GREMLIN Database
DNAC - Replicative DNA helicase
UniProt: P37469 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 454 (433)
Sequences: 3920 (2651)
Seq/√Len: 127.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
366_G369_Q3.9241.00
42_D113_S3.5451.00
305_C317_I3.4181.00
202_R354_Q3.2991.00
191_T440_N3.2421.00
188_T200_F3.1841.00
124_T146_T3.0601.00
262_N272_D2.9671.00
234_S315_G2.9321.00
377_M393_V2.8871.00
233_E315_G2.8421.00
204_D246_Q2.8201.00
40_P53_N2.7521.00
227_V316_M2.6301.00
219_F223_I2.6021.00
374_R413_E2.5401.00
430_A441_L2.5111.00
400_D410_N2.4371.00
236_A308_L2.3621.00
343_S389_D2.2911.00
160_Q244_A2.2911.00
317_I355_V2.2701.00
396_L414_I2.2681.00
196_M425_G2.2091.00
73_E76_N2.1991.00
168_Q245_E2.1971.00
210_A396_L2.1731.00
187_P194_D2.1341.00
224_A318_L2.1251.00
61_R73_E2.0671.00
234_S287_G2.0551.00
207_I390_A2.0351.00
291_D304_K2.0161.00
305_C353_L2.0111.00
370_R379_D2.0101.00
197_T392_I1.9951.00
411_I428_S1.9881.00
213_S421_N1.9801.00
55_M65_V1.9761.00
298_V345_E1.9541.00
205_L346_L1.9441.00
289_Y312_S1.9391.00
193_L394_A1.9371.00
395_F417_A1.9151.00
408_N428_S1.9081.00
214_V402_Y1.9031.00
335_R382_E1.8931.00
189_G194_D1.8891.00
335_R338_E1.8851.00
208_V358_I1.8771.00
399_D403_D1.8751.00
57_V77_T1.8641.00
301_I325_I1.8481.00
25_F70_V1.8351.00
113_S117_R1.8351.00
37_V106_A1.8351.00
162_I248_V1.8351.00
214_V401_Y1.8131.00
210_A214_V1.7411.00
259_N262_N1.7401.00
432_V439_V1.7381.00
31_L56_L1.7341.00
229_T286_S1.6981.00
57_V73_E1.6971.00
190_F429_L1.6661.00
24_I31_L1.6571.00
186_I227_V1.6451.00
112_K115_L1.6391.00
161_N164_D1.6371.00
225_Q255_E1.6361.00
80_L84_G1.6321.00
228_A288_I1.6261.00
207_I386_I1.6221.00
73_E77_T1.6131.00
419_Q423_P1.6101.00
392_I419_Q1.6061.00
21_L48_H1.6041.00
343_S359_A1.6021.00
122_A125_I1.5821.00
256_G435_Y1.5821.00
271_E275_K1.5811.00
128_D142_E1.5701.00
220_A318_L1.5671.00
54_A73_E1.5611.00
318_L358_I1.5581.00
218_A250_R1.5541.00
411_I441_L1.5521.00
159_F236_A1.5471.00
196_M416_I1.5331.00
252_L276_L1.5281.00
172_N176_L1.5271.00
257_N435_Y1.5231.00
236_A317_I1.5211.00
40_P56_L1.5211.00
171_D175_Q1.5191.00
24_I55_M1.5161.00
208_V219_F1.5151.00
415_I426_T1.5111.00
20_V38_L1.5041.00
135_E138_D1.5021.00
41_D49_Q1.4971.00
340_S385_S1.4951.00
52_Y56_L1.4881.00
72_S76_N1.4851.00
18_Q88_Y1.4631.00
119_I129_G1.4621.00
20_V109_V1.4611.00
51_I88_Y1.4601.00
202_R315_G1.4561.00
174_E178_N1.4511.00
145_K149_E1.4421.00
323_Q361_S1.4391.00
213_S424_V1.4371.00
9_L12_Q1.4311.00
218_A436_N1.4271.00
172_N245_E1.4111.00
192_E440_N1.4111.00
203_N243_G1.4081.00
117_R120_R1.4051.00
11_P119_I1.4021.00
264_R419_Q1.3961.00
42_D110_E1.3941.00
236_A305_C1.3901.00
413_E426_T1.3831.00
234_S313_G1.3751.00
71_T89_L1.3641.00
