GREMLIN Database
RSMA - Ribosomal RNA small subunit methyltransferase A
UniProt: P37468 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 292 (256)
Sequences: 4647 (2940)
Seq/√Len: 183.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
270_R274_S3.6911.00
276_S279_E3.0171.00
67_A96_V3.0131.00
270_R279_E2.9351.00
51_G74_V2.7951.00
159_A204_A2.6461.00
72_K97_T2.6451.00
279_E282_A2.5721.00
83_L100_H2.3751.00
33_D194_V2.3661.00
39_R188_M2.2671.00
107_D110_S2.2541.00
160_E186_T2.2301.00
74_V99_I2.2231.00
183_E209_I2.2181.00
185_K207_R2.2031.00
130_Y203_S2.1671.00
183_E211_R2.1651.00
185_K209_I2.1471.00
231_S280_F2.1201.00
156_K189_I2.0891.00
65_Q68_K2.0851.00
192_K202_D2.0651.00
66_L125_V2.0361.00
42_D69_R1.9801.00
80_Q100_H1.9561.00
29_N198_Q1.9311.00
175_S179_Q1.9281.00
163_A184_A1.9211.00
182_T208_L1.9001.00
219_E285_N1.8951.00
238_T269_K1.8671.00
50_T123_M1.8471.00
191_P194_V1.8351.00
275_L279_E1.8171.00
70_A73_V1.7891.00
38_N65_Q1.7801.00
227_L284_S1.7541.00
186_T189_I1.7001.00
187_V207_R1.6921.00
211_R215_A1.6901.00
64_E89_T1.6751.00
57_P75_A1.6611.00
189_I204_A1.6531.00
162_M178_V1.6431.00
123_M149_G1.6391.00
76_F106_A1.6371.00
47_T50_T1.5981.00
176_I228_I1.5981.00
138_M177_A1.5921.00
103_V108_V1.5701.00
87_K100_H1.5681.00
186_T204_A1.5621.00
32_I196_V1.5571.00
238_T241_N1.5321.00
259_Q263_E1.5311.00
149_G207_R1.5251.00
178_V184_A1.5251.00
137_I154_L1.5131.00
23_K81_R1.4881.00
121_E148_K1.4871.00
258_E262_E1.4871.00
153_M190_V1.4871.00
43_H187_V1.4761.00
156_K160_E1.4691.00
76_F103_V1.4491.00
151_V207_R1.4221.00
139_K143_E1.4171.00
37_L65_Q1.4141.00
176_I277_I1.4141.00
66_L73_V1.4091.00
46_V52_V1.3901.00
282_A285_N1.3901.00
22_F196_V1.3711.00
124_V140_L1.3711.00
64_E90_L1.3441.00
192_K200_N1.3431.00
223_F284_S1.3421.00
167_S274_S1.3261.00
267_D270_R1.3251.00
224_F228_I1.3181.00
83_L87_K1.3151.00
26_L78_I1.3141.00
103_V136_I1.3011.00
263_E286_G1.2961.00
266_I270_R1.2941.00
133_T154_L1.2861.00
162_M206_I1.2851.00
264_T286_G1.2681.00
190_V205_V1.2281.00
22_F59_I1.2281.00
231_S272_G1.2271.00
223_F287_L1.2201.00
160_E170_E1.2181.00
180_F224_F1.2101.00
154_L159_A1.2051.00
213_G217_D1.2051.00
193_T198_Q1.1961.00
51_G72_K1.1891.00
128_L152_V1.1841.00
216_V281_A1.1781.00
99_I106_A1.1771.00
141_L182_T1.1731.00
189_I202_D1.1691.00
236_R273_E1.1661.00
156_K202_D1.1581.00
49_K71_K1.1571.00
101_Q106_A1.1491.00
182_T210_L1.1381.00
36_I194_V1.1381.00
41_V125_V1.1371.00
75_A98_V1.1341.00
233_A242_N1.1321.00
179_Q184_A1.1301.00
151_V205_V1.1181.00
188_M205_V1.1111.00
133_T158_V1.1061.00
90_L96_V1.1031.00
34_T65_Q1.0831.00
267_D274_S1.0781.00
74_V97_T1.0731.00
75_A96_V1.0671.00
88_D91_S1.0581.00
231_S239_L1.0551.00
231_S242_N1.0531.00
259_Q262_E1.0521.00
149_G209_I1.0491.00
169_K273_E1.0471.00
