y57_L0.6650.95
24_M158_I0.6610.94
140_M145_Y0.6480.94
5_A59_V0.6440.94
50_F53_G0.6410.93
49_G56_V0.6380.93
133_I146_V0.6360.93
129_I169_C0.6340.93
172_S180_V0.6270.93
4_I87_T0.6200.92
100_I161_A0.6200.92
102_L127_D0.6180.92
3_V76_M0.6170.92
46_Y79_Y0.6160.92
162_V166_V0.6140.92
8_G23_F0.6130.92
11_G64_Y0.6120.92
180_V184_F0.6120.92
38_N47_G0.6080.91
21_V150_F0.6030.91
92_D95_L0.6010.91
97_T159_E0.6000.91
100_I184_F0.5990.91
103_R107_S0.5970.91
178_L182_N0.5970.91
2_L87_T0.5960.91
83_N121_L0.5950.91
137_V145_Y0.5940.90
129_I165_S0.5930.90
119_Q122_G0.5930.90
24_M149_S0.5880.90
76_M83_N0.5870.90
30_A36_E0.5870.90
51_V173_L0.5860.90
89_I165_S0.5750.89
182_N185_N0.5730.89
111_H116_S0.5710.89
94_D142_V0.5690.89
25_V166_V0.5630.88
100_I164_K0.5610.88
160_E167_K0.5580.88
48_T57_L0.5570.87
164_K183_E0.5560.87
13_N149_S0.5550.87
108_A116_S0.5540.87
112_N126_F0.5540.87
67_L120_H0.5520.87
109_G130_R0.5490.87
90_Y105_K0.5430.86
93_L136_P0.5420.86
131_I165_S0.5410.86
114_I130_R0.5410.86
57_L79_Y0.5400.86
26_I60_K0.5390.86
18_R149_S0.5380.86
41_K78_Y0.5380.86
90_Y103_R0.5370.86
111_H114_I0.5360.85
4_I26_I0.5330.85
6_G22_G0.5330.85
64_Y67_L0.5310.85
104_T177_F0.5280.85
100_I129_I0.5270.84
11_G15_E0.5260.84
42_F79_Y0.5230.84
100_I185_N0.5170.83
158_I161_A0.5140.83
97_T154_E0.5140.83
77_D80_D0.5090.82
117_L121_L0.5090.82
51_V170_E0.5080.82
30_A49_G0.5040.82
81_V85_D0.5020.82
149_S155_A0.5020.82
93_L143_V0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pthA 1 1 100 0.01 Contact Map
2mjlA 1 1 100 0.011 Contact Map
4qt4A 1 0.9894 100 0.011 Contact Map
2z2iA 1 0.9309 100 0.011 Contact Map
4qajA 1 1 100 0.014 Contact Map
1rybA 1 0.9734 100 0.015 Contact Map
4lwrA 1 0.9947 100 0.017 Contact Map
3v2iA 1 0.9574 100 0.017 Contact Map
3neaA 1 0.9787 100 0.02 Contact Map
1cfzA 1 0.7766 48.8 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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