412_I438_F1.3581.00
224_A237_I1.3581.00
37_V107_K1.3541.00
281_G285_N1.3421.00
45_R48_H1.3391.00
103_E107_K1.3371.00
54_A70_V1.3341.00
46_M49_Q1.3231.00
255_E282_S1.3211.00
316_M358_I1.3181.00
336_Q340_S1.3181.00
397_Y402_Y1.3091.00
192_E195_R1.3081.00
50_K79_L1.3061.00
225_Q254_A1.3011.00
97_P105_Y1.2991.00
16_A109_V1.2981.00
173_I276_L1.2961.00
301_I319_I1.2951.00
122_A129_G1.2951.00
213_S418_K1.2941.00
200_F316_M1.2911.00
259_N434_E1.2781.00
184_T201_Q1.2771.00
122_A126_A1.2751.00
30_A102_I1.2741.00
200_F223_I1.2701.00
253_C263_L1.2641.00
165_V244_A1.2641.00
146_T149_E1.2551.00
419_Q422_G1.2531.00
18_Q95_S1.2491.00
302_R352_E1.2321.00
219_F414_I1.2311.00
204_D421_N1.2301.00
123_T126_A1.2210.99
220_A360_L1.2170.99
23_A102_I1.2150.99
24_I34_A1.2130.99
14_I45_R1.2120.99
110_E114_I1.2100.99
432_V435_Y1.2100.99
394_A414_I1.1960.99
333_D337_Q1.1960.99
169_T249_M1.1830.99
349_I353_L1.1790.99
374_R426_T1.1780.99
201_Q204_D1.1780.99
381_R388_Q1.1720.99
169_T173_I1.1670.99
228_A235_V1.1650.99
305_C357_V1.1600.99
226_N231_T1.1600.99
309_K354_Q1.1560.99
364_S367_V1.1560.99
53_N57_V1.1550.99
34_A106_A1.1470.99
125_I143_A1.1450.99
102_I106_A1.1440.99
258_I276_L1.1430.99
71_T75_A1.1430.99
398_R402_Y1.1430.99
224_A235_V1.1400.99
13_N72_S1.1350.99
48_H88_Y1.1250.99
370_R376_M1.1230.99
430_A439_V1.1220.99
334_N337_Q1.1150.99
432_V437_K1.1130.99
119_I130_Y1.1110.99
203_N354_Q1.1050.99
79_L82_E1.0980.99
43_F52_Y1.0940.99
237_I288_I1.0930.99
18_Q48_H1.0900.99
365_R387_E1.0880.99
16_A108_I1.0850.99
223_I227_V1.0830.99
309_K314_L1.0820.99
221_L251_M1.0800.99
289_Y308_L1.0750.99
187_P231_T1.0710.99
367_V401_Y1.0670.99
381_R384_G1.0660.99
257_N437_K1.0650.99
142_E146_T1.0500.98
322_L386_I1.0420.98
262_N269_T1.0410.98
309_K313_G1.0400.98
296_I301_I1.0370.98
180_K267_N1.0370.98
333_D336_Q1.0300.98
349_I357_V1.0290.98
374_R415_I1.0290.98
211_R368_E1.0230.98
269_T272_D1.0130.98
319_I346_L1.0080.98
108_I112_K1.0060.98
142_E145_K1.0050.98
159_F308_L1.0040.98
364_S401_Y1.0040.98
191_T195_R1.0020.98
22_G96_V1.0000.98
120_R124_T0.9990.98
160_Q165_V0.9980.98
160_Q164_D0.9910.98
169_T252_L0.9820.98
364_S393_V0.9820.98
396_L412_I0.9800.98
253_C259_N0.9780.98
213_S377_M0.9770.97
190_F222_N0.9750.97
175_Q178_N0.9730.97
221_L237_I0.9700.97
34_A102_I0.9680.97
406_T409_K0.9660.97
160_Q168_Q0.9640.97
115_L139_L0.9600.97
373_K402_Y0.9550.97
293_T296_I0.9540.97
217_T247_L0.9520.97
236_A355_V0.9490.97
227_V233_E0.9450.97
272_D275_K0.9430.97
214_V412_I0.9410.97
368_E373_K0.9380.97
219_F396_L0.9340.97
197_T416_I0.9310.97
166_L280_M0.9300.97
86_I90_T0.9280.97
268_L276_L0.9270.97
87_S91_D0.9250.96
193_L414_I0.9230.96
107_K111_E0.9210.96
175_Q179_R0.9210.96
201_Q264_R0.9200.96
256_G279_A0.9200.96