165_D168_S1.0421.00
265_N282_A1.0391.00
163_A186_T1.0301.00
162_M184_A1.0251.00
144_H221_E1.0241.00
46_V70_A1.0211.00
44_A126_A1.0201.00
53_I76_F1.0160.99
44_A125_V1.0090.99
102_D105_K1.0010.99
67_A95_N1.0000.99
260_V287_L0.9990.99
63_T73_V0.9990.99
44_A52_V0.9890.99
53_I112_I0.9830.99
76_F111_V0.9820.99
51_G71_K0.9800.99
262_E268_G0.9800.99
46_V50_T0.9750.99
35_N38_N0.9680.99
26_L81_R0.9650.99
83_L98_V0.9610.99
55_I124_V0.9580.99
182_T211_R0.9570.99
38_N42_D0.9560.99
101_Q105_K0.9530.99
35_N194_V0.9500.99
126_A152_V0.9500.99
278_E282_A0.9490.99
41_V46_V0.9440.99
242_N272_G0.9430.99
59_I82_L0.9390.99
217_D285_N0.9390.99
181_Y225_F0.9340.99
27_G131_Y0.9340.99
211_R214_P0.9260.99
156_K204_A0.9200.99
34_T64_E0.9150.99
180_F221_E0.9100.99
37_L61_A0.9080.99
180_F277_I0.8990.99
59_I85_I0.8940.99
18_Y88_D0.8940.99
258_E268_G0.8900.99
84_P87_K0.8880.99
104_L132_V0.8850.99
44_A151_V0.8840.99
43_H188_M0.8800.99
137_I162_M0.8780.99
57_P86_L0.8770.99
281_A285_N0.8720.98
240_L258_E0.8680.98
221_E225_F0.8660.98
51_G120_D0.8560.98
192_K198_Q0.8450.98
52_V70_A0.8440.98
230_A272_G0.8330.98
156_K186_T0.8200.98
227_L231_S0.8180.98
86_L98_V0.8110.98
171_Y280_F0.8070.97
132_V136_I0.8070.97
109_K145_L0.8060.97
163_A204_A0.8050.97
123_M148_K0.8040.97
173_S229_K0.8010.97
103_V128_L0.8010.97
123_M151_V0.8000.97
37_L41_V0.7980.97
35_N39_R0.7920.97
150_I210_L0.7900.97
37_L153_M0.7870.97
164_A168_S0.7840.97
34_T38_N0.7820.97
142_E225_F0.7810.97
90_L93_Y0.7780.97
224_F284_S0.7770.97
40_I205_V0.7750.97
75_A86_L0.7710.97
171_Y175_S0.7650.96
223_F227_L0.7630.96
221_E224_F0.7620.96
222_S226_Q0.7590.96
44_A123_M0.7580.96
23_K26_L0.7560.96
39_R193_T0.7560.96
40_I153_M0.7550.96
112_I122_I0.7540.96
226_Q246_N0.7490.96
223_F226_Q0.7470.96
282_A286_G0.7450.96
48_E71_K0.7430.96
108_V136_I0.7380.96
46_V123_M0.7360.96
53_I122_I0.7350.96
50_T148_K0.7340.96
20_F81_R0.7280.95
103_V132_V0.7280.95
183_E215_A0.7270.95
77_E83_L0.7260.95
128_L136_I0.7230.95
147_L150_I0.7210.95
176_I280_F0.7190.95
260_V286_G0.7170.95
180_F218_V0.7160.95
172_G273_E0.7160.95
65_Q69_R0.7150.95
226_Q230_A0.7130.95
124_V147_L0.7120.95
214_P281_A0.7110.95
22_F30_F0.7100.95
137_I178_V0.7090.95
239_L243_L0.7090.95
51_G119_C0.7090.95
180_F225_F0.7010.94
173_S177_A0.6990.94
128_L133_T0.6960.94
227_L246_N0.6940.94
261_L268_G0.6930.94
191_P202_D0.6900.94
143_E147_L0.6860.94
177_A225_F0.6830.93
21_S81_R0.6790.93
218_V285_N0.6780.93
130_Y153_M0.6750.93
180_F281_A0.6740.93
103_V139_K0.6730.93
138_M142_E0.6720.93
188_M204_A0.6700.93
262_E265_N0.6690.93
192_K201_V0.6670.93
190_V201_V0.6640.92
212_D215_A0.6640.92
59_I89_T0.6600.92
234_Q242_N0.6550.92
121_E212_D0.6500.92
142_E222_S0.6500.92
138_M173_S0.6470.92
261_L265_N0.6450.91
109_K143_E0.6450.91