72_S75_A0.9190.96
367_V373_K0.9150.96
121_T146_T0.9120.96
42_D117_R0.9100.96
348_S351_R0.9080.96
67_L71_T0.9060.96
211_R387_E0.9060.96
228_A286_S0.9010.96
80_L85_G0.9000.96
177_H273_W0.8960.96
114_I140_L0.8960.96
232_D285_N0.8950.96
206_I392_I0.8920.96
15_E18_Q0.8910.96
406_T411_I0.8910.96
365_R384_G0.8900.96
21_L92_I0.8890.96
208_V220_A0.8880.96
110_E113_S0.8860.96
336_Q382_E0.8830.95
287_G315_G0.8830.95
205_L343_S0.8810.95
72_S108_I0.8800.95
13_N112_K0.8750.95
31_L59_G0.8740.95
18_Q91_D0.8730.95
71_T80_L0.8730.95
11_P130_Y0.8720.95
343_S385_S0.8710.95
384_G387_E0.8670.95
172_N175_Q0.8660.95
46_M50_K0.8660.95
32_T59_G0.8640.95
51_I89_L0.8610.95
28_P65_V0.8610.95
41_D117_R0.8600.95
305_C314_L0.8590.95
340_S344_R0.8580.95
212_P387_E0.8580.95
31_L35_S0.8560.95
324_L389_D0.8540.95
65_V69_T0.8520.94
165_V248_V0.8500.94
271_E274_G0.8500.94
257_N439_V0.8490.94
399_D406_T0.8480.94
198_A265_T0.8480.94
33_L103_E0.8470.94
240_L296_I0.8450.94
87_S90_T0.8410.94
347_K391_D0.8380.94
315_G355_V0.8330.94
205_L359_A0.8310.94
400_D406_T0.8310.94
57_V61_R0.8300.94
158_A304_K0.8290.94
329_G332_K0.8260.94
168_Q171_D0.8240.93
221_L247_L0.8220.93
11_P44_Y0.8190.93
236_A314_L0.8180.93
38_L43_F0.8180.93
225_Q251_M0.8170.93
28_P70_V0.8170.93
410_N430_A0.8160.93
377_M417_A0.8120.93
66_D105_Y0.8100.93
294_P352_E0.8090.93
224_A228_A0.8070.93
101_N104_Y0.8020.92
124_T128_D0.7970.92
134_D138_D0.7890.92
196_M419_Q0.7890.92
390_A393_V0.7880.92
224_A288_I0.7880.92
377_M395_F0.7850.92
165_V169_T0.7840.92
278_M282_S0.7770.91
144_E148_M0.7770.91
12_Q44_Y0.7770.91
80_L83_V0.7760.91
328_S341_E0.7740.91
27_Q99_A0.7700.91
188_T194_D0.7690.91
200_F227_V0.7680.91
400_D409_K0.7670.91
115_L129_G0.7670.91
400_D433_K0.7660.91
261_Q265_T0.7660.91
385_S389_D0.7650.91
24_I28_P0.7650.91
316_M356_P0.7650.91
346_L359_A0.7640.91
123_T127_Q0.7640.91
121_T150_V0.7640.91
39_I42_D0.7590.90
67_L90_T0.7590.90
141_S299_S0.7580.90
193_L200_F0.7570.90
35_S59_G0.7560.90
218_A221_L0.7560.90
246_Q421_N0.7550.90
209_A363_L0.7550.90
403_D406_T0.7540.90
190_F219_F0.7530.90
66_D101_N0.7510.90
23_A99_A0.7510.90
141_S145_K0.7510.90
212_P368_E0.7500.90
296_I304_K0.7480.90
261_Q423_P0.7480.90
398_R401_Y0.7470.90
251_M288_I0.7450.89
203_N246_Q0.7440.89
217_T221_L0.7440.89
30_A33_L0.7420.89
53_N79_L0.7390.89
238_F317_I0.7340.89
128_D146_T0.7320.89
176_L249_M0.7290.88
26_L97_P0.7280.88
240_L324_L0.7280.88
172_N249_M0.7270.88
193_L416_I0.7270.88
227_V235_V0.7270.88
211_R365_R0.7260.88
212_P390_A0.7250.88
166_L169_T0.7230.88
212_P384_G0.7230.88
63_E107_K0.7190.88
255_E279_A0.7160.88
314_L353_L0.7160.88
16_A68_V0.7130.87
213_S392_I0.7130.87
171_D174_E0.7120.87
59_G65_V0.7120.87
121_T147_I0.7120.87
204_D419_Q0.7110.87
91_D94_N0.7080.87
198_A201_Q0.7080.87
323_Q382_E0.7070.87
368_E378_S0.7070.87
334_N338_E0.7070.87
292_D351_R0.7060.87
225_Q229_T0.7040.87
54_A77_T0.7030.87
67_L89_L0.7000.86
169_T248_V0.6990.86
54_A57_V0.6980.86
235_V316_M0.6970.86
13_N16_A0.6970.86
193_L197_T0.6940.86
138_D141_S0.6910.86
336_Q385_S0.6910.86
413_E428_S0.6910.86
50_K83_V0.6890.85
319_I359_A0.6890.85
296_I300_E0.6880.85
405_E409_K0.6880.85
138_D142_E0.6840.85
414_I427_V0.6830.85
121_T143_A0.6820.85
397_Y401_Y0.6800.85
218_A431_F0.6800.85
260_A436_N0.6800.85
336_Q351_R0.6770.84
14_I18_Q0.6760.84
26_L99_A0.6750.84
401_Y424_V0.6740.84
81_E84_G0.6740.84
101_N105_Y0.6730.84
222_N254_A0.6710.84
309_K315_G0.6710.84
336_Q364_S0.6680.84
58_L69_T0.6630.83
222_N225_Q0.6620.83
372_D397_Y0.6610.83
111_E135_E0.6610.83
216_K320_D0.6610.83
363_L381_R0.6600.83
259_N272_D0.6580.83
242_M420_R0.6580.83
428_S441_L0.6560.83
298_V325_I0.6560.83
223_I316_M0.6540.82
121_T125_I0.6530.82
148_M152_Q0.6530.82
30_A34_A0.6520.82
349_I352_E0.6520.82
56_L60_D0.6510.82
384_G388_Q0.6500.82
50_K53_N0.6490.82
232_D287_G0.6490.82
339_V383_S0.6480.82
19_A66_D0.6470.82
344_R348_S0.6470.82
397_Y415_I0.6460.82
235_V318_L0.6460.82
229_T255_E0.6450.82
51_I54_A0.6440.81
75_A80_L0.6440.81
240_L381_R0.6430.81
220_A358_I0.6420.81
192_E427_V0.6420.81
367_V370_R0.6400.81
200_F358_I0.6400.81
326_Q341_E0.6390.81
58_L63_E0.6370.81
223_I358_I0.6370.81
72_S112_K0.6360.81
414_I429_L0.6360.81
350_A357_V0.6360.81
40_P49_Q0.6340.80
62_G326_Q0.6320.80
319_I357_V0.6310.80
399_D402_Y0.6300.80
57_V60_D0.6300.80
229_T282_S0.6290.80
398_R412_I0.6270.80
124_T127_Q0.6270.80
298_V327_G0.6240.79
23_A105_Y0.6240.79
126_A129_G0.6230.79
214_V380_I0.6230.79
173_I263_L0.6230.79
38_L52_Y0.6230.79
71_T86_I0.6220.79
173_I176_L0.6210.79
124_T142_E0.6200.79
192_E441_L0.6200.79
26_L96_V0.6200.79
97_P109_V0.6190.79
123_T130_Y0.6180.79
369_Q376_M0.6170.79
149_E152_Q0.6160.78
277_T281_G0.6150.78
211_R388_Q0.6150.78
31_L65_V0.6140.78
209_A380_I0.6110.78
309_K353_L0.6090.78
361_S385_S0.6090.78
32_T310_Q0.6080.78
239_S247_L0.6080.78
118_L122_A0.6080.78
305_C349_I0.6070.77
224_A247_L0.6050.77
110_E153_R0.6050.77
380_I395_F0.6050.77
22_G98_T0.6020.77
336_Q343_S0.6010.77
326_Q344_R0.6010.77
74_L84_G0.6000.77
164_D168_Q0.5990.77
339_V343_S0.5990.77
27_Q30_A0.5940.76
25_F55_M0.5930.76
24_I30_A0.5920.76
88_Y92_I0.5920.76
274_G277_T0.5890.75
44_Y116_R0.5890.75
201_Q419_Q0.5880.75
324_L344_R0.5880.75
176_L266_G0.5870.75
262_N267_N0.5870.75
367_V397_Y0.5840.75
144_E151_A0.5840.75
114_I136_V0.5840.75
416_I419_Q0.5840.75
81_E85_G0.5830.75
212_P388_Q0.5810.74
408_N413_E0.5800.74
280_M284_S0.5780.74
104_Y107_K0.5770.74
331_S334_N0.5770.74
185_G266_G0.5760.74
400_D412_I0.5750.74