181_Y221_E0.6430.91
73_V126_A0.6420.91
163_A206_I0.6400.91
108_V139_K0.6390.91
218_V281_A0.6360.91
36_I188_M0.6340.91
22_F82_L0.6310.90
239_L275_L0.6290.90
19_G22_F0.6280.90
124_V152_V0.6250.90
160_E189_I0.6240.90
36_I190_V0.6230.90
20_F85_I0.6230.90
236_R271_R0.6230.90
85_I88_D0.6200.90
39_R42_D0.6190.90
66_L70_A0.6180.90
41_V69_R0.6150.89
61_A65_Q0.6140.89
93_Y96_V0.6120.89
53_I108_V0.6090.89
240_L244_V0.6070.89
29_N200_N0.6070.89
272_G280_F0.6060.89
183_E212_D0.6050.89
161_R164_A0.6040.88
153_M203_S0.6020.88
43_H207_R0.6010.88
41_V65_Q0.5980.88
154_L178_V0.5970.88
55_I140_L0.5960.88
78_I100_H0.5960.88
52_V73_V0.5940.88
30_F82_L0.5940.88
81_R84_P0.5920.88
84_P88_D0.5910.87
266_I279_E0.5900.87
109_K146_P0.5900.87
227_L280_F0.5890.87
20_F59_I0.5870.87
231_S243_L0.5820.87
135_P139_K0.5810.87
36_I191_P0.5800.86
49_K120_D0.5790.86
154_L162_M0.5770.86
37_L62_L0.5770.86
122_I147_L0.5750.86
275_L280_F0.5740.86
50_T120_D0.5740.86
134_T150_I0.5720.86
106_A110_S0.5720.86
144_H147_L0.5710.86
133_T138_M0.5710.86
55_I152_V0.5700.85
67_A90_L0.5700.85
18_Y83_L0.5700.85
233_A272_G0.5670.85
192_K204_A0.5670.85
91_S94_E0.5660.85
76_F242_N0.5620.85
37_L126_A0.5600.84
143_E146_P0.5570.84
101_Q110_S0.5560.84
40_I130_Y0.5560.84
46_V125_V0.5540.84
150_I208_L0.5540.84
140_L150_I0.5530.84
257_I261_L0.5520.84
230_A246_N0.5510.84
154_L173_S0.5500.83
173_S228_I0.5500.83
224_F227_L0.5490.83
179_Q277_I0.5480.83
153_M205_V0.5470.83
134_T173_S0.5470.83
23_K80_Q0.5460.83
257_I287_L0.5450.83
52_V123_M0.5440.83
133_T137_I0.5430.83
39_R43_H0.5420.83
171_Y277_I0.5410.82
152_V210_L0.5360.82
22_F25_S0.5360.82
218_V224_F0.5330.81
67_A93_Y0.5330.81
90_L98_V0.5300.81
235_R273_E0.5300.81
246_N249_E0.5290.81
57_P67_A0.5290.81
134_T138_M0.5280.81
180_F211_R0.5280.81
238_T242_N0.5270.81
144_H210_L0.5270.81
29_N82_L0.5270.81
283_L286_G0.5260.81
184_A206_I0.5260.81
173_S225_F0.5230.80
232_F235_R0.5220.80
52_V69_R0.5200.80
190_V194_V0.5180.80
264_T283_L0.5150.79
46_V71_K0.5150.79
264_T270_R0.5150.79
241_N273_E0.5100.79
63_T96_V0.5090.78
60_G67_A0.5090.78
238_T274_S0.5070.78
40_I158_V0.5060.78
71_K120_D0.5060.78
277_I281_A0.5060.78
57_P78_I0.5050.78
35_N191_P0.5040.78
224_F277_I0.5020.78
67_A98_V0.5000.77
249_E259_Q0.5000.77
31_L36_I0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i4wA 1 0.9281 100 0.27 Contact Map
4gc5A 2 0.976 100 0.276 Contact Map
4jxjA 1 0.839 100 0.296 Contact Map
3futA 1 0.911 100 0.314 Contact Map
3tqsA 1 0.8425 100 0.325 Contact Map
3gruA 1 0.8699 100 0.326 Contact Map
3uzuA 1 0.8767 100 0.33 Contact Map
1qyrA 1 0.863 100 0.332 Contact Map
3ftdA 1 0.8185 100 0.371 Contact Map
1zq9A 2 0.863 100 0.386 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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