103_E106_A0.5750.74
170_Y280_M0.5730.73
298_V346_L0.5730.73
165_V168_Q0.5730.73
122_A147_I0.5730.73
324_L363_L0.5720.73
419_Q427_V0.5670.73
205_L395_F0.5660.72
279_A282_S0.5650.72
203_N351_R0.5650.72
53_N77_T0.5640.72
413_E440_N0.5640.72
243_G246_Q0.5610.72
201_Q421_N0.5610.72
241_E362_Q0.5600.72
237_I318_L0.5590.72
385_S388_Q0.5590.72
429_L440_N0.5580.71
115_L136_V0.5570.71
167_V284_S0.5540.71
98_T126_A0.5530.71
39_I56_L0.5520.71
227_V315_G0.5510.70
333_D338_E0.5500.70
326_Q348_S0.5470.70
54_A74_L0.5470.70
20_V102_I0.5470.70
54_A58_L0.5470.70
344_R389_D0.5470.70
55_M70_V0.5460.70
119_I123_T0.5460.70
202_R356_P0.5450.70
74_L80_L0.5450.70
34_A37_V0.5450.70
270_E275_K0.5450.70
206_I358_I0.5440.69
385_S393_V0.5440.69
295_G326_Q0.5440.69
430_A442_E0.5440.69
204_D213_S0.5430.69
197_T201_Q0.5420.69
86_I91_D0.5410.69
207_I395_F0.5410.69
380_I393_V0.5400.69
412_I433_K0.5380.69
165_V290_I0.5380.69
405_E408_N0.5370.69
212_P380_I0.5370.69
314_L355_V0.5370.69
252_L280_M0.5360.68
302_R349_I0.5350.68
345_E348_S0.5330.68
209_A367_V0.5320.68
24_I65_V0.5310.68
111_E132_R0.5310.68
213_S401_Y0.5290.67
118_L147_I0.5280.67
372_D402_Y0.5280.67
274_G278_M0.5270.67
376_M379_D0.5270.67
309_K312_S0.5270.67
158_A311_E0.5260.67
225_Q286_S0.5260.67
128_D139_L0.5260.67
321_Y339_V0.5250.67
212_P363_L0.5250.67
96_V99_A0.5240.67
205_L347_K0.5240.67
50_K54_A0.5230.66
91_D95_S0.5220.66
215_G320_D0.5220.66
380_I384_G0.5220.66
216_K241_E0.5210.66
300_E417_A0.5200.66
419_Q425_G0.5190.66
143_A147_I0.5190.66
66_D69_T0.5190.66
140_L150_V0.5170.66
257_N432_V0.5170.66
363_L368_E0.5160.65
59_G310_Q0.5150.65
171_D277_T0.5150.65
201_Q213_S0.5140.65
336_Q381_R0.5140.65
308_L312_S0.5140.65
404_K408_N0.5140.65
64_P69_T0.5140.65
401_Y412_I0.5130.65
375_P384_G0.5130.65
183_I187_P0.5120.65
62_G65_V0.5110.65
306_R352_E0.5110.65
169_T172_N0.5110.65
19_A68_V0.5090.64
197_T206_I0.5090.64
45_R63_E0.5090.64
172_N202_R0.5080.64
20_V43_F0.5060.64
51_I92_I0.5060.64
34_A52_Y0.5060.64
283_L288_I0.5060.64
317_I357_V0.5050.64
339_V342_I0.5050.64
193_L427_V0.5030.64
293_T304_K0.5030.64
162_I166_L0.5020.63
194_D223_I0.5010.63
323_Q380_I0.5010.63
287_G312_S0.5000.63
364_S377_M0.5000.63
317_I349_I0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q6tA 1 0.9317 100 0.205 Contact Map
4nmnA 3 0.9405 100 0.207 Contact Map
3bgwA 3 0.9141 100 0.222 Contact Map
2r6aA 5 0.9251 100 0.229 Contact Map
3bh0A 1 0.6167 100 0.511 Contact Map
4a1fA 2 0.6322 100 0.52 Contact Map
1cr0A 3 0.5154 100 0.591 Contact Map
1q57A 3 0.9075 100 0.597 Contact Map
3io5A 2 0.4361 100 0.687 Contact Map
1nlfA 3 0.5198 100 0.699 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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